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Multifunctional Nanomedicine Platform For Concurrent Delivery Of Chemotherapeutic Drugs And Mild Hyperthermia To Ovarian Cancer Cells.

Olena R Taratula, R. Dani, C. Schumann, Hong Xu, A. Wang, H. Song, P. Dhagat, O. Taratula
Published 2013 · Medicine

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A multifunctional tumor-targeting delivery system was developed and evaluated for an efficient treatment of drug-resistant ovarian cancer by combinatorial therapeutic modality based on chemotherapy and mild hyperthermia. The engineered iron oxide nanoparticle (IONPs)-based nanocarrier served as an efficient delivery vehicle for doxorubicin and provided the ability to heat cancer cells remotely upon exposure to an alternating magnetic field (AMF). The nanocarrier was additionally modified with polyethylene glycol and LHRH peptide to improve its biocompatibility and ability to target tumor cells. The synthesized delivery system has an average size of 97.1 nm and a zeta potential close to zero, both parameters favorable for increased stability in biological media and decreased elimination by the immune system. The nanocarrier demonstrated faster drug release in acidic conditions that mimic the tumor environment. It was also observed that the LHRH targeted delivery system could effectively enter drug resistant ovarian cancer cells, and the fate of doxorubicin was tracked with fluorescence microscope. Mild hyperthermia (40°C) generated by IONPs under exposure to AMF synergistically increased the cytotoxicity of doxorubicin delivered by the developed nanocarrier to cancer cells. Thus, the developed IONPs-based delivery system has high potential in the effective treatment of ovarian cancer by combinatorial approach.
This paper references
10.2147/IJN.S2824
Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Xiang-hong Peng (2008)
10.1080/02656730150201552
Hyperthermia in oncology.
M. H. Falk (2001)
10.1021/ja800086u
Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging.
M. Yezhelyev (2008)
10.1021/mp100273t
Superparamagnetic iron oxide nanotheranostics for targeted cancer cell imaging and pH-dependent intracellular drug release.
P. Zou (2010)
10.1166/JBN.2008.007
Development of Receptor Targeted Magnetic Iron Oxide Nanoparticles for Efficient Drug Delivery and Tumor Imaging.
Lily L. Yang (2008)
10.1088/0957-4484/17/17/033
Aqueous dispersion of monodisperse magnetic iron oxide nanocrystals through phase transfer
W. W. Yu (2006)
10.2174/156720111793663642
Multifunctional nanomedicine platform for cancer specific delivery of siRNA by superparamagnetic iron oxide nanoparticles-dendrimer complexes.
O. Taratula (2011)
10.1088/0957-4484/22/31/315102
A study on the thermochemotherapy effect of nanosized As2O3/MZF thermosensitive magnetoliposomes on experimental hepatoma in vitro and in vivo.
L. Wang (2011)
10.1039/c0nr00104j
Engineering biofunctional magnetic nanoparticles for biotechnological applications.
M. Moros (2010)
10.1021/mp800051m
Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
F. Alexis (2008)
10.1016/j.jconrel.2009.10.002
Targeted temperature sensitive magnetic liposomes for thermo-chemotherapy.
P. Pradhan (2010)
10.1016/j.jconrel.2011.02.015
Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer.
Ronak Savla (2011)
10.7150/thno.3463
Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy
M. Yu (2012)
10.1021/JA067457E
Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia.
Jean-Paul Fortin (2007)
10.1200/JCO.2007.15.1258
Nonplatinum topotecan combinations versus topotecan alone for recurrent ovarian cancer: results of a phase III study of the North-Eastern German Society of Gynecological Oncology Ovarian Cancer Study Group.
J. Sehouli (2008)
10.1166/JCSB.2013.1031
Smart Magnetically Engineering Colloids and Biothin Films for Diagnostics Applications
Adeel Ahsan (2013)
10.1016/j.jconrel.2009.06.019
Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery.
O. Taratula (2009)
10.2147/IJN.S28344
Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model
Matthew T. Basel (2012)
10.3322/caac.20113
Recent progress in the diagnosis and treatment of ovarian cancer
D. Jelovac (2011)
10.1021/nn101670k
Multifunctional stable and pH-responsive polymer vesicles formed by heterofunctional triblock copolymer for targeted anticancer drug delivery and ultrasensitive MR imaging.
Xiaoqiang Yang (2010)
10.2174/1875933501103010024
Clinical Relevance of Nanoparticle Induced Hyperthermia for Drug Delivery and Treatment of Abdominal Cancers
N. Levi-Polyachenko (2011)
10.1021/bm901371p
Synthesis, self-assembly, and drug-loading capacity of well-defined cyclodextrin-centered drug-conjugated amphiphilic A(14)B(7) Miktoarm star copolymers based on poly(epsilon-caprolactone) and poly(ethylene glycol).
P. Gou (2010)
10.1038/nmat2569
Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumors after a single injection
J. MacKay (2009)
10.1016/j.jconrel.2011.01.024
Doxorubicin loaded iron oxide nanoparticles overcome multidrug resistance in cancer in vitro.
Forrest M Kievit (2011)
10.3109/1061186X.2011.622404
Innovative strategy for treatment of lung cancer: targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA
O. Taratula (2011)
10.1016/S0142-9612(01)00267-8
Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake.
Y. Zhang (2002)
10.1158/1078-0432.CCR-08-3289
Receptor-Targeted Nanoparticles for In vivo Imaging of Breast Cancer
Lily L. Yang (2009)
10.1016/j.ijpharm.2010.10.038
Tumor selectivity of stealth multi-functionalized superparamagnetic iron oxide nanoparticles.
Caixia Fan (2011)
10.1021/la3022479
Effect of surface modification on magnetization of iron oxide nanoparticle colloids.
Yuan Yuan (2012)
10.1002/ADFM.200801271
Doxorubicin-Conjugated Immuno-Nanoparticles for Intracellular Anticancer Drug Delivery
M. Shi (2009)
10.2353/ajpath.2010.100105
Ovarian cancer development and metastasis.
E. Lengyel (2010)
10.1021/mp200006f
HSA coated iron oxide nanoparticles as drug delivery vehicles for cancer therapy.
Qimeng Quan (2011)
10.1016/j.addr.2010.09.003
Intracellular targeting delivery of liposomal drugs to solid tumors based on EPR effects.
K. Maruyama (2011)
10.2217/17435889.3.5.703
Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats.
M. Longmire (2008)
10.1016/J.JCONREL.2004.11.017
Polymeric micellar pH-sensitive drug delivery system for doxorubicin.
M. Hrubý (2005)
10.1166/JCSB.2012.1021
A Simple Method to Prepare Aqueous Dispersion of Iron Oxide Nanoparticles and Their Biodistribution Study
M. Ahmad (2012)
10.2217/nnm.12.98
The effect of cell cluster size on intracellular nanoparticle-mediated hyperthermia: is it possible to treat microscopic tumors?
M. Hedayati (2013)
10.1159/000338617
Successful Treatment of Advanced Ovarian Cancer with Thermochemotherapy and Adjuvant Immune Therapy
R. Kleef (2012)
10.1016/j.colsurfb.2012.02.029
In vitro application of paclitaxel loaded magnetoliposomes for combined chemotherapy and hyperthermia.
Priyank Kulshrestha (2012)
10.2217/nnm.11.131
Two-in-one: combined targeted chemo and gene therapy for tumor suppression and prevention of metastases.
M. Zhang (2012)
10.1038/nnano.2011.95
Exchange-coupled magnetic nanoparticles for efficient heat induction.
Jae-Hyun Lee (2011)
10.2147/IJN.S28531
Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages
Shann S. Yu (2012)



This paper is referenced by
Development of a Doxorubicin-Loaded Dual pH- and Thermo-Responsive Magnetic Nanocarrier for Application in Magnetic Hyperthermia and Drug Delivery in Cancer Therapy
A. M. M. Hervault (2017)
10.3390/molecules25122874
Magnetic Hyperthermia for Cancer Treatment: Main Parameters Affecting the Outcome of In Vitro and In Vivo Studies
V. Vilas-Boas (2020)
10.1016/j.canlet.2016.01.050
Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy.
K. Jeong (2016)
Developing Multifunctional Iron Oxide Nanoparticles for Novel Cancer Therapeutic Strategies
Christopher A Quinto (2015)
10.1007/s11095-014-1551-8
Strategies to Maximize Liposomal Drug Loading for a Poorly Water-soluble Anticancer Drug
W. Zhang (2014)
10.1016/j.msec.2017.03.024
Combinatorial delivery of superparamagnetic iron oxide nanoparticles (γFe2O3) and doxorubicin using folate conjugated redox sensitive multiblock polymeric nanocarriers for enhancing the chemotherapeutic efficacy in cancer cells.
Chetan Nehate (2017)
10.1039/c4nr03482a
Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer.
Aziliz Hervault (2014)
10.2147/IJN.S81097
Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy
Olena R Taratula (2015)
10.1016/j.ejpb.2016.03.028
Highly efficient photodynamic therapy colloidal system based on chloroaluminum phthalocyanine/pluronic micelles.
K. Py-Daniel (2016)
10.2147/IJN.S69729
Improvement of pharmacokinetic and antitumor activity of layered double hydroxide nanoparticles by coating with PEGylated phospholipid membrane
Mina Yan (2014)
10.1039/c4dt01984a
Magnetic mesoporous silica nanoparticles for potential delivery of chemotherapeutic drugs and hyperthermia.
Cuilian Tao (2014)
10.3389/fphar.2018.00831
Biologically Targeted Magnetic Hyperthermia: Potential and Limitations
D. Chang (2018)
10.3933/applrheol-25-53250
Consequences of Sheep Blood Used as Diluting Agent for The Magnetoviscous Effect in Biocompatible Ferrofluids
J. Nowak (2015)
10.1039/c4nr06050d
Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplatform for near-infrared fluorescence imaging and combinatorial anticancer phototherapy.
Olena R Taratula (2015)
10.1002/ijc.29011
HIPEC ROC I: A phase i study of cisplatin administered as hyperthermic intraoperative intraperitoneal chemoperfusion followed by postoperative intravenous platinum‐based chemotherapy in patients with platinum‐sensitive recurrent epithelial ovarian cancer
O. Zivanovic (2015)
10.1007/s11051-016-3680-y
Synthesis, characterization, and cytotoxicity of glutathione-PEG-iron oxide magnetic nanoparticles
P. Haddad (2016)
10.1016/j.ijpharm.2015.01.029
Carbon encapsulated iron oxide nanoparticles surface engineered with polyethylene glycol-folic acid to induce selective hyperthermia in folate over expressed cancer cells.
S. Sadhasivam (2015)
10.1016/j.addr.2018.10.004
Triggering antitumoural drug release and gene expression by magnetic hyperthermia
M. Moros (2019)
Epithelial ovarian cancer: feasibility of image-guided intratumoral radiofrequency hyperthermia-enhanced direct gene therapy.
G. Jin (2019)
10.1039/c5nr02718g
Multifunctional superparamagnetic iron oxide nanoparticles for combined chemotherapy and hyperthermia cancer treatment.
Christopher A Quinto (2015)
10.1039/c5nr07773g
Doxorubicin loaded dual pH- and thermo-responsive magnetic nanocarrier for combined magnetic hyperthermia and targeted controlled drug delivery applications.
Aziliz Hervault (2016)
10.1002/adhm.201901058
Magnetic Nanoparticles in Cancer Therapy and Diagnosis.
A. Farzin (2020)
10.2217/nnm-2016-0113
An arsenal of magnetic nanoparticles; perspectives in the treatment of cancer.
D. Karponis (2016)
10.20944/PREPRINTS201809.0569.V1
Chemotherapeutic Drug Functionalized Nanoparticles are Beneficial When Treating Breast Cancer Via Magnetic Hyperthermia
S. Piehler (2018)
10.1016/j.colsurfb.2015.04.019
N-Acetyl-D-glucosamine decorated polymeric nanoparticles for targeted delivery of doxorubicin: Synthesis, characterization and in vitro evaluation.
Baocheng Tian (2015)
10.1016/j.carbpol.2015.04.036
Polymeric nanoparticles based on chitooligosaccharide as drug carriers for co-delivery of all-trans-retinoic acid and paclitaxel.
J. Zhang (2015)
Magnetite nanostructures functionalized with cytostatic drugs exhibit great anti-tumoral properties without application of high amplitude alternating magnetic fields.
G. Voicu (2014)
10.1016/j.msec.2017.03.049
Multifunctional nanospheres for co-delivery of methotrexate and mild hyperthermia to colon cancer cells.
S. C. Costa Lima (2017)
10.2147/CMAR.S225607
Local Tumor Ischemia-Reperfusion Mediated By Ultrasound-Targeted Microbubble Destruction Enhances The Anti-Tumor Efficacy Of Doxorubicin Chemotherapy
Manxiang Wu (2019)
10.1016/j.ijpharm.2017.02.010
Asialoglycoprotein receptor-targeted liposomes loaded with a norcantharimide derivative for hepatocyte-selective targeting.
X. Liu (2017)
10.3390/pharmaceutics12111020
Systemically Delivered Magnetic Hyperthermia for Prostate Cancer Treatment.
Hassan A. Albarqi (2020)
10.1021/ACS.CHEMMATER.5B03128
Naphthalocyanine-Based Biodegradable Polymeric Nanoparticles for Image-Guided Combinatorial Phototherapy
Olena R Taratula (2015)
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