← Back to Search
Multifunctional Nanomedicine Platform For Concurrent Delivery Of Chemotherapeutic Drugs And Mild Hyperthermia To Ovarian Cancer Cells.
Olena R Taratula, R. Dani, C. Schumann, Hong Xu, A. Wang, H. Song, P. Dhagat, O. Taratula
Published 2013 · Medicine
Download PDFAnalyze on Scholarcy
A multifunctional tumor-targeting delivery system was developed and evaluated for an efficient treatment of drug-resistant ovarian cancer by combinatorial therapeutic modality based on chemotherapy and mild hyperthermia. The engineered iron oxide nanoparticle (IONPs)-based nanocarrier served as an efficient delivery vehicle for doxorubicin and provided the ability to heat cancer cells remotely upon exposure to an alternating magnetic field (AMF). The nanocarrier was additionally modified with polyethylene glycol and LHRH peptide to improve its biocompatibility and ability to target tumor cells. The synthesized delivery system has an average size of 97.1 nm and a zeta potential close to zero, both parameters favorable for increased stability in biological media and decreased elimination by the immune system. The nanocarrier demonstrated faster drug release in acidic conditions that mimic the tumor environment. It was also observed that the LHRH targeted delivery system could effectively enter drug resistant ovarian cancer cells, and the fate of doxorubicin was tracked with fluorescence microscope. Mild hyperthermia (40°C) generated by IONPs under exposure to AMF synergistically increased the cytotoxicity of doxorubicin delivered by the developed nanocarrier to cancer cells. Thus, the developed IONPs-based delivery system has high potential in the effective treatment of ovarian cancer by combinatorial approach.
This paper references
Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Xiang-hong Peng (2008)
Hyperthermia in oncology.
M. H. Falk (2001)
Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging.
M. Yezhelyev (2008)
Superparamagnetic iron oxide nanotheranostics for targeted cancer cell imaging and pH-dependent intracellular drug release.
P. Zou (2010)
Development of Receptor Targeted Magnetic Iron Oxide Nanoparticles for Efficient Drug Delivery and Tumor Imaging.
Lily L. Yang (2008)
Aqueous dispersion of monodisperse magnetic iron oxide nanocrystals through phase transfer
W. W. Yu (2006)
Multifunctional nanomedicine platform for cancer specific delivery of siRNA by superparamagnetic iron oxide nanoparticles-dendrimer complexes.
O. Taratula (2011)
A study on the thermochemotherapy effect of nanosized As2O3/MZF thermosensitive magnetoliposomes on experimental hepatoma in vitro and in vivo.
L. Wang (2011)
Engineering biofunctional magnetic nanoparticles for biotechnological applications.
M. Moros (2010)
Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
F. Alexis (2008)
Targeted temperature sensitive magnetic liposomes for thermo-chemotherapy.
P. Pradhan (2010)
Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer.
Ronak Savla (2011)
Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy
M. Yu (2012)
Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia.
Jean-Paul Fortin (2007)
Nonplatinum topotecan combinations versus topotecan alone for recurrent ovarian cancer: results of a phase III study of the North-Eastern German Society of Gynecological Oncology Ovarian Cancer Study Group.
J. Sehouli (2008)
Smart Magnetically Engineering Colloids and Biothin Films for Diagnostics Applications
Adeel Ahsan (2013)
Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery.
O. Taratula (2009)
Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model
Matthew T. Basel (2012)
Recent progress in the diagnosis and treatment of ovarian cancer
D. Jelovac (2011)
Multifunctional stable and pH-responsive polymer vesicles formed by heterofunctional triblock copolymer for targeted anticancer drug delivery and ultrasensitive MR imaging.
Xiaoqiang Yang (2010)
Clinical Relevance of Nanoparticle Induced Hyperthermia for Drug Delivery and Treatment of Abdominal Cancers
N. Levi-Polyachenko (2011)
Synthesis, self-assembly, and drug-loading capacity of well-defined cyclodextrin-centered drug-conjugated amphiphilic A(14)B(7) Miktoarm star copolymers based on poly(epsilon-caprolactone) and poly(ethylene glycol).
P. Gou (2010)
Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumors after a single injection
J. MacKay (2009)
Doxorubicin loaded iron oxide nanoparticles overcome multidrug resistance in cancer in vitro.
Forrest M Kievit (2011)
Innovative strategy for treatment of lung cancer: targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA
O. Taratula (2011)
Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake.
Y. Zhang (2002)
Receptor-Targeted Nanoparticles for In vivo Imaging of Breast Cancer
Lily L. Yang (2009)
Tumor selectivity of stealth multi-functionalized superparamagnetic iron oxide nanoparticles.
Caixia Fan (2011)
Effect of surface modification on magnetization of iron oxide nanoparticle colloids.
Yuan Yuan (2012)
Doxorubicin-Conjugated Immuno-Nanoparticles for Intracellular Anticancer Drug Delivery
M. Shi (2009)
Ovarian cancer development and metastasis.
E. Lengyel (2010)
HSA coated iron oxide nanoparticles as drug delivery vehicles for cancer therapy.
Qimeng Quan (2011)
Intracellular targeting delivery of liposomal drugs to solid tumors based on EPR effects.
K. Maruyama (2011)
Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats.
M. Longmire (2008)
Polymeric micellar pH-sensitive drug delivery system for doxorubicin.
M. Hrubý (2005)
A Simple Method to Prepare Aqueous Dispersion of Iron Oxide Nanoparticles and Their Biodistribution Study
M. Ahmad (2012)
The effect of cell cluster size on intracellular nanoparticle-mediated hyperthermia: is it possible to treat microscopic tumors?
M. Hedayati (2013)
Successful Treatment of Advanced Ovarian Cancer with Thermochemotherapy and Adjuvant Immune Therapy
R. Kleef (2012)
In vitro application of paclitaxel loaded magnetoliposomes for combined chemotherapy and hyperthermia.
Priyank Kulshrestha (2012)
Two-in-one: combined targeted chemo and gene therapy for tumor suppression and prevention of metastases.
M. Zhang (2012)
Exchange-coupled magnetic nanoparticles for efficient heat induction.
Jae-Hyun Lee (2011)
Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages
Shann S. Yu (2012)
This paper is referenced by
Development of a Doxorubicin-Loaded Dual pH- and Thermo-Responsive Magnetic Nanocarrier for Application in Magnetic Hyperthermia and Drug Delivery in Cancer Therapy
A. M. M. Hervault (2017)
Magnetic Hyperthermia for Cancer Treatment: Main Parameters Affecting the Outcome of In Vitro and In Vivo Studies
V. Vilas-Boas (2020)
Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy.
K. Jeong (2016)
Developing Multifunctional Iron Oxide Nanoparticles for Novel Cancer Therapeutic Strategies
Christopher A Quinto (2015)
Strategies to Maximize Liposomal Drug Loading for a Poorly Water-soluble Anticancer Drug
W. Zhang (2014)
Combinatorial delivery of superparamagnetic iron oxide nanoparticles (γFe2O3) and doxorubicin using folate conjugated redox sensitive multiblock polymeric nanocarriers for enhancing the chemotherapeutic efficacy in cancer cells.
Chetan Nehate (2017)
Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer.
Aziliz Hervault (2014)
Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy
Olena R Taratula (2015)
Highly efficient photodynamic therapy colloidal system based on chloroaluminum phthalocyanine/pluronic micelles.
K. Py-Daniel (2016)
Improvement of pharmacokinetic and antitumor activity of layered double hydroxide nanoparticles by coating with PEGylated phospholipid membrane
Mina Yan (2014)
Magnetic mesoporous silica nanoparticles for potential delivery of chemotherapeutic drugs and hyperthermia.
Cuilian Tao (2014)
Biologically Targeted Magnetic Hyperthermia: Potential and Limitations
D. Chang (2018)
Consequences of Sheep Blood Used as Diluting Agent for The Magnetoviscous Effect in Biocompatible Ferrofluids
J. Nowak (2015)
Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplatform for near-infrared fluorescence imaging and combinatorial anticancer phototherapy.
Olena R Taratula (2015)
HIPEC ROC I: A phase i study of cisplatin administered as hyperthermic intraoperative intraperitoneal chemoperfusion followed by postoperative intravenous platinum‐based chemotherapy in patients with platinum‐sensitive recurrent epithelial ovarian cancer
O. Zivanovic (2015)
Synthesis, characterization, and cytotoxicity of glutathione-PEG-iron oxide magnetic nanoparticles
P. Haddad (2016)
Carbon encapsulated iron oxide nanoparticles surface engineered with polyethylene glycol-folic acid to induce selective hyperthermia in folate over expressed cancer cells.
S. Sadhasivam (2015)
Triggering antitumoural drug release and gene expression by magnetic hyperthermia
M. Moros (2019)
Epithelial ovarian cancer: feasibility of image-guided intratumoral radiofrequency hyperthermia-enhanced direct gene therapy.
G. Jin (2019)
Multifunctional superparamagnetic iron oxide nanoparticles for combined chemotherapy and hyperthermia cancer treatment.
Christopher A Quinto (2015)
Doxorubicin loaded dual pH- and thermo-responsive magnetic nanocarrier for combined magnetic hyperthermia and targeted controlled drug delivery applications.
Aziliz Hervault (2016)
Magnetic Nanoparticles in Cancer Therapy and Diagnosis.
A. Farzin (2020)
An arsenal of magnetic nanoparticles; perspectives in the treatment of cancer.
D. Karponis (2016)
Chemotherapeutic Drug Functionalized Nanoparticles are Beneficial When Treating Breast Cancer Via Magnetic Hyperthermia
S. Piehler (2018)
N-Acetyl-D-glucosamine decorated polymeric nanoparticles for targeted delivery of doxorubicin: Synthesis, characterization and in vitro evaluation.
Baocheng Tian (2015)
Polymeric nanoparticles based on chitooligosaccharide as drug carriers for co-delivery of all-trans-retinoic acid and paclitaxel.
J. Zhang (2015)
Magnetite nanostructures functionalized with cytostatic drugs exhibit great anti-tumoral properties without application of high amplitude alternating magnetic fields.
G. Voicu (2014)
Multifunctional nanospheres for co-delivery of methotrexate and mild hyperthermia to colon cancer cells.
S. C. Costa Lima (2017)
Local Tumor Ischemia-Reperfusion Mediated By Ultrasound-Targeted Microbubble Destruction Enhances The Anti-Tumor Efficacy Of Doxorubicin Chemotherapy
Manxiang Wu (2019)
Asialoglycoprotein receptor-targeted liposomes loaded with a norcantharimide derivative for hepatocyte-selective targeting.
X. Liu (2017)
Systemically Delivered Magnetic Hyperthermia for Prostate Cancer Treatment.
Hassan A. Albarqi (2020)
Naphthalocyanine-Based Biodegradable Polymeric Nanoparticles for Image-Guided Combinatorial Phototherapy
Olena R Taratula (2015)See more