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The KDEL Receptor: New Functions For An Old Protein
Mirco Capitani, M. Sallese
Published 2009 · Medicine, Biology
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The KDEL receptor is a seven‐transmembrane‐domain protein that was first described about 20 years ago. Its well‐known function is to retrotransport chaperones from the Golgi complex to the endoplasmic reticulum. Recent studies, however, have suggested that the KDEL receptor has additional functions. Indeed, we have demonstrated that chaperone‐bound KDEL receptor triggers the activation of Src family kinases on the Golgi complex. This activity is essential in the regulation of Golgi‐to‐plasma membrane transport. However, the identification of different KDEL receptor interactors that are inconsistent with these established functions opens the possibility of further receptor activities.
This paper references
G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications.
T. Chuang (1996)
Bidirectional Transport by Distinct Populations of COPI-Coated Vesicles
L. Orci (1997)
Coordination of the secretory compartments via inter-organelle signalling.
M. Sallese (2009)
KDEL receptor expression is not coordinatedly up-regulated with ER stress-induced reticuloplasmin expression in HeLa cells.
D. H. Llewellyn (1997)
Large-scale mapping of human protein–protein interactions by mass spectrometry
R. Ewing (2007)
Membrane traffic exploited by protein toxins.
K. Sandvig (2002)
Members of a mammalian SNARE complex interact in the endoplasmic reticulum in vivo and are found in COPI vesicles.
Sophie E Verrier (2008)
Identification of Amino Acids in the Binding Pocket of the Human KDEL Receptor*
A. Scheel (1998)
Expression and Regulation of aERD2, a Gene Encoding the KDEL Receptor Homolog in Plants, and Other Genes Encoding Proteins Involved in ER-Golgi Vesicular Trafficking.
M. Bar-Peled (1995)
Modulation of intracellular transport by transported proteins: insight from regulation of COPI-mediated transport.
T. Aoe (1998)
The KDEL Receptor Modulates the Endoplasmic Reticulum Stress Response through Mitogen-activated Protein Kinase Signaling Cascades*
K. Yamamoto (2003)
Mechanisms of pH Regulation in the Regulated Secretory Pathway*
M. Wu (2001)
A Regulatory Role for cAMP-dependent Protein Kinase in Protein Traffic along the Exocytic Route*
M. Muñiz (1996)
Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin a suggests an ER recycling pathway
J. Lippincott-Schwartz (1990)
Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL
W. Lencer (1995)
Genes that allow yeast cells to grow in the absence of the HDEL receptor.
K. Hardwick (1992)
A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1
V. Hsu (1992)
Src Regulates Golgi Structure and KDEL Receptor-dependent Retrograde Transport to the Endoplasmic Reticulum*
Frédéric Bard (2003)
A genome annotation-driven approach to cloning the human ORFeome
J. Collins (2004)
Towards a proteome-scale map of the human protein–protein interaction network
Jean-François Rual (2005)
The physiology of membrane transport and endomembrane‐based signalling
M. Sallese (2006)
Sed4p functions as a positive regulator of Sar1p probably through inhibition of the GTPase activation by Sec23p
Y. Saito-Nakano (2000)
Organelle pH studies using targeted avidin and fluorescein-biotin.
M. Wu (2000)
Localization of Sed5, a putative vesicle targeting molecule, to the cis- Golgi network involves both its transmembrane and cytoplasmic domains
D. K. Banfield (1994)
The KDEL receptor mediates a retrieval mechanism that contributes to quality control at the endoplasmic reticulum
K. Yamamoto (2001)
Recycling of proteins between the endoplasmic reticulum and Golgi complex.
H. Pelham (1991)
The retrieval function of the KDEL receptor requires PKA phosphorylation of its C-terminus.
M. Cabrera (2003)
KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET.
I. Majoul (2001)
Mammalian MAP kinase signalling cascades
L. Chang (2001)
A molecular specificity code for the three mammalian KDEL receptors
Irina B Raykhel (2007)
GeneCards: a novel functional genomics compendium with automated data mining and query reformulation support
M. Rebhan (1998)
Protein kinase A activity is required for the budding of constitutive transport vesicles from the trans-Golgi network.
M. Muñiz (1997)
Complete sequencing and characterization of 21,243 full-length human cDNAs
T. Ota (2004)
Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile
M. Schuldiner (2005)
A C-terminal signal prevents secretion of luminal ER proteins
S. Munro (1987)
A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway
T. Pulvirenti (2008)
Golgi gets wired up
L. Asp (2008)
SED4 encodes a yeast endoplasmic reticulum protein that binds Sec16p and participates in vesicle formation
R. Gimeno (1995)
Purification and characterization of the human KDEL receptor.
A. Scheel (1996)
Large-scale identification of yeast integral membrane protein interactions.
J. Miller (2005)
pH-dependent binding of KDEL to its receptor in vitro.
D. Wilson (1993)
SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER
C. Barlowe (1993)
Two redundant systems maintain levels of resident proteins within the yeast endoplasmic reticulum.
C. T. Beh (1995)
An early step in Pseudomonas exotoxin action is removal of the terminal lysine residue, which allows binding to the KDEL receptor.
J. Hessler (1997)
Evidence that luminal ER proteins are sorted from secreted proteins in a post‐ER compartment.
H. Pelham (1988)
Toxin entry and trafficking in mammalian cells.
P. Watson (2006)
XIII. Yeast sequencing reports. SED6 is identical to ERG6, and encodes a putative methyltransferase required for ergosterol synthesis
K. Hardwick (1994)
The KDEL retrieval system is exploited by Pseudomonas exotoxin A, but not by Shiga-like toxin-1, during retrograde transport from the Golgi complex to the endoplasmic reticulum.
M. E. Jackson (1999)
Ligand binding and micro-switches in 7TM receptor structures.
R. Nygaard (2009)
Reviews in Molecular Biology and Biotechnology: Transmembrane Signaling by G Protein-Coupled Receptors
L. Luttrell (2008)
A human homologue of the yeast HDEL receptor
M. Lewis (1990)
Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport.
F. Townsley (1993)
Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation
K. J. Travers (2000)
Transmembrane topology of the mammalian KDEL receptor.
P. Singh (1993)
Agonist‐selective mechanisms of GPCR desensitization
E. Kelly (2008)
Cellular functions regulated by Src family kinases.
S. Thomas (1997)
ERD1, a yeast gene required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus.
K. Hardwick (1990)
Localization of the Lys, Asp, Glu, Leu tetrapeptide receptor to the Golgi complex and the intermediate compartment in mammalian cells
G. Griffiths (1994)
SED5 encodes a 39-kD integral membrane protein required for vesicular transport between the ER and the Golgi complex
K. Hardwick (1992)
Sequence of a second human KDEL receptor.
M. Lewis (1992)
ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway
J. C. Semenza (1990)
The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase‐activating protein for ARF1
T. Aoe (1997)
Membrane trafficking heats up in Pavia
J. Donaldson (2009)
The ERD2 gene determines the specificity of the luminal ER protein retention system
M. Lewis (1990)
Dolichol phosphate mannose synthase is required in vivo for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and N glycosylation of protein in Saccharomyces cerevisiae.
P. Orlean (1990)
Role of the putative structural protein Sed1p in mitochondrial genome maintenance.
Naina Phadnis (2004)
Dilated Cardiomyopathy Caused by Aberrant Endoplasmic Reticulum Quality Control in Mutant KDEL Receptor Transgenic Mice
H. Hamada (2004)
Sorting of soluble ER proteins in yeast.
H. Pelham (1988)
Changing the specificity of the sorting receptor for luminal endoplasmic reticulum proteins.
J. C. Semenza (1992)
Recycling of proteins from the Golgi compartment to the ER in yeast
N. Dean (1990)
A journey through the exocytic pathway.
S. Béraud-Dufour (2002)
Determining the Environment of the Ligand Binding Pocket of the Human Angiotensin II Type I (hAT1) Receptor Using the Methionine Proximity Assay*
M. Clement (2005)
A renaissance for SRC
T. Yeatman (2004)
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Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion.
Koh Takeda (2014)
A guide to taming a toxin – recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer
J. Weldon (2011)
Endothelial cell surface expression of protein disulfide isomerase activates β1 and β3 integrins and facilitates dengue virus infection
S. Wan (2012)
Towards the development of a multicomponent, nanoscale oral vaccine delivery system targeting infectious bursal disease (IBD)
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Human single-chain antibodies that neutralize Pseudomonas aeruginosa-exotoxin A-mediated cellular apoptosis
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KDELC 1 , a novel endoplasmic reticulum resident glycoprotein in hepatic dysfunction
Xing-cui Wang (2016)
Improvement of Intracellular Traffic System by Overexpression of KDEL Receptor 1 in Antibody-Producing CHO Cells.
Andrew Samy (2020)
Plant ERD2-like proteins function as endoplasmic reticulum luminal protein receptors and participate in programmed cell death during innate immunity.
Guoyong Xu (2012)
Mesencephalic astrocyte-derived neurotrophic factor and cerebral dopamine neurotrophic factor: New endoplasmic reticulum stress response proteins.
H. Liu (2015)
Prohibitin: A Novel Molecular Player in KDEL Receptor Signalling
Monica Giannotta (2015)
The application of predictive statistical modelling in the investigation of suspected classical Myeloproliferative Neoplasms
F. Cullen (2018)
KDELR2 Promotes Glioblastoma Tumorigenesis Targeted by HIF1a via mTOR Signaling Pathway
Zhangyuan Liao (2019)
Cis/transgene optimization: systematic discovery of some key gene expression elements integrating bioinformatics and computational biology
Saeid Kadkhodaei (2016)
Enabling cytoplasmic delivery and organelle targeting by surface modification of nanocarriers
A. Parodi (2015)
A KDEL Retrieval System for ER-Golgi Transport of Japanese Encephalitis Viral Particles
R. L. Wang (2016)
Chaperony endoplazmatického retikula na povrchu nádorové buňky a v extracelulárním prostředí Endoplasmic Reticulum Chaperones at the Tumor Cell Surface and in the Extracellular
Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections
Arturo Sánchez (2020)
Proteomic Identification of S-Nitrosylated Golgi Proteins: New Insights into Endothelial Cell Regulation by eNOS-Derived NO
Panjamaporn Sangwung (2012)
Recent developments in the pathophysiology of irritable bowel syndrome.
M. El-Salhy (2015)
Phylogeny and distinct properties of major intrinsic proteins in the genomes of six Phytophthora species suggest their novel functions in Phytophthora
A. K. Azad (2018)
Systematic Optimization of C-Terminal Amine-Based Isotope Labeling of Substrates Approach for Deep Screening of C-Terminome.
Y. Zhang (2015)
Regulation of Golgi signaling and trafficking by the KDEL receptor
J. Cancino (2013)
Transcriptional regulation of secretory capacity by bZip transcription factors
R. M. Fox (2014)
Synthetic antibody discovery against native antigens by CRISPR/Cas9-library generation and endoplasmic reticulum screening
J. Ministro (2020)
Cell-type-specific differences in KDEL receptor clustering in mammalian cells
A. Bauer (2020)
Beyond KDEL: the role of positions 5 and 6 in determining ER localization.
H. Alanen (2011)
A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling
A. Caldarelli (2013)
Targeting membrane proteins to inner segments of vertebrate photoreceptors
Y. Pan (2015)
Calcium signalling in human colonic epithelium
George Lines (2019)
Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum
V. Bortnov (2019)
Melanoblast transcriptome analysis reveals novel pathways promoting melanoma metastasis
Kerrie L. Marie (2019)
Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro
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