← Back to Search
Micro And Nanotechnologies For Bone Regeneration: Recent Advances And Emerging Designs
M. Mohammadi, S. A. Mousavi Shaegh, Mona Alibolandi, M. Ebrahimzadeh, A. Tamayol, M. R. Jaafari, M. Ramezani
Published 2018 · Medicine, Chemistry
Download PDFAnalyze on Scholarcy
&NA; Treatment of critical‐size bone defects is a major medical challenge since neither the bone tissue can regenerate nor current regenerative approaches are effective. Emerging progresses in the field of nanotechnology have resulted in the development of new materials, scaffolds and drug delivery strategies to improve or restore the damaged tissues. The current article reviews promising nanomaterials and emerging micro/nano fabrication techniques for targeted delivery of biomolecules for bone tissue regeneration. In addition, recent advances in fabrication of bone graft substitutes with similar properties to normal tissue along with a brief summary of current commercialized bone grafts have been discussed. Graphical abstract Figure. No caption available.
This paper references
A review of bone substitutes.
Solon T. Kao (2007)
Mechanically sti ff , zinc crosslinked nanocomposite sca ff olds with improved osteostimulation and antibacterial properties
E. Carvalho Sehgal (2016)
Seguin Hen (1824)
Repair of rat cranial bone defect by using bone morphogenetic protein-2-related peptide combined with microspheres composed of polylactic acid/polyglycolic acid copolymer and chitosan.
J. Li (2015)
Bio-Hybrid Scaffolds for Bone Tissue Engineering: Nano-Hydroxyapatite/Chitosan Composites
B. Palazzo (2014)
Iron oxide nanoparticle-induced oxidative stress and genotoxicity in human skin epithelial and lung epithelial cell lines.
M. Ahamed (2013)
M. Voorneveld (2004)
Limb-saving medicines sought to prevent amputations
C. Willyard (2012)
Magnetic nanoparticles modified-porous scaffolds for bone regeneration and photothermal therapy against tumors.
Jia-wei Lu (2018)
Nanotechnology in regenerative medicine: the materials side.
E. Engel (2008)
Bioactive Natural Protein-Hydroxyapatite Nanocarriers for Optimizing Osteogenic Differentiation of Mesenchymal Stem Cells.
Z. Ding (2016)
Development of collagen-hydroxyapatite scaffolds incorporating PLGA and alginate microparticles for the controlled delivery of rhBMP-2 for bone tissue engineering.
Elaine Quinlan (2015)
Nanotechnology in bone tissue engineering.
G. Walmsley (2015)
Simvastatin promotes osteogenic differentiation of mouse embryonic stem cells via canonical Wnt/β-catenin signaling
L. J. Qiao (2011)
ff ectiveness and harms of recombinant human bone morphogenetic protein - 2 in spine fusion : a systematic review and meta - analysis
S. Selph (2011)
Polycaprolactone/starch composite: Fabrication, structure, properties, and applications.
Soheila Ali Akbari Ghavimi (2015)
Microfluidic vascularized bone tissue model with hydroxyapatite-incorporated extracellular matrix.
Norhana Jusoh (2015)
ect of organic acids on calcium phosphate nucleation and osteogenic di ff erentiation of human mesenchymal stem cells on peptide functionalized nano fi bers
E. Jabbari X. Yang (2015)
Sustained release emphasizing recombinant human bone morphogenetic protein-2.
A bird's eye view on the use of electrospun nanofibrous scaffolds for bone tissue engineering: Current state-of-the-art, emerging directions and future trends.
Z. Rezvani (2016)
Taking cues from the extracellular matrix to design bone-mimetic regenerative scaffolds.
Andrew S. Curry (2016)
Development and characterisation of silver-doped bioactive glass-coated sutures for tissue engineering and wound healing applications.
J. Blaker (2004)
Tissue engineering strategies for promoting vascularized bone regeneration.
Sarah M Almubarak (2016)
Preparation and application of collagen scaffold-encapsulated silver nanoparticles and bone morphogenetic protein 2 for enhancing the repair of infected
C.-y. Sun (2015)
Biomimetic electrospun nanofibrous structures for tissue engineering.
X. Wang (2013)
3D printing technology to control BMP-2 and VEGF delivery spatially and temporally to promote large-volume bone regeneration.
J. Y. Park (2015)
Chemically modified RNA activated matrices enhance bone regeneration.
S. Elangovan (2015)
Microencapsulated chitosan nanoparticles for lung protein delivery.
A. Grenha (2005)
Towards artificial tissue models: past, present, and future of 3D bioprinting.
Ahu Arslan-Yildiz (2016)
Laser-assisted bioprinting for creating on-demand patterns of human osteoprogenitor cells and nano-hydroxyapatite.
S. Catros (2011)
Functionalisation of PLLA nanofiber scaffolds using a possible cooperative effect between collagen type I and BMP-2: impact on growth and osteogenic differentiation of human mesenchymal stem cells
M. Schofer (2011)
Effects of Immobilized BMP-2 and Nanofiber Morphology on In Vitro Osteogenic Differentiation of hMSCs and In Vivo Collagen Assembly of Regenerated Bone.
Sajeesh Kumar Madhurakkat Perikamana (2015)
How Nanotechnology can Really Improve the Future of Orthopedic Implants and Scaffolds for Bone and Cartilage Defects
P. Parchi (2013)
Tissue engineering of bone: the reconstructive surgeon's point of view
U. Kneser (2006)
Towards the Design of 3D Fiber-Deposited Poly(ε-caprolactone)/lron-Doped Hydroxyapatite Nanocomposite Magnetic Scaffolds for Bone Regeneration.
R. D. De Santis (2015)
Emerging translational research on magnetic nanoparticles for regenerative medicine.
Y. Gao (2015)
Microstructure and mechanical properties of biodegradable poly (D/L) lactic acid/polycaprolactone blends processed from the solvent-evaporation technique.
Javad Esmaeilzadeh (2017)
Diffusion limits of an in vitro thick prevascularized tissue.
Craig K. Griffith (2005)
Nanophase ceramics: The future orthopedic and dental implant material
T. Webster (2001)
Scaffold design for bone regeneration.
Liliana Polo-Corrales (2014)
Jim Euchner (2014)
3D bioprinting of tissues and organs
S. Murphy (2014)
Porous deproteinized bovine bone scaffold with three-dimensional localized drug delivery system using chitosan microspheres
Qing Li (2015)
Enhanced bone tissue regeneration by antibacterial and osteoinductive silica-HACC-zein composite scaffolds loaded with rhBMP-2.
P. Zhou (2014)
Using hydroxyapatite nanoparticles and decreased crystallinity to promote osteoblast adhesion similar to functionalizing with RGD.
G. Balasundaram (2006)
Effect of organic acids on calcium phosphate nucleation and osteogenic differentiation of human mesenchymal stem cells on peptide functionalized nanofibers.
Danial Barati (2015)
Design and Development of Bioceramic Based Functionalized PLGA Nanoparticles of Risedronate for Bone Targeting: In-vitro Characterization and Pharmacodynamic Evaluation
Purnima Rawat (2015)
Cervical disc arthroplasty with PRESTIGE LP disc versus anterior cervical discectomy and fusion: a prospective, multicenter investigational device exemption study.
Matthew F. Gornet (2015)
The role of surface charge on the uptake and biocompatibility of hydroxyapatite nanoparticles with osteoblast cells.
L. Chen (2011)
Review: development of clinically relevant scaffolds for vascularised bone tissue engineering.
Y. Liu (2013)
Preparation, characterization and antimicrobial activity of a bio-composite scaffold containing chitosan/nano-hydroxyapatite/nano-silver for bone tissue engineering.
S. Saravanan (2011)
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
K. Brogden (2005)
Bioactive nanoparticles stimulate bone tissue formation in bioprinted three-dimensional scaffold and human mesenchymal stem cells.
G. Gao (2014)
Electrospun nanofibers for regenerative medicine.
W. Liu (2012)
Cellular bone matrices: viable stem cell-containing bone graft substitutes.
B. Skovrlj (2014)
Nano-structured and functionalized surfaces for cytocompatibility improvement and bactericidal action.
P. Slepička (2015)
Mechanically Stiff, Zinc Cross-Linked Nanocomposite Scaffolds with Improved Osteostimulation and Antibacterial Properties.
R. R. Sehgal (2016)
Regulation of mesenchymal stem cell 3D microenvironment: From macro to microfluidic bioreactors
S. Sart (2016)
Microfluidics for Advanced Drug Delivery Systems
R. Riahi (2015)
Osteogenic Differentiation of Marrow Stromal Cells on Random and Aligned Electrospun Poly(l-lactide) Nanofibers
Junyu Ma (2010)
Priming the Surface of Orthopedic Implants for Osteoblast Attachment in Bone Tissue Engineering
Kiat Hwa Chan (2015)
Multimodal Nanoprobe Based on Upconversion Nanoparticles for Monitoring Implanted Stem Cells in Bone Defect of Big Animal
Dexin Chen (2018)
Enhanced Osteogenesis by Reduced Graphene Oxide/Hydroxyapatite Nanocomposites
J. Lee (2015)
Electrospun PLLA Nanofiber Scaffolds and Their Use in Combination with BMP-2 for Reconstruction of Bone Defects
M. Schofer (2011)
Thermal inkjet printing in tissue engineering and regenerative medicine.
X. Cui (2012)
Thermally triggered release of a pro-osteogenic peptide from a functionalized collagen-based scaffold using thermosensitive liposomes.
A. López-Noriega (2014)
Surface modification of multipass caliber-rolled Ti alloy with dexamethasone-loaded graphene for dental applications.
Ho Sang Jung (2015)
J. Terracol (1954)
Engineering anatomically shaped vascularized bone grafts with hASCs and 3D-printed PCL scaffolds.
Joshua P. Temple (2014)
FDA's regulatory science program for generic PLA/ PLGA-based drug products
Y. Wang (2016)
The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds.
Erica G. Tierney (2012)
Potential of Magnetic Nanofiber Scaffolds with Mechanical and Biological Properties Applicable for Bone Regeneration
R. K. Singh (2014)
Porous nano-HA/collagen/PLLA scaffold containing chitosan microspheres for controlled delivery of synthetic peptide derived from BMP-2.
X. Niu (2009)
Bone Graft and Bone Substitute Biology
Harshpal Singh (2014)
Bisphosphonate-derivatized liposomes to control drug release from collagen/hydroxyapatite scaffolds.
G. Wang (2011)
Bone induction at physiological doses of BMP through localization by clay nanoparticle gels.
D. R. Gibbs (2016)
Mesopattern of immobilised bone morphogenetic protein-2 created by microcontact printing and dip-pen nanolithography influence C2C12 cell fate
Sabine Oberhansl (2014)
3D bioprinting of vascularized
D. B. Kolesky (2014)
Antimicrobial Effect of Polymer-Based Silver Nanoparticle Coated Pedicle Screws: Experimental Research on Biofilm Inhibition in Rabbits
D. B. Hazer (2016)
Design , fabrication and characterization of drug delivery systems based on lab-ona-chip technology
N. Nguyena (2013)
Cerium Oxide Nanoparticle Modified Scaffold Interface Enhances Vascularization of Bone Grafts by Activating Calcium Channel of Mesenchymal Stem Cells.
J. Xiang (2016)
Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38.
V. Bala (2013)
Polymeric Biomaterials in Tissue Engineering
D. Kohane (2008)
Preparation and application of collagen scaffold-encapsulated silver nanoparticles and bone morphogenetic protein 2 for enhancing the repair of infected bone
C. Sun (2014)
Stromal cells and stem cells in clinical bone regeneration
W. Grayson (2015)
Orthopaedic Knowledge Update 10
J. Flynn (2011)
Quantification of angiogenic sprouting under different growth factors in a microfluidic platform.
C. Del Amo (2016)
In situ synthesized novel biocompatible titania-chitosan nanocomposites with high surface area and antibacterial activity.
K. Kavitha (2013)
Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields
M. Chorny (2010)
Electrospun materials as potential platforms for bone tissue engineering.
J. Jang (2009)
Fabrication and Evaluation of Polycaprolactone–Poly(hydroxybutyrate) or Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) Dual-Leached Porous Scaffolds for Bone Tissue Engineering Applications
Napaphat Thadavirul (2017)
T. R. Nayak (2011)
Effects of local delivery of D-amino acids from biofilm-dispersive scaffolds on infection in contaminated rat segmental defects.
C. Sánchez (2013)
Fabrication and in vivo evaluation of an osteoblast-conditioned nano-hydroxyapatite/gelatin composite scaffold for bone tissue regeneration.
A. Samadikuchaksaraei (2016)
Engineering Enriched Microenvironments with Gradients of Platelet Lysate in Hydrogel Fibers.
V. E. Santo (2016)
Titanium Surface Priming with Phase-Transited Lysozyme to Establish a Silver Nanoparticle-Loaded Chitosan/Hyaluronic Acid Antibacterial Multilayer via Layer-by-Layer Self-Assembly
X. Zhong (2016)
A bird ' s eye view on the use of electrospun nano fi brous sca ff olds for bone tissue engineering : Current state - ofthe - art , emerging directions and future trends
N. W. Pensa
Gene-Activated Matrix Comprised of Atelocollagen and Plasmid DNA Encoding BMP4 or Runx2 Promotes Rat Cranial Bone Augmentation
Physical and mechanical properties of PLA, and their functions in widespread applications - A comprehensive review.
Shady Farah (2016)
Effect of starch content on the biodegradation of polycaprolactone/starch composite for fabricating in situ pore-forming scaffolds
S. A. A. Ghavimi (2015)
Nucleation and growth of ordered arrays of silver nanoparticles on peptide nanofibers: hybrid nanostructures with antimicrobial properties
E. Pazos (2016)
Core/shell nanofibers with embedded liposomes as a drug delivery system.
A. Míčková (2012)
Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler
M. Morra (2015)
Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration
Wan-Geun La (2014)
Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion: a case study.
B. Perri (2007)
Polymeric Materials for Bone and Cartilage Repair
D. Puppi (2010)
Bone morphogenetic protein-2 for bone regeneration – Dose reduction through graphene oxide-based delivery
Wan-Geun La (2014)
Biocomposite scaffolds containing chitosan/alginate/nano-silica for bone tissue engineering.
J. Sowjanya (2013)
IN VITRO AND IN VIVO EVALUATION OF IMPLANT SURFACES TREATED WITH TITANIUM OXIDE (TIO2) NANOTUBE ARRAYS TO ENHANCE OSSEOINTEGRATION BETWEEN ARTHROPLASTY IMPLANTS AND SURROUNDING BONE
D O'Guinn Justin (2016)
Local delivery of controlled-release simvastatin/PLGA/HAp microspheres enhances bone repair
I. Tai (2013)
Guided bone regeneration using injectable vascular endothelial growth factor delivery gel.
D. Kaigler (2013)
Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model.
Toshihiro Matsuo (2003)
The origins and the future of microfluidics
G. Whitesides (2006)
d-Amino Acids Trigger Biofilm Disassembly
I. Kolodkin-Gal (2010)
Morphological effects of porous poly-d,l-lactic acid/hydroxyapatite scaffolds produced by supercritical CO2 foaming on their mechanical performance
Davood Rouholamin (2016)
Oxidative stress markers are elevated in exhaled breath condensate of workers exposed to nanoparticles during iron oxide pigment production.
D. Pelclova (2016)
A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering.
H. Yoshimoto (2003)
Fluid shear stress threshold regulates angiogenic sprouting
P. Galie (2014)
Microfluidic strategies for design and assembly of microfibers and nanofibers with tissue engineering and regenerative medicine applications.
M. Daniele (2015)
Next generation bone tissue engineering: non-viral miR-133a inhibition using collagen-nanohydroxyapatite scaffolds rapidly enhances osteogenesis
Irene Mencía Castaño (2016)
Fluid forces control endothelial sprouting
J. W. Song (2011)
Bone grafts, bone substitutes and orthobiologics
T. T. Roberts (2012)
Poly-l-lactic acid modified by etching and grafting with gold nanoparticles
P. Slepička (2013)
Axel M. Gressner (2012)
Current Trends in 3D Printing, Bioprosthetics, and Tissue Engineering in Plastic and Reconstructive Surgery
C. Colasante (2016)
Nanosurface - the future of implants.
G. Thakral (2014)
Use of bone morphogenetic proteins for musculoskeletal applications. An overview.
Michael A Mont (2004)
Nanoscale graphene coating on commercially pure titanium for accelerated bone regeneration
Ho Sang Jung (2016)
BMP-2/PLGA Delayed-Release Microspheres Composite Graft, Selection of Bone Particulate Diameters, and Prevention of Aseptic Inflammation for Bone Tissue Engineering
Ye Ji (2009)
Sandwich-like, graphene-based titania nanosheets with high surface area for fast lithium storage.
Shubin Yang (2011)
Additive manufacturing of scaffolds with dexamethasone controlled release for enhanced bone regeneration.
Pedro F Costa (2015)
PLGA-based nanoparticles: an overview of biomedical applications.
F. Danhier (2012)
Personalized development of human organs using 3D printing technology.
D. Radenkovic (2016)
Stimulation of bone formation in vitro and in rodents by statins.
G. Mundy (1999)
Controlled dual delivery of BMP-2 and dexamethasone by nanoparticle-embedded electrospun nanofibers for the efficient repair of critical-sized rat calvarial defect.
L. Li (2015)
Three-dimensional graphene foams promote osteogenic differentiation of human mesenchymal stem cells.
Spencer W. Crowder (2013)
A novel injectable temperature-sensitive zinc doped chitosan/β-glycerophosphate hydrogel for bone tissue engineering.
R. Niranjan (2013)
A review of the biomaterials technologies for infection-resistant surfaces.
D. Campoccia (2013)
Non-viral gene activated matrices for mesenchymal stem cells based tissue engineering of bone and cartilage.
Sophie Raisin (2016)
Decreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites
Justin T. Seil (2008)
Structure and function of RGD peptides involved in bone biology
P. Schaffner (2003)
Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation.
Qingqing Yao (2017)
Evaluating 3D-printed biomaterials as scaffolds for vascularized bone tissue engineering.
Martha O. Wang (2015)
Antibacterial and cell-adhesive polypeptide and poly(ethylene glycol) hydrogel as a potential scaffold for wound healing.
Airong Song (2012)
Controlled release of injectable liposomal in situ gel loaded with recombinant human bone morphogenetic protein-2 for the repair of alveolar bone clefts in rabbits
Ali H Hassan (2016)
Bone-graft substitutes: facts
A. S. Greenwald (2001)
Origin of enhanced stem cell growth and differentiation on graphene and graphene oxide.
W. Lee (2011)
Phage nanofibers induce vascularized osteogenesis in 3D printed bone scaffolds.
J. Wang (2014)
Nanoparticles meet electrospinning: recent advances and future prospects.
Chuan-ling Zhang (2014)
Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation: a review.
O. Böstman (2000)
Potential of non-mulberry silk protein fibroin blended and grafted poly(Є-caprolactone) nanofibrous matrices for in vivo bone regeneration.
Promita Bhattacharjee (2016)
RGD and BMP-2 mimetic peptide crosstalk enhances osteogenic commitment of human bone marrow stem cells.
I. Bilem (2016)
Preventing bacterial adhesion on scaffolds for bone tissue engineering
S. Sanchez-Salcedo (2016)
A novel nanocomposite for bone tissue engineering based on chitosan–silk sericin/hydroxyapatite: biomimetic synthesis and its cytocompatibility
L. Chen (2015)
Nucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties
Elena Pazos (2016)
Gene therapy returns to centre stage
L. Naldini (2015)
Highly roughened polycaprolactone surfaces using oxygen plasmaetching and in vitro mineralization for bone tissue regeneration: fabrication
Y. Kim (2015)
Bone Grafts and Bone Graft Substitutes in Periodontal Therapy
Alexandrina Lizica Dumitrescu (2011)
Fabrication and characterization of six electrospun poly(alpha-hydroxy ester)-based fibrous scaffolds for tissue engineering applications.
W. Li (2006)
Controlled release of bone morphogenetic protein 2 and dexamethasone loaded in core-shell PLLACL-collagen fibers for use in bone tissue engineering.
Yan Su (2012)
Mechanical properties of monolayer graphene oxide.
J. Suk (2010)
Antibacterial properties and bioactivity of HACC- and HACC-Zein-modified mesoporous bioactive glass scaffolds.
Panyu Zhou (2013)
Fabrication of silver nanoparticle-doped hydroxyapatite coatings with oriented block arrays for enhancing bactericidal effect and osteoinductivity.
Bo Tian (2016)
A simultaneous 3D printing process for the fabrication of bioceramic and cell-laden hydrogel core/shell scaffolds with potential application in bone tissue regeneration.
N. Raja (2016)
Preparation of chitosan/nano hydroxyapatite organic-inorganic hybrid microspheres for bone repair.
Jingdi Chen (2015)
Design, fabrication and characterization of drug delivery systems based on lab-on-a-chip technology.
N. Nguyen (2013)
3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering.
A. Daly (2016)
S. Yang (2011)
Polymeric Scaffolds for Bone Tissue Engineering
X. Liu (2004)
POLYMERIC SCAFFOLDS IN TISSUE ENGINEERING APPLICATION: A REVIEW
Brahatheeswaran Dhandayuthapani (2011)
[Efficacy of using VEGF165 gene in comprehensive treatment of patients with stage 2A-3 lower limb chronic ischaemia].
Roman V. Deev (2014)
Effectiveness and Harms of Recombinant Human Bone Morphogenetic Protein-2 in Spine Fusion
R. Fu (2013)
Fabrication and characterization of functionalized polymer systems using dip-pen nanolithography
Carrie Schindler (2014)
Comparative Efficacies of a 3D-Printed PCL/PLGA/β-TCP Membrane and a Titanium Membrane for Guided Bone Regeneration in Beagle Dogs
Jin-Hyung Shim (2015)
Stimulation of new bone formation by direct transfer of osteogenic plasmid genes.
J. Fang (1996)
Cell-Laden 3D Printed Scaffolds for Bone Tissue Engineering
Charlotte Piard (2015)
Axel M. Gressner (2012)
A preliminary study on osteoinduction of two kinds of calcium phosphate ceramics.
H. Yuan (1999)
Bone Morphogenetic Protein (BMP) signaling in development and human diseases
R. Wang (2014)
Silver coated anionic cellulose nanofiber composites for an efficient antimicrobial activity.
M. Gopiraman (2016)
Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: structural characteristics, mechanical properties and cell adhesion potential.
I. Kwon (2005)
Titanium as a Reconstruction and Implant Material in Dentistry: Advantages and Pitfalls
M. Özcan (2012)
Therapeutic-designed electrospun bone scaffolds: mesoporous bioactive nanocarriers in hollow fiber composites to sequentially deliver dual growth factors.
Min Sil Kang (2015)
Segmental bone regeneration using rhBMP-2-loaded collagen/chitosan microspheres composite scaffold in a rabbit model.
J. Hou (2012)
Use of Nanocrystalline Hydroxyapatite With Autologous BMA and Local Bone in the Lumbar Spine
S. Robbins (2017)
Concise Review: Cell‐Based Strategies in Bone Tissue Engineering and Regenerative Medicine
Jin-ling Ma (2014)
Nanotechnology and Bone Healing
E. Harvey (2010)
An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects.
Y. Kolambkar (2011)
A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates.
C. Murphy (2014)
Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds
J. P. Cattalini (2015)
Material properties and bone marrow stromal cells response to in situ crosslinkable RGD-functionlized lactide-co-glycolide scaffolds.
E. Jabbari (2009)
Biocompatibility and degradation characteristics of PLGA-based electrospun nanofibrous scaffolds with nanoapatite incorporation.
W. Ji (2012)
3D Bioprinting Human Chondrocytes with Nanocellulose-Alginate Bioink for Cartilage Tissue Engineering Applications.
Kajsa Markstedt (2015)
Co-transplantation of endothelial progenitor cells and mesenchymal stem cells promote neovascularization and bone regeneration.
H. Zigdon-Giladi (2015)
Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective
J. Henkel (2013)
Electro-spinning/netting: A strategy for the fabrication of three-dimensional polymer nano-fiber/nets
Xianfeng Wang (2013)
Gene Delivery of TGF-β3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering.
T. Gonzalez-Fernandez (2016)
Morphological comparison of PVA scaffolds obtained by gas foaming and microfluidic foaming techniques.
C. Colosi (2013)
Graphene oxide as an interface phase between polyetheretherketone and hydroxyapatite for tissue engineering scaffolds
Shuping Peng (2017)
Enhanced bone regeneration and visual monitoring via superparamagnetic iron oxide nanoparticle scaffold in rats
Shuying Hu (2018)
Reinforcement of freeze-dried chitosan scaffolds with multiphasic calcium phosphate short fibers.
Z. Mohammadi (2016)
Proliferation and Differentiation of Mesenchymal Stem Cells in Chitosan Scaffolds Loaded with Nanocapsules Containing Bone Morphogenetic Proteins-4, Platelet-Derived Growth Factor and Insulin-Like Growth Factor 1
Işıl Saygun (2014)
Bone graft substitutes
C. Laurencin (2006)
Magnetic resonance imaging of self-assembled biomaterial scaffolds.
S. Bull (2005)
Engineering on the straight and narrow: the mechanics of nanofibrous assemblies for fiber-reinforced tissue regeneration.
R. Mauck (2009)
Microfluidic chip-based fabrication of PLGA microfiber scaffolds for tissue engineering.
C. M. Hwang (2008)
Nanosurfaces and nanostructures for artificial orthopedic implants.
R. Streicher (2007)
Bone regeneration in a rabbit critical femoral defect by means of magnetic hydroxyapatite macroporous scaffolds.
A. Russo (2018)
The enhancement of bone regeneration by gene activated matrix encoding for platelet derived growth factor.
Satheesh Elangovan (2014)
The ability of a collagen/calcium phosphate scaffold to act as its own vector for gene delivery and to promote bone formation via transfection with VEGF(165).
M. Keeney (2010)
3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs.
David B. Kolesky (2014)
Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration.
Daniel Tang (2016)
BMP2 gene delivery to bone mesenchymal stem cell by chitosan-g-PEI nonviral vector
Jianhui Yue (2015)
Combined effect of osteopontin and BMP-2 derived peptides grafted to an adhesive hydrogel on osteogenic and vasculogenic differentiation of marrow stromal cells.
Xuezhong He (2012)
Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: A review.
X. Wang (2016)
Biofabrication of bone tissue: approaches
D. Tang (2016)
Release of magnetic nanoparticles from cell-encapsulating biodegradable nanobiomaterials.
F. Xu (2012)
Enhanced osteogenic differentiation of stem cells via microfluidics synthesized nanoparticles.
M. M. Hasani-Sadrabadi (2015)
Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors
Y. Zhang (2017)
Composite ECM-alginate microfibers produced by microfluidics as scaffolds with biomineralization potential.
M. Angelozzi (2015)
Osteoinductive ceramics as a synthetic alternative to autologous bone grafting
H. Yuan (2010)
Controlled mechanotransduction in therapeutic MSCs: can remotely controlled magnetic nanoparticles regenerate bones?
James R. Henstock (2015)
Bone substitutes: an update.
P. Giannoudis (2005)
Martin P. Catherwood (1824)
Current trends in 3 D printing , bioprosthetics , and tissue engineering in plastic and reconstructive surgery
Y. Chen (2016)
Electrospun poly(l-lactide)-grafted hydroxyapatite/poly(l-lactide) nanocomposite fibers
Xiuling Xu (2007)
Sustained localized presentation of RNA interfering molecules from in situ forming hydrogels to guide stem cell osteogenic differentiation.
Minh K. Nguyen (2014)
Modulation of Bone-Specific Tissue Regeneration by Incorporating Bone Morphogenetic Protein and Controlling the Shell Thickness of Silk Fibroin/Chitosan/Nanohydroxyapatite Core-Shell Nanofibrous Membranes.
K. Shalumon (2015)
Manufacturing Challenges in Regenerative Medicine
I. Martín (2014)
Biomedical Applications of Biodegradable Polymers.
B. Ulery (2011)
Shear Stress Induced by an Interstitial Level of Slow Flow Increases the Osteogenic Differentiation of Mesenchymal Stem Cells through TAZ Activation
K. Kim (2014)
Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms.
A. Barradas (2011)
Yu-Qin Cao (1824)
ect of starch content on the biodegradation of polycaprolactone / starch composite for fabricating in situ pore - forming sca ff olds
X. Chen (2015)
Liposomes in tissue engineering and regenerative medicine
N. Monteiro (2014)
The induction of bone formation by coral-derived calcium carbonate/hydroxyapatite constructs.
U. Ripamonti (2009)
Ensemble Analysis of Angiogenic Growth in Three-Dimensional Microfluidic Cell Cultures
W. Farahat (2012)
In vitro cell-biological performance and structural characterization of selective laser sintered and plasma surface functionalized polycaprolactone scaffolds for bone regeneration.
Simon Van Bael (2013)
Graphene Oxide-Copper Nanocomposite-Coated Porous CaP Scaffold for Vascularized Bone Regeneration via Activation of Hif-1α.
W. Zhang (2016)
Novel preparation of controlled porosity particle/fibre loaded scaffolds using a hybrid micro-fluidic and electrohydrodynamic technique.
M. Parhizkar (2014)
Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
A. Kolk (2012)
Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells.
Tapas R. Nayak (2011)
Generation of alginate microfibers with a roller-assisted microfluidic system.
Jing Su (2009)
Coaxial electrospinning for encapsulation and controlled release of fragile water-soluble bioactive agents.
Hongliang Jiang (2014)
Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds.
Sungsoo S. Lee (2013)
Extracellular matrix-inspired growth factor delivery systems for bone regeneration.
Mikaël M. Martino (2015)
Synthetic biodegradable polymers as orthopedic devices.
J. C. Middleton (2000)
Influence of hydroxyapatite and BMP-2 on bioactivity and bone tissue formation ability of electrospun PLLA nanofibers
Xiaozhan Yang (2015)
Immobilization of bioactive factor-loaded liposomes on the surface of electrospun nanofibers targeting tissue engineering.
N. Monteiro (2014)
Ornamenting 3D printed scaffolds with cell-laid extracellular matrix for bone tissue regeneration.
Falguni Pati (2015)
Nanomaterials promise better bone repair
Q. Wang (2016)
Nanomaterials and bone regeneration
T. Gong (2015)
Highly roughened polycaprolactone surfaces using oxygen plasma-etching and in vitro mineralization for bone tissue regeneration: fabrication, characterization, and cellular activities.
Y. Kim (2015)
An update on the Application of Nanotechnology in Bone Tissue Engineering
M. Griffin (2016)
Magnetic composite biomaterials for tissue engineering.
Sara Gil (2014)
Scaffold-free vascular tissue engineering using bioprinting.
C. Norotte (2009)
R. R. Sehgal (2016)
Injectable Graphene Oxide/Hydrogel-Based Angiogenic Gene Delivery System for Vasculogenesis and Cardiac Repair
A. Paul (2014)
Bioprinting for stem cell research.
S. Tasoglu (2013)
Bone-Graft Substitutes: Facts, Fictions, and Applications
A. Greenwald (2001)
Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
F. Alexis (2008)
Fabrication of a poly(ɛ‐caprolactone)/starch nanocomposite scaffold with a solvent‐casting/salt‐leaching technique for bone tissue engineering applications
Safa Taherkhani (2016)
Strong and bioactive gelatin–graphene oxide nanocomposites
C. Wan (2011)
This paper is referenced by
Hydrogels injectables et éponges à base de complexe polyélectrolytes (chitosane/polymère de cyclodextrine) pour une application en ingénierie tissulaire osseuse
Carla Palomino Durand (2019)
Rotary-jet spun polycaprolactone/nano-hydroxyapatite scaffolds modified by simulated body fluid influenced the flexural mode of the neoformed bone
L. M. R. Vasconcellos (2020)
Artificial Intelligence Applications in Nanosized Biomaterial Development
Rhutu Kallur (2020)
Bioinspired surface hierarchical microstructures of Ti6Al4V alloy with a positive effect on osteoconduction
C. Li (2020)
Hierarchical microchanneled scaffolds modulate multiple tissue-regenerative processes of immune-responses, angiogenesis, and stem cell homing.
Jong-Eun Won (2019)
Morpholino-functionalized phosphorus dendrimers for precision regenerative medicine: osteogenic differentiation of mesenchymal stem cells.
A. Li (2019)
Fabrication of a nanoparticle-containing 3D porous bone scaffold with proangiogenic and antibacterial properties.
J. Paris (2019)
3D‐Printed Sugar‐Based Stents Facilitating Vascular Anastomosis
Ali Farzin (2018)
Thermally induced self-agglomeration 3D scaffolds with BMP-2-loaded core–shell fibers for enhanced osteogenic differentiation of rat adipose-derived stem cells
Shuying Hu (2018)
Influence of the nanofiber chemistry and orientation of biodegradable poly(butylene succinate)-based scaffolds on osteoblast differentiation for bone tissue regeneration.
F. Cristofaro (2018)
Immobilization of BMP-2-derived peptides on 3D-printed porous scaffolds for enhanced osteogenesis.
Xia-shi-yao Zhang (2019)
The immune reaction and degradation fate of scaffold in cartilage/bone tissue engineering.
D. Yang (2019)
Comparison of liposomal formulations incorporating BMP-2 peptide to induce bone tissue engineering
M. Mohammadi (2020)
Nano-based smart pesticide formulations: Emerging opportunities for agriculture.
S. Kumar (2019)
In Vitro Bioactivity and Biocompatibility of Bio-Inspired Ti-6Al-4V Alloy Surfaces Modified by Combined Laser Micro/Nano Structuring
Chang-sheng Li (2020)
Hybrid Vesicular Drug Delivery Systems for Cancer Therapeutics
M. Mohammadi (2018)
A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering
Yihu Wang (2020)
Fabrication of hybrid scaffold based on hydroxyapatite-biodegradable nanofibers incorporated with liposomal formulation of BMP-2 peptide for bone tissue engineering.
M. Mohammadi (2018)
Fabrication of open‐porous PCL/PLA tissue engineering scaffolds and the relationship of foaming process, morphology, and mechanical behavior
Lixia Wang (2019)
Silk Fibroin-Based Scaffold for Bone Tissue Engineering.
J. H. Choi (2018)
Biomimetic hydroxyapatite/gelatin composites for bone tissue regeneration: Fabrication, characterization, and osteogenic differentiation in vitro
H. Lian (2018)
Centrifugal spun osteoconductive ultrafine fibrous mat as a scaffold for bone regeneration
AmalorpavaMary Loordhuswamy (2020)
Advanced Black Phosphorus Nanomaterials for Bone Regeneration
Yun’an Qing (2020)
Advances in Polysaccharide-Based Antimicrobial Delivery Vehicles
Vaishali S. Pawar (2020)