Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Role Of Vitamin E As A Lipid-soluble Peroxyl Radical Scavenger: In Vitro And In Vivo Evidence.

E. Niki
Published 2014 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Multiple reactive oxygen/nitrogen species induce oxidative stress. Mammals have evolved with an elaborate defense network against oxidative stress, in which multiple antioxidant compounds and enzymes with different functions exert their respective roles. Radical scavenging is one of the essential roles of antioxidants and vitamin E is the most abundant and important lipophilic radical-scavenging antioxidant in vivo. The kinetic data and physiological molar ratio of vitamin E to substrates show that the peroxyl radicals are the only radicals that vitamin E can scavenge to break chain propagation efficiently and that vitamin E is unable to act as a potent scavenger of hydroxyl, alkoxyl, nitrogen dioxide, and thiyl radicals in vivo. The preventive effect of vitamin E against the oxidation mediated by nonradical oxidants such as hypochlorite, singlet oxygen, ozone, and enzymes may be limited in vivo. The synergistic interaction of vitamin E and vitamin C is effective for enhancing the antioxidant capacity of vitamin E. The in vitro and in vivo evidence of the function of vitamin E as a peroxyl radical-scavenging antioxidant and inhibitor of lipid peroxidation is presented.
This paper references
10.1152/AJPREGU.00614.2005
Free radical biology and medicine: it's a gas, man!
W. A. Pryor (2006)
10.3109/10715769409056592
Enhancement of nitrogen dioxide-induced lipid peroxidation and DNA strand breaking by cysteine and glutathione.
K. Kikugawa (1994)
10.1016/J.FREERADBIOMED.2007.03.024
Vitamin E, antioxidant and nothing more.
M. Traber (2007)
10.1139/V85-062
Autoxidation in micelles. Synergism of vitamin C with lipid-soluble vitamin E and water-soluble Trolox
L. Barclay (1985)
10.1021/tx800372d
What are the plasma targets of the oxidant hypochlorous acid? A kinetic modeling approach.
D. Pattison (2009)
10.1042/BJ1230823
The stimulatory effects of carbon tetrachloride on peroxidative reactions in rat liver fractions in vitro. Inhibitory effects of free-radical scavengers and other agents.
T. F. Slater (1971)
10.1016/0003-9861(90)90508-V
Free radical-mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C.
K. Sato (1990)
Biokinetics of dietary RRR-alpha-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E. Evidence that vitamin C does not "spare" vitamin E in vivo.
G. W. Burton (1990)
10.1246/BCSJ.59.3113
Stopped-flow investigation of antioxidant activity of tocopherols.
K. Mukai (1986)
10.1002/mnfr.200900445
Vitamin E transport, membrane incorporation and cell metabolism: Is alpha-tocopherol in lipid rafts an oar in the lifeboat?
S. Lemaire-Ewing (2010)
10.1021/TX025670S
Hypochlorous acid-mediated oxidation of lipid components and antioxidants present in low-density lipoproteins: absolute rate constants, product analysis, and computational modeling.
D. Pattison (2003)
10.1016/j.bbamem.2008.10.011
Polyunsaturated fatty acid-cholesterol interactions: domain formation in membranes.
S. Wassall (2009)
10.1159/000343106
A History of Vitamin E
E. Niki (2012)
10.1038/nature04394
Membranes are more mosaic than fluid
D. Engelman (2005)
10.1016/0891-5849(94)90172-4
Mechanisms of radical formation from reactions of ozone with target molecules in the lung.
W. A. Pryor (1994)
10.1074/jbc.273.22.13605
Formation of Isoprostane-like Compounds (Neuroprostanes) in Vivo from Docosahexaenoic Acid*
L. Roberts (1998)
Addition products of alpha-tocopherol with lipid-derived free radicals.
R. Yamauchi (2007)
10.1021/cr200084z
Free radical lipid peroxidation: mechanisms and analysis.
H. Yin (2011)
10.1007/BF01210407
Reaction of thiyl radicals with alcohols, ethers and polyunsaturated fatty acids: A possible role of thiyl free radicals in thiol mutagenesis?
C. Schoeneich (1990)
10.1002/CHIN.198829327
Comparison of the Efficiencies of Several Natural and Synthetic Antioxidants in Aqueous Sodium Dodecyl Sulfate Micelle Solutions
W. A. Pryor (1988)
10.1016/j.freeradbiomed.2009.05.032
Lipid peroxidation: physiological levels and dual biological effects.
E. Niki (2009)
10.1006/ABBI.1996.0130
Efficacy of hypochlorous acid scavengers in the prevention of protein carbonyl formation.
L. J. Yan (1996)
10.1016/0005-2760(88)90098-7
The relationship between alpha-tocopherol and phospholipid fatty acids in rat liver subcellular membrane fractions.
J. Buttriss (1988)
10.1016/B978-0-12-207250-5.50008-7
The fluid mosaic model of the structure of cell membranes.
S. Singer (1972)
10.1074/jbc.M305542200
Cell Death Caused by Selenium Deficiency and Protective Effect of Antioxidants*
Y. Saito (2003)
10.1016/j.plipres.2012.01.001
Lipid-lipid interactions in bilayer membranes: married couples and casual liaisons.
P. Quinn (2012)
editors. 4th ed
B. Halliwell (2007)
10.3177/JNSV.34.507
Free radical-mediated damage of blood and its inhibition by antioxidants.
E. Niki (1988)
10.1016/S0009-2797(86)80062-X
Lipid peroxidation and molecular damage to polyunsaturated fatty acids in rat liver. Recognition of two classes of hydroperoxides formed under conditions in vivo.
F. Corongiu (1986)
10.1073/PNAS.85.24.9748
Antioxidant defenses and lipid peroxidation in human blood plasma.
B. Frei (1988)
10.1016/J.FREERADBIOMED.2007.03.013
Molecular mechanism of α-tocopherol action
A. Azzi (2007)
Vitamin E and blood.
Chow Ck (1985)
10.1002/mnfr.200900439
The location and behavior of alpha-tocopherol in membranes.
J. Atkinson (2010)
Hypochlorous acid-mediated modification of cholesterol and phospholipid: analysis of reaction products by gas chromatography-mass spectrometry.
J. V. D. van den Berg (1993)
10.1007/BF02533546
Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation: Correlation with vitamin E content
D. Kornbrust (2006)
10.1021/jf302021r
Development of singlet oxygen absorption capacity (SOAC) assay method. 3. Measurements of the SOAC values for phenolic antioxidants.
K. Mukai (2012)
10.1016/S0891-5849(00)00198-2
Biomarkers of oxidative stress study: are plasma antioxidants markers of CCl4 poisoning?
M. Kadiiska (2000)
10.1093/ajcn/62.6.1357S
Coantioxidants make alpha-tocopherol an efficient antioxidant for low-density lipoprotein.
S. Thomas (1995)
Oxidation of lipids . VI . Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C
E. Niki (1984)
10.1159/000410266
Vitamin E and Blood1
C. Chow (1985)
10.3109/10715762.2012.677840
Fatty liver induced by free radicals and lipid peroxidation
Mayuko Morita (2012)
10.3233/JBR-2011-018
Antioxidant capacity: Which capacity and how to assess it?
E. Niki (2011)
Vitamin E history
E. Niki (2012)
10.1016/j.biochi.2012.09.017
F(2)-Dihomo-isoprostanes and brain white matter damage in stage 1 Rett syndrome.
T. Durand (2013)
10.1016/j.febslet.2005.12.045
Adaptive response induced by lipid peroxidation products in cell cultures
Z. Chen (2006)
10.1042/BJ2880341
Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant.
V. Bowry (1992)
10.1021/JA9942080
Stability and Reactivity of Aryloxyl Radicals Derived from a Novel Antioxidant BO-653 and Related Compounds. Effects of Substituent and Side Chain in Solution and Membranes
A. Watanabe (2000)
Synergistic inhibition of oxidation in dispersed phosphatidylcholine liposomes by a combination of vitamin E and cysteine
本山 忠 (1990)
Autoxidation of biological molecules
G. W. Burton (1985)
10.3177/JNSV.37.359
Synergistic action of vitamin E and vitamin C in vivo using a new mutant of Wistar-strain rats, ODS, unable to synthesize vitamin C.
O. Igarashi (1991)
Formation of alpha-tocopherol radical and recycling of alpha-tocopherol by ascorbate during peroxidation of phosphatidylcholine liposomes. An electron paramagnetic resonance study.
M. Scarpa (1984)
10.3164/jcbn.11-008FR
Singlet molecular oxygen-quenching activity of carotenoids: relevance to protection of the skin from photoaging
J. Terao (2011)
10.1007/s11745-998-0266-y
Rate constants for quenching singlet oxygen and activities for inhibiting lipid peroxidation of carotenoids and α-tocopherol in liposomes
K. Fukuzawa (1998)
10.1021/JA00067A019
Tocopherol-mediated peroxidation. The prooxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein
V. Bowry (1993)
10.1016/S0076-6879(99)99031-6
Gas chromatography-mass spectrometry analysis of vitamin E and its oxidation products.
D. Liebler (1996)
10.1016/S0300-483X(02)00286-X
Biological reactivity and biomarkers of the neutrophil oxidant, hypochlorous acid.
C. Winterbourn (2002)
10.1042/BJ20111752
Cell signalling by reactive lipid species: new concepts and molecular mechanisms
Ashlee N. Higdon (2012)
10.3109/10715769109088953
Free radical-induced liver injury. II. Effects of intraperitoneally administered 2,2'-azobis(2-amidinopropane) dihydrochloride on the fatty acid profiles of hepatic triacylglycerol and phospholipids.
H. Shimasaki (1991)
Oxidative hemolysis of erythrocytes and its inhibition by free radical scavengers.
E. Niki (1988)
10.1016/s0021-9258(17)43026-2
Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C.
E. Niki (1984)
10.1021/JF0502698
Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements.
R. Prior (2005)
10.1016/0003-9861(92)90016-P
Oxidation of polyunsaturated fatty acids and lipids through thiyl and sulfonyl radicals: reaction kinetics, and influence of oxygen and structure of thiyl radicals.
C. Schoeneich (1992)
10.1042/BJ3390489
Secondary radicals derived from chloramines of apolipoprotein B-100 contribute to HOCl-induced lipid peroxidation of low-density lipoproteins.
L. Hazell (1999)
10.1016/0006-291X(89)91369-7
Vitamin A and glutathione-mediated free radical damage: competing reactions with polyunsaturated fatty acids and vitamin C.
M. D'aquino (1989)
10.1073/PNAS.0508170103
Linoleic acid hydroperoxide reacts with hypochlorous acid, generating peroxyl radical intermediates and singlet molecular oxygen.
S. Miyamoto (2006)
10.1021/JO961039I
Bond Dissociation Energies of O−H Bonds in Substituted Phenols from Equilibration Studies
M. Lucarini (1996)
10.1016/j.chemphyslip.2011.01.001
Kinetic study of aroxyl radical-scavenging action of vitamin E in membranes of egg yolk phosphatidylcholine vesicles.
K. Fukuzawa (2011)
10.1016/j.freeradbiomed.2010.08.016
Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function.
Y. Saito (2010)
10.1021/JA00310A049
Autoxidation of biological molecules. 4. Maximizing the antioxidant activity of phenols
G. W. Burton (1985)
10.1016/J.FREERADBIOMED.2005.10.051
Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation.
R. Bruno (2006)
10.1016/0891-5849(92)90181-F
The role of lipid peroxidation and antioxidants in oxidative modification of LDL.
H. Esterbauer (1992)
10.1021/JO982360Z
Solvent Effects on the Antioxidant Activity of Vitamin E(1).
L. Valgimigli (1999)
A rapid and simple screening test for potential inhibitors of tocopherol-mediated peroxidation of LDL lipids.
P. Witting (1996)
10.1016/0891-5849(90)90206-X
Regeneration of vitamin E in human platelets.
A. C. Chan (1991)
10.1016/S0009-3084(02)00164-0
Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects.
Y. Yoshida (2003)
Determination of the alpha-tocopherol inhibition rate constant for peroxidation in low-density lipoprotein.
S. Culbertson (2002)
10.1021/JA01514A032
Reactivity and Reversibility in the Reaction of Thiyl Radicals with Olefins1
C. Walling (1959)
10.1246/CL.1982.789
REGENERATION OF VITAMIN E FROM α-CHROMANOXYL RADICAL BY GLUTATHIONE AND VITAMIN C
E. Niki (1982)
Model biomembranes: quantitative studies of peroxidation, antioxidant action, partitioning, and oxidative stress
L.R.C. Barclay (1993)
10.1016/j.freeradbiomed.2010.11.023
F2-isoprostanes as an indicator and risk factor for coronary heart disease.
S. Davies (2011)
10.1016/S0083-6729(07)76011-9
Addition Products of α‐Tocopherol with Lipid‐Derived Free Radicals
R. Yamauchi (2007)
10.1006/ABBI.1998.0914
Protection by vitamin C of loss of vitamin E in cultured rat hepatocytes.
A. Halpner (1998)
10.1089/ars.2010.3397
A comparison of thiol peroxidase mechanisms.
L. Flohé (2011)
10.1021/ar200024c
Free radical oxidation of polyunsaturated lipids: New mechanistic insights and the development of peroxyl radical clocks.
D. Pratt (2011)
10.1021/JA00049A037
Electron-transfer reactions of alkylperoxy radicals
S. Jovanovic (1992)
10.1139/V90-348
The antioxidant activities of phenolic antioxidants in free radical peroxidation of phospholipid membranes
L. Barclay (1990)
10.1006/ABBI.1995.1150
Reaction of Ascorbate with the α-Tocopheroxyl Radical in Micellar and Bilayer Membrane Systems
R. Bisby (1995)
10.1016/j.mam.2009.02.005
Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis.
A. Brown (2009)
10.1006/ABBI.1993.1074
The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate.
G. Buettner (1993)
10.1002/hep.25778
Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: New evidence on the potential therapeutic mechanism
C. O. Zein (2012)
10.1021/ja9029076
Rate constants for peroxidation of polyunsaturated fatty acids and sterols in solution and in liposomes.
L. Xu (2009)
10.1073/PNAS.90.1.45
Autoxidation of lipids and antioxidation by alpha-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein.
K. Ingold (1993)
10.1007/BF02535748
Biokinetics of dietaryRRR-α-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E. Evidence that vitamin C does not “spare” vitamin Ein vivo
G. W. Burton (2006)
10.1021/JA00215A036
Comparison of the efficiencies of several natural and synthetic antioxidants in aqueous SDS [sodium dodecyl sulfate] micelle solutions
W. A. Pryor (1988)
10.1139/V93-001
1992 Syntex Award Lecture Model biomembranes: quantitative studies of peroxidation, antioxidant action, partitioning, and oxidative stress
L. Barclay (1993)
10.1016/J.FREERADBIOMED.2007.11.010
Tocopherols and tocotrienols in membranes: a critical review.
J. Atkinson (2008)
10.1021/JA00198A054
Scavenging of radicals by vitamin E in the membranes as studied by spin labeling
M. Takahashi (1989)
Regioisomeric distribution of cholesteryl linoleate hydroperoxides and hydroxides in plasma from healthy humans provides evidence for free radical-mediated lipid peroxidation in vivo.
R. Mashima (2000)
Autoxidation of biological molecules
G. W. Burton (1981)
10.1016/0005-2760(85)90285-1
Antioxidant and co-antioxidant activity of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes.
T. Doba (1985)
10.1021/AR030069M
Dynamics of antioxidant action of vitamin E.
E. Niki (2004)
10.1021/JO0601462
Peroxyl radical clocks.
B. Roschek (2006)
10.1016/0009-3084(87)90053-3
The role of selenium peroxidases in the protection against oxidative damage of membranes.
F. Ursini (1987)
10.1016/0304-4165(90)90176-W
Stopped-flow kinetic study of the regeneration reaction of tocopheroxyl radical by reduced ubiquinone-10 in solution.
K. Mukai (1990)
10.1246/BCSJ.55.1551
Oxidation of Lipids. II. Rate of Inhibition of Oxidation by α-Tocopherol and Hindered Phenols Measured by Chemiluminescence
E. Niki (1982)
10.1021/JA00411A035
Autoxidation of biological molecules. 1. Antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro
G. W. Burton (1981)
10.1161/01.RES.0000156653.05853.b9
Haptoglobin Genotype– and Diabetes-Dependent Differences in Iron-Mediated Oxidative Stress In Vitro and In Vivo
R. Asleh (2005)
10.1016/j.chemphyslip.2011.06.006
Pathways of cholesterol oxidation via non-enzymatic mechanisms.
L. Iuliano (2011)
Hypochlorous acidmediated modification of cholesterol and phospholipid: analysis of reaction products by gas chromatography–mass spectrometry
J. J. van den Berg (2005)
10.1021/BK-1992-0500.CH002
Mechanisms of Lipid Oxidative Processes and Their Inhibition
M. Simic (1992)
10.1063/1.555655
Rate constants for the decay and reactions of the lowest electronically excited singlet state of molecular oxygen in solution
F. Wilkinson (1981)
10.1194/jlr.M007096
Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis[S]
A. Feldstein (2010)
10.1096/fasebj.13.10.1145
Vitamin E: function and metabolism
R. Brigelius-Flohé (1999)
10.1016/0003-9861(90)90556-E
Physical and chemical scavenging of singlet molecular oxygen by tocopherols.
S. Kaiser (1990)
10.1073/PNAS.87.23.9383
A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.
J. Morrow (1990)
10.1246/BCSJ.62.1885
Oxidation of lipids. XVII: Crossover effect of tocopherols in the spontaneous oxidation of methyl linoleate
M. Takahashi (1989)
10.1016/S0891-5849(99)00053-2
Comparative study on dynamics of antioxidative action of α-tocopheryl hydroquinone, ubiquinol, and α-tocopherol against lipid peroxidation
H. Shi (1999)
10.1016/S0014-5793(97)00499-7
Affinity for α‐tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs
A. Hosomi (1997)
10.1016/S0748-5514(86)80070-8
Damage to biological tissues induced by radical initiator 2,2'-azobis(2-amidinopropane) dihydrochloride and its inhibition by chain-breaking antioxidants.
K. Terao (1986)
10.1083/JCB.94.1.1
The concept of lipid domains in membranes
M. Karnovsky (1982)
10.1021/JO026501F
A quantitative approach to the recycling of alpha-tocopherol by coantioxidants.
R. Amorati (2002)
10.1093/ajcn/62.6.1322S
Interaction among vitamin C, vitamin E, and beta-carotene.
E. Niki (1995)
10.1093/AJCN/53.3.702
Can vitamin E protect humans against the pathological effects of ozone in smog?
W. A. Pryor (1991)
10.1007/BF02536067
Fatty acid composition of brain phospholipids in aging and in Alzheimer’s disease
M. Söderberg (2006)
10.1021/tx1000943
Ex vivo oxidation in tissue and plasma assays of hydroxyoctadecadienoates: Z,E/E,E stereoisomer ratios.
W. Liu (2010)
Lipid hydroperoxide generation, turnover, and effector action in biological systems.
A. Girotti (1998)
10.1021/BI00754A020
Dye-sensitized photooxidation of tocopherols. Correlation between singlet oxygen reactivity and vitamin E activity.
G. W. Grams (1972)
10.1016/j.freeradbiomed.2011.03.023
α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome.
M. Shichiri (2011)
10.1016/j.freeradbiomed.2008.05.004
Thiol chemistry and specificity in redox signaling.
C. Winterbourn (2008)
10.1021/JA00280A041
Inhibition kinetics of chain-breaking phenolic antioxidants in SDS micelles. Evidence that intermicellar diffusion rates may be rate-limiting for hydrophobic inhibitors such as .alpha.-tocopherol
L. Castle (1986)
10.1002/biof.1014
Reactivity toward oxygen radicals and antioxidant action of thiol compounds.
Mizuki Takashima (2012)
10.1021/TX020012T
Determination of the α-Tocopherol Inhibition Rate Constant for Peroxidation in Low-Density Lipoprotein
S. Culbertson (2002)
Improved method for the fatty acid analysis of blood lipid
K. Ichihara (2011)
10.1016/0005-2760(95)00005-W
Kinetic study of quenching reaction of singlet oxygen and scavenging reaction of free radical by squalene in n-butanol.
Yoshiro Kohno (1995)
Vitamin E analogue Trolox C. E.s.r. and pulse-radiolysis studies of free-radical reactions.
M. Davies (1988)
10.1016/j.neuropharm.2010.04.005
Oxidative stress in Alzheimer disease: A possibility for prevention
D. Bonda (2010)
10.1152/ajpcell.00283.2008
Radical-free biology of oxidative stress.
D. Jones (2008)
10.3177/JNSV.32.475
Free radical chain oxidation and hemolysis of erythrocytes by molecular oxygen and their inhibition by vitamin E.
Y. Yamamoto (1986)
10.1016/j.ejim.2012.04.009
Haptoglobin genotype and cardiovascular outcomes in diabetes mellitus - natural history of the disease and the effect of vitamin E treatment. Meta-analysis of the medical literature.
M. Vardi (2012)
10.1586/ern.10.74
Antioxidant approaches for the treatment of Alzheimer’s disease
Hyun Pil Lee (2010)
10.1016/J.BMCL.2007.01.080
Advantages and limitation of BODIPY as a probe for the evaluation of lipid peroxidation and its inhibition by antioxidants in plasma.
N. Itoh (2007)
10.1111/j.1751-1097.1974.tb06613.x
REACTIVITY OF CHOLESTEROL AND SOME FATTY ACIDS TOWARD SINGLET OXYGEN
F. Doleiden (1974)
10.1111/j.1749-6632.1949.tb55274.x
TOCOPHEROL AND HEMOLYSIS IN VIVO AND IN VITRO
P. György (1949)
10.1016/0304-4165(84)90070-9
Formation of α-tocopherol radical and recycling of α-tocopherol by ascorbate during peroxidation of phosphatidylcholine liposomes: An electron paramagnetic resonance study
M. Scarpa (1984)
10.1111/j.1751-1097.1974.tb06611.x
CHEMISTRY OF SINGLET OXYGEN—XVIII. RATES OF REACTION AND QUENCHING OF α‐TOCOPHEROL AND SINGLET OXYGEN *
S. Christopher (1974)
10.1074/JBC.271.8.3988
Scavenging of Nitrogen Dioxide, Thiyl, and Sulfonyl Free Radicals by the Nutritional Antioxidant -Carotene (*)
S. Everett (1996)
10.1038/378776A0
Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
J. Busciglio (1995)
10.1016/0003-9861(89)90467-0
Lycopene as the most efficient biological carotenoid singlet oxygen quencher.
P. Di Mascio (1989)
10.3164/jcbn.11-006FR
Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention
M. Davies (2011)
Vitamin E and blood.
C. Chow (1985)
10.1038/278737A0
Direct observation of a free radical interaction between vitamin E and vitamin C
J. Packer (1979)
10.1139/V83-225
The autoxidation of unsaturated lipids in micelles. Synergism of inhibitors vitamins C and E
L. Barclay (1983)
10.1021/JA00145A005
Kinetic Solvent Effects on Hydroxylic Hydrogen Atom Abstractions Are Independent of the Nature of the Abstracting Radical. Two Extreme Tests Using Vitamin E and Phenol
L. Valgimigli (1995)
10.1016/j.febslet.2012.09.025
Do antioxidants impair signaling by reactive oxygen species and lipid oxidation products?
E. Niki (2012)
10.1246/BCSJ.58.1971
Oxidation of lipids. VIII. Synergistic inhibition of oxidation of phosphatidylcholine liposome in aqueous dispersion by vitamin E and vitamin C.
E. Niki (1985)
10.1007/s11745-011-3531-7
Improved Methods for the Fatty Acid Analysis of Blood Lipid Classes
K. Ichihara (2011)
10.1161/ATVBAHA.108.179697
Oxidized low-density lipoprotein and atherosclerosis.
D. Steinberg (2010)
10.1126/science.214.4519.435
Mechanisms of Nitrogen Dioxide Reactions: Initiation of Lipid Peroxidation and the Production of Nitrous Acid
W. A. Pryor (1981)
10.1042/BST0210313
Dynamics of lipid peroxidation and its inhibition by antioxidants.
E. Niki (1993)
10.1016/0003-9861(87)90358-4
Free-radical chain oxidation of rat red blood cells by molecular oxygen and its inhibition by alpha-tocopherol.
M. Miki (1987)
10.1056/NEJMc1006581
Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.
M. Armstrong (2010)
10.18388/ABP.2000_3944
The reactions of hypochlorous acid, the reactive oxygen species produced by myeloperoxidase, with lipids.
C. Spickett (2000)
10.1006/ABBI.2001.2689
Formation of active oxygen species and lipid peroxidation induced by hypochlorite.
N. Noguchi (2002)
10.1246/BCSJ.59.497
Oxidation of Lipids. XIII. Antioxidant Activities of α-, β-, γ-, and δ-Tocopherols
E. Niki (1986)
10.1111/j.1751-1097.1974.tb06610.x
ON THE QUENCHING OF SINGLET OXYGEN BY α‐TOCOPHEROL
S. R. Fahrenholtz (1974)
10.1194/jlr.D000547
High-throughput analysis of fatty acid composition of plasma glycerophospholipids[S]
C. Glaser (2010)
10.1016/0006-291X(85)90971-4
A comparison of the rates of ozonation of biological antioxidants and oleate and linoleate esters.
D. Giamalva (1985)



This paper is referenced by
10.1177/1099800418791028
Oxidative Stress and Preterm Birth: An Integrative Review
T. Moore (2018)
10.1159/000375305
How Effective Are Antioxidant Supplements in Obesity and Diabetes?
D. Abdali (2015)
10.17795/JJNPP-32350
Synthesis of Vitamin E Novel Analogues as Anti-Cancer Compounds
K. Hosseini (2016)
Antioxidant Vitamins, Oxidant Injuries and Diseases
Y. Abba (2015)
10.1007/s00296-016-3426-2
Metabolomics study of fatigue in patients with rheumatoid arthritis naïve to biological treatment
I. Surowiec (2016)
Relations between oxidized low-density lipoproteins and fat-soluble vitamin concentrations in obese children - preliminary study.
J. Gajewska (2017)
10.1016/j.jconrel.2017.11.032
pH‐sensitive polymeric nanoparticles with antioxidant and anti‐inflammatory properties against cisplatin‐induced hearing loss
S. Martín-Saldaña (2018)
10.1002/em.21926
The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review
A. Kermanizadeh (2015)
10.1161/ATVBAHA.119.312946
ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension.
Y. Zhao (2019)
10.1101/422006
Does alpha-tocopherol flip-flop help to protect membranes against oxidation?
P. Boonnoy (2018)
10.1016/j.anireprosci.2019.04.003
Identification of candidate genes in regulation of spermatogenesis in sheep testis following dietary vitamin E supplementation.
Yang-Hua Qu (2019)
10.1007/s00394-016-1182-4
Age-related changes of vitamin E: α-tocopherol levels in plasma and various tissues of mice and hepatic α-tocopherol transfer protein
Keita Takahashi (2016)
10.1007/978-3-030-05315-4
Vitamin E in Human Health
A. Bendich (2019)
10.1007/978-3-030-05315-4_12
The Challenge of Defining Daily Intake Recommendations: Vitamin E and Polyunsaturated Fatty Acids
D. Raederstorff (2019)
10.3390/nu8060361
Isoflavones: Anti-Inflammatory Benefit and Possible Caveats
J. Yu (2016)
10.15199/65.2015.12.4
Witamina E - właściwości i znaczenie dla człowieka
A. Záborská (2015)
10.1080/10715762.2020.1866181
Antioxidant action of vitamin E in vivo as assessed from its reaction products with multiple biological oxidants.
E. Niki (2020)
10.1055/a-1157-9043
Quantitative Redox Biology of Exercise.
M. Nikolaidis (2020)
Lower limit of antioxidant activity in follicular fluid : relationship to embryo quality in IVF cycle
B. Huang (2016)
10.1016/j.fct.2019.110758
Discovery of Keap1−Nrf2 small−molecule inhibitors from phytochemicals based on molecular docking
Maiquan Li (2019)
10.1016/J.DSX.2018.12.022
Increased concentration of serum MDA, decreased antioxidants and altered trace elements and macro-minerals are linked to obesity among Bangladeshi population.
Md. Adnan (2019)
10.1016/j.mam.2017.06.004
Many tocopherols, one vitamin E.
A. Azzi (2018)
10.1007/978-981-15-0006-0_9
Si Nanopowder for Photoluminescence and Hydrogen Generation Materials
Y. Kobayashi (2020)
10.1016/j.abb.2017.10.023
Isomer distribution of hydroxyoctadecadienoates (HODE) and hydroxyeicosatetraenoates (HETE) produced in the plasma oxidation mediated by peroxyl radical, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen.
A. Umeno (2017)
10.3177/jnsv.65.s109
Novel Antioxidative Activity of Astaxanthin and Its Synergistic Effect with Vitamin E.
K. Kogure (2019)
10.1016/j.bmcl.2016.10.033
Inhibition of plasma lipid oxidation induced by peroxyl radicals, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen by clinical drugs.
Mayuko Morita (2016)
10.1016/j.bcp.2017.03.016
Regulation of the nitric oxide oxidase activity of myeloperoxidase by pharmacological agents
Sophie L. Maiocchi (2017)
10.4103/ijnpnd.ijnpnd_17_18
Oxidative Stress Status and Neuroprotection of Tocotrienols in Chronic Cerebral Hypoperfusion-Induced Neurodegeneration Rat Animal Model
Wael M. Y. Mohamed (2018)
10.1111/jvim.15241
Lipid peroxidation biomarkers for evaluating oxidative stress in equine neuroaxonal dystrophy
C. Finno (2018)
10.1016/j.bmc.2018.10.002
ω-Hydroxylation of α-tocopheryl quinone reveals a dual function for cytochrome P450-4F2 in vitamin E metabolism.
L. Taylor (2018)
Alterations in growth and cell death by genetic deletion of the antioxidan response factor Nrf2 ist target, the quinone reductase NQ01
Julia Ariza Gómez (2015)
10.2147/CIA.S186760
Vitamin E and Alzheimer’s disease: what do we know so far?
Declan Browne (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar