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Leucaena Leucocephala (Lam.) Galactomannan Nanoparticles: Optimization And Characterization For Ocular Delivery In Glaucoma Treatment.

Neeraj Mittal, G. Kaur
Published 2019 · Chemistry, Medicine

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In the present study, bioadhesive polymeric nanoparticles for ocular delivery of dorzolamide hydrochloride (DRZ) were formulated using derivatized Leucaena leucocephala galactomannan (LLG). The carboxymethyl (CMLLG) and amine derivative (AMLLG) of LLG were synthesized and used for the preparation of nanoparticles. The preparation method was optimized using 2-factor, 3-level central composite experimental design. The optimized nanoparticles were characterized by FTIR, DSC, SEM, TEM and XRD studies. The results of in vitro release studies and ex vivo transcorneal permeation studies revealed sustained release and higher corneal permeation as compared to conventional formulation of DRZ. The optimized nanoparticles were found to reduce the intra ocular pressure (IOP) for prolonged period of time when compared to conventional eye drops. Overall, the present study suggests a promising role of bioadhesive polymeric nanoparticles for ocular drug delivery in glaucoma treatment.
This paper references
10.32381/JPM.2018.35.04.3
Amination of a Natural Polymer, Leucaena leucocephala (Lam.) galactomannan: Synthesis, Optimization and Characterization
Neeraj Mittal (2019)
10.1155/2013/562727
Development of Dorzolamide Loaded 6-O-Carboxymethyl Chitosan Nanoparticles for Open Angle Glaucoma
U. Shinde (2013)
10.5694/mja2.50020
Current management of glaucoma
J. Lusthaus (2019)
10.1016/j.ijpharm.2014.03.048
Brinzolamide nanocrystal formulations for ophthalmic delivery: reduction of elevated intraocular pressure in vivo.
A. Tuomela (2014)
10.1016/j.ijbiomac.2017.11.090
Nanogel-based natural polymers as smart carriers for the controlled delivery of Timolol Maleate through the cornea for glaucoma.
Roya Ilka (2018)
10.2147/IJN.S162306
Montmorillonite/chitosan nanoparticles as a novel controlled-release topical ophthalmic delivery system for the treatment of glaucoma
J. Li (2018)
10.2147/IJN.S254763
Stimulus Responsive Ocular Gentamycin-Ferrying Chitosan Nanoparticles Hydrogel: Formulation Optimization, Ocular Safety and Antibacterial Assessment
Nabil K. Alruwaili (2020)
10.1016/0169-409X(95)00017-2
Microspheres and nanoparticles used in ocular delivery systems
A. Zimmer (1995)
10.1038/sj.eye.6701428
Comparison of additional intraocular pressure-lowering effects of latanoprost vs brimonidine in primary open-angle glaucoma patients with intraocular pressure uncontrolled by timolol–dorzolamide combination
A. Akman (2005)
10.1016/S0008-6215(00)80772-7
Viscosity-molecular weight relationships, intrinsic chain flexibility, and dynamic solution properties of guar galactomannan
G. Robinson (1982)
10.1016/S0939-6411(03)00153-X
Comparative studies on polyelectrolyte complexes and mixtures of chitosan-alginate and chitosan-carrageenan as prolonged diltiazem clorhydrate release systems.
Cristián Tapia (2004)
10.1016/j.ijbiomac.2011.11.017
Carboxymethyl tamarind kernel polysaccharide nanoparticles for ophthalmic drug delivery.
Harmanmeet Kaur (2012)
10.1080/21691401.2016.1203794
PLGA nanoparticles for ocular delivery of loteprednol etabonate: a corneal penetration study
A. K. Sah (2017)
10.1016/J.CARBPOL.2007.11.007
Chitosan nanoparticles loaded with dorzolamide and pramipexole
Sofia A. Papadimitriou (2008)
10.1016/J.EJPB.2007.09.009
Chitosan-sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: formulation, optimisation and in vitro characterisation.
S. Motwani (2008)
10.1016/S0168-3659(98)00121-7
Lidocaine-loaded biodegradable nanospheres. I. Optimization Of the drug incorporation into the polymer matrix.
T. Görner (1999)
10.1016/j.ijbiomac.2016.07.046
Extraction and derivatization of Leucaena leucocephala (Lam.) galactomannan: Optimization and characterization.
Neeraj Mittal (2016)
10.3109/10717544.2014.908979
Badam gum: a natural polymer in mucoadhesive drug delivery. Design, optimization, and biopharmaceutical evaluation of badam gum-based metoprolol succinate buccoadhesive tablets
Chaithanya Krishna Mylangam (2016)
10.1016/j.ijbiomac.2017.11.170
Formulation and optimization of levofloxacin loaded chitosan nanoparticle for ocular delivery: In-vitro characterization, ocular tolerance and antibacterial activity.
Ameeduzzafar (2018)
10.1016/j.ejpb.2017.03.006
Cyclosporine A delivery to the eye: A comprehensive review of academic and industrial efforts
F. Lallemand (2017)
10.1016/J.SUPFLU.2017.08.010
Loading of vitamin E into silicone hydrogel by supercritical carbon dioxide impregnation toward controlled release of timolol maleate
Yuta Yokozaki (2018)
10.1016/J.IJBIOMAC.2014.10.002
Okra (Hibiscus esculentus) gum-alginate blend mucoadhesive beads for controlled glibenclamide release.
Priyanka Sinha (2015)
10.1016/j.ijbiomac.2018.04.122
Chitosan coated PLGA nanoparticles amplify the ocular hypotensive effect of forskolin: Statistical design, characterization and in vivo studies.
N. Khan (2018)
10.1023/B:PHAM.0000022411.47059.76
The Characteristics and Mechanisms of Uptake of PLGA Nanoparticles in Rabbit Conjunctival Epithelial Cell Layers
Mohamed G. Qaddoumi (2004)
10.1016/j.colsurfb.2010.09.010
Microscopic and spectroscopic evaluation of novel PLGA-chitosan Nanoplexes as an ocular delivery system.
Gaurav K. Jain (2011)
10.1016/j.addr.2009.11.026
Chitosan-based nanostructures: a delivery platform for ocular therapeutics.
M. de la Fuente (2010)
10.1155/2013/958465
Formulation and Evaluation of Chitosan-Chondroitin Sulphate Based Nasal Inserts for Zolmitriptan
Kirandeep Kaur (2013)
10.1002/JBM.B.10046
The preparation of monodisperse biodegradable polyester nanoparticles with a controlled size.
Miechel L T Zweers (2003)
10.1016/j.xphs.2018.08.015
Chitosan-Gelatin Hydrogel Crosslinked With Oxidized Sucrose for the Ocular Delivery of Timolol Maleate.
Gina S. El-Feky (2018)
10.1039/B605640G
Polymeric materials for ophthalmic drug delivery: trends and perspectives
E. Barbu (2006)
10.1016/j.ijbiomac.2014.02.002
Chitosan nanoparticles amplify the ocular hypotensive effect of cateolol in rabbits.
Ameeduzzafar (2014)
10.3109/1061186X.2011.654121
Chitosan nanoparticles: a survey of preparation methods
A. Grenha (2012)
10.1002/JPS.21043
Polymeric enhancers of mucosal epithelia permeability: synthesis, transepithelial penetration-enhancing properties, mechanism of action, safety issues.
G. Di Colo (2008)
10.1111/j.2042-7158.1996.tb03911.x
Improved Ocular Bioavailability of Indomethacin by Novel Ocular Drug Carriers
P. Calvo (1996)
10.1016/j.msec.2016.10.017
A novel nanoparticles impregnated ocular insert for enhanced bioavailability to posterior segment of eye: In vitro, in vivo and stability studies.
Lalaji V Rathod (2017)
10.1007/s40005-019-00427-1
Development and investigation of timolol maleate niosomal formulations for the treatment of glaucoma
Afaf A. Ramadan (2019)
10.1038/srep11337
Chitosan grafted methoxy poly(ethylene glycol)-poly(ε-caprolactone) nanosuspension for ocular delivery of hydrophobic diclofenac
Shuai Shi (2015)
10.1016/j.nano.2011.06.004
Formulation and optimization of nanotransfersomes using experimental design technique for accentuated transdermal delivery of valsartan.
A. Ahad (2012)
10.2165/00003088-200140020-00001
Bioadhesion: new possibilities for drug administration?
J. Woodley (2001)
10.1016/j.xphs.2018.08.013
In Situ Gel Formulation for Enhanced Ocular Delivery of Nepafenac.
Haley Shelley (2018)
10.1016/j.carbpol.2012.11.021
Pharmaceutical applications of various natural gums, mucilages and their modified forms.
Vipul D. Prajapati (2013)
10.1016/j.ejps.2017.04.013
Nanoemulsion‐based electrolyte triggered in situ gel for ocular delivery of acetazolamide
N. Morsi (2017)
10.1007/s11095-008-9694-0
Recent Perspectives in Ocular Drug Delivery
Ripal Gaudana (2008)
10.2147/IJN.S146346
Controlled drug delivery for glaucoma therapy using montmorillonite/Eudragit microspheres as an ion-exchange carrier
Shuangyan Tian (2018)
10.1016/j.ejpb.2008.09.028
Mucoadhesive polymeric platforms for controlled drug delivery.
G. Andrews (2009)
10.1517/17425247.2.5.843
The potential of chitosan for the oral administration of peptides
C. Prego (2005)
10.1016/j.ijbiomac.2018.05.113
Hyaluronic-acid-modified lipid-polymer hybrid nanoparticles as an efficient ocular delivery platform for moxifloxacin hydrochloride.
Dan Liu (2018)
10.1615/CRITREVTHERDRUGCARRIERSYST.V28.I2.20
Newer therapeutic vistas for antiglaucoma medicines.
I. P. Kaur (2011)
10.2174/092986712800784658
Polysaccharide-based nanoparticles: a versatile platform for drug delivery and biomedical imaging.
G. Saravanakumar (2012)
10.1136/bjo.2005.081224
The number of people with glaucoma worldwide in 2010 and 2020
H. Quigley (2006)
10.1002/APP.39788
In situ gelling ophthalmic drug delivery system: Formulation and evaluation
Neeraj Mittal (2014)
10.1111/jphp.12132
Topical delivery of ocular therapeutics: carrier systems and physical methods
Joel G. Souza (2014)
10.1201/9781420015164.ch6
Galactomannans and other cell wall storage polysaccharides in seeds
M. Gidley (2006)
10.1016/j.colsurfb.2014.07.004
Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits.
M. Warsi (2014)
10.1016/j.ygeno.2018.04.006
Glaucoma Pred: Glaucoma prediction based on Myocilin genotype and phenotype information.
K. Rangachari (2018)
10.5497/WJP.V2.I2.47
Ocular drug delivery systems: An overview.
Ashaben D. Patel (2013)
10.1039/C5RA11702J
Carboxymethyl gum katira: synthesis, characterization and evaluation for nanoparticulate drug delivery
Minkal (2015)
10.1002/CBDV.200590013
Seed Galactomannans: An Overview
Manjoosha Srivastava (2005)
10.1016/J.CARBPOL.2004.08.020
32 Factorial design and response surface analysis optimization of N-carboxybutylchitosan synthesis
Kátia Christol Dos Santos (2005)
10.3797/scipharm.0908-10
Chitosan-Carboxymethyl Tamarind Kernel Powder Interpolymer Complexation: Investigations for Colon Drug Delivery
G. Kaur (2010)
10.1016/j.jconrel.2008.12.018
Polymeric nanoparticulate system: a potential approach for ocular drug delivery.
R. C. Nagarwal (2009)
10.1016/J.IJPHARM.2006.01.003
Preparation and in vitro evaluation of mucoadhesive properties of alginate/chitosan microparticles containing prednisolone.
S. Wittaya-areekul (2006)
10.3109/02713683.2010.508867
In Vivo Evaluation of Novel Nanoparticles Containing Dexamethasone for Ocular Drug Delivery on Rabbit Eye
Farzaneh Rafie (2010)
10.1016/j.ijpharm.2018.10.033
TPGS modified nanoliposomes as an effective ocular delivery system to treat glaucoma
Q. Jin (2018)
10.1016/j.jcis.2016.08.018
Moxifloxacin loaded gelatin nanoparticles for ocular delivery: Formulation and in-vitro, in-vivo evaluation.
Alok Mahor (2016)



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