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Noninvasive And Persistent Transfollicular Drug Delivery System Using A Combination Of Liposomes And Iontophoresis.

K. Kajimoto, M. Yamamoto, Misuzu Watanabe, K. Kigasawa, K. Kanamura, H. Harashima, K. Kogure
Published 2011 · Medicine

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Iontophoresis is a promising technique for enhancing transdermal administration of charged drugs. However, conventional iontophoresis is not sufficient for effective delivery of large, hydrophilic, or electrically neutral molecules. In this study, we utilized charged liposomes as carriers, focused on a transfollicular route for delivery of the liposomes, and optimized iontophoretic conditions and lipid composition for this method in both in vitro and in vivo conditions. As a result, we identified the optimum condition (lipid composition: DOTAP/EPC/Chol=2:2:1, current supply: 0.45mA/cm(2), duration: 1h) for effective iontophoretic delivery of aqueous solution, which cannot be transferred into the skin without charged liposomes. We also examined the pharmacological effects of iontophoresis of liposomes encapsulating insulin (INS-lipo) using a rat model of type I diabetes. Interestingly, iontophoresis of INS-lipo onto a diabetes rat skin resulted in a gradual decrease in blood glucose levels, with levels reaching 20% of initial values at 18h after administration. These lower blood glucose levels were maintained for up to 24h. Significant amount of insulin were also detected in plasma 18h after iontophoresis of INS-lipo. We succeeded in developing a non-invasive and persistent transfollicular drug delivery system that used a combination of liposomes and iontophoresis.
This paper references
10.1002/LSM.10204
Site‐specific methylene blue delivery to pilosebaceous structures using highly porous nylon microspheres: An experimental evaluation
S. Mordon (2003)
10.1111/j.1365-2826.2005.01316.x
Central Responsiveness to a Ghrelin Mimetic (GHRP‐6) is Rapidly Altered by Acute Changes in Nutritional Status in Rats
Y. C. Tung (2005)
10.1021/JS9604873
Perifollicular transgenic expression of human interleukin-1 receptor antagonist protein following topical application of novel liposome-plasmid DNA formulations in vivo.
S. Niemiec (1997)
Pilosebaceous unit: anatomical considerations and drug delivery opportunities
Paramjit Singh (2000)
10.1111/j.0906-6705.2004.00123.x
Enhanced transfollicular delivery of adriamycin with a liposome and iontophoresis
I. Han (2004)
10.1016/0168-3659(95)00095-X
Enhanced skin permeation of diclofenac by iontophoresis: in vitro and in vivo studies
Elizabeth Varghese (1996)
10.1358/MF.2000.22.2.796082
The pilosebaceous unit: a pivotal route for topical drug delivery.
R. Agarwal (2000)
excised human-skin during iontophoresis
C. J. Chang (1998)
10.1016/0024-3205(95)02086-X
Topical delivery of growth hormone releasing peptide using liposomal systems: an in vitro study using hairless mouse skin.
D. Fleisher (1995)
10.1111/J.0022-202X.2004.22717.X
Penetration profile of microspheres in follicular targeting of terminal hair follicles.
R. Toll (2004)
10.1038/nbt.1504
Transdermal drug delivery
M. Prausnitz (2008)
10.1016/J.JCONREL.2006.07.008
Inducing effect of liposomalization on the transdermal delivery of hydrocortisone: creation of a drug supersaturated state.
J. Barichello (2006)
10.1023/A:1018922114398
Site-Specific Drug Delivery to Pilosebaceous Structures Using Polymeric Microspheres
A. Rolland (2004)
10.1016/0169-409X(92)90027-N
Skin biological issues in electrically enhanced transdermal delivery
P. Ledger (1992)
10.1007/s00403-005-0613-5
Expression pattern and intensity of protoporphyrin IX induced by liposomal 5-aminolevulinic acid in rat pilosebaceous unit throughout hair cycle
I. Han (2005)
10.1529/BIOPHYSJ.104.044792
Electroosmosis in transdermal iontophoresis: implications for noninvasive and calibration-free glucose monitoring.
A. Sieg (2004)
10.1271/bbb.67.2396
Characterization of Streptozotocin-induced Diabetic Rats and Pharmacodynamics of Insulin Formulations
Jae-jeong Lee (2003)
10.1016/J.IJPHARM.2005.09.025
Transfollicular drug delivery--is it a reality?
V. Meidan (2005)
10.1016/S0165-1838(98)00143-X
Sympathetic hyperactivity in Wistar rats with insulin-resistance.
C. Chang (1998)
10.1016/0005-2760(81)90268-X
Transfer and exchange of phospholipid between small unilamellar liposomes and rat plasma high density lipoproteins. Dependence on cholesterol content and phospholipid composition.
J. Damen (1981)
10.1248/BPB.22.988
New model of progressive non-insulin-dependent diabetes mellitus in mice induced by streptozotocin.
M. Ito (1999)
10.1016/j.ijpharm.2009.08.036
Noninvasive delivery of siRNA into the epidermis by iontophoresis using an atopic dermatitis-like model rat.
K. Kigasawa (2010)
10.1248/BPB.32.684
In vivo transdermal delivery of diclofenac by ion-exchange iontophoresis with geraniol.
K. Kigasawa (2009)
10.1042/BJ1860591
Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro.
C. Kirby (1980)
10.1021/BC000110V
Steric stabilization of fusogenic liposomes by a low-pH sensitive PEG--diortho ester--lipid conjugate.
X. Guo (2001)
10.1016/0168-3659(92)90211-9
How deep do intact liposomes penetrate into human skin
J. Lasch (1992)
10.1016/J.JCONREL.2004.06.015
Skin penetration and distribution of polymeric nanoparticles.
R. Alvarez-Román (2004)
10.1002/JPS.2600761003
Characterization of the permselective properties of excised human skin during iontophoresis.
R. Burnette (1987)
10.1210/EDRV.19.5.0349
Insulin degradation: progress and potential.
W. Duckworth (1998)
10.1002/(SICI)1097-0177(199704)208:4<553::AID-AJA11>3.0.CO;2-Y
Trypsin‐induced follicular papilla apoptosis results in delayed hair growth and pigmentation
M. Seiberg (1997)
10.1023/A:1016327822325
lontophoretic Devices for Drug Delivery
P. Tyle (2004)
10.1016/0003-2697(89)90101-2
Protein measurement using bicinchoninic acid: elimination of interfering substances.
R. Brown (1989)
10.1023/A:1016268027854
Influence of Nonionic Liposomal Composition on Topical Delivery of Peptide Drugs into Pilosebaceous Units: An in Vivo Study Using the Hamster Ear Model
S. Niemiec (2004)
10.1016/0169-409x(92)90024-k
The role of electroosmotic flow in transdermal iontophoresis.
M. J. Pikal (1992)
10.1016/S0168-3659(98)00184-9
Transdermal iontophoretic delivery of bovine insulin and monomeric human insulin analogue.
N. Kanikkannan (1999)
liposomes on their stability invivo and invitro
J. Lasch (1992)
hairless mouse skin
X. Guo (2001)



This paper is referenced by
10.1016/j.addr.2020.06.016
Noninvasive transdermal delivery of liposomes by weak electric current.
Mahadi Hasan (2020)
Transdermal Iontophoresis Delivery Control by Ion-Exchange Fibers and Nanocarriers
K Malinovskaja-Gomez (2016)
10.1080/01932691.2020.1823232
Development of triblock polymersomes for catalase delivery based on quality by design environment
C. A. Oliveira (2020)
10.3390/cells8101158
Nanoparticles Targeting STATs in Cancer Therapy
M. Ashrafizadeh (2019)
FORMULATION AND EVALUATION OF SULFADIAZINE LOADED SILVER NANOPARTICLES
C. P. Jha (2017)
10.1002/jbio.201960020
Optimized skin optical clearing for Optical Coherence Tomography monitoring of encapsulated drug delivery through the hair follicles.
S. Zaytsev (2020)
10.1007/978-1-4939-9516-5_1
Nanovesicles for Nanomedicine: Theory and Practices.
Sheetu Wadhwa (2019)
Interactions of Dendritic Nanomaterials with Skin Layers and Their Applications in Topical Drug Delivery
Y. Yang (2013)
10.1016/j.pharep.2013.09.009
Effects of liposomes with polyisoprenoids, potential drug carriers, on the cardiovascular and excretory system in rats.
O. Gawrys (2014)
Transdermal Iontophoresis – Delivery Control by Ion-Exchange Fibers and Nanocarriers
Dean Jouni Hirvonen (2016)
10.1016/j.jconrel.2020.04.044
Non-invasive delivery of biological macromolecular drugs into the skin by iontophoresis and its application to psoriasis treatment.
T. Fukuta (2020)
10.1002/ADFM.201303253
Dendron‐Based Micelles for Topical Delivery of Endoxifen: A Potential Chemo‐Preventive Medicine for Breast Cancer
Y. Yang (2014)
Conception d'un patch transdermique intelligent pour le monitoring et l'aide à la prise de médicament
Y. Talbi (2018)
10.1016/j.ijpharm.2019.118962
Increased microneedle-mediated transdermal delivery of tetramethylpyrazine to the brain, combined with borneol and iontophoresis, for MCAO prevention.
Sirui Xiao (2019)
10.1248/BPB.35.781
Efficient intradermal delivery of superoxide dismutase using a combination of liposomes and iontophoresis for protection against UV-induced skin damage.
K. Kigasawa (2012)
10.2147/DDDT.S79322
Insulin administration: present strategies and future directions for a noninvasive (possibly more physiological) delivery
E. Matteucci (2015)
10.4236/JCDSA.2012.24054
Enhanced Iontophoretic Delivery of Magnesium Ascorbyl 2-Phosphate and Sodium Fluorescein to Hairless and Hairy Mouse Skin
Min Young Kang (2012)
UNIVERSIDADE FEDERAL DE GOIÁS FACULDADE DE FARMÁCIA PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS FARMACÊUTICAS
L. Antônio (2013)
10.1016/j.addr.2018.12.006
Advances in transdermal insulin delivery.
Y. Zhang (2018)
10.3109/10717544.2015.1013200
Transdermal delivery of vancomycin hydrochloride using combination of nano-ethosomes and iontophoresis: in vitro and in vivo study
Magdy I Mohammed (2016)
10.1002/jps.23216
Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage.
S. Hama (2012)
10.1515/bmt-2019-0019
Non-invasive drug delivery technology: development and current status of transdermal drug delivery devices, techniques and biomedical applications
Naseem Akhtar (2020)
10.1002/adtp.201900116
Recent Advances in the Transdermal Delivery of Protein Therapeutics with a Combinatorial System of Chemical Adjuvants and Physical Penetration Enhancements
Young-Hyeon An (2020)
10.1016/B978-0-323-42978-8.00007-3
Peptide and Protein-Based Therapeutic Agents
Mary Joseph (2017)
10.1016/j.ijpharm.2015.02.024
Anti-cancer vaccination by transdermal delivery of antigen peptide-loaded nanogels via iontophoresis.
Mao Toyoda (2015)
10.1039/c3cs60436e
Emerging micro- and nanotechnology based synthetic approaches for insulin delivery.
Ran Mo (2014)
10.1074/jbc.M113.514414
Electric Stimulus Opens Intercellular Spaces in Skin*
S. Hama (2013)
10.1517/17425247.2012.735658
Liposomal delivery of proteins and peptides
Janani Swaminathan (2012)
10.17795/JJNPP-33968
Superoxide Dismutase-Loaded Solid Lipid Nanoparticles Prepared by Cold Homogenization Method: Characterization and Permeation Study Through Burned Rat Skin
M. Karami (2016)
10.1208/s12249-017-0833-y
Effective Skin Cancer Treatment by Topical Co-delivery of Curcumin and STAT3 siRNA Using Cationic Liposomes
A. Jose (2017)
10.3164/jcbn.15-153
Synergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes
Chihiro Kamezaki (2016)
10.2147/IJN.S109552
Promotion of the transdermal delivery of protein drugs by N-trimethyl chitosan nanoparticles combined with polypropylene electret
Y. Tu (2016)
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