Referencing for people who value simplicity, privacy, and speed.Get Citationsy
← Back to Search
Co-treatment With Riluzole And GDNF Is Necessary For Functional Recovery After Ventral Root Avulsion Injury
A. Bergerot, P. Shortland, P. Anand, S. Hunt, T. Carlstedt
Published 2004 · Medicine
Save to my Library
Download PDFAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Unilateral avulsion of lumbar ventral roots kills approximately 50% of injured motoneurons within 2 weeks of surgery. Immediate treatment involving surgical reimplantation of the ventral root (VRI) or intrathecal glial cell line-derived neurotrophic factor (GDNF) delivery or intraperitoneal injection of riluzole for 2 weeks ameliorates motoneuron death to 80% of control but combining the different treatment paradigms did not further enhance survival except when GDNF was combined with VRI. At 3 months, all combined treatments provided a neuroprotective effect compared to avulsion only, but the neuroprotective effect of surgical reimplantation alone was not maintained unless combined with riluzole and GDNF treatment. Analysis of regenerating motoneurons using retrograde labelling techniques showed that riluzole, but not GDNF, increased the number of dendrites per labelled motoneuron. However, when functional motor recovery was assessed using the BBB locomotor score and rotarod tests, only VRI animals treated with riluzole and GDNF application showed significantly improved locomotor function in both tests. Our results show that functional recovery appears related to a combination of enhanced dendrite formation, increased motoneuron survival and the neurotrophic actions of GDNF. Thus, combination treatment may offer a new therapeutic strategy for treating patients with avulsion injury.
This paper references
Neuroprotective effect of riluzole in a primate model of Parkinson's disease: Behavioral and histological evidence
M. Obinu (2002)
Riluzole promotes survival of rat motoneurons in vitro by stimulating trophic activity produced by spinal astrocyte monolayers
H. Peluffo (1997)
Simultaneous GDNF and BDNF application leads to increased motoneuron survival and improved functional outcome in an experimental model for obstetric brachial plexus lesions.
O. Aszmann (2002)
Riluzole enhances expression of brain‐derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus
Ritsuko‐Semba Katoh (2002)
The pharmacology and mechanism of action of riluzole
A. Doble (1996)
GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle.
C. E. Henderson (1994)
Efficient three‐drug cocktail for disease induced by mutant superoxide dismutase
J. Križ (2003)
Chapter 24 Spinal cord motoneuron maintenance, injury and repair
T. Carlstedt (2000)
Ventral root avulsion: An experimental model of death of adult motor neurons
V. Koliatsos (1994)
An analysis of extended survival in patients with amyotrophic lateral sclerosis treated with riluzole.
M. Rivière (1998)
Adenovirus-mediated GDNF protects cultured motoneurons from glutamate injury
Xiao-Qing Tang (2001)
Spinal nerve root repair and reimplantation of avulsed ventral roots into the spinal cord after brachial plexus injury.
T. Carlstedt (2000)
Spinal cord implantation of avulsed ventral roots in primates; correlation between restored motor function and morphology
R. Hallin (1999)
Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys.
R. Grondin (2002)
Sprouting of A‐fibre primary afferents into lamina II in two rat models of neuropathic pain
P. Shortland (1997)
Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: improved behavioral and neuroanatomical recovery with riluzole.
G. Schwartz (2001)
Pain following human brachial plexus injury with spinal cord root avulsion and the effect of surgery
J. Berman (1998)
A sensitive and reliable locomotor rating scale for open field testing in rats.
D. Basso (1995)
Additivity and potentiation of IGF-I and GDNF in the complete rescue of postnatal motor neurons.
M. Bilak (2001)
The effect of riluzole treatment in rats on the survival of injured adult and grafted embryonic motoneurons
A. Nógrádi (2001)
Brain-derived neurotrophic factor promotes axonal regeneration and long-term survival of adult rat spinal motoneurons in vivo
L. Novikov (1997)
BDNF Prevents and Reverses Adult Rat Motor Neuron Degeneration and Induces Axonal Outgrowth
A. Kishino (1997)
Graded Histological and Locomotor Outcomes after Spinal Cord Contusion Using the NYU Weight-Drop Device versus Transection
D. Basso (1996)
Reinnervation of denervated skeletal muscle by central neurons regenerating via ventral roots implanted into the spinal cord
K. Smith (1991)
Regeneration by supernumerary axons with synaptic terminals in spinal motoneurons of cats
L. Havton (1987)
Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro
A. Zurn (1996)
Brain-derived neurotrophic factor promotes survival and blocks nitric oxide synthase expression in adult rat spinal motoneurons after ventral root avulsion
L. Novikov (1995)
Differential regulation of trophic factor receptor mRNAs in spinal motoneurons after sciatic nerve transection and ventral root avulsion in the rat
H. Hammarberg (2000)
Riluzole stimulates nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis in cultured mouse astrocytes
I. Mizuta (2001)
Increased Expression of Brain-Derived Neurotrophic Factor Induces Formation of Basal Dendrites and Axonal Branching in Dentate Granule Cells in Hippocampal Explant Cultures
S. Danzer (2002)
Bcl-2 and GDNF delivered by HSV-mediated gene transfer after spinal root avulsion provide a synergistic effect.
A. Natsume (2002)
Functional recovery in primates with brachial plexus injury after spinal cord implantation of avulsed ventral roots.
T. Carlstedt (1993)
Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor.
L. Li (1995)
Return of function after spinal cord implantation of avulsed spinal nerve roots
T. Carlstedt (1995)
Delayed application of IGF-I and GDNF can rescue already injured postnatal motor neurons
M. Bilak (2001)
Brachial plexus repair by peripheral nerve grafts directly into the spinal cord in rats. Behavioral and anatomical evidence of functional recovery.
J. Bertelli (1994)
Neuroprotective effects of riluzole in neurotrauma models: a review.
F. Wahl (1999)
Excitotoxic cell death.
D. Choi (1992)
Motoneurons reinnervate skeletal muscle after ventral root implantation into the spinal cord of the cat
S. Cullheim (1989)
Survival and regeneration of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion
H. Chai (2000)
Rescue of lesioned adult rat spinal motoneurons by adenoviral gene transfer of glial cell line‐derived neurotrophic factor
K. Watabe (2000)
Long-term effects of a single dose of brain-derived neurotrophic factor on motoneuron survival following spinal root avulsion in the adult rat
H. Chai (1999)
Effect of Chronic Treatment with Riluzole on the Nigrostriatal Dopaminergic System in Weaver Mutant Mice
A. Douhou (2002)
Physiological adjustments in a reflex pathway following partial loss of target neurons
P. Holmberg (1996)
This paper is referenced by
Erythropoietin Attenuates the Apoptosis of Adult Neurons After Brachial Plexus Root Avulsion by Downregulating JNK Phosphorylation and c-Jun Expression and Inhibiting c-PARP Cleavage
K. Li (2015)
BASIC SCIENCE OF EXPERIMENTAL ROOT INJURIES
T. Carlstedt (2007)
Bionic Upper Limb Reconstruction: A Valuable Alternative in Global Brachial Plexus Avulsion Injuries—A Case Series
L. Hruby (2019)
An Update on the Treatment of Chorea
Erin Feinstein (2018)
Perspectives on the Treatment of the Longitudinal Spinal Cord Injury
T. Carlstedt (2010)
Delayed riluzole treatment is able to rescue injured rat spinal motoneurons
A. Nógrádi (2007)
Neurotrophic factor treatment after spinal root avulsion injury.
Tak-Ho Chu (2009)
Treatment with Riluzole Restores Normal Control of Soleus and Extensor Digitorum Longus Muscles during Locomotion in Adult Rats after Sciatic Nerve Crush at Birth
W. Zmysłowski (2017)
Conditions Affecting Accuracy of Peripheral Nerve Reinnervation and Functional Recovery
T. Ferguson (2015)
The Role of Trophic Factors and Other Drugs in the Treatment of Huntington ’ s Disease in R 6 / 2 Mouse Model by Jessica Ciesler
Increased target reinnervation by rescued cervical motoneurons after ventral root avulsion: the effects of spinal cord – brachial plexus reconnection and riluzole treatment!
Restoration and protection of brachial plexus injury: hot topics in the last decade
Kaizhi Zhang (2014)
Reactive changes in dorsal roots and dorsal root ganglia after C7 dorsal rhizotomy and ventral root avulsion/replantation in rabbits
N. Schlegel (2007)
Riluzole, neuroprotection and amyotrophic lateral sclerosis.
B. Cheah (2010)
Neuroregenerative effects of lentiviral vector-mediated GDNF expression in reimplanted ventral roots
R. Eggers (2008)
Nerve root replantation.
T. Carlstedt (2009)
Combining timed GDNF and ChABC gene therapy to promote long‐distance regeneration following ventral root avulsion and repair
R. Eggers (2020)
Chronic inhibitory effect of riluzole on trophic factor production
Cassandra N. Dennys (2015)
Neuronal death after peripheral nerve injury and experimental strategies for neuroprotection
A. Hart (2008)
Differential effects of riluzole on subpopulations of adult rat dorsal root ganglion neurons in vitro
V. Leinster (2010)
Amyotrophic Lateral Sclerosis: mechanism behind mutant SOD toxicity and improving current therapeutic strategies
Cassandra N. Dennys (2014)
Transgenic human embryonic stem cells overexpressing FGF2 stimulate neuroprotection following spinal cord ventral root avulsion
Marta Rocha Araújo (2017)
Lithium accelerates functional motor recovery by improving remyelination of regenerating axons following ventral root avulsion and reimplantation
Xin-Yu Fang (2016)
Regeneration and Recovery of Function
R. Birch (2013)
Translational potential of preclinical trials of neuroprotection through pharmacotherapy for spinal cord injury.
C. Tator (2012)
Etifoxine provides benefits in nerve repair with acellular nerve grafts
X. Zhou (2014)
Riluzole promotes cell survival and neurite outgrowth in rat sensory neurones in vitro
P. Shortland (2006)
Nerve Root Reimplantation in Brachial Plexus Injuries
V. Vanaclocha-Vanaclocha (2019)
Enhanced regeneration and reinnervation following timed GDNF gene therapy in a cervical ventral root avulsion
R. Eggers (2019)
The Role of Trophic Factors and Other Drugs in the Treatment of Huntington's Disease in R6/2 Mouse Model
Jessica Ciesler (2013)
Stem cell transplantation and regeneration after dorsal root avulsion
Carl Trolle (2016)
Title Lithium enhances axonal regeneration in peripheral nerve byinhibiting glycogen synthase kinase 3 β activation
Huanxing Su (2014)See more