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Lipid-based Nanosuspensions For Oral Delivery Of Peptides, A Critical Review.

Camille Dumont, S. Bourgeois, H. Fessi, V. Jannin
Published 2018 · Chemistry, Medicine

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Peptides are therapeutic molecules that can treat selectively and efficiently a wide range of pathologies. However, their intrinsic properties cause their rapid degradation in the human gastrointestinal (GI) tract resulting in poor bioavailability after oral administration. Yet, their encapsulation in nanocarriers offers them protection from this harsh environment and increases their permeability across the epithelium border. In particular, Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) have proven to improve peptide oral bioavailability. This article details different techniques used to produce SLN and NLC with potential or effective peptide encapsulation. Basic principles of covalent and non-covalent lipidization are described and discussed as a prerequisite to improve hydrophilic peptide encapsulation in lipid-based nanosuspensions. The last part of this review provides the key evaluation techniques to assay SLN and NLC for peptide oral bioavailability enhancement. Methods to assess the protective effects of the carriers are described as well as the techniques to evaluate peptide release upon lipid digestion by lipases. Furthermore, this review suggests different techniques to measure permeability improvements and describes the main in vitro cell models associated.
This paper references
10.1208/s12249-010-9563-0
Recent Advances in Lipid Nanoparticle Formulations with Solid Matrix for Oral Drug Delivery
S. Das (2010)
10.1016/j.ijpharm.2016.02.019
Lipid-based nanoformulations for peptide delivery.
N. Matougui (2016)
10.1016/J.IJPHARM.2004.12.030
New surface-modified lipid nanoparticles as delivery vehicles for salmon calcitonin.
M. Garcia-Fuentes (2005)
10.1080/02652040701532981
Solid lipid nanoparticles formed by solvent-in-water emulsion–diffusion technique: Development and influence on insulin stability
L. Battaglia (2007)
10.1016/j.ijpharm.2014.05.047
In vivo evaluation of an oral self-microemulsifying drug delivery system (SMEDDS) for leuprorelin.
Fabian Hintzen (2014)
10.1128/MMBR.62.3.597-635.1998
Molecular and Biotechnological Aspects of Microbial Proteases
M. Rao (1998)
10.2174/092986712803251548
Peptides as therapeutics with enhanced bioactivity.
D. Goodwin (2012)
10.1016/j.ijpharm.2015.01.028
Biorelevant media resistant co-culture model mimicking permeability of human intestine.
D. Antoine (2015)
10.1021/mp300649z
Improved transport and absorption through gastrointestinal tract by PEGylated solid lipid nanoparticles.
H. Yuan (2013)
10.1016/j.colsurfb.2014.02.045
Ion pairing with linoleic acid simultaneously enhances encapsulation efficiency and antibacterial activity of vancomycin in solid lipid nanoparticles.
Rahul S. Kalhapure (2014)
10.1016/j.ijpharm.2017.03.027
Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione.
G. Hetényi (2017)
10.1016/S0939-6411(02)00130-3
Solvent injection as a new approach for manufacturing lipid nanoparticles--evaluation of the method and process parameters.
M. Schubert (2003)
10.1016/j.ijpharm.2008.10.003
Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products.
J. Pardeike (2009)
10.1016/J.BBALIP.2007.02.009
Comparative study on digestive lipase activities on the self emulsifying excipient Labrasol, medium chain glycerides and PEG esters.
S. Fernandez (2007)
10.1016/j.ijpharm.2009.04.014
The complexation between novel comb shaped amphiphilic polyallylamine and insulin: towards oral insulin delivery.
C. Thompson (2009)
10.1016/j.colsurfb.2008.12.031
Strategic approaches for improving entrapment of hydrophilic peptide drugs by lipid nanoparticles.
Hong Yuan (2009)
10.1016/S1461-5347(98)00075-3
Novel oral drug delivery gateways for biotechnology products: polypeptides and vaccines
D. Brayden (1998)
10.1016/j.ejmech.2014.04.084
Solid lipid nanoparticles for hydrophilic biotech drugs: optimization and cell viability studies (Caco-2 & HEPG-2 cell lines).
P. Severino (2014)
10.1016/J.EJPS.2005.04.015
Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium.
A. des Rieux (2005)
10.1615/CRITREVTHERDRUGCARRIERSYST.V22.I5.10
Polymeric nanoparticles for oral delivery of drugs and vaccines: a critical evaluation of in vivo studies.
S. Galindo-Rodriguez (2005)
10.1016/j.addr.2016.08.007
In vitro toxicity assessment of oral nanocarriers.
S. G. Ciappellano (2016)
10.1016/S0169-409X(01)00105-3
Solid lipid nanoparticles: production, characterization and applications.
W. Mehnert (2001)
10.1177/026119290503300618
An Inter-laboratory Study to Evaluate the Effects of Medium Composition on the Differentiation and Barrier Function of Caco-2 Cell Lines
F. Zucco (2005)
10.1021/mp300331z
Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion.
H. Williams (2012)
10.1166/JBN.2009.443
Improving oral absorption of Salmon calcitonin by trimyristin lipid nanoparticles.
S. Martins (2009)
10.1021/la104221q
How to prepare and stabilize very small nanoemulsions.
Thomas Delmas (2011)
10.1016/j.ijpharm.2009.10.018
Polymer-based nanocapsules for drug delivery.
C. E. Mora-Huertas (2010)
10.1016/J.CARBPOL.2010.12.042
Effect of chitosan coating in overcoming the phagocytosis of insulin loaded solid lipid nanoparticles by mononuclear phagocyte system
B. Sarmento (2011)
10.4155/tde.13.104
Basics and recent advances in peptide and protein drug delivery.
Benjamin J. Bruno (2013)
10.1016/J.JDDST.2017.02.001
Enhancing bioavailability and controlling the release of glibenclamide from optimized solid lipid nanoparticles
Ibrahim A. Elbahwy (2017)
10.2147/IJN.S12125
Preparation and characterization of solid lipid nanoparticles containing cyclosporine by the emulsification-diffusion method
Z. Urbán-Morlán (2010)
Émulsification - Élaboration et étude des émulsions
Pascal Brochette (2013)
10.1016/S0939-6411(00)00087-4
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
R. Mueller (2000)
10.3109/02652048.2011.590615
Formulation of curcumin-loaded solid lipid nanoparticles produced by fatty acids coacervation technique
D. Chirio (2011)
10.1517/17425247.2012.717068
Oral delivery of peptides and proteins using lipid-based drug delivery systems
P. Li (2012)
10.2174/092986712799945003
Converting peptides into drug leads by lipidation.
L. Zhang (2012)
10.1208/s12248-014-9672-x
Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 6: Effects of Varying Pancreatin and Calcium Levels
P. Sassene (2014)
10.1088/0953-8984/19/7/079001
Nanoemulsions: formation, structure, and physical properties
T. Mason (2006)
10.1016/S0927-7765(02)00053-X
Design of lipid nanoparticles for the oral delivery of hydrophilic macromolecules
M. Garcia-Fuentes (2003)
10.1016/S1359-6446(04)03354-9
Cell culture-based models for intestinal permeability: a critique.
P. Balimane (2005)
10.1016/j.ejpb.2014.03.017
A tunable Caco-2/HT29-MTX co-culture model mimicking variable permeabilities of the human intestine obtained by an original seeding procedure.
A. Béduneau (2014)
10.1016/j.jconrel.2014.09.031
Targeting of gastrointestinal tract for amended delivery of protein/peptide therapeutics: strategies and industrial perspectives.
V. Pawar (2014)
10.1016/J.DRUDIS.2006.08.005
Is the oral route possible for peptide and protein drug delivery?
M. Morishita (2006)
10.1023/A:1016121319668
A Novel Phase Inversion-Based Process for the Preparation of Lipid Nanocarriers
B. Heurtault (2004)
10.1016/j.biomaterials.2014.07.026
The impact of nanoparticles on the mucosal translocation and transport of GLP-1 across the intestinal epithelium.
F. Araújo (2014)
10.1021/acs.molpharmaceut.5b00704
Tools for Early Prediction of Drug Loading in Lipid-Based Formulations
Linda C Alskär (2016)
10.1007/s11095-013-1053-0
In Vitro Digestion of the Self-Emulsifying Lipid Excipient Labrasol® by Gastrointestinal Lipases and Influence of its Colloidal Structure on Lipolysis Rate
S. Fernandez (2013)
10.1016/j.jconrel.2010.07.128
In vitro and in vivo characterisation of a novel peptide delivery system: amphiphilic polyelectrolyte-salmon calcitonin nanocomplexes.
Woei-Ping Cheng (2010)
10.1016/j.ejpb.2011.02.015
Reverse micelle-loaded lipid nanocarriers: a novel drug delivery system for the sustained release of doxorubicin hydrochloride.
S. Vrignaud (2011)
10.1016/S0378-5173(00)00457-9
Hydrophobic ion pair formation between leuprolide and sodium oleate for sustained release from biodegradable polymeric microspheres.
S. Choi (2000)
10.1155/2011/132435
Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique
Marina Gallarate (2011)
10.1021/mp500809f
Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs.
J. Wang (2015)
10.1016/S0168-3659(97)00204-6
The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins.
A. Bernkop-Schnürch (1998)
10.1016/J.ADDR.2004.12.001
Tat peptide-mediated cellular delivery: back to basics.
Hilary Brooks (2005)
10.1016/j.jsps.2014.06.004
A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives
Abdul Muheem (2016)
10.1023/A:1011998014474
Hydrophobic Ion Pairing: Altering the Solubility Properties of Biomolecules
J. D. Meyer (2004)
10.3109/02652040903031279
Solid lipid nanoparticles produced through a coacervation method
L. Battaglia (2010)
10.1016/J.ADDR.2012.09.021
Solid lipid nanoparticles
W. Mehnert (2012)
10.1016/j.jconrel.2012.01.017
Oral drug delivery research in Europe.
R. Mrsny (2012)
10.3109/03639045.2014.972412
In vitro lipolysis tests on lipid nanoparticles: comparison between lipase/co-lipase and pancreatic extract
V. Jannin (2015)
10.1016/0169-409X(92)90015-I
C) Means to enhance penetration
E. S. Swenson (1992)
10.1016/j.addr.2016.07.007
Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues.
P. Lundquist (2016)
10.3109/9781420086713
Biodrug Delivery Systems : Fundamentals, Applications and Clinical Development
M. Morishita (2016)
10.1016/j.addr.2016.04.014
Mechanisms of transport of polymeric and lipidic nanoparticles across the intestinal barrier.
A. Beloqui (2016)
10.1002/jps.23205
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles across a range of representative formulations.
H. Williams (2012)
10.1016/S0378-5173(97)04885-0
Peptide-loaded solid lipid nanoparticles (SLN): Influence of production parameters
A. J. Almeida (1997)
10.1016/J.IJPHARM.2004.10.014
Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion-diffusion technique.
M. Trotta (2005)
10.1016/j.jconrel.2009.08.010
Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis.
E. Roger (2009)
10.1016/J.IJPHARM.2003.11.013
In situ intestinal absorption studies on low molecular weight heparin in rats using labrasol as absorption enhancer.
Y. V. Rama Prasad (2004)
10.1016/j.ejpb.2016.10.007
Does the commonly used pH-stat method with back titration really quantify the enzymatic digestibility of lipid drug delivery systems? A case study on solid lipid nanoparticles (SLN).
M. Heider (2016)
10.1023/A:1025065418309
Physicochemical Investigations on Solid Lipid Nanoparticles and on Oil-Loaded Solid Lipid Nanoparticles: A Nuclear Magnetic Resonance and Electron Spin Resonance Study
K. Jores (2004)
10.1016/J.JCONREL.2003.11.012
Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy.
K. Jores (2004)
10.1271/bbb.63.680
Recovery of Caco-2 Cell Monolayers to Normal from the Transport-enhanced State Induced by Capric Acid Sodium Salt and its Monoacylglycerol.
M. Shima (1999)
10.1016/J.IJPHARM.2007.04.027
Nano-emulsions and nanocapsules by the PIT method: an investigation on the role of the temperature cycling on the emulsion phase inversion.
N. Anton (2007)
10.1016/j.vascn.2010.02.004
Defining conditions for the co-culture of Caco-2 and HT29-MTX cells using Taguchi design.
X. Chen (2010)
10.1016/j.ejpb.2015.05.013
Sodium caprate-induced increases in intestinal permeability and epithelial damage are prevented by misoprostol.
D. Brayden (2015)
10.1517/17425247.2015.1068287
Self-emulsifying drug delivery systems in oral (poly)peptide drug delivery
G. Leonavičiūtė (2015)
10.1016/0378-5173(95)04388-8
Thymopentin in solid lipid nanoparticles
S. Morel (1996)
10.1002/9781118644591
Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering: Tiwari/Nanomaterials
A. Tiwari (2013)
10.1016/j.nano.2015.09.004
Nanostructured lipid carriers: Promising drug delivery systems for future clinics.
A. Beloqui (2016)
10.1016/S0731-7085(98)00064-8
Analytical techniques used to study the degradation of proteins and peptides: physical instability.
J. L. Reubsaet (1998)
10.1016/0168-3659(94)90047-7
Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization
C. Schwarz (1994)
10.1142/P432
Nanoparticulates as Drug Carriers
V. Torchilin (2006)
10.1016/j.jconrel.2017.04.038
Lipophilic peptide character - What oral barriers fear the most.
O. Zupančič (2017)
10.1016/j.addr.2016.02.004
Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials.
T. A. Aguirre (2016)
10.1002/(SICI)1520-6017(200001)89:1<63::AID-JPS7>3.0.CO;2-6
Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transport.
C. Hilgendorf (2000)
10.1016/j.ejpb.2012.10.003
Establishment of a triple co-culture in vitro cell models to study intestinal absorption of peptide drugs.
Filipa Antunes (2013)
10.1002/JPS.20555
Drug encapsulation using supercritical fluid extraction of emulsions.
P. Chattopadhyay (2006)
10.1016/j.addr.2011.05.019
Intestinal lymphatic transport for drug delivery☆
J. Yáñez (2011)
10.1016/0378-5173(95)04204-0
Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo
H. Lennernäs (1996)
10.1007/s10565-005-0085-6
The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics
Y. Sambuy (2005)
10.1016/j.ejps.2012.05.010
Are nanostructured lipid carriers (NLCs) better than solid lipid nanoparticles (SLNs): development, characterizations and comparative evaluations of clotrimazole-loaded SLNs and NLCs?
S. Das (2012)
10.3109/10717544.2013.819611
Oral delivery of therapeutic proteins and peptides: a review on recent developments
S. Gupta (2013)
Oral insulin delivery by means of solid lipid nanoparticles
B. Sarmento (2007)
10.1016/S0168-3659(03)00008-7
Reversible lipidization for the oral delivery of salmon calcitonin.
J. Wang (2003)
10.3109/03639045.2014.909840
Physicochemical characterization techniques for solid lipid nanoparticles: principles and limitations
N. Kathe (2014)
10.1016/j.ijpharm.2017.02.019
Hydrophobic ion pairing: Key to highly payloaded self-emulsifying peptide drug delivery systems.
J. Griesser (2017)
10.1016/0378-3812(93)87155-T
Rapid expansion of supercritical solutions (ress ): fundamentals and applications
P. Debenedetti (1993)
10.1016/j.addr.2016.03.011
How to design the surface of peptide-loaded nanoparticles for efficient oral bioavailability?
H. Malhaire (2016)
10.1006/BBRC.2000.4038
Expression of specific markers and particle transport in a new human intestinal M-cell model.
E. Gullberg (2000)
10.1007/s13346-011-0023-5
Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin
P. Fonte (2011)
10.1016/J.JDDST.2016.10.012
Development and evaluation of insulin-loaded cationic solid lipid nanoparticles for oral delivery
J. Hecq (2016)
Cell Viability Assays
T. Riss (2016)
10.1023/A:1015929109894
Stability of Protein Pharmaceuticals
M. Manning (2004)
10.1016/S1350-4177(98)00027-3
Emulsification by ultrasound: drop size distribution and stability.
B. Abismaı̈l (1999)
10.1016/j.ejpb.2014.02.005
Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers - a systematic review of in vitro data.
S. Doktorovová (2014)
10.1016/J.COSSMS.2003.11.002
Particles formation and particle design using supercritical fluids
Ž. Knez (2003)
10.1016/j.ijpharm.2016.10.012
In-vitro investigation regarding the effects of Gelucire® 44/14 and Labrasol® ALF on the secretory intestinal transport of P-gp substrates.
Océane Dubray (2016)
10.1016/j.ejpb.2016.08.001
Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: Current evidence from in vitro and in vivo evaluation.
S. Doktorovová (2016)
10.1016/j.ejpb.2015.04.013
Effective incorporation of insulin in mucus permeating self-nanoemulsifying drug delivery systems.
T. Karamanidou (2015)
10.1016/j.jconrel.2017.12.027
Do drug release studies from SEDDS make any sense?
A. Bernkop-Schnürch (2018)
10.1017/S0954422414000225
Are intact peptides absorbed from the healthy gut in the adult human?
W. Miner-Williams (2014)
10.1111/cbdd.12055
The Future of Peptide‐based Drugs
D. Craik (2013)
10.1080/17425247.2017.1266329
Hydrophobic ion pairing as a strategy to improve drug encapsulation into lipid nanocarriers for the cancer treatment
M. B. Oliveira (2017)
10.1016/j.ijpharm.2010.07.039
Reverse micelle-loaded lipid nano-emulsions: new technology for nano-encapsulation of hydrophilic materials.
N. Anton (2010)
10.1016/j.jconrel.2008.02.007
Design and production of nanoparticles formulated from nano-emulsion templates-a review.
N. Anton (2008)
10.1002/BIP.360330608
Enhanced solubility of proteins and peptides in nonpolar solvents through hydrophobic ion pairing
M. Powers (1993)
10.1016/J.ADDR.2007.04.007
Solid lipid nanoparticles as a drug delivery system for peptides and proteins.
A. Almeida (2007)
10.1016/j.addr.2016.04.001
Lipid-based nanocarriers for oral peptide delivery.
Zhigao Niu (2016)
10.1023/A:1015397811161
Structure-Activity Relationship of Reversibly Lipidized Peptides: Studies of Fatty Acid-Desmopressin Conjugates
J. Wang (2004)
10.1177/2211068214561025
TEER Measurement Techniques for In Vitro Barrier Model Systems
Balaji Srinivasan (2015)
Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells.
T. Lindmark (1998)
10.3109/10717544.2015.1039666
Enhanced oral bioavailability of insulin-loaded solid lipid nanoparticles: pharmacokinetic bioavailability of insulin-loaded solid lipid nanoparticles in diabetic rats
M. J. Ansari (2016)
10.1016/S0378-5173(98)00404-9
Enzymatic degradation of SLN-effect of surfactant and surfactant mixtures.
C. Olbrich (1999)
Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco-2 cell monolayers.
T. Lindmark (1995)
10.1016/J.EJPS.2005.06.001
Adaptation and optimization of the emulsification-diffusion technique to prepare lipidic nanospheres.
D. Quintanar-Guerrero (2005)
10.3109/10837450.2014.971376
The effect of formulative parameters on the size and physical stability of SLN based on “green” components
Elena Soddu (2016)
10.1016/j.ejpb.2013.07.017
Solid lipid particles for oral delivery of peptide and protein drugs I--elucidating the release mechanism of lysozyme during lipolysis.
P. C. Christophersen (2013)
10.1080/03639040802130061
Lipid Nanoparticles with a Solid Matrix (SLN®, NLC®, LDC®) for Oral Drug Delivery
M. Muchow (2008)
10.1002/jps.21434
Production of solid lipid submicron particles for protein delivery using a novel supercritical gas-assisted melting atomization process.
S. Salmaso (2009)
10.1021/JS970372E
P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels.
P. Anderle (1998)
10.1016/j.ijpharm.2016.04.044
Impact of lipases on the protective effect of SEDDS for incorporated peptide drugs towards intestinal peptidases.
G. Leonavičiūtė (2016)
10.1016/S1773-2247(10)50028-5
Amphotericin B loaded SLN prepared with the coacervation technique
M. A. Bianco (2010)
10.1007/s00018-009-0053-z
Nanocarriers’ entry into the cell: relevance to drug delivery
H. Hillaireau (2009)
10.3109/10837450.2013.784336
Modeling the effect of sonication parameters on size and dispersion temperature of solid lipid nanoparticles (SLNs) by response surface methodology (RSM)
A. Siddiqui (2014)
10.1016/S1773-2247(10)50057-1
Cisplatin-loaded SLN produced by coacervation technique
M. Gallarate (2010)
10.1016/J.IJPHARM.2003.12.016
Preparation and characterization of solid lipid nanoparticles containing peptide.
F. Hu (2004)
10.2217/nnm.12.141
Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle-double emulsion method via the combined use of different solid lipids.
Chunhui Chen (2013)
10.1016/S1359-6446(97)01011-8
Prodrug strategies to enhance the intestinal absorption of peptides
S. Gangwar (1997)
10.1016/j.ijpharm.2008.05.016
Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs: II. In vitro transport study.
S. V. R. Rao (2008)
10.1016/S0378-5173(97)00325-6
Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A
Z. Gao (1998)
10.1016/S0076-6879(72)25012-1
[10] Enzymatic hydrolysis with carboxypeptidases.
R. Ambler (1972)
10.1016/j.ejps.2017.09.049
Evaluation of the digestibility of solid lipid nanoparticles of glyceryl dibehenate produced by two techniques: Ultrasonication and spray‐flash evaporation
V. Jannin (2018)
10.3109/03639045.2010.497151
The influence of lipid characteristics on the formation, in vitro release, and in vivo absorption of protein-loaded SLN prepared by the double emulsion process
R. Yang (2011)
10.1007/s00726-005-0241-6
Characterisation of the thiol–disulphide chemistry of desmopressin by LC, μ-LC, LC-ESI-MS and Maldi-Tof
T. Schmitz (2005)
10.1016/j.ijpharm.2008.05.015
Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of protein drugs: III. In vivo oral absorption study.
S. V. R. Rao (2008)
10.1016/j.addr.2009.09.006
Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic.
S. Maher (2009)
10.1007/s11095-014-1532-y
Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase
Jean-Claude Bakala-N’Goma (2014)
10.1016/J.JCONREL.2005.07.023
Preparation of solid lipid nanoparticles using a membrane contactor.
C. Charcosset (2005)
10.1016/S0928-0987(02)00162-8
Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs.
A. A. Raoof (2002)
10.1016/j.jconrel.2014.08.004
Pre-systemic metabolism of orally administered drugs and strategies to overcome it.
I. Pereira de Sousa (2014)
10.2147/IJN.S26450
Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin
S. Sun (2011)



This paper is referenced by
10.1016/j.ijpharm.2020.119581
Solid lipid Nanocarriers diffuse effectively through mucus and enter intestinal cells - but where is my peptide?
Camille Dumont (2020)
10.1016/j.jddst.2019.101394
A proof-of-concept for developing oral lipidized peptide Nanostructured Lipid Carrier formulations
Camille Dumont (2019)
10.1208/s12249-019-1337-8
Potential of Lipid Nanoparticles (SLNs and NLCs) in Enhancing Oral Bioavailability of Drugs with Poor Intestinal Permeability
S. Talegaonkar (2019)
10.1016/j.jddst.2020.102147
Liposomal delivery systems for herbal extracts
Oguz Sogut (2020)
10.1016/j.ijpharm.2019.05.037
In-vitro evaluation of solid lipid nanoparticles: Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract.
Camille Dumont (2019)
10.1016/J.JDDST.2019.04.039
Transformer-ethosomes with palmitoyl pentapeptide for improved transdermal delivery
Jooeun Kim (2019)
10.1016/j.abb.2018.10.011
Recent progress in non-opioid analgesic peptides.
M. J. Pérez de Vega (2018)
10.1016/j.jddst.2019.101250
Self-assembled polyelectrolyte complex nanoparticles as a potential carrier in protein delivery systems
S. Amani (2019)
10.1080/17425247.2020.1813108
Effect of excipients on oral absorption process according to the different gastrointestinal segments.
A. Ruiz‐Picazo (2020)
10.1039/d0na00093k
Nanolipogels as a cell-mimicking platform for controlled release of biomacromolecules
Ye Cao (2020)
PHARMACEUTICAL TECHNIQUES FOR THE FABRICATION OF POOR WATER SOLUBLE DRUGS – A REVIEW REVIEW ARTICLE
Rabia Noor ()
10.5772/INTECHOPEN.88412
Self-Emulsifying Drug Delivery Systems: Easy to Prepare Multifunctional Vectors for Efficient Oral Delivery
K. AboulFotouh (2019)
10.1039/c9bm00873j
Slowing down lipolysis significantly enhances the oral absorption of intact solid lipid nanoparticles.
Z. Yu (2019)
10.23893/1307-2080.APS.05616
Solid lipid nanoparticles: a promising technology for delivery of poorly water-soluble drugs
S. Bhatt (2018)
10.1016/j.jconrel.2019.05.011
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