Subject-specific Finite Element Models Can Accurately Predict Strain Levels In Long Bones.
E. Schileo, F. Taddei, A. Malandrino, L. Cristofolini, M. Viceconti
Published 2007 · Medicine, Engineering
Download PDFAnalyze on Scholarcy
The prediction of the stress-state and fracture risk induced in bones by various loading conditions in individual patients using subject-specific finite element models still represents a challenge in orthopaedic biomechanics. The accuracy of the strain predictions reported in the literature is variable and generally not satisfactory. The aim of the present study was to evaluate if a proper choice of the density-elasticity relationship can lead to accurate strain predictions in the frame of an automatic subject-specific model generation strategy. To this aim, a combined numerical-experimental study was performed comparing finite element predicted strains with strain-gauges measurements obtained on eight cadaver proximal femurs, each instrumented with 15 rosettes mostly concentrated in the bone metaphyses, tested non-destructively in vitro under six different loading scenarios. Three different density-elasticity power relationships were selected from the literature and implemented in the finite element models derived from computed tomography data. The results of the present study confirm the great influence of the density-elasticity relationship used on the accuracy of numerical predictions. One of the tested constitutive laws provided a very good agreement (R(2)=0.91, RMSE lower than 10% of the maximum measured value) between numerical calculations and experimental measurements. The presented results show, in addition, that the adoption of a single density-elasticity relationship over the whole bone density range is adequate to obtain an accuracy that is already suitable for many applications.
This paper references
Finite element analysis of the resurfaced femoral head.
M. Taylor (2006)
A combined RSA and FE study of the implanted proximal tibia: correlation of the post-operative mechanical environment with implant migration.
A. Perillo-Marcone (2004)
Finite element analysis of the mechanical behavior of a scapula implanted with a glenoid prosthesis.
B. Couteau (2001)
Estimation of material properties in the equine metacarpus with use of quantitative computed tomography.
C. Les (1994)
Finite element analysis of the initial stability of ankle arthrodesis with internal fixation: flat cut versus intact joint contours.
A. A. Vázquez (2003)
Development and validation of a three-dimensional finite element model of the pelvic bone.
M. Dalstra (1995)
Critical evaluation of known bone material properties to realize anisotropic FE-simulation of the proximal femur.
D. Wirtz (2000)
Automatic generation of accurate subject-specific bone finite element models to be used in clinical studies.
M. Viceconti (2004)
Predicting the compressive mechanical behavior of bone.
T. Keller (1994)
Tensile and compressive stress yield criteria for cancellous bone.
S. Cowin (2005)
Effect of local density changes on the failure load of the proximal femur.
Z. M. Oden (1999)
Fracture simulation of the femoral bone using the finite-element method: How a fracture initiates and proceeds
T. Ota (1999)
The relationship between the structural and orthogonal compressive properties of trabecular bone.
R. Goulet (1994)
Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography.
R. Crawford (2003)
Effect of Bone Material Properties on the Initial Stability of a Cementless Hip Stem: A Finite Element Study
A. S. Wong (2005)
Tensile yield in compact bone is determined by strain, post-yield behaviour by mineral content.
J. Currey (2004)
Extracting clinically relevant data from finite element simulations.
M. Viceconti (2005)
Trabecular bone modulus-density relationships depend on anatomic site.
E. Morgan (2003)
Subject-specific finite element model of the pelvis: development, validation and sensitivity studies.
A. Anderson (2005)
Sensitivity of periprosthetic stress-shielding to load and the bone density-modulus relationship in subject-specific finite element models.
H. Weinans (2000)
Subject-specific finite element models of long bones: An in vitro evaluation of the overall accuracy.
F. Taddei (2006)
A critical analysis of stress shielding evaluation of hip prostheses.
L. Cristofolini (1997)
A 3D finite element model of an implanted scapula: importance of a multiparametric validation using experimental data.
N. Maurel (2005)
The effect of specimen geometry on the mechanical behaviour of trabecular bone specimens.
F. Linde (1992)
The mechanical properties of bone.
F. G. Evans (1969)
Correlations between orthogonal mechanical properties and density of trabecular bone: use of different densitometric measures.
J. Keyak (1994)
Investigating the effect of remodelling signal type on the finite element based predictions of bone remodelling around the thrust plate prosthesis: A patient-specific comparison
M. Schmitz (2004)
Femoral strength is better predicted by finite element models than QCT and DXA.
D. Cody (1999)
Cross-sectional geometry of Pecos Pueblo femora and tibiae--a biomechanical investigation: I. Method and general patterns of variation.
C. Ruff (1983)
The material mapping strategy influences the accuracy of CT-based finite element models of bones: an evaluation against experimental measurements.
F. Taddei (2007)
Biomechanical Testing of the Proximal Femoral Epiphysis: Intact and Implanted Condition
L. Cristofolini (2006)
The modified super-ellipsoid yield criterion for human trabecular bone.
Harun H. Bayraktar (2004)
Development and experimental validation of a three-dimensional finite element model of the human scapula
S. Gupta (2004)
The effects of side-artifacts on the elastic modulus of trabecular bone.
Kerem Un (2006)
The compressive behavior of bone as a two-phase porous structure.
D. Carter (1977)
Fracture prediction for the proximal femur using finite element models: Part I--Linear analysis.
J. C. Lotz (1991)
A phantom for standardization and quality control in spinal bone mineral measurements by QCT and DXA: design considerations and specifications.
W. Kalender (1992)
A Method for Registration of 3-D Shapes
P. Besl (1992)
Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue.
Harun H. Bayraktar (2004)
An improved method for the automatic mapping of computed tomography numbers onto finite element models.
F. Taddei (2004)
The effect of muscle loading on the simulation of bone remodelling in the proximal femur.
C. Bitsakos (2005)
The effect of impact direction on the structural capacity of the proximal femur during falls
C. M. Ford (1996)
In vitro measured strains in the loaded femur: Quantification of experimental error
L. Cristofolini (1997)
Validation of a finite element model of the human metacarpal.
D. S. Barker (2005)
Validation of an automated method of three-dimensional finite element modelling of bone.
J. Keyak (1993)
Systematic and random errors in compression testing of trabecular bone.
T. M. Keaveny (1997)
Yield strain behavior of trabecular bone.
D. Kopperdahl (1998)
Mechanical strength of a femoral reconstruction in paediatric oncology: A finite element study
F. Taddei (2003)
A 3-dimensional finite-element analysis investigating the biomechanical behavior of the mandible and plate osteosynthesis in cases of fractures of the condylar process.
A. Wagner (2002)
Predicting Proximal Femoral Strength Using Structural Engineering Models
J. Keyak (2005)
Subject-specific finite element analysis of the human medial collateral ligament during valgus knee loading.
J. C. Gardiner (2003)
Hip contact forces and gait patterns from routine activities.
G. Bergmann (2001)
This paper is referenced by
Subchondral cysts create increased intra-osseous stress in early knee OA: A finite element analysis using simulated lesions.
D. McErlain (2011)
Multiscale modelling and nonlinear finite element analysis as clinical tools for the assessment of fracture risk
D. Christen (2010)
Finite Element Simulation of Fracture Profile of Bone Material: A Case of Study Applied to Human Femur Specimen
Awad Bettamer (2014)
Strain and micromotion in intact and resurfaced composite femurs: experimental and numerical investigations.
Bidyut Pal (2010)
Reconstruction of type II+III pelvic resection with a modular hemipelvic endoprosthesis: a finite element analysis study.
T. Ji (2010)
Combined musculoskeletal dynamics/structural finite element analysis of femur physiological loads during walking
David W. Wagner (2010)
Variability of Strain and Strain Rate in the Human Tibial Diaphysis During Walking
Tyler F Rooks (2012)
Estimation of 3D shape, internal density and mechanics of proximal femur by combining bone mineral density images with shape and density templates
Sami P. Väänänen (2012)
The importance of lag screw position for the stabilization of trochanteric fractures with a sliding hip screw: a subject-specific finite element study.
J. Goffin (2013)
Effects of anodizing parameters and heat treatment on nanotopographical features, bioactivity, and cell culture response of additively manufactured porous titanium.
Saber Amin Yavari (2015)
A residual-driven local iterative corrector scheme for the multiscale finite element method
Lam H. Nguyen (2019)
Transversely isotropic and isotropic material considerations in determining the mechanical response of geometrically accurate bovine tibia bone
Reem A. Yassine (2019)
The effect of height on bone strain while performing drop landings
Scott S. Dueball (2010)
Assessment of sagittal split ramus osteotomy rigid internal fixation techniques using a finite element method.
Safieh Albougha (2015)
Comparison of Strain Rosettes and Digital Image Correlation for Measuring Vertebral Body Strain.
H. Gustafson (2016)
Effect of the stiffness of bone substitutes on the biomechanical behaviour of femur for core decompression.
T. N. Tran (2016)
An integration tool for multiscale simulation
Improving outcomes in knee arthroplasty: the lateral unicompartmental knee replacement
S. Newman (2016)
The comparison of density-elastic modulus equations for the distal ulna at multiple forearm positions: a finite element study.
Mark A. C. Neuert (2013)
Establishing the 3-D finite element solid model of femurs in partial by volume rendering.
Yinwang Zhang (2013)
Glenoid implant orientation and cement failure in total shoulder arthroplasty: a finite element analysis.
Charlie Yongpravat (2013)
Finite element modeling of resurfacing hip prosthesis: estimation of accuracy through experimental validation.
Fulvia Taddei (2010)
Sensitivity analysis of a cemented hip stem to implant position and cement mantle thickness
J. Shi (2014)
Comparison of explicit finite element and mechanical simulation of the proximal femur during dynamic drop-tower testing.
O. Ariza (2015)
The Effect of Drop-Landing Height on Tibia Bone Strain
He Wang (2017)
A comparison of density-modulus relationships used in finite element modeling of the shoulder.
Nikolas K. Knowles (2019)
ADDRESSING PARTIAL VOLUME ARTIFACTS WITH QUANTITATIVE COMPUTED TOMOGRAPHY-BASED FINITE ELEMENT MODELING OF THE HUMAN PROXIMAL TIBIA
Hosseini Kalajahi (2018)
Previous Damage Accumulation Can Influence Femoral Fracture Strength: A Finite Element Study.
Ifaz T Haider (2019)
The Craniomaxillofacial Skeleton: New Approaches in Computational Biomechanics and Fracture Stabilization
Pakdel Sefidgar (2014)
Assessment of finite element models for prediction of osteoporotic fracture.
Yeokyeong Lee (2019)
Effects of Scan Resolutions and Element Sizes on Bovine Vertebral Mechanical Parameters from Quantitative Computed Tomography-Based Finite Element Analysis
Meng Zhang (2017)
DEVELOPMENT OF A SUBJECT SPECIFIC FINITE ELEMENT MODEL USED TO PREDICT THE EFFECTS OF A SINGLE LEG EXTENSION EXERCISE
Garrett Thomas Gleeson (2010)See more