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Proteasome Function Is Required For Activation Of Programmed Cell Death In Heat Shocked Tobacco Bright‐Yellow 2 Cells

R. A. Vacca, D. Valenti, A. Bobba, M. D. de Pinto, R. Merafina, L. De Gara, S. Passarella, E. Marra
Published 2007 · Medicine, Biology

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To find out whether and how proteasome is involved in plant programmed cell death (PCD) we measured proteasome function in tobacco cells undergoing PCD as a result of heat shock (HS‐PCD). Reactive oxygen species (ROS) production, cytochrome c levels and caspase‐3‐like protease activation were also measured in the absence or presence of MG132, a proteasome inhibitor. We show that proteasome activation occurs in early phase of HS‐PCD upstream of the caspase‐like proteases activation; moreover inhibition of proteasome function by MG132 results in prevention of PCD perhaps due to the prevention of ROS production, cytochrome c release and caspase‐3‐like protease activation.
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