Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Evaluation Of Geometrical Effects Of Microneedles On Skin Penetration By CT Scan And Finite Element Analysis.
Eriketi Z. Loizidou, N. Inoue, J. Ashton-Barnett, D. Barrow, C. Allender
Published 2016 · Materials Science, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
Computerized tomography scan (CT scan) imaging and finite element analysis were employed to investigate how the geometric composition of microneedles affects their mechanical strength and penetration characteristics. Simulations of microneedle arrays, comprising triangular, square and hexagonal microneedle base, revealed a linear dependence of the mechanical strength to the number of vertices in the polygon base. A laser-enabled, micromoulding technique was then used to fabricate 3×3 microneedle arrays, each individual microneedle having triangular, square or hexagonal base geometries. Their penetration characteristics into ex-vivo porcine skin, were investigated for the first time by CT scan imaging. This revealed greater penetration depths for the triangular and square-based microneedles, demonstrating CT scan as a powerful and reliable technique for studying microneedle skin penetration.
This paper references
Conical indentation of incompressible rubber-like materials
A. Giannakopoulos (2009)
In vitro indentation to determine the mechanical properties of epidermis.
M. Geerligs (2011)
Effect of microneedle geometry and supporting substrate on microneedle array penetration into skin.
J. S. Kochhar (2013)
Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution.
R. Donnelly (2010)
In-vivo dynamic characterization of microneedle skin penetration using optical coherence tomography.
J. Enfield (2010)
Gold Nanoparticle Contrast Agents in Advanced X-ray Imaging Technologies
Sungsook Ahn (2013)
Quantifying the mechanical properties of human skin to optimise future microneedle device design
R. Groves (2012)
Influence of the delivery systems using a microneedle array on the permeation of a hydrophilic molecule, calcein.
J. Oh (2008)
Evaluation needle length and density of microneedle arrays in the pretreatment of skin for transdermal drug delivery.
G. Yan (2010)
High-Resolution X-Ray Computed Tomography in Geosciences: A Review of the Current Technology and Applications. Earth-Sci
V. Cnudde (2013)
Microneedles for transdermal drug delivery.
M. Prausnitz (2004)
Rapidly-dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach.
Katherine A. Moga (2013)
The role of microneedles for drug and vaccine delivery
Helen L. Quinn (2014)
Characterization of Solid Maltose Microneedles and their Use for Transdermal Delivery
C. Kolli (2007)
High-resolution X-ray computed tomography in geosciences: A review of the current technology and applications
V. Cnudde (2013)
In Vitro and In Vivo Characterization of MEMS Microneedles
M. L. Teo (2005)
Parameter optimization toward optimal microneedle-based dermal vaccination.
K. van der Maaden (2014)
Microneedles for drug and vaccine delivery.
Y. Kim (2012)
Influence of array interspacing on the force required for successful microneedle skin penetration: theoretical and practical approaches.
O. Olatunji (2013)
In vivo iontophoretic delivery of salmon calcitonin across microporated skin.
V. Vemulapalli (2012)
Monitoring the penetration process of single microneedles with varying tip diameters
D. L. Badera (2014)
Transdermal delivery of drugs with microneedles: Strategies and outcomes
K. Ita (2015)
The relationship between the Young's modulus of the stratum corneum and age: a pilot study
Y. Hara (2013)
In Vivo, In Situ Imaging of Microneedle Insertion into the Skin of Human Volunteers Using Optical Coherence Tomography
S. Coulman (2010)
Optimizing Microneedle Arrays to Increase Skin Permeability for Transdermal Drug Delivery
Barrak Al-Qallaf (2009)
Structural characterisation and transdermal delivery studies on sugar microneedles: experimental and finite element modelling analyses.
Eriketi Z. Loizidou (2015)
Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies
D. Mcallister (2003)
Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery
Jung-hwan Park (2004)
Microchannels created by sugar and metal microneedles: characterization by microscopy, macromolecular flux and other techniques.
G. Li (2010)
Influence of microneedle shape on the transport of a fluorescent dye into human skin in vivo.
S. Bal (2010)
Geometrical effects in mechanical characterizing of microneedle for biomedical applications
P. Aggarwal (2004)
Dissolving microneedles for transdermal drug delivery.
J. Lee (2008)
Targeted gold nanoparticles enable molecular CT imaging of cancer.
R. Popovtzer (2008)
An anisotropic, hyperelastic model for skin: experimental measurements, finite element modelling and identification of parameters for human and murine skin.
R. Groves (2013)
Design, Optimization and Characterisation of Polymeric Microneedle Arrays Prepared by a Novel Laser-Based Micromoulding Technique
R. Donnelly (2010)
This paper is referenced by
Transdermal Microneedles—A Materials Perspective
R. Ali (2019)
Promozione dell’assorbimento cutaneo in cosmetologia: formulazioni e strumenti
G. Marti-Mestres (2019)
Novel Bletilla striata polysaccharide microneedles: Fabrication, characterization, and in vitro transcutaneous drug delivery.
L. Hu (2018)
Insulin delivery systems combined with microneedle technology.
Xuan Jin (2018)
A review on microfabrication of thermoplastic polymer‐based microneedle arrays
H. Juster (2019)
Microneedles as the technique of drug delivery enhancement in diverse organs and tissues.
A. Rzhevskiy (2018)
Three dimensional simulation of the microneedle penetration process in the skin by finite element method
Yasaman Amiri (2019)
Finite Element Analysis for Predicting Skin Pharmacokinetics of Nano Transdermal Drug Delivery System Based on the Multilayer Geometry Model
Yongwei Gu (2020)
Microfabrication for Drug Delivery
B. Koch (2016)
Microscale Drug Delivery Systems: Current Perspectives and Novel Approaches
I. Negut (2017)
Mechanical properties of surface microstructures of metal dry bioelectrode
W. Zhou (2018)
A Practical Guide to the Development of Microneedle Systems - in Clinical Trials or on the Market.
Kyung Ju Lee (2019)
The evaluation of microneedle performance on a representative in vitro skin model
K. Moronkeji (2017)
Electrical impedance performance of metal dry bioelectrode with different surface coatings
W. Liu (2018)
Recent advances of controlled drug delivery using microfluidic platforms☆
S. Sanjay (2018)
Flexible and porous microneedles of PDMS for continuous glucose monitoring.
K. Takeuchi (2020)
Current trends in polymer microneedle for transdermal drug delivery
Khater Ahmed Saeed AL-Japairai (2020)
Intradermal and transdermal drug delivery using microneedles - Fabrication, performance evaluation and application to lymphatic delivery.
A. Sabri (2019)