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Recent Advances In Nanocarrier-based Mucosal Delivery Of Biomolecules.
Olga Kammona, C. Kiparissides
Published 2012 · Medicine
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This review highlights the recent developments in the area of nanocarrier-based mucosal delivery of therapeutic biomolecules and antigens. Macromolecular drugs have the unique power to tackle challenging diseases but their structure, physicochemical properties, stability, pharmacodynamics, and pharmacokinetics place stringent demands on the way they are delivered into the body (e.g., inability to cross mucosal surfaces and biological membranes). Carrier-based drug delivery systems can diminish the toxicity of therapeutic biomolecules, improve their bioavailability and make possible their administration via less-invasive routes (e.g., oral, nasal, pulmonary, etc.). Thus, the development of functionalized nanocarriers and nanoparticle-based microcarriers for the delivery of macromolecular drugs is considered an important scientific challenge and at the same time a business breakthrough for the biopharmaceutical industry. In order to be translated to the clinic the nanocarriers need to be biocompatible, biodegradable, stable in biological media, non-toxic and non-immunogenic, to exhibit mucoadhesive properties, to cross mucosal barriers and to protect their sensitive payload and deliver it to its target site in a controlled manner, thus increasing significantly its bioavailability and efficacy.
This paper references
Oral and subcutaneous absorption of insulin poly(isobutylcyanoacrylate) nanoparticles.
M. S. Mesiha (2005)
The Impact of Vehicles on the Mucoadhesive Properties of Orally Administrated Nanoparticles: a Case Study with Chitosan-4-Thiobutylamidine Conjugate
D. Sakloetsakun (2010)
TMC-MCC (N-trimethyl chitosan-mono-N-carboxymethyl chitosan) nanocomplexes for mucosal delivery of vaccines.
B. Sayin (2009)
PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration.
Armando Stano (2011)
Surface modified liposomes for nasal delivery of DNA vaccine.
K. Khatri (2008)
Intranasal Immunization with Chitosan/pCAGGS-flaA Nanoparticles Inhibits Campylobacter jejuni in a White Leghorn Model
J. Huang (2010)
Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives.
R. C. Mundargi (2008)
Depot formulation of vasoactive intestinal peptide by protamine-based biodegradable nanoparticles.
K. Wernig (2008)
Preparation of alginate coated chitosan microparticles for vaccine delivery
X. Li (2008)
Solid lipid nanoparticles for pulmonary delivery of insulin.
J. Liu (2008)
Peroral route: an opportunity for protein and peptide drug delivery.
A. Sood (2001)
Self-double-emulsifying drug delivery system (SDEDDS): a new way for oral delivery of drugs with high solubility and low permeability.
X. Qi (2011)
Mono-N-carboxymethyl chitosan (MCC) and N-trimethyl chitosan (TMC) nanoparticles for non-invasive vaccine delivery.
B. Sayin (2008)
Palatal mucosa as a route for systemic drug delivery: A review.
P. Shakya (2011)
Preparation of nanoparticles by the self-organization of polymers consisting of hydrophobic and hydrophilic segments: Potential applications
T. Akagi (2007)
Preparation and Characterization of Innovative Protein-coated Poly(Methylmethacrylate) Core-shell Nanoparticles for Vaccine Purposes
R. Voltan (2007)
Nanoparticles for nasal vaccination.
N. Csaba (2009)
Nanocarrier Aided Nasal Vaccination: An Experimental and Computational Approach
Olga Kammona (2011)
RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system.
K. Howard (2006)
Nanoparticulate systems for nasal delivery of drugs: a real improvement over simple systems?
L. Illum (2007)
Nasal Delivery of High Molecular Weight Drugs
Y. Ozsoy (2009)
Immune response by nasal delivery of hepatitis B surface antigen and codelivery of a CpG ODN in alginate coated chitosan nanoparticles.
O. Borges (2008)
Plasmid DNA loaded chitosan nanoparticles for nasal mucosal immunization against hepatitis B.
Kapil Khatri (2008)
Nasal immunization studies using liposomes loaded with tetanus toxoid and CpG-ODN.
M. Tafaghodi (2006)
Investigation of lectinized liposomes as M-cell targeted carrier-adjuvant for mucosal immunization.
P. Gupta (2011)
Developing macromolecular therapeutics: the future drug-of-choice
Huining He (2010)
PEG-PLA-PEG block copolymeric nanoparticles for oral immunization against hepatitis B.
A. K. Jain (2010)
Alginate/Chitosan Nanoparticles are Effective for Oral Insulin Delivery
B. Sarmento (2007)
Liposomal vasoactive intestinal peptide for lung application: protection from proteolytic degradation.
B. Stark (2008)
Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery.
F. Cui (2007)
Lipid carriers: a versatile delivery vehicle for proteins and peptides.
M. Rawat (2008)
Chitosan nanoparticle as gene therapy vector via gastrointestinal mucosa administration: results of an in vitro and in vivo study.
Fang Zheng (2007)
Nanosized insulin-complexes based on biodegradable amine-modified graft polyesters poly[vinyl-3-(diethylamino)-propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)]-graft-poly(L-lactic acid): protection against enzymatic degradation, interaction with Caco-2 cell monolayers, peptide transport and cy
M. Simon (2007)
Protein direct delivery to dendritic cells using nanoparticles based on amphiphilic poly(amino acid) derivatives.
T. Akagi (2007)
Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin.
N. Zhang (2006)
Past, present, and future technologies for oral delivery of therapeutic proteins.
R. Singh (2008)
Multi-functional nanocarriers for targeted delivery of drugs and genes.
L. Jabr-Milane (2008)
Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform
B. Baudner (2005)
Recent advances in the development of novel mucosal adjuvants and antigen delivery systems
Wangxue Chen (2010)
Mucosal immunosenescence: new developments and vaccines to control infectious diseases.
K. Fujihashi (2009)
Transmucosal macromolecular drug delivery.
C. Prego (2005)
Engineering biodegradable polyester particles with specific drug targeting and drug release properties.
F. Mohamed (2008)
Enhanced antigen-specific primary CD4+ and CD8+ responses by codelivery of ovalbumin and toll-like receptor ligand monophosphoryl lipid A in poly(D,L-lactic-co-glycolic acid) nanoparticles.
S. Hamdy (2007)
Development of a Novel Method for the Preparation of Thiolated Polyacrylic Acid Nanoparticles
M. Greindl (2006)
Helodermin-loaded nanoparticles: characterization and transport across an in vitro model of the follicle-associated epithelium.
A. des Rieux (2007)
Synthesis, characterization and evaluation of novel triblock copolymer based nanoparticles for vaccine delivery against hepatitis B.
A. K. Jain (2009)
Development and characterization of new insulin containing polysaccharide nanoparticles.
B. Sarmento (2006)
Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of protein drugs: III. In vivo oral absorption study.
S. V. R. Rao (2008)
Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery.
Abdallah Makhlof (2011)
Effective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier.
A. Jain (2008)
Pluronic F127 enhances the effect as an adjuvant of chitosan microspheres in the intranasal delivery of Bordetella bronchiseptica antigens containing dermonecrotoxin.
M. L. Kang (2007)
Preparation and characterization of mucoadhesive polymer-coated nanoparticles.
Fuying Cui (2006)
PLA-PEG particles as nasal protein carriers: the influence of the particle size.
A. Vila (2005)
A new intranasal influenza vaccine based on a novel polycationic lipid--ceramide carbamoyl-spermine (CCS) I. Immunogenicity and efficacy studies in mice.
A. Joseph (2006)
Defending the mucosa: adjuvant and carrier formulations for mucosal immunity.
L. Lawson (2011)
Association of vasoactive intestinal peptide with polymer-grafted liposomes: structural aspects for pulmonary delivery.
B. Stark (2007)
Lipid microparticles for mucosal immunization against hepatitis B.
Surbhi Saraf (2006)
Probing insulin's secondary structure after entrapment into alginate/chitosan nanoparticles.
B. Sarmento (2007)
Mechanistic study of the adjuvant effect of biodegradable nanoparticles in mucosal vaccination.
B. Slütter (2009)
Melatonin-loaded lecithin/chitosan nanoparticles: physicochemical characterisation and permeability through Caco-2 cell monolayers.
A. Hafner (2009)
Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery.
Lichen Yin (2009)
Diphtheria toxoid loaded poly-(ε-caprolactone) nanoparticles as mucosal vaccine delivery systems
J. Singh (2006)
Thiomers: preparation and in vitro evaluation of a mucoadhesive nanoparticulate drug delivery system.
A. Bernkop-Schnürch (2006)
Therapeutic application of peptides and proteins: parenteral forever?
Zuzana Antošová (2009)
Chitosan nanoparticle-loaded mannitol microspheres: structure and surface characterization.
A. Grenha (2007)
PLGA:poloxamer and PLGA:poloxamine blend nanostructures as carriers for nasal gene delivery.
N. Csaba (2006)
Rational design of nasal vaccines
B. Slütter (2008)
Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transferrin conjugates.
Nikhil J. Kavimandan (2006)
Pharmaceutical aspects of intranasal delivery of vaccines using particulate systems.
S. Sharma (2009)
New surface-modified lipid nanoparticles as delivery vehicles for salmon calcitonin.
M. Garcia-Fuentes (2005)
Novel Chitosan Particles and Chitosan-Coated Emulsions Inducing Immune Response via Intranasal Vaccine Delivery
Takahiro Nagamoto (2004)
Review articleThiolated chitosans
A. Bernkop-Schnürch (2004)
Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice.
A. Vila (2004)
Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption.
M. Rekha (2009)
Preparation and evaluation of self-nanoemulsified drug delivery systems (SNEDDSs) of matrine based on drug-phospholipid complex technique.
J. Ruan (2010)
Induction of systemic and mucosal immune responses by intranasal administration of alginate microspheres encapsulated with tetanus toxoid and CpG-ODN.
M. Tafaghodi (2006)
New approach on the development of a mucosal vaccine against strangles: Systemic and mucosal immune responses in a mouse model.
H. Florindo (2009)
Nanomedicine in pulmonary delivery
H. M. Mansour (2009)
Mucosal immunity and vaccines
J. Holmgren (2005)
Targeted Delivery of Immunogen to Primate M Cells with Tetragalloyl Lysine Dendrimer1
S. Misumi (2009)
Pharmaceutical and immunological evaluation of mucoadhesive nanoparticles based delivery system(s) administered intranasally.
S. Mangal (2011)
In vivo induction of mucosal immune responses by intranasal administration of chitosan microspheres containing Bordetella bronchiseptica DNT.
M. L. Kang (2006)
Evaluation of Bioadhesive Capacity and Immunoadjuvant Properties of Vitamin B12-Gantrez Nanoparticles
Hesham H. Salman (2008)
Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation.
F. Cui (2006)
Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats.
C. Damgé (2007)
Lectin-conjugated PLGA nanoparticles loaded with thymopentin: ex vivo bioadhesion and in vivo biodistribution.
Yashu Yin (2007)
Intranasal delivery: physicochemical and therapeutic aspects.
H. Costantino (2007)
In vitro and in vivo study of N-trimethyl chitosan nanoparticles for oral protein delivery.
Fu Chen (2008)
Improved bioavailability of orally delivered insulin using Eudragit-L30D coated PLGA microparticles
Pratap C. Naha (2008)
The enhancement of the immune response against S. equi antigens through the intranasal administration of poly-epsilon-caprolactone-based nanoparticles.
H. Florindo (2009)
Surface‐functionalized nanoparticles for targeted gene delivery across nasal respiratory epithelium
Sneha Sundaram (2009)
A mucoadhesive nanoparticulate system for the simultaneous delivery of macromolecules and permeation enhancers to the intestinal mucosa.
Abdallah Makhlof (2011)
Preparation and evaluation of lectin-conjugated PLGA nanoparticles for oral delivery of thymopentin.
Yashu Yin (2006)
New generation of hybrid poly/oligosaccharide nanoparticles as carriers for the nasal delivery of macromolecules.
D. Teijeiro-Osorio (2009)
Nanotechnology solutions for mucosal immunization.
S. Chadwick (2010)
Chitosan nanoparticles encapsulated vesicular systems for oral immunization: preparation, in‐vitro and in‐vivo characterization
S. Jain (2006)
Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs: I. Formulation development.
S. V. R. Rao (2008)
PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination.
M. Garinot (2007)
Preparation and physicochemical characterization of supercritically dried insulin-loaded microparticles for pulmonary delivery.
M. Amidi (2008)
The potential of mannosylated chitosan microspheres to target macrophage mannose receptors in an adjuvant-delivery system for intranasal immunization.
H. Jiang (2008)
Novel Approach for Delivery of Insulin Loaded Poly(lactide-co-glycolide) Nanoparticles Using a Combination of Stabilizers
P. S. Kumar (2007)
Thiomers: a new generation of mucoadhesive polymers.
A. Bernkop-Schnürch (2005)
Preparation and in vitro-in vivo evaluation of Witepsol H35 based self-nanoemulsifying drug delivery systems (SNEDDS) of coenzyme Q(10).
Pushp R Nepal (2010)
Uptake of microparticles into the epithelium of human nasopharyngeal lymphoid tissue
Y. Fujimura (2006)
Chitosan/cyclodextrin nanoparticles as macromolecular drug delivery system.
A. Krauland (2007)
Uptake studies in rat Peyer's patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles for mucosal vaccination.
O. Borges (2006)
Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives.
M. I. Ugwoke (2005)
Carrier-based strategies for targeting protein and peptide drugs to the lungs
Sally-Ann Cryan (2008)
Mechanisms of macromolecule absorption by the lungs
John S. Patton (1996)
Distribution, transition, adhesion and release of insulin loaded nanoparticles in the gut of rats.
Ming-guang Li (2007)
Distribution of thiolated mucoadhesive nanoparticles on intestinal mucosa.
S. Dünnhaupt (2011)
In vivo evidence of oral vaccination with PLGA nanoparticles containing the immunostimulant monophosphoryl lipid A.
Federica Sarti (2011)
Optimized Formulation of High-Payload PLGA Nanoparticles Containing Insulin–Lauryl Sulfate Complex
K. Shi (2009)
Preparation, characterization and transfection efficiency of cationic PEGylated PLA nanoparticles as gene delivery systems.
J. Chen (2007)
Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system.
M. Amidi (2006)
Cyclodextrin-insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery.
S. Sajeesh (2006)
Protective immunity in rats by intranasal immunization with Streptococcus mutans glucan-binding protein D encapsulated into chitosan-coated poly(lactic-co-glycolic acid) microspheres
H. Zhao (2006)
Nanoparticles as carriers for nasal vaccine delivery
M. Köping-Höggård (2005)
A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery.
M. Chen (2011)
Chitosan-NAC nanoparticles as a vehicle for nasal absorption enhancement of insulin.
X. Wang (2009)
Oral nuclear factor-κB decoy oligonucleotides delivery system with chitosan modified poly(D,L-lactide-co-glycolide) nanospheres for inflammatory bowel disease.
Kohei Tahara (2011)
Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach.
A. des Rieux (2006)
Pulmonary drug delivery. Part I: physiological factors affecting therapeutic effectiveness of aerosolized medications.
N. Labiris (2003)
Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs: II. In vitro transport study.
S. V. R. Rao (2008)
Chitosan microspheres enhance the immunogenicity of an Ag85B-based fusion protein containing multiple T-cell epitopes of Mycobacterium tuberculosis.
B. Zhu (2007)
N-trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: biological properties and immunogenicity in a mouse model.
M. Amidi (2007)
Oral bioavailability of insulin contained in polysaccharide nanoparticles.
B. Sarmento (2007)
Manipulating the immune system: humoral versus cell-mediated immunity.
E. McNeela (2001)
Molecular Aspects of Mucoadhesive Carrier Development for Drug Delivery and Improved Absorption
N. Peppas (2009)
Lectin anchored stabilized biodegradable nanoparticles for oral immunization 1. Development and in vitro evaluation.
P. Gupta (2006)
Induction of high antitoxin titers against tetanus toxoid in rabbits by intranasal immunization with dextran microspheres.
S. A. Sajadi Tabassi (2008)
Inhalable liposomal formulation for vasoactive intestinal peptide.
Franz Hajos (2008)
Engineering design and molecular dynamics of mucoadhesive drug delivery systems as targeting agents.
Laura Serra (2009)
Chitosan-alginate blended nanoparticles as carriers for the transmucosal delivery of macromolecules.
F. M. Goycoolea (2009)
Protection against bubonic and pneumonic plague with a single dose microencapsulated sub-unit vaccine.
S. J. Elvin (2006)
Microspheres containing lipid/chitosan nanoparticles complexes for pulmonary delivery of therapeutic proteins.
A. Grenha (2008)
Particle uptake by Peyer’s patches: a pathway for drug and vaccine delivery
Monjed Shakweh (2004)
Nanocomposites of lung surfactant and biodegradable cationic nanoparticles improve transfection efficiency to lung cells.
J. Nguyen (2009)
Nanotechnology advances in controlled drug delivery systems
C. Kiparissides (2008)
Strong systemic and mucosal immune responses to surface-modified PLGA microspheres containing recombinant hepatitis B antigen administered intranasally.
K. S. Jaganathan (2006)
This paper is referenced by
Semi-Automated Nanoprecipitation-System—An Option for Operator Independent, Scalable and Size Adjustable Nanoparticle Synthesis
R. Rietscher (2014)
A thermosensitive gel based on w1/o/w2 multiple microemulsions for the vaginal delivery of small nucleic acid
J. Wang (2019)
Liposome-based mucus-penetrating particles (MPP) for mucosal theranostics: demonstration of diamagnetic chemical exchange saturation transfer (diaCEST) magnetic resonance imaging (MRI).
T. Yu (2015)
The application of polysaccharide-based nanogels in peptides/proteins and anticancer drugs delivery
Lin Zhang (2017)
A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins
W. I. Choi (2014)
Hepatitis B core antigen virus-like particles : characterization and investigation 1 of their stability in simulated and pig gastro-intestinal fluids 2 3
A. Berardi (2018)
Identification and molecular cloning of novel antimicrobial peptides from skin secretions of Odorrana versabilis and Rana palustris
Y. Wu (2017)
Nanomedicine in the Management of Microbial Infection - Overview and Perspectives.
Xi Zhu (2014)
Engineered nanoparticles as a precise delivery system in cancer therapeutics
R. Sharma (2016)
Self-Assembled Nanomedicines for Anticancer and Antibacterial Applications.
Lingyun Zhou (2018)
Enzyme-Functionalized PLGA Nanoparticles with Enhanced Mucus Permeation Rate
E. Samaridou (2014)
Vaginal Bioadhesive Drug Delivery Systems and Their Applications
Anju Sharma (2020)
Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide-coupled chitosan.
Tao Jiang (2014)
Synthesis of Nano Chitosan as Carrier Material of Cinnamon’s Active Component
Ngadiwiyana Ngadiwiyana (2018)
Nasal drug delivery: Design of a novel mucoadhesive and in situ gelling polymer.
Claudia Menzel (2017)
Recent advances in carrier mediated nose‐to‐brain delivery of pharmaceutics
V. Bourganis (2018)
Polycaprolactone based nano-carrier for co-administration of moxifloxacin and rutin and its In-vitro evaluation for sepsis
Mayank Handa (2019)
STOMACH-SPECIFIC MUCOADHESIVE NANOPARTICLES AS A CONTROLLED RELEASE DRUG DELIVERY SYSTEM
Aanand Ankit Kharia (2013)
Synergistic effect of methionine encephalin (MENK) combined with pidotimod(PTD) on the maturation of murine dendritic cells (DCs)
Y. Meng (2013)
Biodegradable Polymers: Protein Therapeutics Delivery
Bhuvaneshwar Vaidya (2015)
Polymer nanotechnology based approaches in mucosal vaccine delivery: challenges and opportunities.
R. Sharma (2015)
Development, characterization, and in vitro‐in vivo evaluation of polymeric nanoparticles containing miconazole and farnesol for treatment of vulvovaginal candidiasis
Adelaide Fernandes Costa (2019)
Chitosan Nanoparticle Based Mucosal Vaccines Delivered Against Infectious Diseases of Poultry and Pigs
S. Renu (2020)
ADME Processes in Vaccines and PK/PD Approaches for Vaccination Optimization
José David Gómez-Mantilla (2015)
Survey of Omp19 immunogenicity against Brucella abortus and Brucella melitensis: influence of nanoparticulation versus traditional immunization
M. Abkar (2015)
Nanoparticulate carrier(s): an emerging paradigm in new generation vaccine development
R. Sharma (2017)
Topical Drug Delivery for Chronic Rhinosinusitis
J. Liang (2012)
Chitosan-based mucosal adjuvants: Sunrise on the ocean
Y. Xia (2015)
Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces.
T. Yu (2016)
Nanoemulsions and thermosensitive nanoemulgels of phenytoin and fosphenytoin for intranasal administration: formulation development and in vitro characterization.
Patrícia C Pires (2019)
Formulasi Nanoemulsi Ekstrak Daun Kelor (Moringa oleifera Lamk)
Nina Jusnita (2019)
Oral delivery of diabetes peptides - Comparing standard formulations incorporating functional excipients and nanotechnologies in the translational context.
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