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The Bioactivity Of Neuronal-Derived Nitric Oxide In Aging And Neurodegeneration: Switching Signaling To Degeneration.
A. Ledo, C. Lourenço, E. Cadenas, R. Barbosa, J. Laranjinha
Published 2020 · Medicine
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The small and diffusible free radical nitric oxide (•NO) has fascinated biological and medical sciences since it was promoted from atmospheric air pollutant to biological ubiquitous signaling molecule. Its unique physical chemical properties expand beyond its radical nature to include fast diffusion in aqueous and lipid environments and selective reactivity in a biological setting determined by bioavailability and reaction rate constants with biomolecules. In the brain, •NO is recognized as a key player in numerous physiological processes ranging from neurotransmission/neuromodulation to neurovascular coupling and immune response. Furthermore, changes in its bioactivity are central to the molecular pathways associated with brain aging and neurodegeneration. The understanding of •NO bioactivity in the brain, however, requires the knowledge of its concentration dynamics with high spatial and temporal resolution upon stimulation of its synthesis. Here we revise the understanding of the role of neuronal-derived •NO in brain physiology, aging and degeneration, focused on changes in the extracellular concentration dynamics of this free radical and the regulation of bioenergetic metabolism and neurovascular coupling.
This paper references
Reactions of cytochrome oxidase.
Wainio Ww (1955)
Reactions of cytochrome oxidase.
W. Wainio (1955)
Oxidation of Ascorbic Acid and Similar Reductones by Nitrous Acid
C. A. Bunton (1959)
ELEVATION OF CYCLIC GMP LEVELS IN CENTRAL NERVOUS SYSTEM BY EXCITATORY AND INHIBITORY AMINO ACIDS 1
J. Ferrendelli (1974)
Reaction of nitrite with ascorbate and its relation to nitrosamine formation.
M. C. Archer (1975)
Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria.
E. Cadenas (1977)
Nitrite and nitrate are formed by endogenous synthesis in the human intestine.
S. Tannenbaum (1978)
Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors
E. Harris (1984)
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
R. Palmer (1987)
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
L. Ignarro (1987)
Nitric oxide: a cytotoxic activated macrophage effector molecule.
J. Hibbs (1988)
Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain
J. Garthwaite (1988)
NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices.
J. Garthwaite (1989)
Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide
D. Stuehr (1989)
An electrochemical microprobe for detecting nitric oxide release in brain tissue
K. Shibuki (1990)
Excitatory amino acid receptors and synaptic plasticity.
G. Collingridge (1990)
Nitric oxide: physiology, pathophysiology, and pharmacology.
S. Moncada (1991)
Selective vulnerability of the hippocampus in brain ischemia
R. Schmidt-Kastner (1991)
Glutamate, nitric oxide and cell-cell signalling in the nervous system
J. Garthwaite (1991)
Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.
T. O'Dell (1991)
A requirement for the intercellular messenger nitric oxide in long-term potentiation.
E. Schuman (1991)
Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex
S. Lei (1992)
Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor
T. Malinski (1992)
Nitric oxide-induced blockade of NMDA receptors
O. Manzoni (1992)
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
S. Lipton (1993)
A synaptic model of memory: long-term potentiation in the hippocampus
T. Bliss (1993)
Rapid changes in extracellular glucose levels and blood flow in the striatum of the freely moving rat
L. Fellows (1993)
Janus faces of nitric oxide
S. Snyder (1993)
Role of nitric oxide synthase-containing vascular nerves in cerebrovasodilation elicited from cerebellum.
C. Iadecola (1993)
Spin-trapping studies of peroxynitrite decomposition and of 3-morpholinosydnonimine N-ethylcarbamide autooxidation: direct evidence for metal-independent formation of free radical intermediates.
O. Augusto (1994)
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.
L. Pellerin (1994)
Simulation of the diffusion and reaction of endogenously produced nitric oxide.
J. Lancaster (1994)
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
G. Brown (1994)
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide
M. Cleeter (1994)
Nitric oxide potently and reversibly deenergizes mitochondria at low oxygen tension.
M. Schweizer (1994)
NMDA receptors: from genes to channels.
N. Sucher (1996)
o-Phenylenediamine-modified carbon fiber electrodes for the detection of nitric oxide.
M. Friedemann (1996)
Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles.
J. Poderoso (1996)
Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains
J. Brenman (1996)
Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide.
V. Borutaite (1996)
Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport.
A. Cassina (1996)
Local Uncoupling of the Cerebrovascular and Metabolic Responses to Somatosensory Stimulation after Neuronal Nitric Oxide Synthase Inhibition
N. Cholet (1997)
A tutorial on the diffusibility and reactivity of free nitric oxide.
J. R. Lancaster (1997)
In vivo nitric oxide sensor using non-conducting polymer-modified carbon fiber.
J. -. Park (1998)
The emergence of the volume transmission concept 1 Published on the World Wide Web on 12 January 1998. 1
M. Zoli (1998)
Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines.
T. Hirata (1998)
Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase gene (PFKFB3)
A. Manzano (1998)
Neurovascular relationships in hippocampal slices: physiological and anatomical studies of mechanisms underlying flow-metabolism coupling in intraparenchymal microvessels
T. Lovick (1999)
Nitric oxide is the predominant mediator of cerebellar hyperemia during somatosensory activation in rats.
G. Yang (1999)
The reaction of nitric oxide with ubiquinol: kinetic properties and biological significance.
J. Poderoso (1999)
Nitric oxide: a modulator, but not a mediator, of neurovascular coupling in rat somatosensory cortex.
U. Lindauer (1999)
The Yield of Hydroxyl Radical from the Decomposition of Peroxynitrous Acid
O. Gerasimov (1999)
PSD-95 Assembles a Ternary Complex with theN-Methyl-d-aspartic Acid Receptor and a Bivalent Neuronal NO Synthase PDZ Domain*
K. S. Christopherson (1999)
Sustained attenuation of the cerebrovascular response to a 10 min whisker stimulation following neuronal nitric oxide synthase inhibition
G. Bonvento (2000)
Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein.
L. Pearce (2000)
Inherent Abnormalities in Energy Metabolism in Alzheimer Disease: Interaction with Cerebrovascular Compromise
J. Blass (2000)
Transport and metabolic degradation of hydrogen peroxide in Chara corallina: model calculations and measurements with the pressure probe suggest transport of H(2)O(2) across water channels.
T. Henzler (2000)
Developmental Profile of the Changing Properties of NMDA Receptors at Cerebellar Mossy Fiber–Granule Cell Synapses
L. Cathala (2000)
NF-κB activation and IκBα dynamism involved in iNOS and chemokine induction in astroglial cells
Y. Nomura (2001)
Nitric oxide synthases: structure, function and inhibition.
W. Alderton (2001)
Intracellular compartmentation of pyruvate in primary cultures of cortical neurons as detected by 13C NMR spectroscopy with multiple 13C labels
F. Cruz (2001)
Laminar Organization of the NMDA Receptor Complex within the Postsynaptic Density
J. Valtschanoff (2001)
Say NO to Alzheimer’s disease: the putative links between nitric oxide and dementia of the Alzheimer’s type
A. Law (2001)
Different responses of astrocytes and neurons to nitric oxide: The role of glycolytically generated ATP in astrocyte protection
A. Almeida (2001)
Stationary-state oxidized platinum microsensor for selective and on-line monitoring of nitric oxide in biological preparations.
A. Cserey (2001)
Mechanistic aspects of the reactions of nitric oxide with transition-metal complexes.
P. C. Ford (2002)
Nitric oxide monitoring in hippocampal brain slices using electrochemical methods.
A. Ledo (2002)
Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON
S. Jaffrey (2002)
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Kenyatta Cosby (2003)
Attenuation of activity-induced increases in cerebellar blood flow in mice lacking neuronal nitric oxide synthase.
G. Yang (2003)
On the Role of Nitric Oxide in Hippocampal Long-Term Potentiation
C. Bon (2003)
Expression of NMDA receptor NR1, NR2A and NR2B subunit mRNAs during development of the human hippocampal formation
A. Law (2003)
Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles Intracellular Aβ and Synaptic Dysfunction
S. Oddo (2003)
Active Nitric Oxide Produced in the Red Cell under Hypoxic Conditions by Deoxyhemoglobin-mediated Nitrite Reduction*
E. Nagababu (2003)
Activation of constitutive nitric oxide synthase(s) and absence of inducible isoform in aged rat brain
H. Jęśko (2003)
Nitric oxide and S‐nitrosylation: excitotoxic and cell signaling mechanism
Eric J. Nelson (2003)
Mitochondrial free radical production and cell signaling.
E. Cadenas (2004)
Cerebral glucose metabolism and the glutamine cycle as detected by in vivo and in vitro 13 C NMR spectroscopy
M. A. García-Espinosa (2004)
On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide.
F. Antunes (2004)
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway
A. Almeida (2004)
Ageing and subcellular distribution of mitochondria: role of mitochondrial DNA deletions and energy production.
B. Drew (2004)
Real time and in vivo monitoring of nitric oxide by electrochemical sensors--from dream to reality.
Xueji Zhang (2004)
Nitric oxide neurotoxicity in neurodegenerative diseases.
K. Boje (2004)
A non-haem iron centre in the transcription factor NorR senses nitric oxide
B. D'autréaux (2005)
Pathophysiological functions of nitric oxide-mediated protein modifications.
H. Ischiropoulos (2005)
Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice
L. Billings (2005)
Focal Cerebral Ischemia Preferentially Affects Neurons Distant from Their Neighboring Microvessels
T. Mabuchi (2005)
Activity‐induced tissue oxygenation changes in rat cerebellar cortex: interplay of postsynaptic activation and blood flow
N. Offenhauser (2005)
Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor.
A. Ledo (2005)
Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism.
P. Ježek (2005)
Electrochemical measurement of endogenously produced nitric oxide in brain slices using Nafion/o-phenylenediamine modified carbon fiber microelectrodes
N. Ferreira (2005)
Signals for the induction of nitric oxide synthase in astrocytes
R. N. Saha (2006)
Ageing and the brain
R. Peters (2006)
The redox switch/redox coupling hypothesis
S. Cerdán (2006)
Soluble guanylate cyclase.
T. Poulos (2006)
Regional age-related changes in neuronal nitric oxide synthase (nNOS), messenger RNA levels and activity in SAMP8 brain
D. Colas (2006)
Selective affection of hippocampal CA-1 neurons in patients with transient global amnesia without long-term sequelae.
T. Bartsch (2006)
BOLD response during uncoupling of neuronal activity and CBF
M. Burke (2006)
Nitric oxide and mitochondrial respiration in the heart.
Guy C. Brown (2007)
Activity‐dependent regulation of energy metabolism by astrocytes: An update
L. Pellerin (2007)
Red wine-dependent reduction of nitrite to nitric oxide in the stomach.
Bruno Gago (2007)
Nitric oxide increases oxidative phosphorylation efficiency
P. Clerc (2007)
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
M. Block (2007)
Functional Uncoupling of Hemodynamic from Neuronal Response by Inhibition of Neuronal Nitric Oxide Synthase
B. Stefanovic (2007)
The chemical biology of nitric oxide: implications in cellular signaling.
Douglas D. Thomas (2008)
Nitric Oxide Is a Volume Transmitter Regulating Postsynaptic Excitability at a Glutamatergic Synapse
J. Steinert (2008)
Focal MR spectroscopy of hippocampal CA-1 lesions in transient global amnesia
T. Bartsch (2008)
A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue.
R. Santos (2008)
Concepts of neural nitric oxide-mediated transmission
J. Garthwaite (2008)
Brain mitochondrial dysfunction in aging
A. Boveris (2008)
The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics
J. Lundberg (2008)
Chronic NMDA Administration Increases Neuroinflammatory Markers in Rat Frontal Cortex: Cross-Talk Between Excitotoxicity and Neuroinflammation
Y. Chang (2008)
Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors
A. Salminen (2009)
Analytical chemistry of nitric oxide.
E. Hetrick (2009)
Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications.
Li Zhou (2009)
Mitochondria Are the Source of Hydrogen Peroxide for Dynamic Brain-Cell Signaling
Li Bao (2009)
How mitochondria produce reactive oxygen species
M. Murphy (2009)
Nitric oxide in health and disease of the nervous system.
A. B. Knott (2009)
Understanding wiring and volume transmission
L. Agnati (2010)
Nitric oxide and neuronal death.
Guy C. Brown (2010)
Dynamic and interacting profiles of *NO and O2 in rat hippocampal slices.
A. Ledo (2010)
NMDAR‐mediated EPSCs are maintained and accelerate in time course during maturation of mouse and rat auditory brainstem in vitro
J. Steinert (2010)
Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease.
C. Villanueva (2010)
Nitrite reduction by xanthine oxidase family enzymes: a new class of nitrite reductases
L. Maia (2010)
Age-related alterations in mitochondrial physiological parameters and nitric oxide production in synaptic and non-synaptic brain cortex mitochondria
S. Lores-Arnaiz (2011)
Glutamate Transport Decreases Mitochondrial pH and Modulates Oxidative Metabolism in Astrocytes
G. Azarias (2011)
Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation.
M. Bélanger (2011)
Evidence for a pathway that facilitates nitric oxide diffusion in the brain
R. Santos (2011)
Brain nitric oxide inactivation is governed by the vasculature.
R. Santos (2011)
Oxygen radicals and related species in principles of free radical biomedicine
Connecting the chemical and biological properties of nitric oxide.
J. C. Toledo (2012)
Intragastric nitration by dietary nitrite: implications for modulation of protein and lipid signaling.
B. Rocha (2012)
Mitochondria and cell bioenergetics: increasingly recognized components and a possible etiologic cause of Alzheimer's disease.
R. Swerdlow (2012)
Classification of H₂O₂as a neuromodulator that regulates striatal dopamine release on a subsecond time scale.
J. Patel (2012)
Elevated Oxidative Stress and Decreased Antioxidant Function in the Human Hippocampus and Frontal Cortex with Increasing Age: Implications for Neurodegeneration in Alzheimer’s Disease
C. Venkateshappa (2012)
A longitudinal study of brain volume changes in normal aging.
H. Takao (2012)
Specificity in S-nitrosylation: a short-range mechanism for NO signaling?
A. Martínez-Ruiz (2013)
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
P. Paoletti (2013)
The role of nitric oxide in pre-synaptic plasticity and homeostasis
N. Hardingham (2013)
Biological nitric oxide signalling: chemistry and terminology
T. A. Heinrich (2013)
S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke
Zhong-Qing Shi (2013)
The biological chemistry of hydrogen peroxide.
C. Winterbourn (2013)
Biomimetic sensor based on hemin/carbon nanotubes/chitosan modified microelectrode for nitric oxide measurement in the brain.
R. Santos (2013)
Genetically encoded fluorescent probe for the selective detection of peroxynitrite.
Zhi-jie Chen (2013)
Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration.
F. Yin (2014)
Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide.
G. Bienert (2014)
Sites of Superoxide and Hydrogen Peroxide Production by Muscle Mitochondria Assessed ex Vivo under Conditions Mimicking Rest and Exercise*
Renata L. S. Goncalves (2014)
Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide.
C. Lourenço (2014)
Astrocytic metabolic and inflammatory changes as a function of age
Tianyi Jiang (2014)
Age-Associated Changes of Nitric Oxide Concentration Dynamics in the Central Nervous System of Fisher 344 Rats
A. Ledo (2014)
Kinetic and mechanistic considerations to assess the biological fate of peroxynitrite.
S. Carballal (2014)
Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses.
Igor Rafalovich (2015)
Neurovascular and neurometabolic derailment in aging and Alzheimer's disease
C. Lourenço (2015)
Nitric Oxide Signaling Is Recruited As a Compensatory Mechanism for Sustaining Synaptic Plasticity in Alzheimer's Disease Mice
Shreaya Chakroborty (2015)
Measurement of NO in biological samples
C. Csonka (2015)
Control of the neurovascular coupling by nitric oxide-dependent regulation of astrocytic Ca2+ signaling
Manuel F. Muñoz (2015)
J. Knierim (2015)
Visualization of NO3−/NO2− Dynamics in Living Cells by Fluorescence Resonance Energy Transfer (FRET) Imaging Employing a Rhizobial Two-component Regulatory System*♦
Masafumi Hidaka (2015)
Highly sensitive amperometric Pt-Nafion gas phase nitric oxide sensor: Performance and application in characterizing nitric oxide-releasing biomaterials.
Zheng Zheng (2015)
The impact of thiol peroxidases on redox regulation
L. Flohé (2016)
Getting to NO Alzheimer's Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide
Rachelle Balez (2016)
Energy metabolism and inflammation in brain aging and Alzheimer's disease.
F. Yin (2016)
Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation
Cândida Dias (2016)
Intact mitochondrial Ca2+ uniport is essential for agonist‐induced activation of endothelial nitric oxide synthase (eNOS)
Suphachai Charoensin (2017)
Ceramic-Based Multisite Platinum Microelectrode Arrays: Morphological Characteristics and Electrochemical Performance for Extracellular Oxygen Measurements in Brain Tissue.
A. Ledo (2017)
Combined in Vivo Amperometric Oximetry and Electrophysiology in a Single Sensor: A Tool for Epilepsy Research.
A. Ledo (2017)
PDI regulates seizure activity via NMDA receptor redox in rats
Ji Yang Kim (2017)
Endogenous nitric oxide inhibits spinal NMDA receptor activity and pain hypersensitivity induced by nerve injury
Shao-rui Chen (2017)
Mitochondrial cytochrome c oxidase: catalysis, coupling and controversies.
P. Rich (2017)
Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte–neuron lactate shuttle in brain
G. Dienel (2017)
Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling
C. Lourenço (2017)
Neurovascular‐neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration
C. Lourenço (2017)
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
J. Egea (2017)
Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress☆
H. Sies (2017)
H. Sies (2017)
Astroglial Glutamate Signaling and Uptake in the Hippocampus
C. Rose (2018)
Genetic biosensors for imaging nitric oxide in single cells☆
Emrah Eroglu (2018)
Diffusion of nitric oxide and oxygen in lipoproteins and membranes studied by pyrene fluorescence quenching
M. Möller (2018)
Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices.
Cândida Dias (2018)
Age-Dependent Impairment of Neurovascular and Neurometabolic Coupling in the Hippocampus
C. Lourenço (2018)
What is the key mediator of the neurovascular coupling response?
P. Hosford (2018)
The importance of controlling in vitro oxygen tension to accurately model in vivo neurophysiology
E. Bordt (2018)
Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases
E. Meneghetti (2019)
The effect of nitric oxide on mitochondrial respiration.
J. Poderoso (2019)
Acute and Chronic Sleep Deprivation-Related Changes in N-methyl-D-aspartate Receptor—Nitric Oxide Signalling in the Rat Cerebral Cortex with Reference to Aging and Brain Lateralization
Z. Krištofíková (2019)
Oxygen and mammalian cell culture: are we repeating the experiment of Dr. Ox?
T. Ast (2019)
Interneuronal NMDA receptors regulate long‐term depression and motor learning in the cerebellum
Maya Kono (2019)
Enhanced selectivity and stability of ruthenium purple-modified carbon fiber microelectrodes for detection of hydrogen peroxide in brain tissue
A. Ledo (2020)
Tau induces PSD95-nNOS uncoupling and neurovascular dysfunction independent of neurodegeneration
L. Park (2020)
Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis
Feihua Wu (2020)
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A High Fat/Cholesterol Diet Recapitulates Some Alzheimer's Disease-Like Features in Mice: Focus on Hippocampal Mitochondrial Dysfunction.
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