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Self-assembly Of Gd3+/SDS/HEPES Complex And Curcumin Entrapment For Enhanced Stability, Fluorescence Image In Cellular System.

Chonticha Sahub, G. Tumcharern, P. Chirawatkul, Vithaya Ruangpornvisuti, S. Ekgasit, Supasorn Wanichweacharungruang, Thawatchai Tuntulani, T. Palaga, Boosayarat Tomapatanaget
Published 2017 · Chemistry, Medicine

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At present, strategies to disperse hydrophobic molecules in water without altering their chemical structures include conventional surfactant-based micellar and vesicular systems, encapsulation into water dispersible polymeric nanoparticles, and loading onto the surface of various metal nanoparticles. Here, we report a simple and low cost platform to incorporate hydrophobic molecules into a stable water dispersible nanostructure that can significantly increase the stability of the encapsulated materials. The platform is based on the incorporation of hydrophobic molecules into the self-assembled complex of gadolinium ion (Gd3+), sodium dodecyl sulfate (SDS), and 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) called GdSH. After being incorporated, the two model hydrophobic dyes, curcumin and curcumin borondifluoride show approximately 50% and 30% improved stability, respectively. Investigation of the self-assembled 10-14 multilayered 60nm spheres with inter-layer distances of 4.25nm indicates coordination of SDS and HEPES with Gd3+. Incorporation of the hydrophobic molecules into the multilayered spheres results in reduction of the interlayer distance of the multilayer spheres to 4.17nm, suggesting enhanced packing of the hydrophobic chain of SDS and HEPES around the Gd3+. The incorporation of the two curcuminoids into the self-assembled complex also causes an increase in fluorescence quantum yield of the two dyes, thus suggesting spatial confinement of the packed dye molecules. The better cellular uptake of the nanoparticles is responsible for the expected enhancement in fluorescence image of the encapsulated materials.
This paper references
10.1179/016164110X12656393665044
Diagnosis and treatment in stroke: a report from the 10th Tiantan International Stroke Conference
Y. Ding (2010)
10.1021/NL035139X
Interaction of Fatty Acid Monolayers with Cobalt Nanoparticles
Nianqiang Wu (2004)
10.1021/ja8058843
Nanoparticles of adaptive supramolecular networks self-assembled from nucleotides and lanthanide ions.
Ryuhei Nishiyabu (2009)
10.1002/ijc.24336
Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice
N. Narayanan (2009)
10.4314/TJPR.V12I3.5
Characterization of Microemulsions Prepared using Isopropyl Palmitate with various Surfactants and Cosurfactants
H. S. Basheer (2013)
10.1021/IC061861X
Gadolinium acetylacetonate tetraphenyl monoporphyrinate complex and some of its derivatives: EXAFS study and molecular dynamics simulation.
J. Agondanou (2007)
10.1016/J.JTICE.2010.09.013
Reducibility of Ni and NiPt supported on zeolite beta investigated by XANES
Sirinuch Loiha (2011)
10.1016/J.CARBPOL.2010.08.008
Efficient water soluble O-carboxymethyl chitosan nanocarrier for the delivery of curcumin to cancer cells
A. Anitha (2011)
10.1016/j.ijpharm.2008.09.009
An in vitro study of liposomal curcumin: stability, toxicity and biological activity in human lymphocytes and Epstein-Barr virus-transformed human B-cells.
C. Chen (2009)
10.1016/J.TET.2010.05.088
Synthesis, photophysical properties, and cyanide detection in aqueous solution of BF2-curcumin dyes
Anusak Chaicham (2010)
10.1016/S0968-0896(00)82152-5
Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes.
Z. Sui (1993)
10.1021/ja9047043
Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits.
Chongzhao Ran (2009)
10.1002/anie.200904124
Confining molecules within aqueous coordination nanoparticles by adaptive molecular self-assembly.
Ryuhei Nishiyabu (2009)
10.1158/1535-7163.MCT-06-0556
Liposomal curcumin with and without oxaliplatin: effects on cell growth, apoptosis, and angiogenesis in colorectal cancer
L. Li (2007)
10.1111/j.2042-7158.1992.tb03608.x
Safety Aspects of Non‐ionic Surfactant Vesicles: A Toxicity Study Related to the Physicochemical Characteristics of Non‐ionic Surfactants
H. E. Hofland (1992)
10.1016/j.biomaterials.2010.06.007
Curcumin polymers as anticancer conjugates.
Huadong Tang (2010)
10.1021/JM700988F
Design and development of water-soluble curcumin conjugates as potential anticancer agents.
A. Safavy (2007)
10.1039/c3ob42201a
Syntheses and photophysical properties of BF2 complexes of curcumin analogues.
Guifeng Bai (2014)
10.2174/138955710791330891
Perspectives on chemopreventive and therapeutic potential of curcumin analogs in medicinal chemistry.
S. Padhye (2010)
10.1002/JPS.20283
Correlation between epithelial toxicity and surfactant structure as derived from the effects of polyethyleneoxide surfactants on caco-2 cell monolayers and pig nasal mucosa.
K. Ekelund (2005)
10.2174/1381612820666140826154601
Curcumin in combined cancer therapy.
Koraljka Gall Trošelj (2014)
10.1039/C4TC00543K
Two-photon excited fluorescence of BF2 complexes of curcumin analogues: toward NIR-to-NIR fluorescent organic nanoparticles
A. D’Aléo (2014)
Molecular docking and inhibition of matrix metalloproteinase-2 by novel difluorinatedbenzylidene curcumin analog.
A. Ahmad (2015)
10.1148/RADIOL.2422060245
Cytotoxicity of iodinated and gadolinium-based contrast agents in renal tubular cells at angiographic concentrations: in vitro study.
M. Heinrich (2007)
10.1021/CR940055H
The Binary Rare Earth Oxides.
Gin-ya Adachi (1998)
10.1016/J.NANTOD.2010.05.003
Functionalisation of nanoparticles for biomedical applications
N. T. Thanh (2010)
10.1021/jo400389h
Synthesis and photophysical properties of difluoroboron complexes of curcuminoid derivatives bearing different terminal aromatic units and a meso-aryl ring.
Abdellah Felouat (2013)
10.1007/s00280-006-0355-x
Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine
T. H. Marczylo (2006)
10.1107/S0909049505012719
ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT.
B. Ravel (2005)
10.1016/J.COLSURFA.2010.09.011
Nanosized magnetofluorescent Fe3O4-curcumin conjugate for multimodal monitoring and drug targeting
L. Tran (2010)
10.1021/CM0700100
Seedless, Surfactantless, High-Yield Synthesis of Branched Gold Nanocrystals in HEPES Buffer Solution
J. Xie (2007)
10.1007/s00216-009-2846-1
Lewis acid–base interactions enhance explosives sensing in silacycle polymers
J. C. Sanchez (2009)
10.2116/ANALSCI.30.1129
Naked-eye and colorimetric detection of arsenic(III) using difluoroboron-curcumin in aqueous and resin bead support systems.
Sirinya Sirawatcharin (2014)
10.1016/J.MATCHEMPHYS.2010.01.011
Reducibility of cobalt species impregnated on NaY and HY zeolites
P. Khemthong (2010)
10.1179/174367509X12581069052090
Long-term safety of combined intracerebral delivery of free gadolinium and targeted chemotherapeutic agent PRX321
D. Ding (2010)
10.1021/OL702370M
Synthesis of monofunctional curcumin derivatives, clicked curcumin dimer, and a PAMAM dendrimer curcumin conjugate for therapeutic applications.
W. Shi (2007)
10.1007/s12393-015-9115-1
Encapsulation of Functional Lipophilic Food and Drug Biocomponents
Ş. Dima (2015)
10.2174/138161213805289273
A review of therapeutic effects of curcumin.
A. Noorafshan (2013)
10.6028/nbs.nsrds.36
Critical Micelle Concentrations of Aqueous Surfactant Systems
P. Mukerjee (2018)
10.1016/S0731-7085(96)02024-9
Stability of curcumin in buffer solutions and characterization of its degradation products.
Y. Wang (1997)
10.1016/j.saa.2015.07.064
Fluorescent difluoroboron-curcumin analogs: An investigation of the electronic structures and photophysical properties.
Sachin N. Margar (2016)
10.1021/nn7003525
Boron polylactide nanoparticles exhibiting fluorescence and phosphorescence in aqueous medium.
A. Pfister (2008)



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