← Back to Search
Solid-state Nanoparticle Coated Emulsions For Encapsulation And Improving The Chemical Stability Of All-trans-retinol.
Nasrin Ghouchi-Eskandar, S. Simović, C. Prestidge
Published 2012 · Medicine, Chemistry
Save to my Library
Download PDFAnalyze on Scholarcy
Submicron oil-in-water (o/w) emulsions stabilised with conventional surfactants and silica nanoparticles were prepared and freeze-dried to obtain free-flowing powders with good redispersibility and a three-dimensional porous matrix structure. Solid-state emulsions were characterised for visual appearance, particle size distribution, zeta potential and reconstitution properties after freeze-drying with various sugars and at a range of sugar to oil ratios. Comparative degradation kinetics of all-trans-retinol from freeze-dried and liquid emulsions was investigated as a function of storage temperatures. Optimum stability was observed for silica-coated oleylamine emulsions at 4 °C in their wet state. The half-life of all-trans-retinol was 25.66 and 22.08 weeks for silica incorporation from the oil and water phases respectively. This was ∼4 times higher compared to the equivalent solid-state emulsions with drug half-life of 6.18 and 6.06 weeks at 4 °C. Exceptionally, at a storage temperature of 40 °C, the chemical stability of the drug was 3 times higher in the solid-state compared to the wet emulsions which confirmed that freeze-drying is a promising approach to improve the chemical stability of water-labile compounds provided that the storage conditions are optimised.
This paper references
Process characteristics and compaction of spray-dried emulsions containing a drug dissolved in lipid.
T. Hansen (2004)
How to stabilize phospholipid liposomes (using nanoparticles).
L. Zhang (2006)
Silica nanoparticles to control the lipase-mediated digestion of lipid-based oral delivery systems.
A. Tan (2010)
Formation and Stability of the Dispersed Particles Composed of Retinyl Palmitate and Phosphatidylcholine
Y. Asai (2000)
Evaluation of emulsifiable glasses for the oral administration of cyclosporin in beagle dogs
C. H. Porter (1996)
Banana Stalks as a Source of Potash.
H. Billings (1917)
Preparation and characterization of emulsifiable glasses: Oil-in-water and water-in-oil-in-water emulsions
S. Myers (1992)
Stabilization of retinol through incorporation into liposomes.
S. Lee (2002)
Surface behaviour of C5, C6, C7 and C8 lecithins at the aqueous solution/air interface
Pablo Martínez-Landeira (2003)
Composition for Dermatologic Preparation. Shiseido Company
T Yanagida (2004)
Tretinoin in a Gel Vehicle for Acne Treatment
A M Marks (1981)
Oxidation of methyl linoleate encapsulated in amorphous lactose-based food model
Y. Shimada (1991)
Analysis and stability study of retinoids in pharmaceuticals by LC with fluorescence detection.
R. Gatti (2000)
Measurement of Contact Angles for Fumed Silica Nanospheres Using Enthalpy of Immersion Data.
Synergistic effect of silica nanoparticles and charged surfactants in the formation and stability of submicron oil-in-water emulsions.
Nasrin Ghouchi Eskandar (2007)
Particle-stabilized emulsions: a bilayer or a bridging monolayer?
T. S. Horozov (2006)
The electrokinetic properties of phospholipid-stabilized fat emulsions: III. Interdroplet potentials and stability ratios in monovalent electrolytes
C. Washington (1990)
Stabiliza - tion of all - trans - retinol by cyclodextrins : a comparative study using HPLC and fluorescence spectroscopy
E. M. Semenova
Oxidative stability of semi-solid excipient mixtures with corn oil and its implication in the degradation of vitamin A
L. Halbaut (1997)
Emulsions and Foams
P. Coussot (2014)
Emulsions and foams
Sophia Berkman (1941)
Silica-lipid hybrid (SLH) microcapsules: a novel oral delivery system for poorly soluble drugs.
A. Tan (2009)
Chemical stability and phase distribution of all-trans-retinol in nanoparticle-coated emulsions.
Nasrin Ghouchi Eskandar (2009)
Solid-State Emulsions: The Effects of Maltodextrin on Microcrystalline Aging
S. Myers (2004)
Formation and structure of stably dispersed particles composed of retinal with dipalmitoylphosphatidylcholine: coexistence of emulsion particles with bilayer vesicles.
Y. Asai (1999)
Influence of Particle Wettability on the Type and Stability of Surfactant-Free Emulsions†
B. P. B. and (2000)
Stability of oil-in-water emulsions stabilised by silica particles
B. Binks (1999)
Stable W/O/W emulsion and its use as cosmetic and/or dermatological composition
I Afria (2000)
Comparison of surface properties and thermodynamic behavior of lyso- and diacylphosphatidylcholines
Jinru Bian (1992)
Model lipophilic formulations of retinyl palmitate: influence of conservative agents on light-induced degradation.
M. Scalzo (2004)
Influence of Liposomes on the Stability of Vitamin A Incorporated in Polyacrylate Hydrogel
I. Arsic (1999)
Notification of the GRAS Determination of Silicon Dioxide When Added Directly or Indirectly to Human Food
Harrison Lewis (2010)
Surface behaviour of C 5 , C 6 , C 7 and C 8 lecithins at the aqueous solution / air interface
S. Myers (2003)
Comparison of surface properties and thermodynamic behavior of lyso - and diacylphosphatidylcholines
M. F. Roberts (1992)
Improvement of bioavailability and photostability of amlodipine using redispersible dry emulsion.
D. Jang (2006)
Effect of relative humidity on lipid oxidation in freeze - dried emulsions
C. J. H. Porter
Preparation of Powdered Redispersible Vitamin E Acetate Emulsion by Spray-Drying Technique.
Using freezing and drying techniques of emulsions for the microencapsulation of fish oil to improve oxidation stability
Katrin Heinzelmann (1999)
ADSORPTION OF GASES IN MULTIMOLECULAR LAYERS
S. Brunauer (1938)
Effect of relative humidity on lipid oxidation in freezedried emulsions
L. Ponginebbi (2000)
How Do Emulsions Evaporate
I. Aranberri (2002)
Preparation of redispersible dry emulsion using Eudragit E100 as both solid carrier and unique emulsifier
F. Cui (2007)
In vivo evaluation of tablets and capsules containing spray-dried o/w-emulsions for oral delivery of poorly soluble drugs.
T. Hansen (2005)
Encapsulation of retinoids in solid lipid nanoparticles (SLN).
V. Jenning (2001)
Liposome encapsulated vitamin A compounds exhibit greater stability and diminished toxicity.
A. Singh (1998)
Inhibition of Ostwald ripening in local anesthetic emulsions by using hydrophobic excipients in the disperse phase.
K. Welin-Berger (2000)
Improvement of Photostability of Ubidecarenone in the Formulation of a Novel Powdered Dosage Form Termed Redispersible Dry Emulsion.
Silica-lipid hybrid microcapsules: influence of lipid and emulsifier type on in vitro performance.
Li Hui Lim (2011)
Hybrid lipid-silica microcapsules engineered by phase coacervation of Pickering emulsions to enhance lipid hydrolysis.
S. Simović (2010)
Stabilization of All-trans-retinol by Cyclodextrins: A Comparative Study Using HPLC and Fluorescence Spectroscopy
E. M. Semenova (2002)
Handbook of Pharmaceutical Excipients
Pharmaceutical Press (2012)
Vitamin A and vitamin A palmitate stability over time and under UVA and UVB radiation.
M. E. Carlotti (2002)
Dry hybrid lipid-silica microcapsules engineered from submicron lipid droplets and nanoparticles as a novel delivery system for poorly soluble drugs.
S. Simović (2009)
Stabilised retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof
A Shefer (2003)
This paper is referenced by
Formulation and preparation of a stable intravenous disulfiram-loaded lipid emulsion
X. Chen (2015)
Enhanced stability of vitamin A palmitate microencapsulated by γ-cyclodextrin metal-organic frameworks
G. Zhang (2018)
Whey Protein/Polysaccharide-Stabilized Oil Powders for Topical Application—Release and Transdermal Delivery of Salicylic Acid from Oil Powders Compared to Redispersed Powders
M. Kotzé (2014)
Improving Bioavailability of Vitamin A in Food by Encapsulation: An Update
V. K. Maurya (2020)
Nanomedical research in Australia and New
M. Cortie (2013)
Structuring Food Emulsions to Improve Nutrient Delivery During Digestion
Like Mao (2015)
Encapsulation of nutraceuticals in novel delivery systems
J. Fangueiro (2016)
Tailoring Flavonoids’ Antioxidant Properties Through Covalent Immobilization Into Dual Stimuli Responsive Polymers
M. Curcio (2015)
Whey protein-or polysaccharide-stabilised oil powders for topical application : comparison of the release and topical delivery of salicylic acid from oil powders and from their redispersed oil powders
M. Kotzé (2015)
Stabilization of oxidable vitamins by flavonoid-based hydrogels
U. G. Spizzirri (2013)
Controlled Release of Retinol in Cationic Co-Polymeric Nanoparticles for Topical Application
Fabien Goudon (2020)
Evaluation of Glabridin loaded nanostructure lipid carriers
C. Zhang (2017)
Formulation, characterisation and topical application of oil powders from whey protein stabilised emulsions
M. Kotzé (2014)
Nanomedical research in Australia and New Zealand.
M. Cortie (2013)
Controlled release of retinyl acetate from β-cyclodextrin functionalized poly(vinyl alcohol) electrospun nanofibers.
S. Lemma (2015)
Effect of storage temperature and relative humidity on long-term colloidal stability of reconstitutable emulsions stabilised by hydrophobically modified starch
Mingduo Mu (2019)
Study of SOPC with embedded pristine and amide-functionalized single wall carbon nanotubes by DSC and FTIR spectroscopy
J. Genova (2020)
Perspectives on percutaneous penetration: Silica nanoparticles
Shohreh Nafisi (2015)
UV and storage stability of retinol contained in oil-in-water nanoemulsions.
H. Park (2019)
Tableting lipid-based formulations for oral drug delivery: a case study with silica nanoparticle-lipid-mannitol hybrid microparticles.
K. Bremmell (2013)
Measuring Silica Nanoparticles in the Skin
Shohreh Nafisi (2017)
Development of a simple and practical method for estimating the liquid absorption of pharmaceutical porous materials using a capillary rise technique
Takuma Oba (2018)