Biomechanical Modeling To Improve Coronary Artery Bifurcation Stenting: Expert Review Document On Techniques And Clinical Implementation.
A. Antoniadis, P. Mortier, G. Kassab, G. Dubini, N. Foin, Y. Murasato, A. Giannopoulos, S. Tu, Kiyotaka Iwasaki, Y. Hikichi, F. Migliavacca, C. Chiastra, J. Wentzel, F. Gijsen, J. Reiber, P. Barlis, P. Serruys, Deepak L. Bhatt, G. Stanković, E. Edelman, G. Giannoglou, Y. Louvard, Y. Chatzizisis
Published 2015 · Medicine
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Treatment of coronary bifurcation lesions remains an ongoing challenge for interventional cardiologists. Stenting of coronary bifurcations carries higher risk for in-stent restenosis, stent thrombosis, and recurrent clinical events. This review summarizes the current evidence regarding application and use of biomechanical modeling in the study of stent properties, local flow dynamics, and outcomes after percutaneous coronary interventions in bifurcation lesions. Biomechanical modeling of bifurcation stenting involves computational simulations and in vitro bench testing using subject-specific arterial geometries obtained from in vivo imaging. Biomechanical modeling has the potential to optimize stenting strategies and stent design, thereby reducing adverse outcomes. Large-scale clinical studies are needed to establish the translation of pre-clinical findings to the clinical arena.
This paper references
Inhibition of Atherosclerosis Associated with Reduction of Arterial Intramural Stress in Rabbits
M. Thubrikar (1988)
Threedimensional modeling of double-stent techniques at the left main coronary artery bifurcation using micro-focus X-ray computed tomography. Catheter Cardiovasc Interv 2007;70:211–20
Y Murasato (2007)
Tools & techniques clinical: optimising stenting strategy in bifurcation lesions with insights from in vitro bifurcation models.
N. Foin (2013)
Static circumferential tangential modulus of human atherosclerotic tissue.
H. Loree (1994)
Finite Element Analysis of the Implantation of a Self-Expanding Stent: Impact of Lesion Calcification
Shijia Zhao (2012)
Mis-sizing of stent promotes intimal hyperplasia: impact of endothelial shear and intramural stress.
H. Chen (2011)
Cardiology is fl ow
Y Richter (2006)
Hemodynamically Driven Stent Strut Design
J. M. Jiménez (2009)
The role of low endothelial shear stress in the conversion of atherosclerotic lesions from stable to unstable plaque
K. Koskinas (2009)
Consensus from the 7th European Bifurcation Club meeting.
G. Stankovic (2013)
Crush, culotte, T and protrusion: which 2-stent technique for treatment of true bifurcation lesions? - insights from in vitro experiments and micro-computed tomography.
N. Foin (2013)
Percutaneous coronary intervention for coronary bifurcation disease: consensus from the first 10 years of the European Bifurcation Club meetings.
J. Lassen (2014)
Final proximal post-dilatation is necessary after kissing balloon in bifurcation stenting.
N. Foin (2011)
Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance: Implications for the Management of Incomplete Stent Apposition
N. Foin (2014)
Modelling of the provisional side-branch stenting approach for the treatment of atherosclerotic coronary bifurcations: effects of stent positioning
D. Gastaldi (2010)
Stent Thrombogenicity Early in High-Risk Interventional Settings Is Driven by Stent Design and Deployment and Protected by Polymer-Drug Coatings
K. Kolandaivelu (2011)
Late thrombosis after double versus single drug-eluting stent in the treatment of coronary bifurcations: a meta-analysis of randomized and observational Studies.
M. Zimarino (2013)
New advances in cardiac computed tomography
P. G. Ramkumar (2009)
The influence of plaque composition on underlying arterial wall stress during stent expansion: the case for lesion-specific stents.
Ian Owens Pericevic (2009)
Lesion complexity determines arterial drug distribution after local drug delivery.
A. Tzafriri (2010)
Drug delivery patterns for different stenting techniques in coronary bifurcations: a comparative computational study
E. Cutri (2013)
Bench Testing of Coronary Bifurcation Stenting Techniques: How Is It Done? Does It Help Technical Decision Making?
Y. Murasato (2010)
Is it safe to implant bioresorbable scaffolds in ostial side-branch lesions? Impact of 'neo-carina' formation on main-branch flow pattern. Longitudinal clinical observations.
A. Karanasos (2015)
Double Versus Single Stenting for Coronary Bifurcation Lesions: A Meta-Analysis
D. Katritsis (2009)
Patient-specific computer modelling of coronary bifurcation stenting: the John Doe programme.
P. Mortier (2015)
Simulation of stent deployment in a realistic human coronary artery
Frank JH Gijsen (2008)
Geometrically correct three-dimensional optical coherence tomography: first self-expanding bifurcation stent evaluation.
A. Antoniadis (2013)
Accurate and reproducible reconstruction of coronary arteries and endothelial shear stress calculation using 3D OCT: comparative study to 3D IVUS and 3D QCA.
K. Toutouzas (2015)
Flow and atherosclerosis in coronary bifurcations.
G. Giannoglou (2010)
Pathological findings at bifurcation lesions: the impact of flow distribution on atherosclerosis and arterial healing after stent implantation.
G. Nakazawa (2010)
Optical Coherence Tomography for Patient-specific 3D Artery Reconstruction and Evaluation of Wall Shear Stress in a Left Circumflex Coronary Artery
L. Ellwein (2011)
Stent deformation, physical stress, and drug elution obtained with provisional stenting, conventional culotte and Tryton-based culotte to treat bifurcations: a virtual simulation study.
Stefano Morlacchi (2014)
Impact of local flow haemodynamics on atherosclerosis in coronary artery bifurcations.
Antonios P. Antoniadis (2015)
Spatial Distribution of Platelet Deposition in Stented Arterial Models Under Physiologic Flow
Nandini Duraiswamy (2005)
Consensus from the 5th European Bifurcation Club meeting.
D. Hildick-Smith (2010)
Recent perspective on coronary bifurcation intervention: statement of the "Bifurcation Club in KOKURA".
Yoshinobu Murasato (2010)
Computational fluid dynamics of stented coronary bifurcations studied with a hybrid discretization method
C. Chiastra (2012)
Mechanical properties of human atherosclerotic intima tissue.
A. Akyildiz (2014)
Changes in the mechanical environment of stenotic arteries during interaction with stents: computational assessment of parametric stent designs.
G. Holzapfel (2005)
Modeling Stented Coronary Arteries: Where We are, Where to Go
Stefano Morlacchi (2012)
Dynamic flow alterations dictate leukocyte adhesion and response to endovascular interventions.
Yoram Richter (2004)
Comparison of near-wall hemodynamic parameters in stented artery models.
Nandini Duraiswamy (2009)
Patient-specific computational haemodynamics: generation of structured and conformal hexahedral meshes from triangulated surfaces of vascular bifurcations
Gianluca De Santis (2011)
3D Modeling of Coronary Artery Bifurcations from CTA and Conventional Coronary Angiography
Rubén Cárdenes (2011)
Virtual bench testing to study coronary bifurcation stenting.
F. Migliavacca (2015)
Influence of residual stenosis after percutaneous coronary intervention with stent implantation on development of restenosis and stent thrombosis.
P. Sick (2003)
The "crush" technique for coronary artery bifurcation stenting: insights from micro-computed tomographic imaging of bench deployments.
J. Ormiston (2008)
Alterations in wall shear stress predict sites of neointimal hyperplasia after stent implantation in rabbit iliac arteries.
J. LaDisa (2005)
Fusion of 3D QCA and IVUS/OCT
S. Tu (2011)
Expansion of the Multi-Link Frontier™ Coronary Bifurcation Stent: Micro-Computed Tomographic Assessment in Human Autopsy and Porcine Heart Samples
S. Kralev (2011)
Accurate and reproducible reconstruction of coronary arteries and endothelial shear stress calculation using 3D OCT: comparative study to 3D IVUS and3DQCA. Atherosclerosis 2015;240:510–9
K Toutouzas (2015)
Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior.
Y. Chatzizisis (2007)
Environmental influences on endovascular stent platelet reactivity: an in vitro comparison of stainless steel and gold surfaces.
K. Kolandaivelu (2004)
Analysis of Side Branch Access During Bifurcation Stenting
P. Mortier (2008)
Effects of stent sizing on endothelial and vessel wall stress: potential mechanisms for in-stent restenosis.
H. Chen (2009)
Patient-specific simulations of stenting procedures in coronary bifurcations: two clinical cases.
Stefano Morlacchi (2013)
Provisional stenting of coronary bifurcations: insights into final kissing balloon post-dilation and stent design by computational modeling.
P. Mortier (2014)
Drug-Eluting Stents in Bifurcations: Bench Study of Strut Deformation and Coating Lesions
P. Guérin (2010)
Computer modelling of coronary bifurcation stenting
Peter Mortier (2010)
Medical 3D Printing for the Radiologist.
D. Mitsouras (2015)
Role of endothelial shear stress in stent restenosis and thrombosis: pathophysiologic mechanisms and implications for clinical translation.
K. Koskinas (2012)
Micro-computed tomographic assessment following extremely oversized partial postdilatation of drug-eluting stents.
M. Z. Basalus (2010)
Cardiology is flow.
Yoram Richter (2006)
The effect of flow and mass transport in thrombogenesis
D. Basmadjian (1990)
Impact of stent overlap on angiographic and long-term clinical outcome in patients undergoing drug-eluting stent implantation.
L. Räber (2010)
In-vivo validation of spatially correct three-dimensional reconstruction of human coronary arteries by integrating intravascular ultrasound and biplane angiography
G. Giannoglou (2006)
Kissing balloon or sequential dilation of the side branch and main vessel for provisional stenting of bifurcations: lessons from micro-computed tomography and computational simulations.
N. Foin (2012)
Drug-eluting stents for coronary bifurcations: bench testing of provisional side-branch strategies. Catheter Cardiovasc Interv 2006;67:49–55
JA Ormiston (2006)
Computational structural modelling of coronary stent deployment: a review
David Mingot Martín (2011)
Location of side branch access critically affects results in bifurcation stenting: Insights from bench modeling and computational flow simulation.
N. Foin (2013)
Optimal kissing balloon inflation after single-stent deployment in a coronary bifurcation model.
Y. Murasato (2014)
Examination of stent deformation and gap formation after complex stenting of left main coronary artery bifurcations using microfocus computed tomography.
Y. Murasato (2009)
A Rapid and Computationally Inexpensive Method to Virtually Implant Current and Next-Generation Stents into Subject-Specific Computational Fluid Dynamics Models
Timothy J. Gundert (2010)
Randomized Study to Evaluate Sirolimus-Eluting Stents Implanted at Coronary Bifurcation Lesions
A. Colombo (2004)
Sequential structural and fluid dynamic numerical simulations of a stented bifurcated coronary artery.
Stefano Morlacchi (2011)
Three‐dimensional modeling of double‐stent techniques at the left main coronary artery bifurcation using micro‐focus X‐ray computed tomography
Y. Murasato (2007)
In vivo flow simulation at coronary bifurcation reconstructed by fusion of 3-dimensional X-ray angiography and optical coherence tomography.
S. Tu (2013)
Computational fluid dynamic simulations of image-based stented coronary bifurcation models
C. Chiastra (2013)
Drug‐eluting stents for coronary bifurcations: Bench testing of provisional side‐branch strategies
J. Ormiston (2006)
domized study to evaluate sirolimus - eluting stents implanted at coronary bifurcation lesions
A Colombo (2004)
Predicting response to endovascular therapies: dissecting the roles of local lesion complexity, systemic comorbidity, and clinical uncertainty.
K. Kolandaivelu (2014)
Comparison of drug-eluting stent cell size using micro-CT: important data for bifurcation stent selection.
P. Mortier (2008)
Biomechanical considerations in the design of graft: the homeostasis hypothesis.
G. Kassab (2006)
Stent deformation following simulated side‐branch dilatation: A comparison of five stent designs
J. Ormiston (1999)
Usefulness of shear stress pattern in predicting neointima distribution in sirolimus-eluting stents in coronary arteries.
F. Gijsen (2003)
Predicting neointimal hyperplasia in stented arteries using time-dependant computational fluid dynamics: A review
J. Murphy (2010)
IVUS Validation of Patient Coronary Artery Lumen Area Obtained from CT Images
T. Luo (2014)
Optical coherence tomography for guidance of distal cell recrossing in bifurcation stenting: choosing the right cell matters.
E. Alegría-Barrero (2012)
This paper is referenced by
A framework for computational fluid dynamic analyses of patient-specific stented coronary arteries from optical coherence tomography images.
S. Migliori (2017)
Applications of 3D printing in cardiovascular diseases
A. Giannopoulos (2016)
Clinical outcome after percutaneous coronary intervention with drug-eluting stent in bifurcation and nonbifurcation lesions: a meta-analysis of 23 981 patients
F. Burzotta (2020)
In vivo and in vitro evaluation of a biodegradable magnesium vascular stent designed by shape optimization strategy.
Chenxin Chen (2019)
Understanding the role of non-coding RNA (ncRNA) in stent restenosis.
Shaoyan Liu (2018)
Bifurcation Lesion Stenting
Y. Louvard (2016)
An in silico biomechanical analysis of the stent–esophagus interaction
Mathias Peirlinck (2018)
Effects of bifurcation-specific and conventional stents on coronary bifurcation flow. An experimental and numerical study.
Jorge García García (2017)
Histopathologic and physiologic effect of bifurcation stenting: current status and future prospects
A. Cornelissen (2020)
Percutaneous coronary intervention in left main coronary artery disease: the 13th consensus document from the European Bifurcation Club.
F. Burzotta (2018)
Application of Patient-Specific Computational Fluid Dynamics in Coronary and Intra-Cardiac Flow Simulations: Challenges and Opportunities
L. Zhong (2018)
Biomechanical Impact of Wrong Positioning of a Dedicated Stent for Coronary Bifurcations: A Virtual Bench Testing Study
Claudio Chiastra (2018)
Characteristics of stent thrombosis in bifurcation lesions analysed by optical coherence tomography.
Mohamed Yahya Bechiri (2018)
Percutaneous coronary interventions of bifurcation lesions
Maik J Grundeken (2016)
Reversal of flow between serial bifurcation lesions: insights from computational fluid dynamic analysis in a population-based phantom model.
P. Barlis (2015)
Modified Stent Design for a Coronary Bifurcation Lesion
Abigail Nowell (2020)
Microstructure-based biomechanics of coronary arteries in health and disease.
Huan Chen (2016)
A review on the biomechanics of coronary arteries
H. J. Carpenter (2020)
The Impact of the Geometric Characteristics on the Hemodynamics in the Stenotic Coronary Artery
Changnong Peng (2016)
Behaviour of two typical stents towards a new stent evolution
Mariana Simão (2016)
Unraveling Endothelial Cell Phenotypic Regulation By Spatial Hemodynamic Flows With Microfluidics
Sarvesh Varma (2020)
Computational Fluid Modeling to Understand the Role of Anatomy in Bifurcation Lesion Disease
Madhurima Vardhan (2018)
Elucidating the role of graft compliance mismatch on intimal hyperplasia using an ex vivo organ culture model.
Allison Post (2019)
A fully coupled computational fluid dynamics - agent-based model of atherosclerotic plaque development: Multiscale modeling framework and parameter sensitivity analysis
Anna Corti (2020)
Contemporary techniques in percutaneous coronary intervention for bifurcation lesions
Carlos A. Collet (2018)
POLITECNICO DI TORINO Repository ISTITUZIONALE A framework for computational fluid dynamic analyses of patient-specific stented coronary arteries from optical coherence tomography
Claudio Chiastra ()
Location-Specific Comparison Between a 3D In-Stent Restenosis Model and Micro-CT and Histology Data from Porcine In Vivo Experiments
P. Zun (2019)
Stents: Biomechanics, Biomaterials, and Insights from Computational Modeling
G. Karanasiou (2017)
Computational Fluid Dynamics Simulations with Applications in Virtual Reality Aided Health Care Diagnostics
Vishwanath Panwar (2020)
Impact of guidewire recrossing point into stent jailed side branch for optimal kissing balloon dilatation: core lab 3D optical coherence tomography analysis.
Takayuki Okamura (2018)
Differences in rotational positioning and subsequent distal main branch rewiring of the Tryton stent: An optical coherence tomography and computational study
M. Grundeken (2018)
NUMERICAL ANALYSIS OF BALLOON EXPANDABLE STENT DEPLOYMENT INSIDE A PATIENT-SPECIFIC STENOTIC CORONARY ARTERY TO INVESTIGATE THE INSTANT MECHANICAL BEHAVIORS
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