Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Repeat Cytoreductive Surgery And Hyperthermic Intraperitoneal Chemotherapy For Recurrent Diffuse Malignant Peritoneal Mesothelioma.

Y. Huang, N. Alzahrani, W. Liauw, D. Morris
Published 2015 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
INTRODUCTION Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has shown to improve survival outcomes for patients with diffuse malignant peritoneal mesothelioma (DMPM). PATIENTS AND METHODS This is a retrospective study of prospectively collected data of 44 consecutive patients with DMPM who underwent CRS and HIPEC by the same surgical team at St George Hospital in Sydney, Australia. A total of 58 operations were performed. Clinical data were divided according to the number of operation and HIPEC the patient had undergone (Group 1 = initial CRS and HIPEC; Group 2 = 2nd CRS and HIPEC; Group 3 included 3rd CRS and HIPEC; Group 4 = 4th CRS and HIPEC). A significant difference was defined as p < 0.05. RESULTS There were no significant differences in mortality and morbidity results among the four groups. The median survival for those who only had one operation was 22 months (95% confidence interval (CI) = 0-47.2), whereas the median survival for those who had a second operation was 62 months (95% CI = 22.9-101.1). However, such a difference did not translate into a statistical significance (p = 0.141). CONCLUSION We report an encouraging median survival of 62 months in patients who had recurrence of disease and had repeat CRS and HIPEC with similar morbidity and mortality with the initial operation. Due to the learning curve of this technique, patients with recurrent mesothelioma should be referred to specialised tertiary care centres for evaluation. Selected patients may experience prolonged survival after repeat CRS and HIPEC.
This paper references
Outcomes of repeat cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for the treatment of peritoneal surface malignancy.
K. Votanopoulos (2012)
Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: a multi-institutional study.
O. Glehen (2004)
Learning curve for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal surface malignancies: Analysis of two centres
S. Kusamura (2013)
Comprehensive management of diffuse malignant peritoneal mesothelioma.
P. Sugarbaker (2006)
Should the Treatment of Peritoneal Carcinomatosis by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Still be Regarded as a Highly Morbid Procedure?: A Systematic Review of Morbidity and Mortality
T. Chua (2009)
Prospective trial for the treatment of malignant peritoneal mesothelioma.
B. Loggie (2001)
A systematic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for diffuse malignancy peritoneal mesotheli
T Yan (2007)
Failure Analysis of Recurrent Disease Following Complete Cytoreduction and Perioperative Intraperitoneal Chemotherapy in Patients with Peritoneal Carcinomatosis from Colorectal Cancer
L. Bijelić (2007)
Peritonectomy procedures.
P. Sugarbaker (1996)
Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis.
P. Jacquet (1996)
Critical Analysis of Treatment Failure After Complete Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy for Peritoneal Dissemination From Appendiceal Mucinous Neoplasms
T. Yan (2007)
Diffuse Malignant Peritoneal Mesothelioma: Failure Analysis Following Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
D. Baratti (2008)
Differential Expression of Ki-67 and Sex Steroid Hormone Receptors Between Genders in Peritoneal Mesothelioma
Terence C. Chua (2009)
Treatment of Primary Peritoneal Mesothelioma by Continuous Hyperthermic Peritoneal Perfusion (CHPP)
B. Park (1999)
Prognostic Analysis of Clinicopathologic Factors in 49 Patients With Diffuse Malignant Peritoneal Mesothelioma Treated With Cytoreductive Surgery and Intraperitoneal Hyperthermic Perfusion
M. Deraco (2006)
Diffuse malignant mesothelioma of the peritoneum.
Giles Td (1967)
Peritoneal mesothelioma: current understanding and management
T. Chua (2009)
Iterative Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Recurrent or Progressive Diffuse Malignant Peritoneal Mesothelioma: Clinicopathologic Characteristics and Survival Outcome
Facs Chukwuemeka Ihemelandu MD (2014)
Experience with peritoneal mesothelioma at the Milan National Cancer Institute.
M. Deraco (2010)
Multi‐institutional experience of diffuse intra‐abdominal multicystic peritoneal mesothelioma
T. Chua (2011)
A systematic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for diffuse malignancy peritoneal mesothelioma
T. Yan (2007)
Institutional Learning Curve of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion for Peritoneal Malignancies
P. Polanco (2014)
Results of treatment of 33 patients with peritoneal mesothelioma
G. Sebbag (2000)
Peritoneal mesothelioma treated by induction chemotherapy, cytoreductive surgery, and intraperitoneal hyperthermic perfusion
M. Deraco (2003)
Consensus statement on peritoneal mesothelioma
M. Deraco (2008)

This paper is referenced by
The Safety of Iterative Cytoreductive Surgery and HIPEC for Peritoneal Carcinomatosis: A High Volume Center Prospectively Maintained Database Analysis
E. Bekhor (2019)
Pseudomixoma peritoneal tratado con cirugía citorreductora y con quimioterapia hipertérmica intraperitoneal
L. Téllez (2016)
Variation in Clinical Application of Hyperthermic Intraperitoneal Chemotherapy: A Review
Roxan F C P A Helderman (2019)
The incidence and risk factors of hepatotoxicity induced by perioperative hyperthermic intraperitoneal chemotherapy in gastrointestinal carcinoma patients: a retrospective study
Zhewen Zheng (2018)
Preventing recurrence of diffuse malignant peritoneal mesothelioma
Joshua C. Leinwand (2016)
Repeat Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Is Not Associated with Prohibitive Complications: Results of a Multiinstitutional Retrospective Study
B. Powers (2020)
Two-Stage Cytoreductive Surgery and Intraperitoneal Chemotherapy for Diffuse Malignant Peritoneal Mesothelioma: Predictors of Overall Survival in an Intention-to-Treat Series
Joshua C. Leinwand (2019)
Unusual Indications of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Review of Outcomes and Report of the Literature
N. Alzahrani (2017)
Lokalisation von Rezidiven bei Tumoren des Peritoneums
I. Gockel (2018)
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for the Elderly: Is It Reasonable? A Meta-Analysis
J. Gagnière (2017)
Recurrence of Optimally Treated Malignant Peritoneal Mesothelioma with Cytoreduction and Heated Intraperitoneal Chemotherapy
Danielle R. Heller (2017)
Manejo del mesotelioma peritoneal maligno con citorreducción quirúrgica más quimioterapia hipertérmica intraperitoneal en el Instituto Nacional de Cancerología, Colombia: reporte de un caso y revisión bibliográfica
Juliana Restrepo lópez (2019)
Unusual Cases in Peritoneal Surface Malignancies
E. Canbay (2017)
50 Patients with Malignant Mesothelioma of Both the Pleura and Peritoneum: A Single-Institution Experience
Allison S. Letica-Kriegel (2019)
Repeat cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: review of indications and outcomes.
Harveshp Mogal (2016)
Semantic Scholar Logo Some data provided by SemanticScholar