← Back to Search
A Retinyl Palmitate-loaded Solid Lipid Nanoparticle System: Effect Of Surface Modification With Dicetyl Phosphate On Skin Permeation In Vitro And Anti-wrinkle Effect In Vivo.
H. S. Jeon, Jo Eun Seo, M. Kim, M. Kang, D. H. Oh, Sang Ok Jeon, Seong Hoon Jeong, Y. Choi, Sangkil Lee
Published 2013 · Chemistry, Medicine
Download PDFAnalyze on Scholarcy
Surface-modified solid lipid nanoparticles (SLNs) containing retinyl palmitate (Rpal) were prepared by the hot-melt method using Gelucire 50/13(®) and Precirol ATO5(®). Dicetyl phosphate (DCP) was added to negatively charge the surfaces of the SLNs and thereby enhance the skin distribution properties of Rpal. In vitro skin permeation and in vivo anti-aging studies were performed using SLNs dispersed in a hydrogel. The SLNs were under 100 nm in size with an even polydispersity index (PDI), and the high absolute zeta-potential value was sufficient to maintain the colloidal stability of the SLNs. DCP-modified negative SLNs (DCPmod-SLNs) enhanced the skin distribution of Rpal 4.8-fold and delivered Rpal to a greater depth than did neutral SLNs. The in vivo anti-wrinkle effect of the DCPmod-SLN formulation was Rpal dose-dependent. However, the anti-wrinkle effects of the DCPmod-SLN formulations were significantly different from that of the negative control and effectively prevented the reduction of elastin and superoxide dismutase by UV irradiation. In conclusion, the DCPmod-SLN system presented is a good candidate for topical Rpal delivery.
This paper references
Characterization of the 13-cis-retinoic acid/cyclodextrin inclusion complexes by phase solubility, photostability, physicochemical and computational analysis.
K. L. Yap (2005)
Comparative characterization of the physicochemical behavior and skin permeation of extruded DPPC liposomes modified by selected additives.
Babette Biruss (2007)
Enhancement of topical delivery of a lipophilic drug from charged multilamellar liposomes.
N. Katahira (1999)
Retinoids in aging.
H. Torras (1996)
Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery.
J. Liu (2007)
Particle size of liposomes influences dermal delivery of substances into skin.
D. Verma (2003)
Improved efficacy and tolerability of retinoic acid in acne vulgaris: a new topical formulation with cyclodextrin complex ψ
R. Anadolu (2004)
Pathophysiology of premature skin aging induced by ultraviolet light.
G. Fisher (1997)
Rheological evaluation and ocular contact time of some carbomer gels for ophthalmic use
K. Edsman (1996)
Liposomes as an ocular delivery system for acetazolamide: In vitro and in vivo studies
Rania M. Hathout (2008)
DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way
D. Kulms (2002)
Formation of ion pairing as an alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles.
Gisele A. Castro (2009)
Surface Modification of Pharmaceutical Nanocarriers with Ascorbate Residues Improves their Tumor-Cell Association and Killing and the Cytotoxic Action of Encapsulated Paclitaxel In Vitro
G. D’Souza (2008)
Antioxidant defense mechanisms in murine epidermis and dermis and their responses to ultraviolet light.
Y. Shindo (1993)
Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin.
V. Jenning (2000)
In‐vivo effects of solar‐simulated ultraviolet irradiation on antioxidant enzymes and lipid peroxidation in human epidermis
K. Punnonen (1991)
Potential of solid lipid nanoparticles in brain targeting.
I. P. Kaur (2008)
Chemical stability and phase distribution of all-trans-retinol in nanoparticle-coated emulsions.
Nasrin Ghouchi Eskandar (2009)
Encapsulation of retinoids in solid lipid nanoparticles (SLN).
V. Jenning (2001)
Retinoids: new use by innovative drug-delivery systems
E. Trapasso (2009)
The role of liposome charge on immune response generated in BALB/c mice immunized with recombinant major surface glycoprotein of Leishmania (rgp63).
A. Badiee (2009)
AN ANIMAL MODEL OF SOLAR‐AGED SKIN: HISTOLOGICAL, PHYSICAL, and VISIBLE CHANGES IN UV‐IRRADIATED HAIRLESS MOUSE SKIN *
DonaldL. Bissett (1987)
Increasing bioavailability of silymarin using a buccal liposomal delivery system: preparation and experimental design investigation.
M. El-Samaligy (2006)
Accelerated photostability study of tretinoin and isotretinoin in liposome formulations.
G. Ioele (2005)
Niosomes as carriers for tretinoin. I. Preparation and properties.
M. Manconi (2002)
Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye.
K. Hironaka (2009)
Preparation and purification of cationic solid lipid nanospheres--effects on particle size, physical stability and cell toxicity.
A. V. Heydenreich (2003)
Addition of hydrophilic and lipophilic compounds of biological relevance to the monoolein/water system. I. Phase behavior.
F. Caboi (2001)
Solid lipid nanoparticles (SLN) of tretinoin: potential in topical delivery.
Kumar A. Shah (2007)
Stabilization of All-trans-retinol by Cyclodextrins: A Comparative Study Using HPLC and Fluorescence Spectroscopy
E. M. Semenova (2002)
Recent advances in technologies for vitamin A protection in foods
S. M. Loveday (2008)
Aging versus photoaging: postulated mechanisms and effectors.
M. Yaar (1998)
Altered chemical and biological activities of all-trans retinoic acid incorporated in solid lipid nanoparticle powders.
Soo-Jeong Lim (2004)
Skin permeation enhancement of ascorbyl palmitate by liposomal hydrogel (lipogel) formulation and electrical assistance.
Sangkil Lee (2007)
Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymers.
Tamer M Shehata (2008)
c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid.
G. Fisher (2000)
PREPARATION AND IN VITRO CHARACTERIZATION OF TRETINOIN-CONTAINING MICROSPHERES SUITED FOR DERMATOLOGICAL PREPARATIONS
M. Tabbakhian (2008)
Liposomes increase skin penetration of entrapped and non-entrapped hydrophilic substances into human skin: a skin penetration and confocal laser scanning microscopy study.
D. Verma (2003)
Topical retinoids in the treatment of aging of the skin.
A. Katsambas (1999)
Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin.
Y. Shindo (1994)
Solid lipid nanoparticles (SLN/Lipopearls)--a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products.
A. Dingler (1999)
Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products.
J. Pardeike (2009)
Cytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal application.
W. Weyenberg (2007)
Development of SLNs from natural lipids: application to topical delivery of tretinoin.
S. D. Mandawgade (2008)
Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles.
V. Venkateswarlu (2004)
Photoaging: pathogenesis, prevention, and treatment.
S. Kang (2001)
Formulation parameters determining the physicochemical characteristics of solid lipid nanoparticles loaded with all-trans retinoic acid.
Soo-Jeong Lim (2002)
The effects of a novel synthetic retinoid, seletinoid G, on the expression of extracellular matrix proteins in aged human skin in vivo.
M. Kim (2005)
Retinoid metabolism in the skin.
T. Roos (1998)
Time-dependent effect of chronic UV irradiation on superoxide dismutase and catalase activity in hairless mice skin(ヘアレスマウス皮膚における長期紫外線照射のスーパーオキシドジスムターゼおよびカタラーゼ活性に及ぼす経期的影響)
Physicochemical characteristics and in vivo deposition of liposome-encapsulated tea catechins by topical and intratumor administrations
Jia-You Fang (2005)
Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential
K. Westesen (1997)
Liposomes as carriers for dermal delivery of tretinoin: in vitro evaluation of drug permeation and vesicle-skin interaction.
C. Sinico (2005)
Interest of Multifunctional Lipid Excipients: Case of Gelucire® 44/14
O. Chambin (2005)
Mechanisms of photoaging and chronological skin aging.
G. Fisher (2002)
Molecular mechanisms of cutaneous aging: connective tissue alterations in the dermis.
J. Uitto (1998)
Spectrophotometric assay for superoxide dismutase based on tetrazolium salt 3'--1--(phenylamino)-carbonyl--3, 4-tetrazolium]-bis(4-methoxy-6-nitro)benzenesulfonic acid hydrate reduction by xanthine-xanthine oxidase.
H. Ukeda (1997)
This paper is referenced by
In vitro lipolysis tests on lipid nanoparticles: comparison between lipase/co-lipase and pancreatic extract
V. Jannin (2015)
Recent advances in nanoparticle-mediated drug delivery
B. Kumar (2017)
QbD approach to investigate product and process variabilities for brain targeting liposomes
Nahid Kamal (2015)
Formulation Effects on Topical Nanoparticle Penetration
Heather A. E. Benson (2016)
Glycosylated Sertraline-Loaded Liposomes for Brain Targeting: QbD Study of Formulation Variabilities and Brain Transport
Ibrahim Harbi (2016)
Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route.
A. Lauterbach (2015)
Formulation and in-vivo Evaluation of Novel Topical Gel of Lopinavir for Targeting HIV
Huda Ansari (2018)
Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: A review
A. Garcés (2018)
Antioxidant Polymers as Biomaterial
R. Lith (2016)
Enhanced topical delivery of fish scale collagen employing negatively surface-modified nanoliposome
Joeun Seo (2017)
Advances in Hybrid Polymer-Based Materials for Sustained Drug Release
Lígia N M Ribeiro (2017)
SLN and NLC for topical, dermal, and transdermal drug delivery
E. B. Souto (2020)
Nanoparticles and nanofibers for topical drug delivery.
R. Goyal (2016)
Current developments in the nanomediated delivery of photoprotective phytochemicals
Nimmy Kumar (2020)
Analytical tools and evaluation strategies for nanostructured lipid carrier-based topical delivery systems
Sheefali Mahant (2020)
Emerging trends in nanomedicine for topical delivery in skin disorders: Current and translational approaches
P. Pandey (2020)
Safety Assessment of Alkyl Phosphates as Used in Cosmetics
Monice M. Fiume (2019)
Solid lipid nanoparticles made of self-emulsifying lipids for efficient encapsulation of hydrophilic substances
A. Trapani (2019)
Going skin deep: A direct comparison of penetration potential of lipid‐based nanovesicles on the isolated perfused human skin flap model
Selenia Ternullo (2017)
Role of Excipients in formulation development and biocompatibility of lipid nanoparticles (SLNs/NLCs)
S. Doktorovová (2017)
Preparation of Solid Lipid Nanoparticles and Its Applications in Cosmetics
M. Cheng (2020)
Influence of vegetable oil on the synthesis of bioactive nanocarriers with broad spectrum photoprotection
G. Niculae (2014)
Gelucire-Based Nanoparticles for Curcumin Targeting to Oral Mucosa: Preparation, Characterization, and Antimicrobial Activity Assessment.
Heba A Hazzah (2015)
Podophyllotoxin-Loaded Nanostructured Lipid Carriers for Skin Targeting: In Vitro and In Vivo Studies
Jihui Zhao (2016)
Lipid nanoparticles for the topical delivery of retinoids and derivatives.
Javier O Morales (2015)
Pharmacokinetics and biodistribution of the nanoparticles
K. Raza (2017)
Anti-oxidation and Anti-wrinkling Effects of Jeju Horse Leg Bone Hydrolysates
D. Kim (2014)
Quantitative analysis of curcumin-loaded alginate nanocarriers in hydrogels using Raman and attenuated total reflection infrared spectroscopy
Lynda Miloudi (2017)
High-Throughput Continuous Flow Production of Nanoscale Liposomes by Microfluidic Vertical Flow Focusing.
R. R. Hood (2015)
Nanoemulsions to Prevent Photoaging
A. Afornali (2016)
Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration
D. M. Tichota (2014)
Over-the-counter anti-ageing topical agents and their ability to protect and repair photoaged skin.
Eleanor J Bradley (2015)See more