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Emerging Role Of Damage-associated Molecular Patterns Derived From Mitochondria In Inflammation.
D. Krysko, P. Agostinis, O. Krysko, Abhishek D Garg, C. Bachert, B. Lambrecht, P. Vandenabeele
Published 2011 · Biology, Medicine
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Cell death and injury often lead to release or exposure of intracellular molecules called damage-associated molecular patterns (DAMPs) or cell death-associated molecules. These molecules are recognized by the innate immune system by pattern recognition receptors - the same receptors that detect pathogen-associated molecular patterns, thus revealing similarities between pathogen-induced and non-infectious inflammatory responses. Many DAMPs are derived from the plasma membrane, nucleus, endoplasmic reticulum and cytosol. Recently, mitochondria have emerged as other organelles that function as a source of DAMPs. Here, we highlight the significance of mitochondrial DAMPs and discuss their contribution to inflammation and development of human pathologies.
This paper references
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
M. Elliott (2009)
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference definitions of the systemic inflammatory response syndrome and allied disorders in relation to critically injured patients.
D. Muckart (1997)
Toxic proteins released from mitochondria in cell death
X. Saelens (2004)
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
G. Kroemer (2005)
Cardiolipin synthesis for the assembly of bacterial and mitochondrial membranes.
M. Schlame (2008)
Release of intact, monomeric cytochrome c from apoptotic and necrotic cells
R. Jemmerson (2002)
Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses
L. V. Collins (2004)
Calreticulin exposure dictates the immunogenicity of cancer cell death
M. Obeid (2007)
Molecular mechanisms of necroptosis: an ordered cellular explosion
P. Vandenabeele (2010)
Circulating levels of cytochrome c after resuscitation from cardiac arrest: a marker of mitochondrial injury and predictor of survival
J Radhakrishnan (2007)
Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses
S. Seong (2004)
Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria
G. Denecker (2001)
Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury
Q. Zhang (2010)
Pattern Recognition Receptor–Dependent Mechanisms of Acute Lung Injury
M. Xiang (2010)
immunogenicity of cancer cell death
L Apetoh (2007)
Phagocytosis and development: back to the future.
N. C. Franc (1999)
L. Zitvogel (2010)
Tolerance, danger, and the extended family.
P. Matzinger (1994)
Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease
G. Paradies (2010)
Autoantigens in primary biliary cirrhosis
D. Jones (2000)
Mitochondrial oxidative stress: implications for cell death.
S. Orrenius (2007)
Mitochondria, oxidative stress and cell death
M. Ott (2007)
Mitochondrial peptides are potent immune activators that activate human neutrophils via FPR-1.
M. Raoof (2010)
Human mitochondria‐derived N‐formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes‐derived peptides preferentially activate FPR
M. Rabiet (2005)
Analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin)
A. Rouhiainen (2007)
Human Eosinophils Recognize Endogenous Danger Signal Crystalline Uric Acid and Produce Proinflammatory Cytokines Mediated by Autocrine ATP
T. Kobayashi (2010)
A role for mitochondria in NLRP3 inflammasome activation
Rongbin Zhou (2011)
Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps
Maren von Köckritz-Blickwede (2009)
Disruption of Mitochondrial Function during Apoptosis Is Mediated by Caspase Cleavage of the p75 Subunit of Complex I of the Electron Transport Chain
Jean-Ehrland Ricci (2004)
DAMPs, PAMPs and alarmins: all we need to know about danger
M. Bianchi (2007)
Molecular mechanisms and pathophysiology of necrotic cell death.
Nele Vanlangenakker (2008)
Extracellular adenosine triphosphate and adenosine in cancer
J. Stagg (2010)
Autophagy regulates selective HMGB1 release in tumor cells that are destined to die
J. Thorburn (2009)
Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox.
A. Rubartelli (2007)
Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion
M. Cohen (2009)
RELEASE OF THE MITOCHONDRIAL ENZYME CARBAMOYL PHOSPHATE SYNTHASE UNDER SEPTIC CONDITIONS
J. Struck (2005)
High mobility group box-1 recognition: The beginning of a RAGEless era?
Filipe Branco-Madeira (2010)
Rapid extracellular release of cytochrome c is specific for apoptosis and marks cell death in vivo.
A. Renz (2001)
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family
R. Ye (2009)
Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
L. Apetoh (2007)
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
F. Ghiringhelli (2009)
Pattern recognition receptors and control of adaptive immunity
Noah W. Palm (2009)
Mitochondrial evolution : Mitochondria
M. Gray (1999)
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
H. Yanai (2009)
Are formyl peptide receptors novel targets for therapeutic intervention in ischaemia–reperfusion injury?
F. Gavins (2010)
Cardiolipin and its metabolites move from mitochondria to other cellular membranes during death receptor-mediated apoptosis
M. Sorice (2004)
The apoptosome: signalling platform of cell death
S. Riedl (2007)
Similarity of human mitochondrial transcription factor 1 to high mobility group proteins.
M. Parisi (1991)
Serum cytochrome c indicates in vivo apoptosis and can serve as a prognostic marker during cancer therapy
Katarzyna Barczyk (2005)
Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis.
Z. Schug (2009)
Decoding Cell Death Signals in Inflammation and Immunity
L. Zitvogel (2010)
Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein.
H. Kazama (2008)
Circulating levels of cytochrome c after resuscitation from cardiac arrest: a marker of mitochondrial injury and predictor of survival.
Jeejabai Radhakrishnan (2007)
Cytochrome c: a non‐invasive biomarker of drug‐induced liver injury
T. J. Miller (2008)
Mitochondrial N-formylmethionyl proteins as chemoattractants for neutrophils
H. Carp (1982)
Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players
K. Kruse (2010)
Extracellular ATP and Cancer—An Overview with Special Reference to P2 Purinergic Receptors
Tamás Deli (2008)
Human platelets exhibit chemotaxis using functional N-formyl peptide receptors.
Meggan Czapiga (2005)
HMGB1: Endogenous Danger Signaling
J. Klune (2008)
K. Schroder (2010)
The specificity of human anti-cytochrome c autoantibodies that arise in autoimmune disease.
M. Mamula (1990)
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Faraaz B. Chekeni (2010)
Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2.
L. Ronfani (2001)
M. Gray (2012)
New Facet of Antiphospholipid Antibodies
G. Valesini (2005)
Origins. On the origin of eukaryotes.
C. Zimmer (2009)
Methods for distinguishing apoptotic from necrotic cells and measuring their clearance.
D. Krysko (2008)
The neurotrophic protein S100B: value as a marker of brain damage and possible therapeutic implications.
A. Kleindienst (2007)
Physicians/Society of Critical Care Medicine Committee. American College of Chest sepsis. The ACCP/SCCM Consensus Conference guidelines for the use of innovative therapies in Definitions for sepsis and organ failure and
R. Schein (2007)
Inhibition of Phosphatidylserine Recognition Heightens the Immunogenicity of Irradiated Lymphoma Cells In Vivo
A. Bondanza (2004)
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine.
R. Bone (1992)
Peptides from the amino-terminus of mouse mitochondrially encoded NADH dehydrogenase subunit 1 are potent chemoattractants.
S. M. Shawar (1995)
Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR21
K. Scheibner (2006)
Extracellular ATP stimulates interleukin-dependent cultured mast cells and eosinophils through calcium mobilization.
H. Saito (1991)
The N-formyl peptide receptors and the anaphylatoxin C5a receptors: An overview
M. Rabiet (2007)
Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis
Jean-Ehrland Ricci (2003)
The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors.
F. Boulay (1990)
Rapid extracellular release of cytochrome c is specific for apoptosis andmarks cell death
A Renz (2001)
Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation.
Abhishek D Garg (2010)
Clearance of apoptotic and necrotic cells and its immunological consequences
D. Krysko (2006)
Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors
E. Crouser (2009)
death signals in inflammation and immunity
K. A. Scheibner (2006)
HMGB1 loves company
M. Bianchi (2009)
Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1
R. Codina (2009)
Lipid domains in bacterial membranes and the action of antimicrobial agents.
R. Epand (2009)
Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses.
I. Migeotte (2006)
Anthracycline Cardiomyopathy Is Mediated by Depletion of the Cardiac Stem Cell Pool and Is Rescued by Restoration of Progenitor Cell Function
A. De Angelis (2010)
Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs): role in the inflammatory response within tumors.
R. Lotfi (2007)
Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense
S. Yousefi (2008)
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
S. Iyer (2009)
MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE
Q. Zhang (2010)
CD24 and Siglec-10 Selectively Repress Tissue Damage–Induced Immune Responses
Guo-Yun Chen (2009)
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
P. Scaffidi (2010)
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
A. Degterev (2005)
Major cell death pathways at a glance.
Linde Duprez (2009)
Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation
B. McDonald (2010)
Extracellular cytochrome c, a mitochondrial apoptosis-related protein, induces arthritis.
R. Pullerits (2005)
Human Mitochondrial DNA Nucleoids Are Linked to Protein Folding Machinery and Metabolic Enzymes at the Mitochondrial Inner Membrane*
Yousong Wang (2006)
Chemotherapy induces ATP release from tumor cells
I. Martins (2009)
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
G. Kroemer (2009)
Serum cytochrome c level as a prognostic indicator in patients with systemic inflammatory response syndrome.
N. Adachi (2004)
Early changes in intramitochondrial cardiolipin distribution during apoptosis.
M. G. Garcia Fernandez (2002)
Apoptosis under hypercytokinemia is a possible pathogenesis in influenza‐associated encephalopathy
H. Nunoi (2005)
This paper is referenced by
Dipeptide HCH6‐1 inhibits neutrophil activation and protects against acute lung injury by blocking FPR1
S. Yang (2017)
Circulating cell‐free mitochondrial deoxyribonucleic acid is increased in coronary heart disease patients with diabetes mellitus
J. Liu (2016)
Inflammatory response to trauma: implications for coagulation and resuscitation
A. Pierce (2014)
Necroptosis: the release of damage-associated molecular patterns and its physiological relevance.
A. Kaczmarek (2013)
Beyond pattern recognition: NOD-like receptors in dendritic cells.
J. K. Krishnaswamy (2013)
Detection of Ferroptosis by BODIPY™ 581/591 C11.
Alejandra M Martinez (2020)
Organ Preservation, Ischemia Reperfusion Injury, and Nanotherapeutics in Transplantation
Kunal J. Patel (2017)
Local and Systemic Pathogenesis and Consequences of Regimen-Induced Inflammatory Responses in Patients with Head and Neck Cancer Receiving Chemoradiation
E. Russi (2014)
Effects of a human recombinant alkaline phosphatase during impaired mitochondrial function in human renal proximal tubule epithelial cells
E. Peters (2017)
Controlling Neuroinflammation: Lessons from Rabies Virus
Monique Lafon (2013)
The Role of Damage-Associated Molecular Patterns (DAMPs) in Human Diseases: Part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine.
W. Land (2015)
The ex vivo and in vitro transcriptomic profiles of equine endometrium using an explant model to further study endometritis
Maithe De Barros (2019)
Necroptosis in Hepatosteatotic Ischaemia-Reperfusion Injury
R. Baidya (2020)
Toll-like receptor 9 and the inflammatory response to surgical trauma and cardiopulmonary bypass
H. Naase (2020)
Basic Shock Physiology and Critical Care
B. K. Roberts (2016)
An Endogenous Vaccine Based on Fluorophores and Multivalent Immunoadjuvants Regulates Tumor Micro-Environment for Synergistic Photothermal and Immunotherapy
L. Li (2018)
The many faces of HMGB1: molecular structure‐functional activity in inflammation, apoptosis, and chemotaxis
H. Yang (2013)
Propofol inhibits endogenous formyl peptide-induced neutrophil activation and alleviates lung injury
Chun-Yu Chen (2018)
The Inflammasome in Liver Injury and Non-Alcoholic Fatty Liver Disease
W. Mehal (2014)
The sensing of mitochondrial DAMPs by non-immune cells
Aida Rodríguez-Nuevo (2019)
The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation
Ekta Bajwa (2019)
The levels and significance of inflammasomes in the mouse retina following optic nerve crush.
Zheng Qijun (2019)
Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury
Meghan J. Hotz (2018)
Identification of novel oligonucleotides from mitochondrial DNA that spontaneously induce plasmacytoid dendritic cell activation
M. Ries (2013)
An “inflammatory” mitochondrial myopathy. A case report
M. Mancuso (2013)
Oxidative Stress in the Critically Ill Patients: Pathophysiology and Potential Interventions
D. Makris (2018)
Pathophysiology of Sickle Cell Disease.
P. Sundd (2019)
Integration of cellular bioenergetics with mitochondrial quality control and autophagy
B. Hill (2012)
Programmed cell death and its possible relationship with periodontal disease.
H. Tsuda (2012)
Mitochondrial redox signaling enables repair of injured skeletal muscle cells
A. Horn (2017)
Potential contribution of mitochondrial DNA damage associated molecular patterns in transfusion products to the development of acute respiratory distress syndrome after multiple transfusions
J. Simmons (2017)
The Human Immune System Recognizes Neopeptides Derived from Mitochondrial DNA Deletions
Bhargavi Duvvuri (2014)See more