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Encapsulation Of Artemisia Scoparia Extract In Chitosan-myristate Nanogel With Enhanced Cytotoxicity And Apoptosis Against Hepatocellular Carcinoma Cell Line (Huh-7)

S. Haghighi, F. Tafvizi, A. Mirzaie
Published 2020 · Chemistry

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Abstract In the current study, encapsulation by chitosan (CS)-myristic acid (MA) nanogel was used to enhance the cytotoxic and apoptosis activities of Artemisia scoparia extract against Hepato-carcinoma cell line (Huh-7). The synthesized CS-MA nanogel had uniform size distribution below 100 nm with the spherical structure. Subsequently, cytotoxicity of free A. scopari extract, CS-MA nanogel and CS-MA nanogel-encapsulated extract was evaluated on Huh-7 cell line using MTT (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Finally, the apoptotic effects of CS-MA nanogel-encapsulated extract was evaluated using Real-time PCR and flow cytometry techniques. The results of MTT assay showed that the CS-MA nanogel-encapsulated extract was more effective against Huh-7 cell line comparing to the free extract. In addition, CS-MA nanogel-encapsulated extract induced the apoptosis in Huh-7 cell line with up-regulation of Bax, and miR192 genes along with the suppression of Bcl-2, MMP2, MMP9 and cyclin D1 (P
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