Online citations, reference lists, and bibliographies.

Impact Of Dose And Surface Features On Plasmatic And Liver Concentrations Of Biodegradable Polymeric Nanocapsules

L. T. Oliveira, Mônica Auxiliadora de Paula, B. M. Roatt, G. M. Garcia, Luan Silvestro Bianchini Silva, A. B. Reis, C. S. de Paula, José Mário Carneiro Vilela, M. Andrade, Gwenaelle Pound-Lana, Vanessa Carla Furtado Mosqueira
Published 2017 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
ABSTRACT The effect of polymeric nanocapsule dose on plasmatic and liver concentrations 20 min after intravenous administration in mice was evaluated. Nanocapsules were prepared with different polymers, namely, poly(D,L‐lactide) (PLA), polyethylene glycol‐block‐poly(D,L‐lactide) (PLA‐PEG), and PLA with chitosan (PLA‐Cs) and compared with a nanoemulsion. These formulations were labelled with a phthalocyanine dye for fluorescent detection. The nanostructures had narrow size distributions upon separation by asymmetric flow field flow fractionation with static and dynamic light scattering detection, with average hydrodynamic diameters in the 130–300 nm range, negative zeta potentials, except PLA‐Cs nanocapsules, which had a positive zeta potential. Flow cytometry revealed uptake mostly by monocytes and neutrophils in mice and human blood. PLA nanocapsules and the nanoemulsion showed dose‐dependent plasma concentrations, where the percentage of plasmatic fluorescence increased with increasing administered dose. In contrast, PLA‐PEG nanocapsules led to a dose‐independent plasmatic profile. PLA‐Cs nanocapsules showed the lowest plasmatic and liver levels of fluorescence at all administered doses and significant intravenous toxicity in mice. This work demonstrates the importance of considering the nanocarrier dose when evaluating pharmacokinetic and biodistribution data and emphasizes the role of surface features in determining the plasmatic and liver concentrations of a poorly soluble lipophilic encapsulated compound. Graphical abstract Figure. No Caption available.
This paper references
10.1016/J.JCONREL.2005.06.005
Core-shell structure of Miglyol/poly(D,L-lactide)/Poloxamer nanocapsules studied by small-angle neutron scattering.
A. Rübe (2005)
10.1016/j.ijpharm.2015.08.050
Stability of fluorescent labels in PLGA polymeric nanoparticles: Quantum dots versus organic dyes.
Mona M. A. Abdel-Mottaleb (2015)
10.1016/J.IJPHARM.2006.01.035
Diffusion and mathematical modeling of release profiles from nanocarriers.
L. Cruz (2006)
10.1016/j.ijbiomac.2015.09.031
Cytotoxicity of chitosans with different acetylation degrees and molecular weights on bladder carcinoma cells.
Islem Younes (2016)
10.1016/j.jconrel.2011.09.098
The journey of a drug-carrier in the body: an anatomo-physiological perspective.
N. Bertrand (2012)
10.1021/BM0200074
Structure of artificial cytoskeleton containing liposomes in aqueous solution studied by static and dynamic light scattering.
Oliver Stauch (2002)
10.1039/C5TX00030K
Do poly(epsilon-caprolactone) lipid-core nanocapsules induce oxidative or inflammatory damage after in vivo subchronic treatment?
Rachel Picada Bulcão (2015)
10.1007/s00396-012-2669-z
Chitosan-based nanocapsules: physical characterization, stability in biological media and capsaicin encapsulation
Francisco M. Goycoolea (2012)
10.1007/s11095-005-8343-0
Poly(Ethylene Oxide)-Modified Poly(β-Amino Ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part 2. In Vivo Distribution and Tumor Localization Studies
D. Shenoy (2005)
10.1016/0005-2736(91)90201-I
Pharmacokinetics of stealth versus conventional liposomes: effect of dose.
T. Allen (1991)
10.1016/j.vaccine.2014.01.059
Biodistribution and lymph node retention of polysaccharide-based immunostimulating nanocapsules.
Sara Vicente (2014)
10.1023/A:1012128907225
Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines
P. Calvo (2004)
10.1002/wnan.1334
Improving drug biological effects by encapsulation into polymeric nanocapsules.
L. A. Frank (2015)
10.1016/j.ijpharm.2008.12.007
Enhanced electrostatic interaction between chitosan-modified PLGA nanoparticle and tumor.
R. Yang (2009)
10.1016/J.EURPOLYMJ.2014.01.033
Strategies to improve chitosan hemocompatibility: A review
V. Balan (2014)
10.1016/j.addr.2009.10.003
Targeted delivery of low molecular drugs using chitosan and its derivatives.
J. H. Park (2010)
10.1017/S143192760505083X
Polymeric Nanostructures for Drug Delivery: Characterization by Atomic Force Microscopy
V. Mosqueira (2005)
10.1016/j.ejps.2013.03.011
Chloroaluminium phthalocyanine polymeric nanoparticles as photosensitisers: photophysical and physicochemical characterisation, release and phototoxicity in vitro.
Carina Silva de Paula (2013)
10.1126/science.8128245
Biodegradable long-circulating polymeric nanospheres.
R. Gref (1994)
10.11606/9788585285098
Manual de cuidados e procedimentos com animais de laboratório do biotério de produção e experimentação da FCF-IQ/USP
Silvânia M. P. Neves (2013)
10.3109/10611869909085493
Interactions between a macrophage cell line (J774A1) and surface-modified poly (D,L-lactide) nanocapsules bearing poly(ethylene glycol).
V. Mosqueira (1999)
10.1016/S0142-9612(01)00043-6
Relationship between complement activation, cellular uptake and surface physicochemical aspects of novel PEG-modified nanocapsules.
V. Mosqueira (2001)
10.1023/A:1012248721523
Biodistribution of Long-Circulating PEG-Grafted Nanocapsules in Mice: Effects of PEG Chain Length and Density
V. Mosqueira (2004)
10.1016/j.jpba.2011.04.016
HPLC-FLD methods to quantify chloroaluminum phthalocyanine in nanoparticles, plasma and tissue: application in pharmacokinetic and biodistribution studies.
L. T. Oliveira (2011)
10.1021/ac100711j
Complete physicochemical characterization of DNA/chitosan complexes by multiple detection using asymmetrical flow field-flow fractionation.
P. Ma (2010)
10.1016/S0927-7765(99)00156-3
'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption.
Gref (2000)
10.1016/j.ijpharm.2009.10.018
Polymer-based nanocapsules for drug delivery.
C. E. Mora-Huertas (2010)
10.1016/j.ijpharm.2012.01.051
Hemocompatibility of poly(ɛ-caprolactone) lipid-core nanocapsules stabilized with polysorbate 80-lecithin and uncoated or coated with chitosan.
E. A. Bender (2012)
10.1016/j.addr.2013.12.009
Nanoprecipitation and the "Ouzo effect": Application to drug delivery devices.
E. Lepeltier (2014)
10.1016/j.chroma.2015.09.048
Size fractionation and size characterization of nanoemulsions of lipid droplets and large unilamellar lipid vesicles by asymmetric-flow field-flow fractionation/multi-angle light scattering and dynamic light scattering.
Valerija Vezočnik (2015)
10.1017/S1431927605050865
Poly-Caprolactone Nanocapsules Morphological Features by Atomic Force Microscopy
E. A. Leite (2005)
10.1016/J.IJPHARM.2007.08.002
Release profiles and morphological characterization by atomic force microscopy and photon correlation spectroscopy of 99mTechnetium-fluconazole nanocapsules.
Danielle Nogueira de Assis (2008)
10.1186/s13046-015-0273-z
Polymeric nanocapsules prevent oxidation of core-loaded molecules: evidence based on the effects of docosahexaenoic acid and neuroprostane on breast cancer cells proliferation
Jérôme Roy (2015)
10.1016/j.tiv.2014.12.021
Biodegradable nanoparticles designed for drug delivery: The number of nanoparticles impacts on cytotoxicity.
L. Mendes (2015)
10.1016/J.LFS.2006.12.019
Cardiotoxicity reduction induced by halofantrine entrapped in nanocapsule devices.
E. A. Leite (2007)
10.1007/BF01415033
Dynamic light scattering from spherical particles
D. Kunz (1983)
10.1016/S0378-5173(01)00676-7
Effect of dose on the biodistribution and pharmacokinetics of PLGA and PLGA-mPEG nanoparticles.
Z. Panagi (2001)
10.1016/j.cis.2013.10.027
Block copolymers at interfaces: interactions with physiological media.
A. Torcello-Gómez (2014)
10.1016/J.EJPS.2007.09.007
PLA-PEG nanocapsules radiolabeled with 99mTechnetium-HMPAO: release properties and physicochemical characterization by atomic force microscopy and photon correlation spectroscopy.
M. A. Pereira (2008)
10.1016/j.colsurfb.2010.12.013
Polymeric nanocapsules ultra stable in complex biological media.
Cesar Rodriguez-Emmenegger (2011)
10.1038/srep18423
Immune cell impact of three differently coated lipid nanocapsules: pluronic, chitosan and polyethylene glycol
Cristiano Farace (2016)
10.1002/(SICI)1097-4636(199607)31:3<401::AID-JBM15>3.0.CO;2-L
Effect of polymeric nanoparticle administration on the clearance activity of the mononuclear phagocyte system in mice.
R. Fernández-Urrusuno (1996)
10.1016/j.biomaterials.2014.04.019
Improving drug accumulation and photothermal efficacy in tumor depending on size of ICG loaded lipid-polymer nanoparticles.
P. Zhao (2014)
10.1007/s00216-008-2319-y
Particle size characterization by quadruple-detector hydrodynamic chromatography
Amandaa K. Brewer (2009)
Polymeric nanocapsules as drug delivery systems. A review
P. Legrand (1999)
10.1016/0378-5173(89)90281-0
Nanocapsule formation by interfacial polymer deposition following solvent displacement
H. Fessi (1989)
10.1016/j.jconrel.2012.06.020
Effects of block copolymer properties on nanocarrier protection from in vivo clearance.
Suzanne M. D’Addio (2012)
Polymer-based nanocapsules for drug
C. E. Mora-Huertas (2010)
10.1166/JNN.2006.444
Surface-modified and conventional nanocapsules as novel formulations for parenteral delivery of halofantrine.
V. Mosqueira (2006)
10.2147/IJN.S94370
Toward a general physiologically-based pharmacokinetic model for intravenously injected nanoparticles
Ulrika Carlander (2016)
10.1016/j.jconrel.2015.04.033
Improved nonclinical pharmacokinetics and biodistribution of a new PPAR pan-agonist and COX inhibitor in nanocapsule formulation.
G. M. Garcia (2015)
10.1016/J.IJPHARM.2005.10.010
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles.
Donald E. Owens (2006)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar