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Facile Fabrication Of Well-defined Hydrogel Beads With Magnetic Nanocomposite Shells.

H. Liu, C. Wang, Quanxing Gao, Jian-Xin Chen, B. Ren, X. Liu, Zhen Tong
Published 2009 · Materials Science, Medicine

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Well-defined magnetic nanocomposite beads with alginate gel cores and shells of iron oxide (gamma-Fe(2)O(3)) nanoparticles were prepared by self-assembly of colloidal particles at liquid-liquid interfaces and subsequent in situ gelation. Fe(2)O(3) nanoparticles could spontaneously adsorb onto the water droplet surfaces to stabilize water-in-hexane emulsions. Water droplets containing sodium alginate were in situ gelled by calcium cations, which were released from calcium-ethylenediamine tetraacetic acid (Ca-EDTA) chelate by decreasing pH value through slow hydrolysis of d-glucono-delta-lactone (GDL). The resulting hybrid beads with a core-shell structure were easily collected by removing hexane. This facile and high efficient fabrication had a 100% yield and could be carried out at room temperature. Insulin microcrystal was encapsulated into the hybrid beads by dispersing them in the aqueous solution of alginate sodium in the fabrication process. The sustained release could be obtained due to the dual barriers of the hydrogel core and the close-packed inorganic shell. The release curves were nicely fitted by the Weibull equation and the release followed Fickian diffusion. The hybrid beads may find applications as delivery vehicles for biomolecules, drugs, cosmetics, food supplements and living cells.
This paper references
10.1016/J.JCONREL.2006.01.015
New loading process and release properties of insulin from polysaccharide microcapsules fabricated through layer-by-layer assembly.
S. Ye (2006)
10.1002/CPHC.200700359
Embedding magnetic nanoparticles into polysaccharide-based hydrogels for magnetically assisted bioseparation.
Y. Liang (2007)
10.1016/J.CARBPOL.2007.06.018
Alginate–calcium carbonate porous microparticle hybrid hydrogels with versatile drug loading capabilities and variable mechanical strengths
C. Wang (2008)
10.1016/J.JCIS.2007.09.019
Fabrication of colloidosomes at low temperature for the encapsulation of thermally sensitive compounds.
Samia Lai͏̈b (2008)
10.1039/B411359D
Fabrication of novel colloidosome microcapsules with gelled aqueous cores
O. Cayre (2004)
10.1021/CM0608286
Emulsion-Based Synthesis of Reversibly Swellable, Magnetic Nanoparticle-Embedded Polymer Microcapsules
H. Koo (2006)
10.1021/NL0505391
Magnetic colloidosomes derived from nanoparticle interfacial self-assembly.
H. Duan (2005)
10.1021/JP0757457
Structural and Magnetic Properties of Gold and Silica Doubly Coated γ-Fe2O3 Nanoparticles
Keeseong Park (2007)
10.1016/J.IJPHARM.2007.09.019
Fabrication of novel core-shell hybrid alginate hydrogel beads.
H. Liu (2008)
10.1063/1.1603731
Fractal kinetics in drug release from finite fractal matrices
K. Kosmidis (2003)
10.1016/S0001-8686(02)00069-6
Emulsions stabilised solely by colloidal particles
R. Aveyard (2003)
10.1126/SCIENCE.1078616
Nanoparticle Assembly and Transport at Liquid-Liquid Interfaces
Y. Lin (2003)
10.1021/BM050126U
Difference in concentration dependence of relaxation critical exponent N for alginate solutions at sol-gel transition induced by calcium cations.
Lu Lu (2005)
10.1002/ADMA.200602447
Organic–Inorganic Hybrid Hollow Spheres Prepared from TiO2‐Stabilized Pickering Emulsion Polymerization
T. Chen (2007)
10.1002/CPHC.200700147
Facile fabrication of hybrid colloidosomes with alginate gel cores and shells of porous CaCO3 microparticles.
C. Wang (2007)
10.1002/CHIN.200138289
Hydrogels for Tissue Engineering
K. Lee (2001)
10.1111/j.1749-6632.2001.tb03823.x
Hydrogels for Biomedical Applications
A. Hoffman (2001)
10.1016/J.JCONREL.2004.11.032
Controlled release based on the dissolution of a calcium carbonate layer deposited on hydrogels.
D. Ogomi (2005)
10.1023/A:1024497920145
A Reappraisal of Drug Release Laws Using Monte Carlo Simulations: The Prevalence of the Weibull Function
K. Kosmidis (2004)
10.1039/B606965G
Formation of liquid core-polymer shell microcapsules.
H. N. Yow (2006)
10.1016/S0928-0987(01)00095-1
Modeling and comparison of dissolution profiles.
P. Costa (2001)
10.1021/LA9506786
Assembly of Latex Particles by Using Emulsion Droplets as Templates. 1. Microstructured Hollow Spheres
O. Velev (1996)
10.1021/LA701691G
Poly(N-vinylcaprolactam-co-glycidyl methacrylate) aqueous microgels labeled with fluorescent LaF3:Eu nanoparticles.
Nadine Häntzschel (2007)
10.1038/355242A0
A polymer gel with electrically driven motility
Y. Osada (1992)
10.1016/J.BIOMATERIALS.2003.11.028
Calcium phosphate-alginate microspheres as enzyme delivery matrices.
C. C. Ribeiro (2004)
10.1016/S0169-409X(01)00203-4
Environment-sensitive hydrogels for drug delivery
Y. Qiu (2001)
10.1248/CPB.23.3288
Rate of release of medicaments from ointment bases containing drugs in suspension.
Toshiaki Koizumi (1975)
10.1126/SCIENCE.8134835
New challenges in biomaterials.
N. Peppas (1994)
10.1016/J.IJPHARM.2005.10.044
On the use of the Weibull function for the discernment of drug release mechanisms.
V. Papadopoulou (2006)
10.1021/JA047808U
Fabrication of "hairy" colloidosomes with shells of polymeric microrods.
Paul F Noble (2004)
10.1002/ANIE.200501073
Temperature-induced inversion of nanoparticle-stabilized emulsions.
B. Binks (2005)
10.1002/ADMA.200502545
Hybrid Biocomposites Based on Calcium Phosphate Mineralization of Self‐Assembled Supramolecular Hydrogels
Z. Schnepp (2006)
10.1126/SCIENCE.1074868
Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles
A. Dinsmore (2002)
10.1081/DDC-100107254
A Novel Bending Point Criterion for Dissolution Profile Interpretation
L. Van Vooren (2001)
10.1016/S0169-409X(98)00075-1
Oral insulin delivery.
Carino (1999)



This paper is referenced by
10.3390/POLYM4021157
Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields
G. Giani (2012)
10.1039/B9PY00255C
Dual nanocomposite multihollow polymer microspheres prepared by suspension polymerization based on a multiple pickering emulsion
Quanxing Gao (2010)
10.1016/j.ijbiomac.2017.05.138
Can natural polymers assist in delivering insulin orally?
M. Nur (2017)
10.1039/b917702g
Prussian blue microcrystals prepared by selective etching and their conversion to mesoporous magnetic iron(III) oxides.
M. Hu (2010)
10.4236/JBNB.2014.52014
Influence of Alternating and Static Magnetic Fields on Drug Release from Hybrid Hydrogels Containing Magnetic Nanoparticles
M. Uva (2014)
10.1002/asia.201100075
Synthesis of a titanium-containing Prussian-blue analogue with a well-defined cube structure and its thermal conversion into a nanoporous titanium-iron-based oxide.
M. Hu (2011)
10.1007/s11051-018-4437-6
Magnetic nanoparticle-crosslinked ferrohydrogel as a novel class of forward osmosis draw agent
A. Shakeri (2018)
10.1016/j.ijbiomac.2016.05.023
Characterization and behavior of composite hydrogel prepared from bamboo shoot cellulose and β-cyclodextrin.
Shumin Liu (2016)
10.1371/journal.pone.0168727
Monitoring Endothelial and Tissue Responses to Cobalt Ferrite Nanoparticles and Hybrid Hydrogels
F. Finetti (2016)
10.3390/pharmaceutics11100524
Enhanced Treatment Effects of Tilmicosin Against Staphylococcus aureus Cow Mastitis by Self-Assembly Sodium Alginate-Chitosan Nanogel
K. Zhou (2019)
10.1002/mabi.201200310
Core-shell capsules based on supramolecular hydrogels show shell-related erosion and release due to confinement.
M. Guo (2013)
10.1201/B19751-13
Polysaccharide Hydrogels with Magnetic Nanoparticles
S. Fedi (2016)
10.1080/1539445X.2011.591867
Designing Nanoparticle Colloidal Shells for Selective Transport
R. Rosenberg (2013)
10.1201/B19751-12
Properties and Biomedical Applications of Gellan Gum Hydrogels
Cencetti Claudia (2016)
10.1002/ANGE.201001623
Synthese von Nano‐/Mikrostrukturen an fluiden Grenzflächen
Z. Niu (2010)
10.1039/C1SM05174A
A novel strategy for engineering hydrogels with ferromagnetic nanoparticles as crosslinkers of the polymer chains. Potential applications as a targeted drug delivery system
R. Barbucci (2011)
10.1016/j.watres.2016.10.008
A holistic review of hydrogel applications in the adsorptive removal of aqueous pollutants: Recent progress, challenges, and perspectives.
Musharib Khan (2016)
10.1007/s00289-011-0622-9
To prepare chitosan capsules via interfacial initiated chitosan macromonomer in situ polymerization
Weijun Liu (2011)
10.1007/S10404-013-1325-3
On-chip fabrication of magnetic alginate hydrogel microfibers by multilayered pneumatic microvalves
Chengzhi Hu (2014)
10.1016/J.COCIS.2012.03.003
Transport through self-assembled colloidal shells (colloidosomes)
N. Dan (2012)
10.1016/B978-0-12-804304-2.00004-4
Engineering effective nanoscale nutrient carriers
N. Dan (2017)
10.1039/C3TA15242A
Encapsulated phase change materials stabilized by modified graphene oxide
Y. Zhang (2014)
10.1007/s00396-011-2524-7
Magnetic switchable alginate beads
P. Degen (2011)
10.4236/ANP.2014.34019
Synthesis and Biological Activity of Drug Delivery System Based on Chitosan Nanocapsules
M. Gouda (2014)
10.1007/S10853-011-5632-3
Sacrificial functional polystyrene template to prepare chitosan nanocapsules and in vitro drug release properties
Weijun Liu (2011)
10.1002/9781118311974.CH12
Intelligent Nanocomposite Hydrogels
M. Sirousazar (2012)
10.1016/J.CEJ.2012.08.078
Synthesis and characterization of iron-PVA hydrogel microspheres and their use in the arsenic (V) removal from aqueous solution
A. Santos (2012)
Designer Collagen-Fibril Biograft Materials for Tunable Molecular Delivery
R. V. Joshi (2016)
10.1088/0953-8984/27/19/194105
Magneto-responsive alginate capsules.
P. Degen (2015)
10.1016/J.CCR.2012.05.032
Applications of metal–organic coordination polymers as precursors for preparation of nano-materials
M. Masoomi (2012)
10.1080/01932691.2012.657947
Surfactant-Free Multiple Pickering Emulsions Stabilized by Combining Hydrophobic and Hydrophilic Nanoparticles
S. Zou (2013)
10.1039/C8RA01059E
A conductive sodium alginate and carboxymethyl chitosan hydrogel doped with polypyrrole for peripheral nerve regeneration
Bu Ying (2018)
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