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In Vitro Replication Of Spontaneous Fractures Of The Proximal Human Femur.

L. Cristofolini, M. Juszczyk, S. Martelli, F. Taddei, M. Viceconti
Published 2007 · Engineering, Medicine

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Spontaneous fractures (i.e. caused by sudden loading and muscle contraction, not by trauma) represent a significant percentage of proximal femur fractures. They are particularly relevant as may occur in elderly (osteoporotic) subjects, but also in relation to epiphyseal prostheses. Despite its clinical and legal relevance, this type of fracture has seldom been investigated. Studies concerning spontaneous fractures are based on a variety of loading scenarios. There is no evidence, nor consensus on the most relevant loading scenario. The aim of this work was to develop and validate an experimental method to replicate spontaneous fractures in vitro based on clinically relevant loading. Primary goals were: (i) repeatability and reproducibility, (ii) clinical relevance. A validated numerical model was used to identify the most critical loading scenario that can lead to head-neck fractures, and to determine if it is necessary to include muscle forces when the head-neck region is under investigation. The numerical model indicated that the most relevant loading scenario is when the resultant joint force is applied to the head at 8 degrees from the diaphysis. Furthermore, it was found that it is not essential to include the muscles when investigating head-neck fractures. The experimental setup was consequently designed. The procedure included high-speed filming of the fracture event. Clinically relevant fracture modes were obtained on 10 cadaveric femurs. Failure load should be reported as a fraction of donor's body-weight to reduce variability. The proposed method can be used to investigate the reason and mechanism of failure of natural and operated proximal femurs.
This paper references
10.1016/S8756-3282(97)00072-0
Volumetric quantitative computed tomography of the proximal femur: precision and relation to bone strength.
T. Lang (1997)
10.5144/0256-4947.1994.75
Rockwood and Green’s Fractures in Adults
P. G. Moreau (1994)
Comments on: ‘‘Fractures of the proximal femur
L. Cristofolini (2007)
10.1016/J.JBIOMECH.2005.07.018
Subject-specific finite element models of long bones: An in vitro evaluation of the overall accuracy.
F. Taddei (2006)
10.1115/1.1835347
Finite element prediction of proximal femoral fracture patterns under different loads.
M. Gomez-Benito (2005)
10.3109/17453677608988728
Bone mineral content and mechanical strength of the femoral neck.
N. Dalén (1976)
10.2106/00004623-200409000-00003
Fracture of the neck of the femur after surface arthroplasty of the hip.
H. Amstutz (2004)
10.32388/qy0tt1
Bone mineral content.
R. L. Bell (1976)
10.1007/BF00932160
Cancellous bone and mechanical strength of the femoral neck
O. Delaere (2004)
Comments on : ‘ ‘ Fractures of the proximal femur : correlates of radiological evidence of osteoporosis ’ ’ ( published on
L. Cristofolini (2007)
10.1016/S0021-9290(97)00123-1
Prediction of femoral fracture load using automated finite element modeling.
J. Keyak (1998)
10.1016/J.OCL.2005.01.002
Complications associated with hip resurfacing arthroplasty.
A. Shimmin (2005)
10.1056/NEJM199105093241905
Risk factors for falls as a cause of hip fracture in women. The Northeast Hip Fracture Study Group.
J. Grisso (1991)
10.1115/1.2796045
The relationship between loading conditions and fracture patterns of the proximal femur.
K. Yang (1994)
10.1016/S0021-9290(99)00099-8
Femoral strength is better predicted by finite element models than QCT and DXA.
D. Cody (1999)
10.1615/CRITREVBIOMEDENG.V25.I4-5.30
A critical analysis of stress shielding evaluation of hip prostheses.
L. Cristofolini (1997)
10.1007/s00256-005-0065-1
Fractures of the proximal femur: correlates of radiological evidence of osteoporosis
S. H. Patel (2005)
10.1302/0301-620X.44B3.543
Spontaneous fractures of the femoral neck.
C. Jeffery (1962)
10.1055/b-0038-160811
AO Principles of Fracture Management
T. Rüedi (2001)
10.1023/B:ABME.0000007797.92559.5e
The Toughness of Cortical Bone and Its Relationship with Age
X. Wang (2004)
10.1007/s00223-001-2132-5
Structure Analysis of High Resolution Magnetic Resonance Imaging of the Proximal Femur: In Vitro Correlation with Biomechanical Strength and BMD
T. Link (2002)
10.1243/095441105X69079
Lessons learned from early clinical experience and results of 300 ASR® hip resurfacing implantations
T. Siebel (2006)
10.1302/0301-620X.87B4.15498
Femoral neck fractures following Birmingham hip resurfacing: a national review of 50 cases.
A. Shimmin (2005)
10.1016/S0021-9290(99)00202-X
Relationships between femoral fracture loads for two load configurations.
J. Keyak (2000)
10.1007/s00256-007-0312-8
Reply to L. Cristofolini’s comments on the article “Fractures of the proximal femur: correlates of radiological evidence of osteoporosis”
K. Murphy (2007)
10.1016/S0021-9290(06)85045-1
One-legged stance — a representative body position for the long term effect of the hip contact stress
M. Daniel (2006)
10.1016/S0021-9290(06)82910-6
Femoral neck stiffness critically depends on loading direction
R. Voide (2006)
10.1016/0379-0738(94)90265-8
Are hip fractures caused by falling and breaking or breaking and falling? Photoelastic stress analysis.
D. Cotton (1994)
10.1016/S1350-4533(01)00094-7
Prediction of fracture location in the proximal femur using finite element models.
J. Keyak (2001)
10.1016/J.MEDENGPHY.2006.10.014
The material mapping strategy influences the accuracy of CT-based finite element models of bones: an evaluation against experimental measurements.
F. Taddei (2007)
Hip 98—loading of the hip joint
G. Bergmann (2001)
10.1016/S0021-9290(01)00040-9
Hip contact forces and gait patterns from routine activities.
G. Bergmann (2001)
10.1016/0020-1383(76)90041-3
Iatrogenic factors in femoral neck fractures.
D. Muckle (1976)
10.1016/J.JBIOMECH.2005.08.024
Comparative in vitro study on the long-term performance of cemented hip stems: validation of a protocol to discriminate between "good" and "bad" designs.
J. Paul (2006)
10.1243/0309324991513579
Towards the standardization of in vitro load transfer investigations of hip prostheses
X. Ke (1999)
Fracture of the neck
H. C. Amstutz (2004)
10.1115/1.2895412
Fracture prediction for the proximal femur using finite element models: Part I--Linear analysis.
J. C. Lotz (1991)
10.1002/ajpa.1330600308
Cross-sectional geometry of Pecos Pueblo femora and tibiae--a biomechanical investigation: I. Method and general patterns of variation.
C. Ruff (1983)
10.1007/s001980070126
In Situ Femoral Dual-Energy X-ray Absorptiometry Related to Ash Weight, Bone Size and Density, and its Relationship with Mechanical Failure Loads of the Proximal Femur
E. Lochmüller (2000)
10.1016/0021-9290(94)00106-E
Influence of thigh muscles on the axial strains in a proximal femur during early stance in gait.
L. Cristofolini (1995)
Der Schenkenholsbruck, em mechanisches Problem
F. Pauwels (1935)
Femoral fracture load and failure energy in two load configurations: an in vitro study
L. Duchemin (2006)
10.1016/S8756-3282(01)00621-4
Mechanical strength of the proximal femur as predicted from geometric and densitometric bone properties at the lower limb versus the distal radius.
E. Lochmüller (2002)
10.1007/s001980050104
Correlation of Femoral and Lumbar DXA and Calcaneal Ultrasound, Measured In Situ with Intact Soft Tissues, with the In Vitro Failure Loads of the Proximal Femur
E. Lochmüller (1998)
Epidemiology of Hip Fractures Among the Elderly: Risk Factors for Fracture Type
J. Michelson (1995)
The proximal end of the femur: investigations with special reference to the etiology of femoral neck fractures; anatomical studies; roentgen projections; theoretical stress calculations; experimental production of fractures.
S. Backman (1957)
10.1097/01.blo.0000164400.37905.22
Predicting Proximal Femoral Strength Using Structural Engineering Models
J. Keyak (2005)
10.1016/S0736-0266(00)00046-2
Effect of force direction on femoral fracture load for two types of loading conditions
J. Keyak (2001)
10.1007/s007740050072
Fracture simulation of the femoral bone using the finite-element method: How a fracture initiates and proceeds
T. Ota (1999)
10.1016/J.MEDENGPHY.2005.02.001
Anatomical hip model for the mechanical testing of hip protectors.
S. Derler (2005)
Bone mineral content.
Bell Rl (1976)
10.1359/JBMR.050211
Revival of Bone Strength: The Bottom Line
T. Järvinen (2005)
10.1016/S1350-4533(03)00138-3
An improved method for the automatic mapping of computed tomography numbers onto finite element models.
F. Taddei (2004)
10.1097/00003086-198802000-00035
Bone mineral content and mechanical strength. An ex vivo study on human femora at autopsy.
A. Alho (1988)
10.1097/00003086-199210000-00034
Proximal femoral bone density and its correlation to fracture load and hip-screw penetration load.
M. D. Smith (1992)
10.1016/S0140-6736(05)66870-5
Relation between age, femoral neck cortical stability, and hip fracture risk
Paul M. Mayhew (2005)
10.1016/S0021-9290(03)00191-X
Comparative in vitro study on the long term performance of cemented hip stems: validation of a protocol to discriminate between "good" and "bad" designs.
L. Cristofolini (2003)
10.1359/JBMR.0301247
Reproducibility and Side Differences of Mechanical Tests for Determining the Structural Strength of the Proximal Femur
F. Eckstein (2004)



This paper is referenced by
prediction of proximal femur fracture : finite element modeling based on mechanical damage and experimental validation
A. Bettamer (2013)
10.4028/WWW.SCIENTIFIC.NET/AMR.998-999.214
Computational Modeling of the Patient-Specific Femoral Head before and after the Treatment
Yu Mei (2014)
10.1007/s10237-017-0996-1
Plausibility and parameter sensitivity of micro-finite element-based joint load prediction at the proximal femur
Alexander Synek (2018)
10.2170/physiolsci.RP009908
The Virtual Physiological Human - a European initiative for in silico human modelling -.
M. Viceconti (2008)
10.1016/j.jbiomech.2014.12.010
In vitro evidence of the structural optimization of the human skeletal bones.
L. Cristofolini (2015)
10.1016/j.medengphy.2018.07.016
Rate and age-dependent damage elasticity formulation for efficient hip fracture simulations.
C. C. Villette (2018)
10.1111/J.1475-1305.2008.00500.X
A Method to Improve Experimental Validation of Finite-Element Models of Long Bones
M. Juszczyk (2008)
10.1007/s10439-013-0864-9
A Robust 3D Finite Element Simulation of Human Proximal Femur Progressive Fracture Under Stance Load with Experimental Validation
R. Hambli (2013)
10.1243/09544119JEIM470
Stress shielding and stress concentration of contemporary epiphyseal hip prostheses
Luca Cristofolini (2009)
10.3109/17453674.2012.678804
Experimental evaluation of new concepts in hip arthroplasty
T. Wik (2012)
10.1007/s10237-019-01233-2
Influence of femoral external shape on internal architecture and fracture risk
C. C. Villette (2019)
10.1016/j.clinbiomech.2008.01.009
Multiscale modelling of the skeleton for the prediction of the risk of fracture.
M. Viceconti (2008)
10.1159/000240045
Osteon Classification in Human Fibular Shaft by Circularly Polarized Light
A. Beraudi (2009)
10.1097/TA.0b013e3181e99ff1
Biomechanical evaluation for mechanisms of periprosthetic femoral fractures.
M. Rupprecht (2011)
10.1016/j.injury.2012.03.032
Biomechanical femoral neck fracture experiments--a narrative review.
Trude Basso (2012)
10.1080/23335432.2015.1117395
The use of digital image correlation in the biomechanical area: a review
M. Palanca (2016)
10.1016/J.PROENG.2013.07.051
Simulation based upon medical data offers a fast and robust method for the prediction of fracture risk
Nicholas J. Emerson (2013)
10.1016/J.RECOTE.2018.05.004
Experimental validation of finite elements model in hip fracture and its clinical applicability.
Ricardo Larraínzar-Garijo (2019)
10.1038/s41598-019-46739-y
QCT-based finite element prediction of pathologic fractures in proximal femora with metastatic lesions
E. Benca (2019)
10.1243/09544119JEIM278
In-vitro method for assessing femoral implant—bone micromotions in resurfacing hip implants under different loading conditions
L. Cristofolini (2007)
10.1016/j.jbiomech.2011.11.048
Are spontaneous fractures possible? An example of clinical application for personalised, multiscale neuro-musculo-skeletal modelling.
M. Viceconti (2012)
10.1016/j.arthro.2018.03.036
Mechanical Strength of the Proximal Femur After Arthroscopic Osteochondroplasty for Femoroacetabular Impingement: Finite Element Analysis and 3-Dimensional Image Analysis.
M. Oba (2018)
10.1016/J.JBIOMECH.2007.09.009
Subject-specific finite element models implementing a maximum principal strain criterion are able to estimate failure risk and fracture location on human femurs tested in vitro.
E. Schileo (2008)
10.1111/STR.12029
Patient-Specific Finite Element Modelling and Validation of Porcine Femora in Torsion
Nicholas J. Emerson (2013)
Development of a computational approach to assess hip fracture and repair: Considerations of intersubject and surgical alignment variability
A. Ali (2013)
10.1016/j.medengphy.2013.04.008
DXA predictions of human femoral mechanical properties depend on the load configuration.
E. Dallara (2013)
10.1007/978-1-4419-1788-1_184
Anatomical Reference Frames for Long Bones: Biomechanical Applications
Luca Cristofolini (2012)
10.1016/j.cmpb.2017.11.007
Fully automated segmentation of a hip joint using the patient-specific optimal thresholding and watershed algorithm
Jung Jin Kim (2018)
10.1007/s10237-010-0200-3
A nonlocal constitutive model for trabecular bone softening in compression
M. Charlebois (2010)
10.1109/MPUL.2015.2428682
Moving Along: In biomechanics, rehabilitation engineering, and movement analysis, Italian researchers are making great strides.
Eugenio Gugliellmelli (2015)
10.1016/J.RECOT.2018.05.006
Validación experimental de un modelo de análisis de elementos finitos en fractura de cadera y su aplicabilidad clínica
Ricardo Larraínzar-Garijo (2019)
10.1016/j.medengphy.2017.11.002
Validation of an alignment method using motion tracking system for in-vitro orientation of cadaveric hip joints with reduced set of anatomical landmarks.
S. Bsat (2018)
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