Online citations, reference lists, and bibliographies.
← Back to Search

Emerging Role Of Damage-associated Molecular Patterns Derived From Mitochondria In Inflammation.

D. Krysko, P. Agostinis, O. Krysko, Abhishek D Garg, C. Bachert, B. Lambrecht, P. Vandenabeele
Published 2011 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Cell death and injury often lead to release or exposure of intracellular molecules called damage-associated molecular patterns (DAMPs) or cell death-associated molecules. These molecules are recognized by the innate immune system by pattern recognition receptors - the same receptors that detect pathogen-associated molecular patterns, thus revealing similarities between pathogen-induced and non-infectious inflammatory responses. Many DAMPs are derived from the plasma membrane, nucleus, endoplasmic reticulum and cytosol. Recently, mitochondria have emerged as other organelles that function as a source of DAMPs. Here, we highlight the significance of mitochondrial DAMPs and discuss their contribution to inflammation and development of human pathologies.
This paper references
10.1038/nature08296
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
M. Elliott (2009)
10.1097/00003246-199711000-00014
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference definitions of the systemic inflammatory response syndrome and allied disorders in relation to critically injured patients.
D. Muckart (1997)
10.1038/sj.onc.1207523
Toxic proteins released from mitochondria in cell death
X. Saelens (2004)
10.1038/sj.cdd.4401724
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
G. Kroemer (2005)
10.1194/JLR.R700018-JLR200
Cardiolipin synthesis for the assembly of bacterial and mitochondrial membranes.
M. Schlame (2008)
10.1038/sj.cdd.4400981
Release of intact, monomeric cytochrome c from apoptotic and necrotic cells
R. Jemmerson (2002)
10.1189/jlb.0703328
Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses
L. V. Collins (2004)
10.1038/nm1523
Calreticulin exposure dictates the immunogenicity of cancer cell death
M. Obeid (2007)
10.1038/nrm2970
Molecular mechanisms of necroptosis: an ordered cellular explosion
P. Vandenabeele (2010)
Circulating levels of cytochrome c after resuscitation from cardiac arrest: a marker of mitochondrial injury and predictor of survival
J Radhakrishnan (2007)
10.1038/nri1372
Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses
S. Seong (2004)
10.1038/sj.cdd.4400883
Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria
G. Denecker (2001)
10.1038/nature08780
Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury
Q. Zhang (2010)
10.2119/molmed.2009.00097
Pattern Recognition Receptor–Dependent Mechanisms of Acute Lung Injury
M. Xiang (2010)
immunogenicity of cancer cell death
L Apetoh (2007)
10.1016/S0952-7915(99)80009-0
Phagocytosis and development: back to the future.
N. C. Franc (1999)
Decoding
L. Zitvogel (2010)
10.1146/ANNUREV.IY.12.040194.005015
Tolerance, danger, and the extended family.
P. Matzinger (1994)
10.1111/j.1600-079X.2010.00759.x
Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease
G. Paradies (2010)
10.1136/jcp.53.11.813
Autoantigens in primary biliary cirrhosis
D. Jones (2000)
10.1146/ANNUREV.PHARMTOX.47.120505.105122
Mitochondrial oxidative stress: implications for cell death.
S. Orrenius (2007)
10.1007/s10495-007-0756-2
Mitochondria, oxidative stress and cell death
M. Ott (2007)
10.1097/TA.0b013e3181dcd28d
Mitochondrial peptides are potent immune activators that activate human neutrophils via FPR-1.
M. Raoof (2010)
10.1002/eji.200526338
Human mitochondria‐derived N‐formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes‐derived peptides preferentially activate FPR
M. Rabiet (2005)
10.1189/jlb.0306200
Analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin)
A. Rouhiainen (2007)
10.4049/jimmunol.0902673
Human Eosinophils Recognize Endogenous Danger Signal Crystalline Uric Acid and Produce Proinflammatory Cytokines Mediated by Autocrine ATP
T. Kobayashi (2010)
10.1038/nature10156
A role for mitochondria in NLRP3 inflammasome activation
Rongbin Zhou (2011)
10.1007/s00109-009-0481-0
Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps
Maren von Köckritz-Blickwede (2009)
10.1016/j.cell.2004.05.008
Disruption of Mitochondrial Function during Apoptosis Is Mediated by Caspase Cleavage of the p75 Subunit of Complex I of the Electron Transport Chain
Jean-Ehrland Ricci (2004)
10.1189/jlb.0306164
DAMPs, PAMPs and alarmins: all we need to know about danger
M. Bianchi (2007)
10.2174/156652408784221306
Molecular mechanisms and pathophysiology of necrotic cell death.
Nele Vanlangenakker (2008)
10.1038/onc.2010.292
Extracellular adenosine triphosphate and adenosine in cancer
J. Stagg (2010)
10.1038/cdd.2008.143
Autophagy regulates selective HMGB1 release in tumor cells that are destined to die
J. Thorburn (2009)
10.1016/J.IT.2007.08.004
Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox.
A. Rubartelli (2007)
10.1186/cc8152
Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion
M. Cohen (2009)
10.1097/01.shk.0000162236.75253.9e
RELEASE OF THE MITOCHONDRIAL ENZYME CARBAMOYL PHOSPHATE SYNTHASE UNDER SEPTIC CONDITIONS
J. Struck (2005)
10.1002/emmm.201000077
High mobility group box-1 recognition: The beginning of a RAGEless era?
Filipe Branco-Madeira (2010)
10.1182/BLOOD.V98.5.1542
Rapid extracellular release of cytochrome c is specific for apoptosis and marks cell death in vivo.
A. Renz (2001)
10.1124/pr.109.001578
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family
R. Ye (2009)
10.1038/nm1622
Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
L. Apetoh (2007)
10.1038/nm.2028
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
F. Ghiringhelli (2009)
10.1111/j.1600-065X.2008.00731.x
Pattern recognition receptors and control of adaptive immunity
Noah W. Palm (2009)
Mitochondrial evolution : Mitochondria
M. Gray (1999)
10.1038/nature08512
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
H. Yanai (2009)
10.1016/j.tips.2010.04.001
Are formyl peptide receptors novel targets for therapeutic intervention in ischaemia–reperfusion injury?
F. Gavins (2010)
10.1038/sj.cdd.4401457
Cardiolipin and its metabolites move from mitochondria to other cellular membranes during death receptor-mediated apoptosis
M. Sorice (2004)
10.1038/nrm2153
The apoptosome: signalling platform of cell death
S. Riedl (2007)
10.1126/SCIENCE.2035027
Similarity of human mitochondrial transcription factor 1 to high mobility group proteins.
M. Parisi (1991)
10.1002/ijc.21037
Serum cytochrome c indicates in vivo apoptosis and can serve as a prognostic marker during cancer therapy
Katarzyna Barczyk (2005)
10.1016/j.bbamem.2009.05.004
Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis.
Z. Schug (2009)
10.1016/j.cell.2010.02.015
Decoding Cell Death Signals in Inflammation and Immunity
L. Zitvogel (2010)
10.1016/j.immuni.2008.05.013
Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein.
H. Kazama (2008)
10.1152/AJPHEART.00468.2006
Circulating levels of cytochrome c after resuscitation from cardiac arrest: a marker of mitochondrial injury and predictor of survival.
Jeejabai Radhakrishnan (2007)
10.1002/jat.1347
Cytochrome c: a non‐invasive biomarker of drug‐induced liver injury
T. J. Miller (2008)
10.1084/JEM.155.1.264
Mitochondrial N-formylmethionyl proteins as chemoattractants for neutrophils
H. Carp (1982)
10.1007/s10495-010-0478-8
Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players
K. Kruse (2010)
10.1007/s12253-008-9071-7
Extracellular ATP and Cancer—An Overview with Special Reference to P2 Purinergic Receptors
Tamás Deli (2008)
10.1016/J.EXPHEM.2004.09.010
Human platelets exhibit chemotaxis using functional N-formyl peptide receptors.
Meggan Czapiga (2005)
10.2119/2008-00034.Klune
HMGB1: Endogenous Danger Signaling
J. Klune (2008)
10.1016/j.cell.2010.01.040
The Inflammasomes
K. Schroder (2010)
The specificity of human anti-cytochrome c autoantibodies that arise in autoimmune disease.
M. Mamula (1990)
10.1038/nature09413
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Faraaz B. Chekeni (2010)
Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2.
L. Ronfani (2001)
10.1101/cshperspect.a011403
Mitochondrial evolution.
M. Gray (2012)
10.1196/annals.1361.089
New Facet of Antiphospholipid Antibodies
G. Valesini (2005)
10.1126/science.325_666
Origins. On the origin of eukaryotes.
C. Zimmer (2009)
10.1016/S0076-6879(08)01416-X
Methods for distinguishing apoptotic from necrotic cells and measuring their clearance.
D. Krysko (2008)
10.1016/S0079-6123(06)61022-4
The neurotrophic protein S100B: value as a marker of brain damage and possible therapeutic implications.
A. Kleindienst (2007)
Physicians/Society of Critical Care Medicine Committee. American College of Chest sepsis. The ACCP/SCCM Consensus Conference guidelines for the use of innovative therapies in Definitions for sepsis and organ failure and
R. Schein (2007)
10.1084/jem.20040327
Inhibition of Phosphatidylserine Recognition Heightens the Immunogenicity of Irradiated Lymphoma Cells In Vivo
A. Bondanza (2004)
10.1378/CHEST.101.6.1644
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine.
R. Bone (1992)
10.1006/BBRC.1995.1884
Peptides from the amino-terminus of mouse mitochondrially encoded NADH dehydrogenase subunit 1 are potent chemoattractants.
S. M. Shawar (1995)
10.4049/jimmunol.177.2.1272
Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR21
K. Scheibner (2006)
10.1159/000235327
Extracellular ATP stimulates interleukin-dependent cultured mast cells and eosinophils through calcium mobilization.
H. Saito (1991)
10.1016/j.biochi.2007.02.015
The N-formyl peptide receptors and the anaphylatoxin C5a receptors: An overview
M. Rabiet (2007)
10.1083/jcb.200208089
Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis
Jean-Ehrland Ricci (2003)
10.1021/BI00502A016
The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors.
F. Boulay (1990)
Rapid extracellular release of cytochrome c is specific for apoptosis andmarks cell death
A Renz (2001)
10.1016/j.bbcan.2009.08.003
Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation.
Abhishek D Garg (2010)
10.1007/s10495-006-9527-8
Clearance of apoptotic and necrotic cells and its immunological consequences
D. Krysko (2006)
10.1097/CCM.0b013e3181a001ae
Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors
E. Crouser (2009)
death signals in inflammation and immunity
K. A. Scheibner (2006)
10.1189/jlb.1008585
HMGB1 loves company
M. Bianchi (2009)
10.1007/s10495-009-0412-0
Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1
R. Codina (2009)
10.1016/j.bbamem.2008.08.023
Lipid domains in bacterial membranes and the action of antimicrobial agents.
R. Epand (2009)
10.1016/J.CYTOGFR.2006.09.009
Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses.
I. Migeotte (2006)
10.1161/CIRCULATIONAHA.109.895771
Anthracycline Cardiomyopathy Is Mediated by Depletion of the Cardiac Stem Cell Pool and Is Rescued by Restoration of Progenitor Cell Function
A. De Angelis (2010)
10.1097/01.CJI.0000211324.53396.F6
Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs): role in the inflammatory response within tumors.
R. Lotfi (2007)
10.1038/nm.1855
Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense
S. Yousefi (2008)
10.1073/pnas.0908698106
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
S. Iyer (2009)
10.1097/SHK.0b013e3181cd8c08
MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE
Q. Zhang (2010)
10.1126/science.1168988
CD24 and Siglec-10 Selectively Repress Tissue Damage–Induced Immune Responses
Guo-Yun Chen (2009)
10.1038/nature09475
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
P. Scaffidi (2010)
10.1038/NCHEMBIO711
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
A. Degterev (2005)
10.1016/j.micinf.2009.08.013
Major cell death pathways at a glance.
Linde Duprez (2009)
10.1126/science.1195491
Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation
B. McDonald (2010)
10.1093/RHEUMATOLOGY/KEH406
Extracellular cytochrome c, a mitochondrial apoptosis-related protein, induces arthritis.
R. Pullerits (2005)
10.1074/jbc.M604501200
Human Mitochondrial DNA Nucleoids Are Linked to Protein Folding Machinery and Metabolic Enzymes at the Mitochondrial Inner Membrane*
Yousong Wang (2006)
10.4161/cc.8.22.10026
Chemotherapy induces ATP release from tumor cells
I. Martins (2009)
10.1038/cdd.2008.150
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
G. Kroemer (2009)
10.1016/J.CCCN.2003.12.011
Serum cytochrome c level as a prognostic indicator in patients with systemic inflammatory response syndrome.
N. Adachi (2004)
Early changes in intramitochondrial cardiolipin distribution during apoptosis.
M. G. Garcia Fernandez (2002)
10.1111/j.1442-200x.2005.02042.x
Apoptosis under hypercytokinemia is a possible pathogenesis in influenza‐associated encephalopathy
H. Nunoi (2005)



This paper is referenced by
10.1016/j.freeradbiomed.2017.02.038
Dipeptide HCH6‐1 inhibits neutrophil activation and protects against acute lung injury by blocking FPR1
S. Yang (2017)
10.1111/jdi.12366
Circulating cell‐free mitochondrial deoxyribonucleic acid is increased in coronary heart disease patients with diabetes mellitus
J. Liu (2016)
10.1097/ACO.0000000000000047
Inflammatory response to trauma: implications for coagulation and resuscitation
A. Pierce (2014)
10.1016/j.immuni.2013.02.003
Necroptosis: the release of damage-associated molecular patterns and its physiological relevance.
A. Kaczmarek (2013)
10.1016/j.it.2012.12.003
Beyond pattern recognition: NOD-like receptors in dendritic cells.
J. K. Krishnaswamy (2013)
10.1007/978-1-0716-0247-8_11
Detection of Ferroptosis by BODIPY™ 581/591 C11.
Alejandra M Martinez (2020)
10.1007/978-3-319-62142-5_7
Organ Preservation, Ischemia Reperfusion Injury, and Nanotherapeutics in Transplantation
Kunal J. Patel (2017)
10.1155/2014/518261
Local and Systemic Pathogenesis and Consequences of Regimen-Induced Inflammatory Responses in Patients with Head and Neck Cancer Receiving Chemoradiation
E. Russi (2014)
10.1016/j.ejphar.2016.12.034
Effects of a human recombinant alkaline phosphatase during impaired mitochondrial function in human renal proximal tubule epithelial cells
E. Peters (2017)
10.1201/B13907-5
Controlling Neuroinflammation: Lessons from Rabies Virus
Monique Lafon (2013)
The Role of Damage-Associated Molecular Patterns (DAMPs) in Human Diseases: Part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine.
W. Land (2015)
The ex vivo and in vitro transcriptomic profiles of equine endometrium using an explant model to further study endometritis
Maithe De Barros (2019)
10.3390/ijms21165931
Necroptosis in Hepatosteatotic Ischaemia-Reperfusion Injury
R. Baidya (2020)
10.1186/s13019-020-01179-y
Toll-like receptor 9 and the inflammatory response to surgical trauma and cardiopulmonary bypass
H. Naase (2020)
10.1016/j.cvex.2016.01.010
Basic Shock Physiology and Critical Care
B. K. Roberts (2016)
10.7150/thno.19826
An Endogenous Vaccine Based on Fluorophores and Multivalent Immunoadjuvants Regulates Tumor Micro-Environment for Synergistic Photothermal and Immunotherapy
L. Li (2018)
10.1189/jlb.1212662
The many faces of HMGB1: molecular structure‐functional activity in inflammation, apoptosis, and chemotaxis
H. Yang (2013)
10.1101/340711
Propofol inhibits endogenous formyl peptide-induced neutrophil activation and alleviates lung injury
Chun-Yu Chen (2018)
10.1159/000360495
The Inflammasome in Liver Injury and Non-Alcoholic Fatty Liver Disease
W. Mehal (2014)
10.15698/cst2019.06.190
The sensing of mitochondrial DAMPs by non-immune cells
Aida Rodríguez-Nuevo (2019)
10.1155/2019/4050796
The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation
Ekta Bajwa (2019)
10.1016/j.intimp.2019.03.029
The levels and significance of inflammasomes in the mouse retina following optic nerve crush.
Zheng Qijun (2019)
10.1164/rccm.201706-1161OC
Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury
Meghan J. Hotz (2018)
10.1189/jlb.0612278
Identification of novel oligonucleotides from mitochondrial DNA that spontaneously induce plasmacytoid dendritic cell activation
M. Ries (2013)
10.1016/j.nmd.2013.07.011
An “inflammatory” mitochondrial myopathy. A case report
M. Mancuso (2013)
10.1155/2018/2353128
Oxidative Stress in the Critically Ill Patients: Pathophysiology and Potential Interventions
D. Makris (2018)
10.1146/annurev-pathmechdis-012418-012838
Pathophysiology of Sickle Cell Disease.
P. Sundd (2019)
10.1515/hsz-2012-0198
Integration of cellular bioenergetics with mitochondrial quality control and autophagy
B. Hill (2012)
10.2334/JOSNUSD.54.137
Programmed cell death and its possible relationship with periodontal disease.
H. Tsuda (2012)
10.1126/scisignal.aaj1978
Mitochondrial redox signaling enables repair of injured skeletal muscle cells
A. Horn (2017)
10.1097/TA.0000000000001421
Potential contribution of mitochondrial DNA damage associated molecular patterns in transfusion products to the development of acute respiratory distress syndrome after multiple transfusions
J. Simmons (2017)
10.4049/jimmunol.1300774
The Human Immune System Recognizes Neopeptides Derived from Mitochondrial DNA Deletions
Bhargavi Duvvuri (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar