← Back to Search
Facile Fabrication Of Well-defined Hydrogel Beads With Magnetic Nanocomposite Shells.
H. Liu, C. Wang, Quanxing Gao, Jian-Xin Chen, B. Ren, X. Liu, Zhen Tong
Published 2009 · Materials Science, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
Well-defined magnetic nanocomposite beads with alginate gel cores and shells of iron oxide (gamma-Fe(2)O(3)) nanoparticles were prepared by self-assembly of colloidal particles at liquid-liquid interfaces and subsequent in situ gelation. Fe(2)O(3) nanoparticles could spontaneously adsorb onto the water droplet surfaces to stabilize water-in-hexane emulsions. Water droplets containing sodium alginate were in situ gelled by calcium cations, which were released from calcium-ethylenediamine tetraacetic acid (Ca-EDTA) chelate by decreasing pH value through slow hydrolysis of d-glucono-delta-lactone (GDL). The resulting hybrid beads with a core-shell structure were easily collected by removing hexane. This facile and high efficient fabrication had a 100% yield and could be carried out at room temperature. Insulin microcrystal was encapsulated into the hybrid beads by dispersing them in the aqueous solution of alginate sodium in the fabrication process. The sustained release could be obtained due to the dual barriers of the hydrogel core and the close-packed inorganic shell. The release curves were nicely fitted by the Weibull equation and the release followed Fickian diffusion. The hybrid beads may find applications as delivery vehicles for biomolecules, drugs, cosmetics, food supplements and living cells.
This paper references
New loading process and release properties of insulin from polysaccharide microcapsules fabricated through layer-by-layer assembly.
S. Ye (2006)
Embedding magnetic nanoparticles into polysaccharide-based hydrogels for magnetically assisted bioseparation.
Y. Liang (2007)
Alginate–calcium carbonate porous microparticle hybrid hydrogels with versatile drug loading capabilities and variable mechanical strengths
C. Wang (2008)
Fabrication of colloidosomes at low temperature for the encapsulation of thermally sensitive compounds.
Samia Lai͏̈b (2008)
Fabrication of novel colloidosome microcapsules with gelled aqueous cores
O. Cayre (2004)
Emulsion-Based Synthesis of Reversibly Swellable, Magnetic Nanoparticle-Embedded Polymer Microcapsules
H. Koo (2006)
Magnetic colloidosomes derived from nanoparticle interfacial self-assembly.
H. Duan (2005)
Structural and Magnetic Properties of Gold and Silica Doubly Coated γ-Fe2O3 Nanoparticles
Keeseong Park (2007)
Fabrication of novel core-shell hybrid alginate hydrogel beads.
H. Liu (2008)
Fractal kinetics in drug release from finite fractal matrices
K. Kosmidis (2003)
Emulsions stabilised solely by colloidal particles
R. Aveyard (2003)
Nanoparticle Assembly and Transport at Liquid-Liquid Interfaces
Y. Lin (2003)
Difference in concentration dependence of relaxation critical exponent N for alginate solutions at sol-gel transition induced by calcium cations.
Lu Lu (2005)
Organic–Inorganic Hybrid Hollow Spheres Prepared from TiO2‐Stabilized Pickering Emulsion Polymerization
T. Chen (2007)
Facile fabrication of hybrid colloidosomes with alginate gel cores and shells of porous CaCO3 microparticles.
C. Wang (2007)
Hydrogels for Tissue Engineering
K. Lee (2001)
Hydrogels for Biomedical Applications
A. Hoffman (2001)
Controlled release based on the dissolution of a calcium carbonate layer deposited on hydrogels.
D. Ogomi (2005)
A Reappraisal of Drug Release Laws Using Monte Carlo Simulations: The Prevalence of the Weibull Function
K. Kosmidis (2004)
Formation of liquid core-polymer shell microcapsules.
H. N. Yow (2006)
Modeling and comparison of dissolution profiles.
P. Costa (2001)
Assembly of Latex Particles by Using Emulsion Droplets as Templates. 1. Microstructured Hollow Spheres
O. Velev (1996)
Poly(N-vinylcaprolactam-co-glycidyl methacrylate) aqueous microgels labeled with fluorescent LaF3:Eu nanoparticles.
Nadine Häntzschel (2007)
A polymer gel with electrically driven motility
Y. Osada (1992)
Calcium phosphate-alginate microspheres as enzyme delivery matrices.
C. C. Ribeiro (2004)
Environment-sensitive hydrogels for drug delivery
Y. Qiu (2001)
Rate of release of medicaments from ointment bases containing drugs in suspension.
Toshiaki Koizumi (1975)
New challenges in biomaterials.
N. Peppas (1994)
On the use of the Weibull function for the discernment of drug release mechanisms.
V. Papadopoulou (2006)
Fabrication of "hairy" colloidosomes with shells of polymeric microrods.
Paul F Noble (2004)
Temperature-induced inversion of nanoparticle-stabilized emulsions.
B. Binks (2005)
Hybrid Biocomposites Based on Calcium Phosphate Mineralization of Self‐Assembled Supramolecular Hydrogels
Z. Schnepp (2006)
Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles
A. Dinsmore (2002)
A Novel Bending Point Criterion for Dissolution Profile Interpretation
L. Van Vooren (2001)
Oral insulin delivery.
This paper is referenced by
Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields
G. Giani (2012)
Dual nanocomposite multihollow polymer microspheres prepared by suspension polymerization based on a multiple pickering emulsion
Quanxing Gao (2010)
Can natural polymers assist in delivering insulin orally?
M. Nur (2017)
Prussian blue microcrystals prepared by selective etching and their conversion to mesoporous magnetic iron(III) oxides.
M. Hu (2010)
Influence of Alternating and Static Magnetic Fields on Drug Release from Hybrid Hydrogels Containing Magnetic Nanoparticles
M. Uva (2014)
Synthesis of a titanium-containing Prussian-blue analogue with a well-defined cube structure and its thermal conversion into a nanoporous titanium-iron-based oxide.
M. Hu (2011)
Magnetic nanoparticle-crosslinked ferrohydrogel as a novel class of forward osmosis draw agent
A. Shakeri (2018)
Characterization and behavior of composite hydrogel prepared from bamboo shoot cellulose and β-cyclodextrin.
Shumin Liu (2016)
Monitoring Endothelial and Tissue Responses to Cobalt Ferrite Nanoparticles and Hybrid Hydrogels
F. Finetti (2016)
Enhanced Treatment Effects of Tilmicosin Against Staphylococcus aureus Cow Mastitis by Self-Assembly Sodium Alginate-Chitosan Nanogel
K. Zhou (2019)
Core-shell capsules based on supramolecular hydrogels show shell-related erosion and release due to confinement.
M. Guo (2013)
Polysaccharide Hydrogels with Magnetic Nanoparticles
S. Fedi (2016)
Designing Nanoparticle Colloidal Shells for Selective Transport
R. Rosenberg (2013)
Properties and Biomedical Applications of Gellan Gum Hydrogels
Cencetti Claudia (2016)
Synthese von Nano‐/Mikrostrukturen an fluiden Grenzflächen
Z. Niu (2010)
A novel strategy for engineering hydrogels with ferromagnetic nanoparticles as crosslinkers of the polymer chains. Potential applications as a targeted drug delivery system
R. Barbucci (2011)
A holistic review of hydrogel applications in the adsorptive removal of aqueous pollutants: Recent progress, challenges, and perspectives.
Musharib Khan (2016)
To prepare chitosan capsules via interfacial initiated chitosan macromonomer in situ polymerization
Weijun Liu (2011)
On-chip fabrication of magnetic alginate hydrogel microfibers by multilayered pneumatic microvalves
Chengzhi Hu (2014)
Transport through self-assembled colloidal shells (colloidosomes)
N. Dan (2012)
Engineering effective nanoscale nutrient carriers
N. Dan (2017)
Encapsulated phase change materials stabilized by modified graphene oxide
Y. Zhang (2014)
Magnetic switchable alginate beads
P. Degen (2011)
Synthesis and Biological Activity of Drug Delivery System Based on Chitosan Nanocapsules
M. Gouda (2014)
Sacrificial functional polystyrene template to prepare chitosan nanocapsules and in vitro drug release properties
Weijun Liu (2011)
Intelligent Nanocomposite Hydrogels
M. Sirousazar (2012)
Synthesis and characterization of iron-PVA hydrogel microspheres and their use in the arsenic (V) removal from aqueous solution
A. Santos (2012)
Designer Collagen-Fibril Biograft Materials for Tunable Molecular Delivery
R. V. Joshi (2016)
Magneto-responsive alginate capsules.
P. Degen (2015)
Applications of metal–organic coordination polymers as precursors for preparation of nano-materials
M. Masoomi (2012)
Surfactant-Free Multiple Pickering Emulsions Stabilized by Combining Hydrophobic and Hydrophilic Nanoparticles
S. Zou (2013)
A conductive sodium alginate and carboxymethyl chitosan hydrogel doped with polypyrrole for peripheral nerve regeneration
Bu Ying (2018)See more