← Back to Search
Peptide Ligand-mediated Liposome Distribution And Targeting To EGFR Expressing Tumor In Vivo.
S. Song, D. Liu, J. Peng, Y. Sun, Z. Li, J. Gu, Yuhong Xu
Published 2008 · Medicine, Chemistry
Download PDFAnalyze on Scholarcy
Epidermal growth factor receptor (EGFR) is an important anti-cancer therapy target that is applicable to many cancer types. We had previously reported the screening and discovery of a novel peptide ligand against EGFR named GE11. It was shown to bind to EGFR competitively with EGF and mediate gene delivery to cancer cells with high-EGFR expression. In this study, we conjugated GE11 on to liposome surface and examined their binding and distribution to EGFR expressing cancer cells in vitro and in vivo using fluorescence imaging techniques. GE11 liposomes were found to bind specifically and efficiently to EGFR high-expressing cancer cells. In vivo in H1299 xenograft mouse model, GE11 liposomes also extravasated and accumulated into the tumor site preferentially, and demonstrated better targeting and drug delivery capacities.
This paper references
Attachment of antibodies to sterically stabilized liposomes: evaluation, comparison and optimization of coupling procedures.
C. B. Hansen (1995)
Use of the Post-Insertion Technique to Insert Peptide Ligands into Pre-Formed Stealth Liposomes with Retention of Binding Activity and Cytotoxicity
J. Moreira (2004)
Sterically stabilized liposomes.
M. Woodle (1992)
Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times.
D. Lasic (1991)
A novel small peptide as a targeting ligand for receptor tyrosine kinase Tie2.
X. Wu (2004)
In vitro and in vivo comparison of immunoliposomes made by conventional coupling techniques with those made by a new post-insertion approach.
D. Iden (2001)
Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo.
T. Allen (1991)
Preparation and functional evaluation of RGD-modified proteins as alpha(v)beta(3) integrin directed therapeutics.
R. J. Kok (2002)
Characterization of liposomal systems containing doxorubicin entrapped in response to pH gradients.
L. Mayer (1990)
Cyclic RGD Peptide-Conjugated Polyplex Micelles as a Targetable Gene Delivery System Directed to Cells Possessing αvβ3 and αvβ5 Integrins
M. Oba (2007)
Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome.
N. Maeda (2004)
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
S. Hobbs (1998)
Chemistry for peptide and protein PEGylation.
M. Roberts (2002)
Near-infrared fluorescent deoxyglucose analogue for tumor optical imaging in cell culture and living mice.
Z. Cheng (2006)
Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature-specific ligands potentiates therapeutic efficacy.
F. Pastorino (2006)
Development of EGF-conjugated liposomes for targeted delivery of boronated DNA-binding agents.
Erika Bohl Kullberg (2002)
Suppression of GD1α ganglioside‐mediated tumor metastasis by liposomalized WHW‐peptide
M. Takikawa (2000)
An approach to increased polyplex gene delivery by peptides selected from a phage display library.
M. Morpurgo (2002)
In vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphoma.
D. E. Lopes de Menezes (1998)
Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models.
D. Kirpotin (2006)
A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers.
Justin M Saul (2006)
Sterically stabilized polyplex: ligand-mediated activity.
M. Woodle (2001)
Anti‐neovascular therapy by liposomal DPP‐CNDAC targeted to angiogenic vessels
T. Asai (2002)
Therapy of primary and metastatic mouse mammary carcinomas with doxorubicin encapsulated in long circulating liposomes
J. Vaage (1992)
In vivo fate of folate-targeted polyethylene-glycol liposomes in tumor-bearing mice.
A. Gabizon (2003)
Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin.
R. Schiffelers (2003)
Targetability of novel immunoliposomes modified with amphipathic poly(ethylene glycol)s conjugated at their distal terminals to monoclonal antibodies.
K. Maruyama (1995)
Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases.
G. Haran (1993)
Construction and functional characterization of scFv(14E1)-ETA - a novel, highly potent antibody-toxin specific for the EGF receptor.
M. Schmidt (1997)
Membrane models with phospholipids.
A. Bangham (1968)
Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging
V. Ntziachristos (2002)
Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo.
C. Mamot (2005)
Tumor targeting based on the effect of enhanced permeability and retention (EPR) and the mechanism of receptor-mediated endocytosis (RME).
T. Tanaka (2004)
Pharmacokinetics and antitumor activity of epirubicin encapsulated in long‐circulating liposomes incorporating a polyethylene glycol‐derivatized phospholipid
E. Mayhew (1992)
Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue.
N. Wu (1993)
Antibody-targeted delivery of doxorubicin entrapped in sterically stabilized liposomes can eradicate lung cancer in mice.
I. Ahmad (1993)
Diffusion of univalent ions across the lamellae of swollen phospholipids.
A. Bangham (1965)
EGFR-targeted immunoliposomes derived from the monoclonal antibody EMD72000 mediate specific and efficient drug delivery to a variety of colorectal cancer cells
C. Mamot (2006)
Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeutics
Z. Li (2005)
A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs
T. Ishida (1999)
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
F. Yuan (1995)
Cytotoxic and Antitumor Activities of Doxorubicin Conjugates with the Epidermal Growth Factor and its Receptor-binding Fragment
S. Lutsenko (2002)
Epidermal growth factor receptor (EGFR)-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR- and EGFRvIII-overexpressing tumor cells.
C. Mamot (2003)
This paper is referenced by
New strategies to enhance photodynamic therapy for solid tumors
M. Broekgaarden (2016)
Cetuximab-oxaliplatin-liposomes for epidermal growth factor receptor targeted chemotherapy of colorectal cancer.
S. Zalba (2015)
Progress on GE 11 Peptide-Modified EGFR-Targeting Nano Delivery System and the Delivery Barriers to Solid Tumor
H. Tang (2020)
Phthalocyanine-peptide conjugates for epidermal growth factor receptor targeting.
B. Ongarora (2012)
Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells.
Shin-ichiro Ohno (2013)
Preclinical Development An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor
Richard S. Agnes (2012)
PolyIC GE11 polyplex inhibits EGFR‐overexpressing tumors
Galith Abourbeh (2012)
Determinación de la eficiencia de incorporación y especificidad de nanoparticulas biodegradables con diferentes quimioterapéuticos en células de cáncer de mama
G. Castro (2012)
HAase-sensitive dual-targeting irinotecan liposomes enhance the therapeutic efficacy of lung cancer in animals
L. Zhang (2018)
99mTc-radiolabeled GE11-modified peptide for ovarian tumor targeting
Najmeh Rahmanian (2017)
Targeting the EGF Receptor for Ovarian Cancer Therapy
Reema Zeineldin (2010)
Pharmacokinetics and biodistribution of lonidamine/paclitaxel loaded, EGFR-targeted nanoparticles in an orthotopic animal model of multi-drug resistant breast cancer.
L. Milane (2011)
脑胶质瘤靶向脂质体的制备和表征 Preparation and Characterization of Glioma Targeted Liposomes
Biodistribution and pharmacokinetics of EGFR-targeted thiolated gelatin nanoparticles following systemic administration in pancreatic tumor-bearing mice.
J. Xu (2013)
Archaeosomes with encapsulated antigens for oral vaccine delivery.
Z. Li (2011)
Liposomal systems as viable drug delivery technology for skin cancer sites with an outlook on lipid-based delivery vehicles and diagnostic imaging inputs for skin conditions'.
N. Akhtar (2016)
Constructing a better binding peptide for drug delivery targeting the interleukin-4 receptor
Xue-Di Bai (2020)
An Optical Probe for Non-invasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor
Richard S. Agnes (2012)
Design, Synthesis, and Evaluation of Innovative BODIPY-Peptidic Conjugates for Biological Application
Tyrslai M. Williams (2017)
Brain-targeting gene delivery using a rabies virus glycoprotein peptide modulated hollow liposome: bio-behavioral study
Youhua Tao (2012)
Effects of surface displayed targeting ligand GE11 on liposome distribution and extravasation in tumor.
H. Tang (2014)
Chapter 9 Liposomal Nanoformulations as Current Tumor-Targeting Approach to Cancer Therapy
A. Porfire (2019)
Ligand-functionalized nanoliposomes for targeted delivery of galantamine.
M. S. Mufamadi (2013)
Targeted delivery of cargoes into a murine solid tumor by a cell-penetrating peptide and cleavable poly(ethylene glycol) comodified liposomal delivery system via systemic administration.
Rui Kuai (2011)
Polymerizable Peptide Monomers for the Targeted and Intracellular Delivery of Cancer Therapeutics
H. Kern (2016)
Nanoparticulate targeted drug delivery using peptides and proteins
H. Santos (2012)
Gemcitabine versus Modified Gemcitabine: a review of several promising chemical modifications.
Elodie Moysan (2013)
Liposomal Nanoformulations as Current Tumor-Targeting Approach to Cancer Therapy
A. Porfire (2017)
CNS drug targeting: have we travelled in right path?
A. Punitha (2013)
Targeted lipid-coated nanoparticles: delivery of tumor necrosis factor-functionalized particles to tumor cells.
Sylvia K E Messerschmidt (2009)
Signal analysis with Zetasizer on the effect of Poly (Ethylene Glycol) (PEG) to stabilize and unify colloidal gold nanoparticles
G. F. Chin (2012)
Tumor-targeting peptides from combinatorial libraries.
R. Liu (2017)See more