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MicroRNA-134 Suppresses Endometrial Cancer Stem Cells By Targeting POGLUT1 And Notch Pathway Proteins.

Yongtao Gao, Te Liu, Yongyi Huang
Published 2015 · Biology, Medicine
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We aimed to ascertain the role of microRNAs (miRNAs) in regulating human endometrial cancer stem cells (HuECSCs). The expression level of miRNA-134 (miR-134), a member of the DLK1-DIO3 genomic imprinted miRNA cluster, differed significantly between HuECSCs and human endometrial cancer cells (HuECCs). miR-134 inhibited HuECSCs proliferation and migration by targeting protein O-glucosyltransferase 1 (POGLUT1) expression. Exogenous miR-134 overexpression downregulated POGLUT1 and Notch pathway proteins in HuECSCs in vitro. miR-134 overexpression affected the G2/M phase of HuECSCs and suppressed the growth of xenograft tumours formed. Thus, endogenous miR-134 regulation in HuECSCs may suppress tumourigenesis in human endometrial carcinoma.
This paper references
10.1074/jbc.M111.229831
DLK1-DIO3 Genomic Imprinted MicroRNA Cluster at 14q32.2 Defines a Stemlike Subtype of Hepatocellular Carcinoma Associated with Poor Survival
John Moon-Ching Luk (2011)
10.1016/j.febslet.2012.09.016
miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells.
Jipeng Li (2012)
10.1152/physrev.00006.2010
MicroRNAs in development and disease.
Danish Sayed (2011)
10.1074/jbc.M112.387761
MicroRNAs in the Imprinted DLK1-DIO3 Region Repress the Epithelial-to-Mesenchymal Transition by Targeting the TWIST1 Protein Signaling Network*
Christopher L. Haga (2012)
10.1242/dev.02726
Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region
Shau-Ping Lin (2007)
10.3892/ol.2014.2197
Protein O-glucosyltransferase 1 overexpression downregulates p16 in BT474 human breast cancer cells
Gang Jin (2014)
10.1371/journal.pone.0087665
Genome-Wide Screening Identified That miR-134 Acts as a Metastasis Suppressor by Targeting Integrin β1 in Hepatocellular Carcinoma
Ruopeng Zha (2014)
10.1155/2013/130362
Emerging Therapeutic Biomarkers in Endometrial Cancer
Peixin Dong (2013)
10.3892/or.2012.1807
Isolation and characterization of proliferative, migratory and multidrug-resistant endometrial carcinoma-initiating cells from human type II endometrial carcinoma cell lines.
Yongtao Gao (2012)
10.1016/j.febslet.2013.03.023
MicroRNA-155 is a novel suppressor of ovarian cancer-initiating cells that targets CLDN1.
Wenxing Qin (2013)
10.1111/cpr.12037
Overexpression of hCLP46 enhances Notch activation and regulates cell proliferation in a cell type-dependent manner.
Qiaoyun Chu (2013)
10.1016/j.bbrc.2011.03.124
hCLP46 regulates U937 cell proliferation via Notch signaling pathway.
Wenzhan Ma (2011)
10.1007/s00018-012-1080-8
The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis
Leonidas Benetatos (2012)
10.1016/j.ajog.2013.03.008
Chemopreventive effects of metformin on obesity-associated endometrial proliferation.
Qian Zhang (2013)
10.1016/j.ygyno.2009.10.041
Promising novel therapies for the treatment of endometrial cancer.
Paola A. Gehrig (2010)
Isolation and characterization of proliferative, migratory and multidrug-resistant endometrial carcinomainitiating cells from human type II endometrial carcinoma cell lines
Y. Gao (2012)
10.1093/glycob/cwq053
Role of glycans and glycosyltransferases in the regulation of Notch signaling.
Hamed Jafar-Nejad (2010)
Protein Oglucosyltransferase 1 overexpression downregulates p16 in BT474 human breast cancer cells
G. Jin (2014)
10.3892/ijmm.2011.679
microRNA-182 inhibits the proliferation and invasion of human lung adenocarcinoma cells through its effect on human cortical actin-associated protein.
L Zhang (2011)
10.1038/ncb2924
A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions
Robin G. Lerner (2014)
10.1073/pnas.1307107110
Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer
Yong Peng (2013)
10.1016/j.bbcan.2014.02.002
Regulation of microRNAs in cancer metastasis.
Juliette M Bouyssou (2014)
10.1186/1471-2407-11-425
MiR-125b promotes proliferation and migration of type II endometrial carcinoma cells through targeting TP53INP1 tumor suppressor in vitro and in vivo
Feizhou Jiang (2011)
10.1016/j.devcel.2009.03.010
Notch signaling: the core pathway and its posttranslational regulation.
Mark E. Fortini (2009)
10.1074/jbc.275.13.9604
Mammalian Notch1 Is Modified with Two Unusual Forms ofO-Linked Glycosylation Found on Epidermal Growth Factor-like Modules*
D. Moloney (2000)
10.1002/hep.26573
Hepatocyte nuclear factor-4α reverses malignancy of hepatocellular carcinoma through regulating miR-134 in the DLK1-DIO3 region.
Chuan Yin (2013)
Genome-wide screening identified that miR-134 acts as a metastasis suppressor by targeting integrin beta1 in hepatocellular carcinoma
R. Zha (2014)
10.1186/s12967-014-0231-0
The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer
P. Dong (2014)
10.1111/j.1742-4658.2012.08589.x
MicroRNA-199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells.
Weiwei Cheng (2012)
10.1016/j.cell.2007.12.016
Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling
M. Acar (2008)
10.3892/mmr.2012.967
Microarray analysis of microRNA expression patterns in the semen of infertile men with semen abnormalities.
T. Liu (2012)
Differential regulation of imprinting
S. P. Lin (2007)
10.1089/scd.2012.0653
MicroRNA-122 influences the development of sperm abnormalities from human induced pluripotent stem cells by regulating TNP2 expression.
Te Liu (2013)
10.1074/jbc.M802027200
Roles of Pofut1 and O-Fucose in Mammalian Notch Signaling*
Mark C Stahl (2008)



This paper is referenced by
CMAR_A_221150 10229..10238
B Sun (2019)
10.1155/2016/4591468
Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis
F. Budak (2016)
10.1101/682773
Notch signaling is required for survival of the germline stem cell lineage in testes of Drosophila melanogaster
Chun Leung Ng (2019)
10.18632/oncotarget.13991
Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells
James A McCubrey (2017)
microRNA-134 inhibits melanoma growth and metastasis by negatively regulating collagen triple helix repeat containing-1 (CTHRC1).
Y. Li (2018)
10.1007/s10555-015-9574-0
Clinical translation for endometrial cancer stem cells hypothesis
Maria João Carvalho (2015)
10.18632/oncotarget.8482
Hsa-miR-134 suppresses non-small cell lung cancer (NSCLC) development through down-regulation of CCND1
Cheng-Cao Sun (2016)
10.1016/j.ncrna.2016.07.001
Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention
Bernhard Biersack (2016)
10.1371/journal.pgen.1005551
Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2
Nitya Ramkumar (2015)
10.1016/j.gene.2018.04.029
miR-758 mediates oxLDL-dependent vascular endothelial cell damage by suppressing the succinate receptor SUCNR1.
H. Zhang (2018)
10.7150/jca.15515
Magnetofection Based on Superparamagnetic Iron Oxide Nanoparticles Weakens Glioma Stem Cell Proliferation and Invasion by Mediating High Expression of MicroRNA-374a
Zhiguang Pan (2016)
10.1080/09168451.2020.1736508
Actin‑like protein 8 executes a promoting function in the malignant progression of endometrial cancer: identification of a promising biomarker
Lingli Li (2020)
10.1007/978-1-4939-8859-4_14
Notch Signaling in Estrogen-Dependent Cancers
Judy S Crabtree (2018)
10.1038/srep24720
miRs-134 and -370 function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling
Sherien M. El-Daly (2016)
Role of MicroRNA in Endometrial Carcinoma
Zeeshan Javed (2016)
10.1016/j.dnarep.2018.04.002
Cross-regulation between Notch signaling pathway and miRNA machinery in cancer.
M. Majidinia (2018)
10.2147/CMAR.S221150
miR-194 Inhibits the Proliferation of SW620 Colon Cancer Stem Cells Through Downregulation of SSH2 Expression
Bo Sun (2019)
10.1016/j.gene.2016.12.030
MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.
C. F. Chang (2017)
10.1016/j.ncrna.2016.10.001
Interactions between anticancer active platinum complexes and non-coding RNAs/microRNAs
Bernhard Biersack (2017)
10.1016/j.gene.2019.04.058
miR-412-5p targets Xpo1 to regulate angiogenesis in hemorrhoid tissue.
Chen Wang (2019)
10.1007/s13105-018-0642-0
miR-9 inhibits the metastatic ability of hepatocellular carcinoma via targeting beta galactoside alpha-2,6-sialyltransferase 1
Yi Han (2018)
10.3748/wjg.v22.i2.801
Noncoding RNAs and pancreatic cancer.
Juan-Fei Peng (2016)
10.1007/s13346-020-00811-7
Exogenous delivery of microRNA-134 (miR-134) using α-tocopherol-based PEGylated liposome for effective treatment in skin squamous cell carcinoma
Chen Jing (2020)
10.1089/GTMB.2017.0179
Curcumin Suppresses In Vitro Proliferation and Invasion of Human Prostate Cancer Stem Cells by Modulating DLK1-DIO3 Imprinted Gene Cluster MicroRNAs
ZhangHu (2017)
10.1007/s00404-016-4194-7
The future therapy of endometrial cancer: microRNA’s functionality, capability, and putative clinical application
M. Stope (2016)
10.1186/s12943-017-0595-x
Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells
Catharina Melzer (2017)
10.3390/cancers11111820
Endometrial Cancer Stem Cells: Role, Characterization and Therapeutic Implications
G. Giannone (2019)
10.1101/615237
Integrated analysis of the miRNA-mRNA network associated with LMP1 gene in nasopharyngeal carcinoma
Yang Yang (2019)
10.1371/journal.pone.0222471
Notch and Delta are required for survival of the germline stem cell lineage in testes of Drosophila melanogaster
Chun Ng (2019)
10.4252/wjsc.v7.i8.1078
Emerging role of microRNAs in cancer stem cells: Implications in cancer therapy.
M. Garg (2015)
10.3390/ijms20163985
Antitumor Effect of Pyrogallol via miR-134 Mediated S Phase Arrest and Inhibition of PI3K/AKT/Skp2/cMyc Signaling in Hepatocellular Carcinoma
Hyojin Ahn (2019)
10.2147/IJN.S200480
Superparamagnetic iron oxide nanoparticle-mediated expression of miR-326 inhibits human endometrial carcinoma stem cell growth
Yongtao Gao (2019)
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