Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Single-component Solid Lipid Nanocarriers Prepared With Ultra-long Chain Amphiphilic Lipids.

W. Wei, X. Lu, Z. Wang, B. Pérez, Jingying Liu, Chengyu Wu, M. Dong, Fengqin Feng, H. Mu, Zheng Guo
Published 2017 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
HYPOTHESIS Synthetic sugar alcohol mono-behenates with high melting points, surface activity and resistance to enzymatic lipolysis, are expected to form stable single-component solid lipid nanocarriers (SC-SLNs). The preparation methods and the polar head group of the molecules should affect the size and drug encapsulation efficiency. EXPERIMENTS SC-SLNs of sugar alcohol mono-behenates with varied polar heads were prepared using emulsification-diffusion method and melting-probe sonication method. Model lipophilic drug fenofibrate was formulated into nanocarriers. The drug release was assessed using the lipolysis model. The structure and drug distribution of the nanocarriers were studied using AFM and TEM. FINDINGS Both the polar head group of the molecules and the preparation methods affect the particle size and size distribution. Nanocarriers prepared with sorbitol mono-behenates showed the smallest mean size (∼100nm with PdI of 0.26). In addition, they displayed high entrapment efficiency of fenofibrate (95%) and long term drug release. Nanocarriers prepared by emulsification-diffusion method entrapped fenofibrate into lipid bilayers. In contrast, Nanocarriers prepared by melting-probe sonication method had a micelle structure with fenofibrate incorporated into a lipid monolayer. This study provides an insight into the systematic development of novel amphiphilic lipids for solid lipid-based drug delivery system.
This paper references
Synthesis and optimization of ceftriaxone-loaded solid lipid nanocarriers.
S. Kumar (2016)
Solid lipid based nanocarriers: An overview / Nanonosači na bazi čvrstih lipida: Pregled
C. Pardeshi (2012)
Influence of process and formulation parameters on the formation of submicron particles by solvent displacement and emulsification-diffusion methods critical comparison.
C. E. Mora-Huertas (2011)
Atomic Force Microscopy Studies of Solid Lipid Nanoparticles
A. Mühlen (2004)
Nanocarrier systems for oral drug delivery: do we really need them?
A. Bernkop-Schnürch (2013)
Effect of lipid core material on characteristics of solid lipid nanoparticles designed for oral lymphatic delivery.
Rishi Paliwal (2009)
Surfactant systems: their use in drug delivery
M. Lawrence (1994)
Impact of surfactant properties on oxidative stability of beta-carotene encapsulated within solid lipid nanoparticles.
T. Helgason (2009)
Enzymatic Degradation of Dynasan 114 SLN – Effect of Surfactants and Particle Size
C. Olbrich (2002)
Lipophilic prodrugs of apomorphine I: preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media.
Nrupa Borkar (2015)
Preparation, characterization and physico-chemical properties of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC): their benefits as colloidal drug carrier systems.
Melike Üner (2006)
In Vitro Digestion of the Self-Emulsifying Lipid Excipient Labrasol® by Gastrointestinal Lipases and Influence of its Colloidal Structure on Lipolysis Rate
S. Fernandez (2013)
FA-loaded lipid drug delivery systems: preparation, characterization and biological studies.
C. Carbone (2014)
New approach for the preparation of nanoparticles by an emulsification-diffusion method
J. Leroux (1995)
Lipid nanocapsules: a new platform for nanomedicine.
N. Huynh (2009)
Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN)--effect of surfactants, storage time and crystallinity.
C. Olbrich (2002)
Preparation and characterization of solid lipid nanoparticles containing cyclosporine by the emulsification-diffusion method
Z. Urbán-Morlán (2010)
A comparison of atomic force microscopy (AFM) and dynamic light scattering (DLS) methods to characterize nanoparticle size distributions
C. Hoo (2008)
Influence of emulsifiers on the crystallization of solid lipid nanoparticles.
H. Bunjes (2003)
Solid lipid nanoparticles from amphiphilic calixpyrroles.
Kaisa Helttunen (2016)
Enzymatic degradation of SLN-effect of surfactant and surfactant mixtures.
C. Olbrich (1999)
Surface tensions of aqueous solutions of 1-O-monoacyl sugar alcohols
J. Piao (2006)
Influence of co-surfactants on crystallization and stability of solid lipid nanoparticles.
H. Salminen (2014)
Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating
Cung An Nguyen (2008)
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
R. Mueller (2002)
Toward surfactant-free and water-free microemulsions.
V. Fischer (2015)
Synthetic ultra-long chain fatty acyl based amphiphilic lipids as a dual function excipient for the production of surfactant-free solid lipid nanoparticles (SF-SLNs): a physico-chemical study
W. Wei (2016)
Effect of surfactant surface coverage on formation of solid lipid nanoparticles (SLN).
T. Helgason (2009)
Calculation of hydrophile-lipophile balance for polyethoxylated surfactants by group contribution method.
Xiaowen Guo (2006)
Surfactant-free emulsions
T. Sakai (2008)
Influence of Surfactant and Lipid Type on the Physicochemical Properties and Biocompatibility of Solid Lipid Nanoparticles
C. D. Pizzol (2014)
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
R. Mueller (2000)
Degradable, Surfactant-Free, Monodisperse Polymer-Encapsulated Emulsions as Anticancer Drug Carriers
S. Sivakumar (2009)
Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium.
Nrupa Borkar (2014)
Formulation of solid lipid nanoparticles (SLN): the value of different alkyl polyglucoside surfactants.
C. Keck (2014)
Solid lipid-based nanocarriers as efficient targeted drug and gene delivery systems
J. E. N. Dolatabadi (2016)
Surfactant, but not the size of solid lipid nanoparticles (SLN) influences viability and cytokine production of macrophages.
N. Schöler (2001)
Biocatalytic synthesis of ultra-long-chain fatty acid sugar alcohol monoesters
W. Wei (2015)
Influence of surfactants on the physical stability of solid lipid nanoparticle (SLN) formulations.
M. Uner (2004)
Coadsorption of HIV-1 p24 and gp120 proteins to surfactant-free anionic PLA nanoparticles preserves antigenicity and immunogenicity.
Delphine Lamalle-Bernard (2006)
Comparative surface activities of di- and trisaccharide fatty acid esters
Manuel Ferrer (2002)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar