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Oral Delivery Of Anticancer Drugs III: Formulation Using Drug Delivery Systems.

Silvia Mazzaferro, K. Bouchemal, G. Ponchel
Published 2013 · Chemistry, Medicine

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In the past few years, the growth of nanometric size drug delivery systems (DDS) has burst into challenging innovations enabling real progresses to achieve oral delivery of anticancer drugs. DDS, such as polymeric nanoparticles, micelles, dendrimers and lipid-based formulations enable physico-chemical properties of cytotoxic agents to be improved and oral bioavailability to be enhanced. In this review we highlight current DDS used for the oral delivery of anticancer drugs.
This paper references
10.1021/JS950477M
Oral administration of recombinant human erythropoietin in liposomes in rats: influence of lipid composition and size of liposomes on bioavailability.
Y. Maitani (1996)
10.1016/j.jconrel.2009.08.015
Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation.
Yong-mei Yin (2009)
10.1023/A:1018902031370
Ability of Doxorubicin-Loaded Nanoparticles to Overcome Multidrug Resistance of Tumor Cells After Their Capture by Macrophages
C. E. Soma (2004)
10.1080/10717540260397873
Sequestration and Ultrasound-Induced Release of Doxorubicin from Stabilized Pluronic P105 Micelles
J. Pruitt (2002)
10.1016/J.BIOMATERIALS.2004.07.050
Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs.
K. Y. Win (2005)
10.1016/S0378-5173(03)00158-3
Polyethylene glycol-coated liposomes for oral delivery of recombinant human epidermal growth factor.
H. Li (2003)
10.1016/j.ejpb.2010.07.004
Formulation of mucoadhesive vaginal hydrogels insensitive to dilution with vaginal fluids.
Armelle Aka-Any-Grah (2010)
10.1016/J.IJPHARM.2005.01.018
Investigation of lectin-modified insulin liposomes as carriers for oral administration.
N. Zhang (2005)
Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance.
J. Coon (1991)
10.1016/S0168-3659(02)00050-0
Microemulsion formulation for enhanced absorption of poorly soluble drugs. II. In vivo study.
K. Kawakami (2002)
Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake.
Hiromichi Imanaka (2008)
10.1016/J.IJPHARM.2004.07.006
The effect of PAMAM dendrimer generation size and surface functional group on the aqueous solubility of nifedipine.
B. Devarakonda (2004)
10.1016/j.biomaterials.2009.02.045
Poly(lactide)-vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of Docetaxel.
S. Feng (2009)
10.1016/0024-3205(81)90728-1
Can intact liposomes be absorbed in the gut?
D. S. Deshmukh (1981)
10.1016/S0168-3659(02)00419-4
Effects of polyether-modified poly(acrylic acid) microgels on doxorubicin transport in human intestinal epithelial Caco-2 cell layers.
L. Bromberg (2003)
10.1016/S0928-0987(02)00055-6
Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers.
B. Rege (2002)
10.1016/S0927-7765(99)00063-6
Stabilization and activation of Pluronic micelles for tumor-targeted drug delivery
N. Rapoport (1999)
10.1016/j.jconrel.2009.04.024
Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs.
Ho-chul Shin (2009)
10.1016/j.jconrel.2008.10.002
Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles.
Houli Li (2009)
10.1021/JS980235X
Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin.
K. Iwanaga (1999)
10.1158/0008-5472.CAN-06-2066
Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro.
Meredith T. Morgan (2006)
10.1016/J.JCONREL.2004.09.021
Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound.
Z. Gao (2005)
10.1016/S0168-3659(99)00133-9
Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-L-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance.
K. Kataoka (2000)
10.1023/A:1018888927852
Body Distribution of Camptothecin Solid Lipid Nanoparticles After Oral Administration
Shicheng Yang (2004)
The use of p-glycoprotein inhibitor surfactants at the surface of the colloidal carrier
アルフ、ランプレヒト (2003)
10.1016/J.IJPHARM.2004.05.030
Bioadhesive properties and rheology of polyether-modified poly(acrylic acid) hydrogels.
L. Bromberg (2004)
10.1016/S0378-5173(98)00404-9
Enzymatic degradation of SLN-effect of surfactant and surfactant mixtures.
C. Olbrich (1999)
10.1016/S0168-3659(03)00093-2
Application of polyethyleneglycol (PEG)-modified liposomes for oral vaccine: effect of lipid dose on systemic and mucosal immunity.
Seiichiro Minato (2003)
10.1023/A:1016214332030
In Vitro Evaluation of Polymerized Liposomes as an Oral Drug Delivery System
J. Okada (2004)
10.1016/J.BIOMATERIALS.2004.03.011
Synthesis and in vitro evaluation of a novel thiolated chitosan.
K. Kafedjiiski (2005)
10.1016/j.ijpharm.2009.05.069
The gastrointestinal stability of lipid nanocapsules.
E. Roger (2009)
10.1023/A:1007587523543
Anionic PAMAM Dendrimers Rapidly Cross Adult Rat Intestine In Vitro: A Potential Oral Delivery System?
R. Wiwattanapatapee (2004)
Hypoglycemic efficacy of chitosan-coated insulin liposomes after oral administration in mice
Wu (2004)
In vitro evaluation of polymerized liposomes as an oral drug delivery system
J Okada (1995)
10.1080/10717540490280769
Stability of Liposomal Formulations in Physiological Conditions for Oral Drug Delivery
M. C. Taira (2004)
10.1023/A:1022286422439
Enhanced Oral Bioavailability of Paclitaxel by Coadministration of the P-Glycoprotein Inhibitor KR30031
J. Woo (2004)
Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization.
E. Batrakova (2001)
10.1023/A:1011942814300
Effects of Pluronic P85 Unimers and Micelles on Drug Permeability in Polarized BBMEC and Caco-2 Cells
E. Batrakova (2004)
10.1016/0168-3659(95)00059-H
Nanoparticles as carriers for oral peptide absorption: Studies on particle uptake and fate
A. T. Florence (1995)
10.1016/J.IJPHARM.2007.01.052
Synthesis of high loading and encapsulation efficient paclitaxel-loaded poly(n-butyl cyanoacrylate) nanoparticles via miniemulsion.
C. Huang (2007)
10.1002/JPS.21155
Enhanced oral bioavailability of doxorubicin in a dendrimer drug delivery system.
Weilun Ke (2008)
10.1007/s11095-006-0022-2
Enhanced Oral Paclitaxel Bioavailability After Administration of Paclitaxel-Loaded Lipid Nanocapsules
S. Peltier (2006)
10.1021/BC060240P
Dendrimer versus linear conjugate: Influence of polymeric architecture on the delivery and anticancer effect of paclitaxel.
J. Khandare (2006)
10.1016/j.ejps.2009.09.010
Combined hydroxypropyl-beta-cyclodextrin and poly(anhydride) nanoparticles improve the oral permeability of paclitaxel.
M. Agüeros (2009)
10.1016/J.IJPHARM.2005.08.022
The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds.
H. Araya (2005)
10.1023/A:1018987928936
Self-Emulsifying Drug Delivery Systems: Formulation and Biopharmaceutic Evaluation of an Investigational Lipophilic Compound
S. Charman (2004)
10.1023/B:PHAM.0000016238.44452.f1
Enhanced Oral Absorption of Paclitaxel in a Novel Self-Microemulsifying Drug Delivery System with or Without Concomitant Use of P-Glycoprotein Inhibitors
Shicheng Yang (2004)
10.1007/s10439-005-8973-8
Oral Chemotherapeutic Delivery: Design and Cellular Response
J. Blanchette (2005)
10.1016/S0378-5173(99)00463-9
Polyamidoamine Starburst dendrimers as solubility enhancers.
O. M. Milhem (2000)
10.1016/S0169-409X(98)00041-6
Evaluation of nano- and microparticle uptake by the gastrointestinal tract.
Delie (1998)
10.1021/BM070226V
Solubilization of docetaxel in poly(ethylene oxide)-block-poly(butylene/styrene oxide) micelles.
Mahmoud Elsabahy (2007)
10.1016/S0168-3659(02)00049-4
Microemulsion formulation for enhanced absorption of poorly soluble drugs. I. Prescription design.
K. Kawakami (2002)
10.1002/JPS.20780
Lipid formulation strategies for enhancing intestinal transport and absorption of P-glycoprotein (P-gp) substrate drugs: in vitro/in vivo case studies.
P. Constantinides (2007)
10.1016/j.ejpb.2011.01.021
Development and characterization of a novel lipid nanocapsule formulation of Sn38 for oral administration.
E. Roger (2011)
10.1016/S0142-9612(99)00125-8
Reversion of multidrug resistance by co-encapsulation of doxorubicin and cyclosporin A in polyalkylcyanoacrylate nanoparticles.
C. E. Soma (2000)
10.1016/S0928-0987(99)00064-0
Stability of SUV liposomes in the presence of cholate salts and pancreatic lipases: effect of lipid composition.
M. Kokkona (2000)
10.1021/BC970118D
Interactions of pluronic block copolymers with brain microvessel endothelial cells: evidence of two potential pathways for drug absorption.
D. Miller (1997)
10.1016/j.jconrel.2010.11.022
G3.5 PAMAM dendrimers enhance transepithelial transport of SN38 while minimizing gastrointestinal toxicity.
Deborah S. Goldberg (2011)
10.1016/S0168-3659(02)00087-1
Transepithelial transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers.
M. Elsayed (2002)
10.1002/jps.21993
Self-emulsifying O/W formulations of paclitaxel prepared from mixed nonionic surfactants.
Jen-Ting Lo (2010)
10.1111/j.1349-7006.2001.tb01099.x
Cisplatin‐incorporated Polymeric Micelles Eliminate Nephrotoxicity, While Maintaining Antitumor Activity
Y. Mizumura (2001)
10.1016/S0378-5173(96)04731-X
Biodegradation of solid lipid nanoparticles as a function of lipase incubation time
R. Mueller (1996)
10.1016/J.CARBPOL.2010.09.009
Preparation and characterization of chitosan–polylactide composites blended with Cloisite 30B for control release of the anticancer drug paclitaxel
Rajashree Nanda (2011)
Hypoglycemic efficacy of chitosan-coated insulin liposomes after oral administration in mice.
Z. Wu (2004)
10.1211/0022357044959
Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs
L. Hu (2004)
10.1016/J.EJPS.2005.04.003
Enhanced oral paclitaxel absorption with vitamin E-TPGS: effect on solubility and permeability in vitro, in situ and in vivo.
M. Varma (2005)
10.1016/S0378-5173(03)00271-0
Thiolated polymers--thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates.
A. Bernkop-Schnürch (2003)
10.1016/S0141-3910(02)00113-1
Hydrolysis of poly (n-butylcyanoacrylate) nanoparticles using esterase
C. O'sullivan (2002)
10.1016/J.IJPHARM.2005.07.023
Comparison of the aqueous solubilization of practically insoluble niclosamide by polyamidoamine (PAMAM) dendrimers and cyclodextrins.
B. Devarakonda (2005)
10.1007/s11095-011-0634-z
The Counterbalanced Effect of Size and Surface Properties of Chitosan-Coated poly(isobutylcyanoacrylate) Nanoparticles on Mucoadhesion Due to Pluronic F68 Addition
B. Petit (2011)
10.1016/S0168-3659(02)00025-1
Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol).
L. Mu (2002)
10.1016/S0378-5173(03)00391-0
Transport mechanism(s) of poly (amidoamine) dendrimers across Caco-2 cell monolayers.
M. Elsayed (2003)
10.1007/s11095-008-9572-9
Potential Oral Delivery of 7-Ethyl-10-Hydroxy-Camptothecin (SN-38) using Poly(amidoamine) Dendrimers
Rohit B. Kolhatkar (2008)
10.1016/j.biomaterials.2010.09.036
Development and in vivo evaluation of an oral drug delivery system for paclitaxel.
J. Iqbal (2011)
10.1016/0168-3659(96)01459-9
Polymerized liposomes as potential oral vaccine carriers: Stability and bioavailability
Hongming Chen (1996)
10.1016/j.ejps.2009.02.010
Bioadhesive properties and biodistribution of cyclodextrin-poly(anhydride) nanoparticles.
M. Agüeros (2009)
10.1016/J.IJPHARM.2006.02.037
Elaboration and characterization of thiolated chitosan-coated acrylic nanoparticles.
I. Bravo-Osuna (2006)
10.1016/0014-5793(81)80015-4
Uptake of free and liposome‐entrapped horseradish peroxidase by rat intestinal sacs in vitro
R. Rowland (1981)
10.1016/j.jconrel.2009.08.010
Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis.
E. Roger (2009)
10.1016/S0378-5173(03)00231-X
Colloidal anticancer drugs bioavailabilities in oral administration models.
V. Moutardier (2003)
10.1016/J.BIOMATERIALS.2005.05.104
Nanoparticles of poly(lactide)/vitamin E TPGS copolymer for cancer chemotherapy: synthesis, formulation, characterization and in vitro drug release.
Z. Zhang (2006)



This paper is referenced by
10.1016/j.drudis.2016.04.007
Intracellular transport of nanocarriers across the intestinal epithelium.
W. Fan (2016)
10.1016/j.ejpb.2017.09.012
Concomitant solubility‐permeability increase: Vitamin E TPGS vs. amorphous solid dispersion as oral delivery systems for etoposide
A. Beig (2017)
10.1016/j.ejpb.2017.04.020
Mucoadhesive properties of low molecular weight chitosan‐ or glycol chitosan‐ and corresponding thiomer‐coated poly(isobutylcyanoacrylate) core‐shell nanoparticles
C. Palazzo (2017)
10.3109/1061186X.2014.945090
Stable phosphatidylcholine-bile salt mixed micelles enhance oral absorption of paclitaxel: preparation and mechanism in rats
Yanli Zhao (2014)
10.1002/9781118462157.CH4
Interfacial science and the creation of nanoparticles
S. R. Dungan (2015)
Fonctionnalisation de biopolymères extraits de macroalgues pour encapsuler des principes actifs hydrophobes
Latufa Youssouf (2016)
10.33974/IJRHCP.V2I3.232
Clinical implications of novel polymer and lipid based drug delivery systems
Kallem Sharat Venkat Reddy (2020)
10.1021/bm401890x
Immobilization of coacervate microcapsules in multilayer sodium alginate beads for efficient oral anticancer drug delivery.
C. Feng (2014)
10.1111/jphp.12887
Enhancement of oral bioavailability of magnolol by encapsulation in mixed micelles containing pluronic F127 and L61
Hongxue Shen (2018)
10.1016/j.ijpharm.2020.119655
Pyridoclax-loaded nanoemulsion for enhanced anticancer effect on ovarian cancer.
A. Groo (2020)
Natural Polyphenol-Dendrimers Nano-Formulations for Therapeutic Applications in Medicine
E. Halevas (2018)
10.1016/j.carbpol.2019.115484
Polylysine and cysteine functionalized chitosan nanoparticle as an efficient platform for oral delivery of paclitaxel.
X. Du (2020)
POLYMERIC MICELLAR NETWORK DERIVED FROM THE POLYMERIZATION OF BICONTIUOUS MICROEMULSION FOR ORAL DRUG DELIVERY APPLICATION A Thesis
Oluyomi Sodunke (2015)
10.2147/IJN.S106116
Self-assembled nanoparticles based on amphiphilic chitosan derivative and arginine for oral curcumin delivery
M. A. Raja (2016)
10.3390/nano8100825
Nanoemulsion-Enabled Oral Delivery of Novel Anticancer ω-3 Fatty Acid Derivatives
Gabriela Garrastazu Pereira (2018)
LIPID NANOPARTICLES: APPLICATION IN CANCER THERAPY
S. M. Salunkhe (2014)
10.1016/j.biotechadv.2014.10.011
Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer.
S. Wang (2015)
10.2174/0929867321666140716092512
Nanoparticles in melanoma.
M. Berciano-Guerrero (2014)
10.3109/03639045.2013.829487
Pluronic-poly (acrylic acid)-cysteine/Pluronic L121 mixed micelles improve the oral bioavailability of paclitaxel
Yanli Zhao (2014)
10.1517/17425247.2015.1060219
Novel dietary lipid-based self-nanoemulsifying drug delivery systems of paclitaxel with p-gp inhibitor: implications on cytotoxicity and biopharmaceutical performance
Premjeet Singh Sandhu (2015)
10.3109/1061186X.2013.848453
Subcellular drug targeting, pharmacokinetics and bioavailability
S. Leucuţa (2014)
10.1016/j.jconrel.2013.12.030
Emerging integrated nanohybrid drug delivery systems to facilitate the intravenous-to-oral switch in cancer chemotherapy.
C. Luo (2014)
10.1016/j.ijpharm.2017.05.030
Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs.
G. Salzano (2017)
10.1016/j.ijbiomac.2020.11.117
Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease.
Shangwen Zhang (2020)
10.1517/17425247.2014.865014
Advances in P-glycoprotein-based approaches for delivering anticancer drugs: pharmacokinetic perspective and clinical relevance
A. Saneja (2014)
10.1016/j.chemphyslip.2016.02.008
Development of pH-sensitive self-nanoemulsifying drug delivery systems for acid-labile lipophilic drugs.
Tianjing Zhao (2016)
10.3109/10837450.2014.991877
A comparative study on the effects of amphiphilic and hydrophilic polymers on the release profiles of a poorly water-soluble drug
A. W. Irwan (2016)
10.2174/1389200220666191007154017
Oral Delivery of Anticancer Agents using Nanoparticulate Drug Delivery System.
Prateek Mathur (2019)
10.3109/08982104.2013.868476
Comparing different sterol containing solid lipid nanoparticles for targeted delivery of quercetin in hepatocellular carcinoma
J. Varshosaz (2014)
10.1039/c9tb01081e
Biomaterial-tight junction interaction and potential impacts.
Xiangfei Han (2019)
10.1080/03639045.2019.1628041
Enhanced oral delivery and anti-gastroesophageal reflux activity of curcumin by binary mixed micelles
Yongshun Sun (2019)
Synthesis of a nanoparticle system for theenhanced accumulation of fluorescently-labelledamino acids encapsulated in monodispersedchitosan nanoparticle system
U. A. Hassan (2017)
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