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Chitosan-based Drug Nanocarriers: Where Do We Stand?

M. Garcia-Fuentes, M. Alonso
Published 2012 · Medicine

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Chitosan-based nanocarriers have become one of the most intensively studied transmucosal nanometric drug delivery platforms. This is due to a number of factors, including their simple and mild preparation technique as well as their capacity to associate macromolecules and facilitate their transport across mucosal barriers. In this review, we first describe our contribution to the origin of chitosan nanocarriers in the mid 90s, and summarize the early work that has impacted the development of this delivery technology. Secondly, we present our perspective regarding the potential of chitosan nanocarriers for some relevant applications: (i) vaccination, (ii) transmucosal protein delivery and (iii) gene therapy. Finally, we offer our perspective on the plausible advances in this area in the near future.
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10.1016/J.CARBPOL.2019.115004
Advances in chitosan-based nanoparticles for oncotherapy.
E. Zhang (2019)
10.1039/C5TB00431D
Factors affecting the stability of chitosan/tripolyphosphate micro- and nanogels: resolving the opposing findings.
Yan Huang (2015)
10.1088/1361-6528/aa5188
Characterization of Gd loaded chitosan-TPP nanohydrogels by a multi-technique approach combining dynamic light scattering (DLS), asymetrical flow-field-flow-fractionation (AF4) and atomic force microscopy (AFM) and design of positive contrast agents for molecular resonance imaging (MRI).
G. Rigaux (2017)
10.1021/acs.biomac.7b00668
Synthesis and Characterization of PEGylated and Fluorinated Chitosans: Application to the Synthesis of Targeted Nanoparticles for Drug Delivery.
Yamina Belabassi (2017)
10.1115/1.4030899
Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents.
M. Goldberg (2014)
10.1016/J.COCIS.2016.12.003
Protein–polysaccharide associative interactions in the design of tailor-made colloidal particles
M. Semenova (2017)
10.1016/j.nut.2016.05.001
Selenium nanoparticles as a nutritional supplement.
S. Skalickova (2017)
10.1007/s13762-013-0358-1
Poly(ε-caprolactone) nanocapsules carrying the herbicide atrazine: effect of chitosan-coating agent on physico-chemical stability and herbicide release profile
R. Grillo (2013)
10.1016/j.jcis.2017.01.066
Analysis of chitosan/tripolyphosphate micro- and nanogel yields is key to understanding their protein uptake performance.
Yuhang Cai (2017)
10.1016/j.addr.2013.07.005
Chitosans for delivery of nucleic acids☆
M. Buschmann (2013)
10.1021/acsnano.8b09679
Delivery of MicroRNAs by Chitosan Nanoparticles to Functionally Alter Macrophage Cholesterol Efflux in Vitro and in Vivo.
My-anh nguyen (2019)
10.1016/B978-1-78242-086-6.00007-8
Functionalization of marine materials for drug delivery systems
Serap Şenel (2015)
10.5772/52704
Non-Viral Delivery Systems in Gene Therapy
A. R. Gascón (2013)
10.1016/j.biotechadv.2015.05.010
Nanoengineering of vaccines using natural polysaccharides
A. S. Cordeiro (2015)
10.1016/J.IFSET.2017.07.002
Comparative study of the structural and physicochemical properties of two food derived antihypertensive tri-peptides, Isoleucine-Proline-Proline and Leucine-Lysine-Proline encapsulated into a chitosan based nanoparticle system
Minna K. Danish (2017)
10.2217/nnm-2019-0459
HER-2/neu and MYC gene silencing in breast cancer: therapeutic potential and advancement in nonviral nanocarrier systems.
Jananee Padayachee (2020)
10.1016/j.ijbiomac.2016.01.042
Chitosan-tripolyphosphate nanoparticles: Optimization of formulation parameters for improving process yield at a novel pH using artificial neural networks.
Rania A Hashad (2016)
10.4314/TJPR.V12I1.3
Formulation and Evaluation of Bupivacaine-Loaded Glutaraldehyde-Crosslinked High Molecular Weight Chitosan Microspheres
M. Shivashankar (2013)
Nanoparticles: An Advance Technique for Drug Delivery
Kuldeep Malodia (2012)
10.1007/978-1-4614-9164-4_6
The Potential of Nanoemulsions in Biomedicine
M. Mazza (2013)
10.1016/j.ejps.2019.02.015
Cromolyn‐crosslinked chitosan nanoparticles for the treatment of allergic rhinitis
A. Abruzzo (2019)
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