← Back to Search
Childhood Immune Thrombocytopenic Purpura: Diagnosis And Management.
V. Blanchette, P. Bolton-Maggs
Published 2010 · Medicine
Save to my Library
Download via 🐼 PaperPanda Download via oaDOI Download via OAB Download via LibKey Download via Google Google ScholarAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by a low circulating platelet count caused by destruction of antibody-sensitized platelets in the reticuloendothelial system. ITP can be classified as childhood versus adult, acute versus chronic, and primary versus secondary. Persistence of thrombocytopenia defines the chronic form of the disorder. Secondary causes of ITP include collagen vascular disorders, immune deficiencies, and some chronic infections. This review focuses on the diagnosis and management of children who have acute and chronic ITP. Emphasis is placed on areas of controversy and new therapies.
This paper references
Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura.
W. Harrington (1951)
SIMILARITIES BETWEEN KNOWN ANTIPLATELET ANTIBODIES AND THE FACTOR RESPONSIBLE FOR THROMBOCYTOPENIA IN IDIOPATHIC PURPURA. PHYSIOLOGIC, SEROLOGIC AND ISOTOPIC STUDIES
N. Shulman (1965)
Idiopathic thrombocytopenic purpura in childhood.
J. Lusher (1966)
Effect of live measles vaccine on the platelet count.
F. A. Oski (1966)
Idiopathic thrombocytopenic purpura in childhood.
S. I. Choi (1967)
HIGH-DOSE INTRAVENOUS GAMMAGLOBULIN FOR IDIOPATHIC THROMBOCYTOPENIC PURPURA IN CHILDHOOD
P. Imbach (1981)
Intracranial hemorrhage in children with idiopathic thrombocytopenic purpura.
S. Woerner (1981)
EFFECT OF INTRAVENOUS IMMUNOGLOBULIN IN IMMUNE THROMBOCYTOPENIA Competitive Inhibition of Reticuloendothelial System Function by Sequestration of Autologous Red Blood Cells?
A. Salama (1983)
Steroid treatment of idiopathic thrombocytopenic purpura in children. Preliminary results of a randomized cooperative study.
J. Sartorius (1984)
Pseudothrombocytopenia: a laboratory artifact with potentially serious consequences.
B. Payne (1984)
Prednisone therapy for children with newly diagnosed idiopathic thrombocytopenic purpura: A randomized clinical trial
G. Buchanan (1984)
INTRAVENOUS IMMUNOGLOBULIN VERSUS ORAL CORTICOSTEROIDS IN ACUTE IMMUNE THROMBOCYTOPENIC PURPURA IN CHILDHOOD
P. Imbach (1985)
Urgent treatment of idiopathic thrombocytopenic purpura with single-dose gammaglobulin infusion followed by platelet transfusion.
M. Baumann (1986)
High-dose steroids in childhood acute idiopathic thrombocytopenia purpura.
C. Suarez (1986)
Use of Intravenous Methylprednisolone in Acute Idiopathic Thrombocytopenic Purpura
S. Jayabose (1987)
Evans Syndrome in Childhood: Pathophysiology, Clinical Course, and Treatment
W. Wang (1988)
Pulse methylprednisolone therapy for acute childhood idiopathic thrombocytopenic purpura.
J. van Hoff (1988)
Role of intravenous immunoglobulin G in autoimmune hematologic disorders.
V. Blanchette (1992)
Guidelines for management of idiopathic thrombocytopenic purpura. The British Paediatric Haematology Group.
O. Eden (1992)
A prospective, randomized trial of high-dose intravenous immune globulin G therapy, oral prednisone therapy, and no therapy in childhood acute immune thrombocytopenic purpura.
V. Blanchette (1993)
Oral megadose methylprednisolone versus intravenous immunoglobulin for acute childhood idiopathic thrombocytopenic purpura.
S. Ozsoylu (1993)
Randomised trial of intravenous immunoglobulin G, intravenous anti-D, and oral prednisone in childhood acute immune thrombocytopenic purpura
V. Blanchette (1994)
Clinical and Therapeutic Experience in 712 Israeli Patients with Idiopathic Thrombocytopenic Purpura
D. Ben-Yehuda (1994)
Intracranial haemorrhage in idiopathic thrombocytopenic purpura. Paediatric Haematology Forum of the British Society for Haematology.
J. Lilleyman (1994)
Idiopathic thrombocytopenia and neutropenia in childhood.
S. Calderwood (1994)
Chronic idiopathic thrombocytopenic purpura: incidence, treatment, and outcome.
M. Reid (1995)
Evans Syndrome: Results of a Pilot Study Utilizing a Multiagent Treatment Protocol
A. Scaradavou (1995)
Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology.
J. George (1996)
Assessment of UK practice for management of acute childhood idiopathic thrombocytopenic purpura against published guidelines
P. Bolton-Maggs (1997)
International study to compare antigen‐specific methods used for the measurement of antiplatelet autoantibodies
P. Berchtold (1997)
The spectrum of Evans’ syndrome
S. Savaşan (1997)
Intravenous Anti-D Treatment of Immune Thrombocytopenic Purpura: Experience in 272 Patients
A. Scaradavou (1997)
The site of destruction of autologous 111In‐labelled platelets and the efficiency of splenectomy in children and adults with idiopathic thrombocytopenic purpura: a study of 578 patients with 268 splenectomies
Y. Najean (1997)
Evans Syndrome: Results of a National Survey
Prasad Mathew (1997)
Is Bone Marrow Aspiration Needed in Acute Childhood Idiopathic Thrombocytopenic Purpura to Rule Out Leukemia
C. Calpin (1998)
Major hemorrhage in children with idiopathic thrombocytopenic purpura: immediate response to therapy and long-term outcome.
D. Medeiros (1998)
Intracranial hemorrhage associated with idiopathic thrombocytopenic purpura: Report of seven patients and a meta-analysis
M. Lee (1998)
Short‐course oral prednisone therapy in children presenting with acute immune thrombocytopenic purpura (ITP)
M. Carcao (1998)
Treatment of refractory Evans' syndrome with cyclosporine and prednisone.
B. Uçar (1999)
Influence of monoclonal antiplatelet glycoprotein antibodies on in vitro human megakaryocyte colony formation and proplatelet formation.
R. Takahashi (1999)
Platelet kinetic studies in patients with idiopathic thrombocytopenic purpura.
H. Louwes (1999)
Serum levels of thrombopoietin, IL-11, and IL-6 in pediatric thrombocytopenias
M. Cremer (1999)
Management of childhood idiopathic thrombocytopenic purpura
J. Lilleyman (1999)
Acute childhood idiopathic thrombocytopenic purpura: AIEOP consensus guidelines for diagnosis and treatment. Associazione Italiana di Ematologia e Oncologia Pediatrica.
D. De Mattia (2000)
Elective splenectomy in children with idiopathic thrombocytopenic purpura.
E. Mantadakis (2000)
The clinical course of immune thrombocytopenic purpura in children who did not receive intravenous immunoglobulins or sustained prednisone treatment.
R. Dickerhoff (2000)
The nontreatment of childhood ITP (or "the art of medicine consists of amusing the patient until nature cures the disease").
P. Bolton-Maggs (2001)
Acute immune thrombocytopenia (ITP) in childhood: retrospective and prospective survey in Germany.
A. Sutor (2001)
Thrombocytopenia caused by the development of antibodies to thrombopoietin.
J. Li (2001)
Do the acute platelet responses of patients with immune thrombocytopenic purpura (ITP) to IV anti‐D and to IV gammaglobulin predict response to subsequent splenectomy?
J. Bussel (2001)
Outcome measures and treatment endpoints other than platelet count in childhood idiopathic thrombocytopenic purpura.
G. Buchanan (2001)
Newly diagnosed idiopathic thrombocytopenic purpura in childhood: an observational study
T. Kühne (2001)
A dose of 75 μg/kg/d of i.v. anti‐D increases the platelet count more rapidly and for a longer period of time than 50 μg/kg/d in adults with immune thrombocytopenic purpura
G. Newman (2001)
Idiopathic thrombocytopenic purpura and MMR vaccine
E. Miller (2001)
Immune thrombocytopenic purpura.
D. Cines (2002)
Grading of hemorrhage in children with idiopathic thrombocytopenic purpura.
G. Buchanan (2002)
Idiopathic thrombocytopenic purpura diagnosed during the second decade of life.
E. Lowe (2002)
Hematologic complications of primary immune deficiencies.
C. Cunningham-Rundles (2002)
MMR vaccine and idiopathic thrombocytopaenic purpura.
C. Black (2003)
Response to intravenous immunoglobulin predicts splenectomy response in children with immune thrombocytopenic purpura.
Derick G. Holt (2003)
Childhood acute immune thrombocytopenic purpura: 20 years later.
V. Blanchette (2003)
Childhood Chronic Immune Thrombocytopenic Purpura: Unresolved Issues
V. Blanchette (2003)
Combination Therapy for Refractory Idiopathic Thrombocytopenic Purpura in Adolescents
J. A. Williams (2003)
Autoimmune lymphoproliferative syndrome
M. Sneller (2003)
Development of Disease-Specific Health-Related Quality-of-Life Instruments for Children With Immune Thrombocytopenic Purpura and Their Parents
D. Barnard (2003)
Duration and morbidity of newly diagnosed idiopathic thrombocytopenic purpura in children: A prospective Nordic study of an unselected cohort.
S. Rosthøj (2003)
A prospective comparative study of 2540 infants and children with newly diagnosed idiopathic thrombocytopenic purpura (ITP) from the Intercontinental Childhood ITP Study Group.
T. Kühne (2003)
Intracranial Hemorrhage in Immune Thrombocytopenic Purpura: A Retrospective Analysis
L. Butros (2003)
Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy
D. Provan (2003)
The efficacy and safety of B‐cell depletion with anti‐CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura
N. Cooper (2004)
Autoimmune lymphoproliferative syndrome
J. Oliveira (2004)
Management of Adult Patients with Persistent Idiopathic Thrombocytopenic Purpura Following Splenectomy
S. Vesely (2004)
Retrospective evaluation of long‐term efficacy and safety of splenectomy in chronic idiopathic thrombocytopenic purpura in children
S. Aronis (2004)
Autoimmune Thrombocytopenic Purpura and Common Variable Immunodeficiency: Analysis of 21 Cases and Review of the Literature
M. Michel (2004)
Inherited thrombocytopenia: when a low platelet count does not mean ITP.
J. Drachman (2004)
How I treat idiopathic thrombocytopenic purpura (ITP).
D. Cines (2005)
Corticosteroids versus intravenous immune globulin for the treatment of acute immune thrombocytopenic purpura in children: a systematic review and meta-analysis of randomized controlled trials.
C. Beck (2005)
Immunthrombocytopenic purpura as a model for pathogenesis and treatment of autoimmunity
P. Imbach (2005)
[Evans' syndrome: a retrospective study from the ship (French Society of Pediatric Hematology and Immunology) (36 cases)].
P. Blouin (2005)
Recombinant FVIIa in the management of intracerebral haemorrhage in severe thrombocytopenia unresponsive to platelet‐enhancing treatment
C. Barnes (2005)
Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS).
D. Teachey (2005)
Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist.
C. Erickson-Miller (2005)
Use of mycophenolate mofetil for chronic, refractory immune cytopenias in children with autoimmune lymphoproliferative syndrome
V. Koneti Rao (2005)
Syndrome d'Evans : étude rétrospective de la société d'hématologie et d'immunologie pédiatrique (36 cas)
P. Blouin (2005)
Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rho(D) immune globulin intravenous administration for immune thrombocytopenic purpura
A. Gaines (2005)
Treatment and outcome of autoimmune hematologic disease in common variable immunodeficiency (CVID).
Julie Wang (2005)
An open‐label, unit dose‐finding study of AMG 531, a novel thrombopoiesis‐stimulating peptibody, in patients with immune thrombocytopenic purpura
A. Newland (2006)
Development of a disease‐specific quality of life questionnaire for children & adolescents with idiopathic thrombocytopenic purpura (ITP‐QoL)
S. von Mackensen (2006)
Single dose of anti-D immune globulin at 75 microg/kg is as effective as intravenous immune globulin at rapidly raising the platelet count in newly diagnosed immune thrombocytopenic purpura in children.
M. Tarantino (2006)
Common variable immune deficiency and autoimmunity.
D. Brandt (2006)
AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP.
J. Bussel (2006)
Inflammatory and autoimmune complications of common variable immune deficiency.
A. Knight (2006)
Childhood ITP: 12 months follow‐up data from the prospective registry I of the Intercontinental Childhood ITP Study Group (ICIS)
P. Imbach (2006)
Management of Evans syndrome
A. Norton (2006)
The prevention and treatment of bacterial infections in children with asplenia or hyposplenia: Practice considerations at the Hospital for Sick Children, Toronto
V. Price (2006)
Prospective phase 1/2 study of rituximab in childhood and adolescent chronic immune thrombocytopenic purpura.
C. Bennett (2006)
Severe hematological side effects following Rituximab therapy in children.
S. Larrar (2006)
Autoimmune lymphoproliferative syndrome: molecular basis of disease and clinical phenotype
A. Worth (2006)
Re-treatment of Chronic Idiopathic Thrombocytopenic Purpura With Rituximab: Literature Review
A. Perrotta (2006)
Causes and consequences of the autoimmune lymphoproliferative syndrome
V. Koneti Rao (2006)
Splenectomy for Chronic Idiopathic Thrombocytopenic Purpura in Children: A Single Center Study in China
T. Wang (2006)
Validity, reliability, and responsiveness of a new measure of health-related quality of life in children with immune thrombocytopenic purpura: the Kids' ITP Tools.
R. Klaassen (2007)
Management of immune thrombocytopenic purpura
P. Bolton-Maggs (2007)
Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura.
J. Bussel (2007)
Splenectomy in children with idiopathic thrombocytopenic purpura: A prospective study of 134 children from the Intercontinental Childhood ITP Study Group
T. Kühne (2007)
Increased lymphocyte Fas expression and high incidence of common variable immunodeficiency disorder in childhood Evans' syndrome.
S. Savaşan (2007)
The immune thrombocytopenic purpura (ITP) bleeding score: assessment of bleeding in patients with ITP
L. Page (2007)
New thrombopoietic growth factors.
D. Kuter (2007)
Systematic Review: Efficacy and Safety of Rituximab for Adults with Idiopathic Thrombocytopenic Purpura
D. Arnold (2007)
A clinical score predicting a brief and uneventful course of newly diagnosed idiopathic trombocytopenic purpura in children
Pernille Wendtland Edslev (2007)
A cost‐utility analysis of treatment for acute childhood idiopathic thrombocytopenic purpura (ITP)
Sarah H. O'Brien (2007)
This paper is referenced by
Increased Expression of IL-17A and IL-17F Is Correlated With RUNX1 and RORγT in Pediatric Patients With Primary Immune Thrombocytopenia
Wafaa A Elnaenaey (2021)
Treatment lines of childhood chronic ITP: A retrospective single-center analysis
A. Yasser (2020)
Fatigue, executive function and psychological effects in children with immune thrombocytopenia: a cross‐sectional study
S. Towner (2020)
Teetering on a liver’s edge: a case report highlighting clinical decision-making in thrombocytopenia
Adam Yan (2019)
Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease
D. Petrović (2019)
Idiopathic thrombocytopenic purpura (ITP) – new era for an old disease
M. Onisâi (2019)
Modifying risk factors of chronicity in children with immune thrombocytopenia: Still underway.
Tsung-Yen Chang (2019)
Thrombotic Microangiopathies (TTP, HUS, HELLP).
Shane B. Kappler (2017)
Neutrophil to Lymphocyte Ratio (NLR) as a Predictive Marker for Prognosis in the Patients with Immune Thrombocytopenic Purpura (ITP)
G. E. Yang (2016)
Comparative efficacy and cost effectiveness of splenectomy and thrombopoietin prior to peginterferon and ribavirin therapy with compensatory cirrhosis associated with hepatitis C and thrombocytopenia.
B. Li (2015)
Serum cystatin C and microalbuminuria in children with immune thrombocytopenia under short course of corticosteroids
S. Ragab (2015)
Comparative of three methods (ELIZA, MAIPA and flow cytometry) to determine anti-platelet antibody in children with ITP.
M. Hamidpour (2014)
A Pediatric Case of Chronic Immune Thrombocytopenic Purpura Treated with Sirolimus
Wenliang Geng (2014)
Aplicaciones terapéuticas de las inmunoglobulinas humanas en Pediatría
A. N. Albelo (2013)
UNIVERSIDADE FEDERAL DA PARAÍBA CENTRO DE CIÊNCIAS DA SAÚDE CURSO DE GRADUAÇÃO EM FARMÁCIA
A. S. D. Silva (2013)
Surgical Implications of Hematologic Disease
Kelly J. Walkovich (2012)
Current therapies in primary immune thrombocytopenia.
Salley G. Pels (2011)
Rituximab in Steroid Refractory Autoimmune Hemolytic Anemia
N. Gupta (2011)
Recognition and Management of Immune Thrombocytopenic Purpura and Autoimmune Hemolytic Anemia in the Emergency Department
A. Sobota (2011)
Detection of Anti-Platelet Glycoprotein Antibodies Using MAIPA Method
M. Hamidpour (2010)