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Specific Permeability Modulation Of Intestinal Paracellular Pathway By Chitosan-poly(isobutylcyanoacrylate) Core-shell Nanoparticles.

I. Bravo-Osuna, C. Vauthier, H. Chacun, G. Ponchel
Published 2008 · Medicine, Chemistry

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This work is focused on the evaluation of the in vitro permeation modulation of chitosan and thiolated chitosan (chitosan-TBA) coated poly(isobutylcyanoacrylate) (PIBCA) nanoparticles as drug carriers for mucosal administration. Core-corona nanoparticles were obtained by radical emulsion polymerisation of isobutylcyanoacrylate (IBCA) with chitosan of different molecular weights and different proportions of chitosan/chitosan-TBA. In this work, the effect of these nanoparticles on the paracellular permeability of intestinal epithelium was investigated using the Ussing chamber technique, by adding nanoparticle suspensions in the mucosal side of rat intestinal mucosa. Results showed that permeation of the tracer [14C]mannitol and the reduction of transepithelial electrical resistance (TEER) in presence of nanoparticles were more pronounced in those formulations prepared with intermediate amounts of thiolated polymer. This effect was explained thanks to the high diffusion capacity of those nanoparticles through the mucus layer that allowed them to reach the tight junctions in higher extent. It was concluded that, although a first contact between nanoparticles and mucus was a mandatory condition for the development of a permeation enhancement effect, the optimal effect depended on the chitosan/chitosan-TBA balance and the conformational structure of the particles shell.
This paper references
10.1016/s1773-2247(10)50007-8
Thiolated chitosans.
A. Bernkop-Schnürch (2004)
10.1023/A:1012160102740
Chitosans as Absorption Enhancers for Poorly Absorbable Drugs 2: Mechanism of Absorption Enhancement
N. G. Schipper (2004)
10.1016/J.ADDR.2003.10.045
Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins.
A. Fasano (2004)
10.1016/J.JCONREL.2005.04.004
The use of thiolated polymers as carrier matrix in oral peptide delivery--proof of concept.
A. Bernkop-Schnürch (2005)
10.1016/J.IJPHARM.2004.12.016
Diethyl methyl chitosan as an intestinal paracellular enhancer: ex vivo and in vivo studies.
M. R. Avadi (2005)
10.1016/J.EJPS.2006.10.007
Tuning of shell and core characteristics of chitosan-decorated acrylic nanoparticles.
I. Bravo-Osuna (2007)
10.1016/S0939-6411(01)00172-2
Enhancing the permeation of marker compounds and enaminone anticonvulsants across Caco-2 monolayers by modulating tight junctions using zonula occludens toxin.
D. S. Cox (2001)
10.1016/J.BIOMATERIALS.2007.01.005
Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles.
I. Bravo-Osuna (2007)
10.1016/S1381-5148(00)00038-9
A review of chitin and chitosan applications
M. Kumar (2000)
10.1016/J.JCONREL.2004.07.030
Transmucosal macromolecular drug delivery.
C. Prego (2005)
10.1016/J.IJPHARM.2004.05.019
The depolymerization of chitosan: effects on physicochemical and biological properties.
S. Mao (2004)
10.1152/AJPGI.00346.2004
Luminal adenosine stimulates chloride secretion through A1 receptor in mouse jejunum.
E. Ghanem (2005)
10.1023/A:1011982211632
Combined Poly(isobutylcyanoacrylate) and Cyclodextrins Nanoparticles for Enhancing the Encapsulation of Lipophilic Drugs
A. M. da Silveira (2004)
10.1016/0005-2736(93)90159-W
Polycation-induced enhancement of epithelial paracellular permeability is independent of tight junctional characteristics.
G. Mcewan (1993)
10.1515/9783111697888-007
E
Adam S. Opalski (1824)
10.1016/S0939-6411(03)00157-7
Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluation.
M. Roldo (2004)
10.1021/MA034097W
Radical Emulsion Polymerization of Alkylcyanoacrylates Initiated by the Redox System Dextran−Cerium(IV) under Acidic Aqueous Conditions
C. Chauvierre (2003)
10.1515/9783111548050-024
M
M. Sankar (1824)
10.1016/J.BBAMEM.2004.06.017
Prolactin directly stimulated the solvent drag-induced calcium transport in the duodenum of female rats.
Chaiyot Tanrattana (2004)
10.1016/J.TOXICON.2004.07.003
Permeability of human jejunal segments to gonyautoxins measured by the Ussing chamber technique.
P. Mardones (2004)
10.1016/J.JCONREL.2003.05.001
Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems.
A. Bernkop-Schnürch (2003)
10.1002/CHIN.199531306
In vitro Systems for Studying Intestinal Drug Absorption
K. Hillgren (2010)
Junginger, The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption: effect of chitosan-glutamate and carbomer on epithelial tight junctions in vitro
G. Borchard (1996)
10.1016/J.IJPHARM.2007.03.019
Characterization of chitosan thiolation and application to thiol quantification onto nanoparticle surface.
I. Bravo-Osuna (2007)
10.1016/J.IJPHARM.2007.01.039
In vitro evaluation of calcium binding capacity of chitosan and thiolated chitosan poly(isobutyl cyanoacrylate) core-shell nanoparticles.
I. Bravo-Osuna (2007)
10.1016/S0955-2863(01)00208-X
The effect of chitosan and other polycations on tight junction permeability in the human intestinal Caco-2 cell line(1).
G. Ranaldi (2002)
10.1016/S0939-6411(00)00084-9
Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?
T. Jung (2000)
10.1023/B:PHAM.0000016249.52831.a5
Uptake and Cytotoxicity of Chitosan Molecules and Nanoparticles: Effects of Molecular Weight and Degree of Deacetylation
M. Huang (2004)
10.1016/J.JCONREL.2005.12.015
Chitosan-PEG nanocapsules as new carriers for oral peptide delivery. Effect of chitosan pegylation degree.
C. Prego (2006)
Comparison of the effect of different chitosan salts Ntrimethyl chitosan chloride on the permeability of intestinal epithelial cells
A. F. Kotzé (1998)
10.1023/B:PHAM.0000003376.57954.2a
Novel Polysaccharide-Decorated Poly(Isobutyl Cyanoacrylate) Nanoparticles
C. Chauvierre (2004)
10.1016/0168-3659(94)90071-X
Overcoming enzymatic and absorption barriers to non-parenterally administered protein and peptide drugs
X. Zhou (1994)
10.1016/S0378-5173(98)00277-4
The enhancement of the bioadhesive properties of calcium alginate gel beads by coating with chitosan
O. Gåserød (1998)
10.1016/J.IJPHARM.2006.02.037
Elaboration and characterization of thiolated chitosan-coated acrylic nanoparticles.
I. Bravo-Osuna (2006)
10.1016/S0169-409X(01)00171-5
Chitosan as a novel nasal delivery system for vaccines.
L. Illum (2001)
10.1111/j.2042-7158.1996.tb07111.x
Chemical Approaches to Improve the Oral Bioavailability of Peptidergic Molecules
J. Samanen (1996)
10.1016/S0899-9007(02)00927-9
Effect of gamma-linolenic acid or docosahexaenoic acid on tight junction permeability in intestinal monolayer cells and their mechanism by protein kinase C activation and/or eicosanoid formation.
M. Usami (2003)
Mechanical, bioadhesive strength and biological evaluations of chitosan films for wound dressing.
K. Peh (2000)
10.1016/S0168-3659(97)00154-5
Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2).
A. Kotzé (1998)
10.1016/S0928-0987(98)00023-2
Nasal drug delivery--evaluation of an in vitro model using porcine nasal mucosa.
C. Wadell (1999)
10.1023/A:1025575730542
Plug-in Spectrometry with Optical Fibers as a Novel Analytical Tool for Nanoparticles Technology: Application to the Investigation of the Emulsion Polymerization of the Alkylcyanoacrylate
C. Chauvierre (2003)
10.1016/0168-3659(95)00146-8
The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro
G. Borchard (1996)
10.1016/J.EJPB.2004.03.023
Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs.
S. M. van der Merwe (2004)
10.1016/S0196-9781(01)00435-1
Permeability of the peptidic GH secretagogues hexarelin and EP 51389, across rat jejunum
M. Roumi (2001)
10.1515/9783111419787-003
H
Yu-Qin Cao (1824)
10.1016/0378-5173(95)00022-B
Bisphosphonates increase tight junction permeability in the human intestinal epithelial (Caco-2) model
X. Boulenc (1995)
10.1007/3-540-26367-5_1
A
A. Spring (2005)
10.1016/S0169-409X(01)00196-X
Chemically modified chitosans as enzyme inhibitors.
A. Bernkop-Schnürch (2001)
10.1016/S0169-409X(98)00040-4
Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract.
Ponchel (1998)
The effect of chitosan and other polycations on tight junction permeability in the human intestinal Caco-2 cell line
G. Ranaedi (2002)
10.1016/S0939-6411(03)00147-4
Review articleThiolated chitosans
A. Bernkop-Schnürch (2004)
10.1016/J.EJPB.2004.03.029
A possibility to predict the absorbability of poorly water-soluble drugs in humans based on rat intestinal permeability assessed by an in vitro chamber method.
E. Watanabe (2004)
10.5040/9781474284028.0024
S
A. Kumar (1824)



This paper is referenced by
10.1016/j.actbio.2010.02.007
Thiol functionalized polymethacrylic acid-based hydrogel microparticles for oral insulin delivery.
S. Sajeesh (2010)
10.1016/j.ejpb.2009.09.001
Surface-functionalized polymethacrylic acid based hydrogel microparticles for oral drug delivery.
S. Sajeesh (2010)
10.1016/B978-0-323-47720-8.00022-5
Phytonanoconjugates in oral medicine
L. Bharathi Priya (2017)
Thiolated Chitosan Preparation, Properties, and Applications
Nazma N. Inamdar (2013)
Design, preparation, and characterization of nanoparticles as delivery systems for bioactive phenolic phytochemicals
Zheng Li (2013)
10.1016/j.nano.2008.09.006
Preparation and in vitro evaluation of mucoadhesion and permeation enhancement of thiolated chitosan-pHEMA core-shell nanoparticles.
Firooze Aghaei Moghaddam (2009)
ARTÍCULO ORIGINAL
C. Albrecht (2018)
10.1208/s12249-010-9561-2
Recent Advancement of Chitosan-Based Nanoparticles for Oral Controlled Delivery of Insulin and Other Therapeutic Agents
Anumita Chaudhury (2010)
10.1517/17425247.2011.572069
Cyclodextrin-poly(anhydride) nanoparticles as new vehicles for oral drug delivery
M. Agüeros (2011)
10.1007/12_2011_109
Chitosan and Thiolated Chitosan
Federica Sarti (2011)
Preparation and Characterization of Myristoylated Chitosan Nanogel as Carrier of Silibinin for Breast Cancer Therapy
Maliheh Entezari (2017)
10.3390/biomimetics4020032
Interaction Between Chitosan and Mucin: Fundamentals and Applications
Mar Collado-González (2019)
10.1016/j.ijpharm.2010.08.020
Tight junction modulation by chitosan nanoparticles: comparison with chitosan solution.
D. Vllasaliu (2010)
10.1016/S1773-2247(09)50006-8
Conjugation of aspirin with vitamin C: uptake and stability studies
Alessandro Dalpiaz (2009)
10.1016/j.ijpharm.2014.07.049
Preparation and characterization of PEG-coated silica nanoparticles for oral insulin delivery.
T. Andreani (2014)
10.1016/j.jconrel.2010.08.007
Cyclodextrin complexed insulin encapsulated hydrogel microparticles: An oral delivery system for insulin.
S. Sajeesh (2010)
10.1080/15533174.2015.1137012
Investigation of In Vitro Release of Cisplatin from Electrostatically Crosslinked Chitosan-Alginate Nanoparticles
Gurvindar Kaur Maan (2016)
10.2147/IJN.S51837
Fate of paclitaxel lipid nanocapsules in intestinal mucus in view of their oral delivery
A. Groo (2013)
10.1016/j.ejpb.2012.04.001
Oral administration of paclitaxel with pegylated poly(anhydride) nanoparticles: permeability and pharmacokinetic study.
V. Zabaleta (2012)
10.1016/B978-0-12-804305-9.00014-2
Bioavailability and delivery of nutraceuticals by nanoparticles
C. Tamer (2016)
10.1002/jps.24354
Controlled Release, Intestinal Transport, and Oral Bioavailablity of Paclitaxel Can be Considerably Increased Using Suitably Tailored Pegylated Poly(Anhydride) Nanoparticles.
P. Calleja (2015)
10.1016/B978-0-323-52725-5.00006-X
Nanometric Biopolymer Devices for Oral Delivery of Macromolecules with Clinical Significance
Sabyasachi Maiti (2017)
10.1080/10611860701603372
Design aspects of poly(alkylcyanoacrylate) nanoparticles for drug delivery
C. Vauthier (2007)
10.1515/entl-2015-0004
Human epithelial cells in vitro – Are they an advantageous tool to help understand the nanomaterial-biological barrier interaction?
B. Rothen-Rutishauser (2012)
10.1007/s11095-013-1280-4
Development of 2D and 3D Mucus Models and Their Interactions with Mucus-Penetrating Paclitaxel-Loaded Lipid Nanocapsules
Anne-Claire Groo (2013)
Preparation, Properties, and Applications
N. Inamdar (2013)
10.1016/j.ijbiomac.2015.01.008
Synthesis of chitosan-g-poly(acrylamide)/ZnS nanocomposite for controlled drug delivery and antimicrobial activity.
D. Gupta (2015)
10.3390/md18010055
Complex Polysaccharide-Based Nanocomposites for Oral Insulin Delivery
Mar Collado-González (2020)
10.1016/J.COLSURFA.2017.02.055
Experimental design approach applied to the development of chitosan coated poly(isobutylcyanoacrylate) nanocapsules encapsulating copaiba oil
Francisco Humberto Xavier-Junior (2018)
INCLUSION COMPLEX OF HYDROCHLOROTHIAIZDE-γ- CYCLODEXTRIN: THE EFFECT ON AQUEOUS SOLUBILITY, DISSOLUTION RATE, BIOAVAILABILITY AND THE EFFECT ON INTESTINAL PERMEABILITY USING USSING CHAMBER TECHNIQUE
Sanae Masmoudi (2013)
Systèmes disperses pour l'administration orale de paclitaxel à base de microemulsion et de nanocapsules mucoadhesives contenant de l'huile de copaïba
F. H. Xavier-Júnior (2015)
10.1111/j.1469-7580.2010.01304.x
Macrophages increase microparticle uptake by enterocyte‐like Caco‐2 cell monolayers
S. M. Moyes (2010)
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