Online citations, reference lists, and bibliographies.
← Back to Search

Novel Ultrasmall Nanomicelles Based On Rebaudioside A: A Potential Nanoplatform For The Ocular Delivery Of Pterostilbene.

Kaichao Song, Meng Xin, Feng-lin Zhang, Wenjing Xie, M. Sun, Xianggen Wu
Published 2020 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Rebaudioside A (RA) self-assembled into ultrasmall nanomicelles can be utilized as ocular drug delivery system; nevertheless, the therapeutic efficacy of RA micelles has not evaluated thus far. In this manuscript, the RA micelles are thought to strengthen the therapeutic effects of pterostilbene (Pt). Results showed that Pt can be highly encapsulated into RA micelles with ultrasmall particle sizes (3.99 ± 0.03 nm) with a uniform distribution (polydispersity index, PDI = 0.184 ± 0.008). RA-Pt exhibited pronounced improvement for the in vitro antioxidant activity and the in vitro membrane permeation of Pt. RA-Pt exhibited good ocular tolerance. The use of RA-Pt led to the significant improvement in the in vivo intraocular permeation of Pt as well as the improvement in the in vivo anti-inflammatory efficacy. The in vivo evaluation of antioxidant effects revealed that RA-Pt exhibits improvement in suppressing the generation of oxidative stress and inducing the enzymes of reactive oxygen species (ROS) degradation. Furthermore, RA-Pt was confirmed to exhibit a strong treatment efficiency for corneal alkali burns. These findings indicate that RA-based self-assembled ultrasmall nanomicelles demonstrate tremendous potential toward the improvement in the ocular bioavailability as well as a therapeutic effect of poor aqueous soluble drugs such as Pt.
This paper references
10.1111/aos.13995
The subthreshold micropulse laser treatment of the retina restores the oxidant/antioxidant balance and counteracts programmed forms of cell death in the mice eyes
S. De Cillà (2019)
10.1007/s13197-018-3370-0
Effect of various food processing and handling methods on preservation of natural antioxidants in fruits and vegetables
F. Al-Juhaimi (2018)
10.1097/ICO.0000000000002072
Development of New Pharmaceutical Candidates With Antioxidant Activity for the Treatment of Corneal Disorders.
A. Higuchi (2019)
Transient downregulation of microRNA-206 protects alkali burn injury in mouse cornea by regulating connexin 43.
X. Li (2015)
10.1080/03639045.2017.1349787
New nanomicelle curcumin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment
Mengshuang Li (2017)
10.1159/000065608
Enhanced Ocular Anti-Inflammatory Activity of Ibuprofen Carried by an Eudragit RS100® Nanoparticle Suspension
C. Bucolo (2002)
10.1080/10717544.2019.1568624
Ultra-small micelles based on polyoxyl 15 hydroxystearate for ocular delivery of myricetin: optimization, in vitro, and in vivo evaluation
Yuzhen Hou (2019)
10.1007/s11095-017-2319-8
Optimization, Biopharmaceutical Profile and Therapeutic Efficacy of Pioglitazone-loaded PLGA-PEG Nanospheres as a Novel Strategy for Ocular Inflammatory Disorders
Marcelle Silva-Abreu (2017)
10.1167/iovs.17-23402
Potential Role of Oxidative Stress in Ocular Surface Inflammation and Dry Eye Disease.
M. Doğru (2018)
10.1016/j.ijpharm.2018.09.053
Soluplus micelles for acyclovir ocular delivery: Formulation and cornea and sclera permeability
Angela Varela-García (2018)
10.1167/iovs.10-6167
Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model.
M. Kubota (2011)
10.2147/IJN.S173198
Gelatin–epigallocatechin gallate nanoparticles with hyaluronic acid decoration as eye drops can treat rabbit dry-eye syndrome effectively via inflammatory relief
Hsin-Yi Huang (2018)
10.1021/jf803011r
Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays.
Stéphanie Dudonné (2009)
10.1002/ptr.6478
Stevia rebaudiana Bertoni bioactive effects: From in vivo to clinical trials towards future therapeutic approaches
B. Salehi (2019)
10.1038/srep19408
Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway
J. Li (2016)
10.2174/1381612822666161021142835
A Review on the Pharmacology and Toxicology of Steviol Glycosides Extracted from Stevia rebaudiana.
A. A. Momtazi-Borojeni (2017)
10.1097/ICO.0000000000001018
Evaluation of Serum Superoxide Dismutase Activity, Malondialdehyde, and Zinc and Copper Levels in Patients With Keratoconus
R. Kılıç (2016)
10.1016/j.ijpharm.2011.01.004
Ocular biocompatibility of novel Cyclosporin A formulations based on methoxy poly(ethylene glycol)-hexylsubstituted poly(lactide) micelle carriers.
C. Di Tommaso (2011)
10.1155/2016/3164734
The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults
M. Nita (2016)
10.1042/CS20171246
Oxidative stress and reactive oxygen species: a review of their role in ocular disease.
L. Ung (2017)
10.1208/s12249-014-0129-4
Nanoemulsion for Solubilization, Stabilization, and In Vitro Release of Pterostilbene for Oral Delivery
Y. Zhang (2014)
10.1016/j.jfda.2016.07.004
Biological actions and molecular effects of resveratrol, pterostilbene, and 3'-hydroxypterostilbene.
H. Tsai (2017)
10.1016/j.exer.2008.04.002
Hyaluronic acid coated poly-epsilon-caprolactone nanospheres deliver high concentrations of cyclosporine A into the cornea.
I. Yenice (2008)
10.2147/DDDT.S175297
The long-term effect of tacrolimus on alkali burn-induced corneal neovascularization and inflammation surpasses that of anti-vascular endothelial growth factor
Ling Chen (2018)
10.1167/iovs.17-21544
SERPINA3K Ameliorates the Corneal Oxidative Injury Induced by 4-Hydroxynonenal.
Xiling Zheng (2017)
10.1016/j.nano.2009.02.003
Nanomedicines for ocular NSAIDs: safety on drug delivery.
J. Araújo (2009)
10.1016/j.nano.2015.01.004
Design and optimization of oleanolic/ursolic acid-loaded nanoplatforms for ocular anti-inflammatory applications.
H. Alvarado (2015)
10.1016/j.exer.2013.10.002
Suppression of alkali-induced oxidative injury in the cornea by mesenchymal stem cells growing on nanofiber scaffolds and transferred onto the damaged corneal surface.
J. Cejková (2013)
10.1080/08923973.2019.1628044
Sulglycotide ameliorates inflammation in lipopolysaccharide-stimulated mouse macrophage cells by blocking the NF-κB signaling pathway
E. Park (2019)
10.2174/1871520619666190528091648
Correlation between Antioxidant/Antimutagenic and Antiproliferative Activity of Some Phytochemicals; A Prediction Model.
Doaa T Ramadan (2019)
10.2147/IJN.S131973
Polyphenol nanoformulations for cancer therapy: experimental evidence and clinical perspective
Yasamin Davatgaran-Taghipour (2017)
10.2147/IJN.S135133
Apatinib-loaded nanoparticles suppress vascular endothelial growth factor-induced angiogenesis and experimental corneal neovascularization
J. Lee (2017)
10.1080/02713683.2019.1597127
Effects of Anti-Glaucoma Prostaglandin Ophthalmic Solutions on Cultured Human Corneal Epithelial Cells
L. Tong (2019)
10.1038/s41598-017-18113-3
Peroxisome proliferator-activated receptor alpha agonist suppresses neovascularization by reducing both vascular endothelial growth factor and angiopoietin-2 in corneal alkali burn
Takeshi Arima (2017)
10.1111/jphp.12355
Age‐related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens
Hamdy Abdelkader (2015)
10.1016/j.ejphar.2018.01.020
New application of the commercial sweetener rebaudioside a as a hepatoprotective candidate: Induction of the Nrf2 signaling pathway
Y. Wang (2018)
10.1080/10717544.2019.1622608
New micelle myricetin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment
Fengyuan Sun (2019)
10.1167/iovs.16-19702
Naringenin Eye Drops Inhibit Corneal Neovascularization by Anti-Inflammatory and Antioxidant Mechanisms.
A. T. Oguido (2017)
10.2147/OPTH.S208700
Use of topical bromfenac for treating ocular pain and inflammation beyond cataract surgery: a review of published studies
B. Schechter (2019)
10.2147/IJN.S191337
Novel self-nanomicellizing solid dispersion based on rebaudioside A: a potential nanoplatform for oral delivery of curcumin
Yuzhen Hou (2019)
Pterostilbene impact on retinal endothelial cells under high glucose environment.
H. Shen (2015)
10.1016/j.jsps.2013.03.006
Enhanced solubility and intestinal absorption of candesartan cilexetil solid dispersions using everted rat intestinal sacs.
S. Gurunath (2014)
10.1016/j.ijpharm.2018.10.006
Novel ultra‐small micelles based on rebaudioside A: A potential nanoplatform for ocular drug delivery
Kaichao Song (2018)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar