Online citations, reference lists, and bibliographies.
← Back to Search

Anti‐tumor Efficacy Of Hyaluronan‐based Nanoparticles For The Co‐delivery Of Drugs In Lung Cancer

V. Jeannot, C. Gauche, S. Mazzaferro, Morgane Couvet, Laetitia Vanwonterghem, Maxime Henry, C. Didier, J. Vollaire, V. Josserand, J. Coll, C. Schatz, S. Lecommandoux, A. Hurbin
Published 2018 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
&NA; Combinations of therapeutic agents could synergistically enhance the response of lung cancer cells. Co‐delivery systems capable of transporting chemotherapeutics with different physicochemical properties and with the simultaneous release of drugs remain elusive. Here, we assess the ability of nanoparticles of 30‐nm diameter obtained from the self‐assembly of hyaluronan‐based copolymer targeting CD44 receptors to encapsulate both gefitinib and vorinostat for effective combinational lung cancer treatment. Drug loading was performed by nanoprecipitation. Drug release experiments showed a slow release of both drugs after 5 days. Using two‐ and three‐dimensional lung adenocarcinoma cell cultures, we observed that the nanoparticles were mostly found at the periphery of the CD44‐expressing spheroids. These drug‐loaded nanoparticles were as cytotoxic as free drugs in the two‐ and three‐dimensional systems and toxicity was due to apoptosis induction. In mouse models, intravenous injection of hyaluronan‐based nanoparticles showed a selective delivery to subcutaneous CD44‐overexpressing tumors, despite a significant liver capture. In addition, the systemic toxicity of the free drugs was reduced by their co‐delivery using the nanoparticles. Finally, intrapulmonary administration of drug‐loaded nanoparticles, to avoid a possible hepatic toxicity due to their accumulation in the liver, showed a stronger inhibition of orthotopic lung tumor growth compared to free drugs. In conclusion, hyaluronan‐based nanoparticles provide active targeting partially mediated by CD44, less‐toxic drug release and improved antitumor efficiency. Graphical abstract Figure. No Caption available.
This paper references
10.1002/ijc.28594
The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase‐dependent mechanism
V. Jeannot (2014)
10.1016/j.nano.2015.11.018
Targeting CD44 receptor-positive lung tumors using polysaccharide-based nanocarriers: Influence of nanoparticle size and administration route.
V. Jeannot (2016)
On the airways
Josephine E. Phillips (1942)
10.1166/JBN.2014.1939
Lung toxicity of biodegradable nanoparticles.
E. Fattal (2014)
10.1016/B978-0-7020-7222-2.00022-6
V
M. Millodot (2018)
10.15406/JNMR.2015.02.00018
Gelatin Nanoparticles as a Delivery System for Proteins
Reena Kaintura (2015)
10.1038/mt.2009.227
Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation.
B. Busser (2010)
10.1071/CH03115
Flash NanoPrecipitation of Organic Actives and Block Copolymers using a Confined Impinging Jets Mixer
B. Johnson (2003)
10.1016/j.biomaterials.2009.12.043
The intracellular drug delivery and anti tumor activity of doxorubicin loaded poly(gamma-benzyl L-glutamate)-b-hyaluronan polymersomes.
K. K. Upadhyay (2010)
10.1016/j.ejpb.2013.06.003
Hyaluronic acid-coated liposomes for active targeting of gemcitabine.
S. Arpicco (2013)
Self-assembly of rod-coil diblock oligomers based on a-helical peptides., Macromolecules
S. Lecommandoux (2001)
10.1089/adt.2010.0276
Activity of anticancer agents in a three-dimensional cell culture model.
V. S. Nirmalanandhan (2010)
10.1016/j.jconrel.2014.10.003
Fate of inhaled monoclonal antibodies after the deposition of aerosolized particles in the respiratory system.
L. Guilleminault (2014)
10.1016/J.ADDR.2006.09.017
Freeze-drying of nanoparticles: formulation, process and storage considerations.
W. Abdelwahed (2006)
Freeze-drying of nanoparticles: formulation
W. Abdelwahed (2006)
10.1002/smll.201401284
Nebulized gadolinium-based nanoparticles: a theranostic approach for lung tumor imaging and radiosensitization.
S. Dufort (2015)
10.1103/PHYSREVLETT.91.118302
Mechanism for rapid self-assembly of block copolymer nanoparticles.
B. Johnson (2003)
10.1021/bm9006419
Biomimetic doxorubicin loaded polymersomes from hyaluronan-block-poly(gamma-benzyl glutamate) copolymers.
K. K. Upadhyay (2009)
10.1016/j.biomaterials.2011.01.021
The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles.
K. Xiao (2011)
10.1016/j.ymthe.2016.11.002
Systemic Delivery of Tumor-Targeted Bax-Derived Membrane-Active Peptides for the Treatment of Melanoma Tumors in a Humanized SCID Mouse Model.
A. Karageorgis (2017)
10.2147/OTT.S117743
Synergistic activity of vorinostat combined with gefitinib but not with sorafenib in mutant KRAS human non-small cell lung cancers and hepatocarcinoma
V. Jeannot (2016)
10.3322/caac.20121
Cancer statistics, 2011
R. Siegel (2011)
10.1371/JOURNAL.PMED.0020017
KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib
W. Pao (2005)
10.1038/cddis.2013.330
The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells
M-C Chen (2013)
Prud’homme, Principles of nanoparticle formation by flash
R.K.W.S. Saad (2016)
10.1016/j.biomaterials.2008.03.033
Targeting efficiency and biodistribution of biotinylated-EGF-conjugated gelatin nanoparticles administered via aerosol delivery in nude mice with lung cancer.
Ching-Li Tseng (2008)
10.1016/J.NANTOD.2016.04.006
Principles of nanoparticle formation by flash nanoprecipitation
W. Saad (2016)
10.1056/NEJMoa0810699
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma.
T. Mok (2009)
10.1021/MA010940J
Self-Assembly of Rod−Coil Diblock Oligomers Based on α-Helical Peptides
S. Lecommandoux (2001)
10.2217/fon.11.2
Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer.
K. Thurn (2011)
10.1038/nnano.2007.387
Nanocarriers as an emerging platform for cancer therapy.
D. Peer (2007)
10.1038/nbt.1696
Rapid translocation of nanoparticles from the lung airspaces to the body
H. Choi (2010)
10.1021/acsnano.5b01320
Clearance Pathways and Tumor Targeting of Imaging Nanoparticles.
M. Yu (2015)
10.1074/JBC.M211462200
A Blocking Antibody to the Hyaluronan Receptor for Endocytosis (HARE) Inhibits Hyaluronan Clearance by Perfused Liver*
J. A. Weigel (2003)
10.1097/JTO.0b013e31827ed0ff
Epidermal growth factor receptor inhibition in lung cancer: status 2012.
F. Hirsch (2013)
10.1021/MA021176J
Small-Angle Neutron Scattering from Diblock Copolymer Poly(styrene-d8)-b-poly(γ-benzyl l-glutamate) Solutions: Rod−Coil to Coil−Coil Transition
J. S. Crespo (2003)
10.1021/mp400610b
Polymersome-mediated delivery of combination anticancer therapy to head and neck cancer cells: 2D and 3D in vitro evaluation.
H. Colley (2014)
The effect of molecular weight on the biodistribution of hyaluronic acid radiolabeled with 111In after intravenous administration to rats
E. Svanovsky (2008)
10.1021/mp2000428
Characterization of CD44-mediated cancer cell uptake and intracellular distribution of hyaluronan-grafted liposomes.
H. S. Qhattal (2011)
10.1007/s11095-011-0442-5
The Airways, a Novel Route for Delivering Monoclonal Antibodies to Treat Lung Tumors
A. Maillet (2011)
10.1002/wnan.1183
Smart polymersomes for therapy and diagnosis: fast progress toward multifunctional biomimetic nanomedicines.
Hugo de Oliveira (2012)
10.1016/j.addr.2011.09.009
Physico-chemical parameters that govern nanoparticles fate also dictate rules for their molecular evolution.
S. Dufort (2012)
10.1016/j.jconrel.2011.06.031
Hyaluronan-coated nanoparticles: the influence of the molecular weight on CD44-hyaluronan interactions and on the immune response.
Shoshy Mizrahy (2011)
10.3816/CLC.2006.S.008
Rash as a surrogate marker for efficacy of epidermal growth factor receptor inhibitors in lung cancer.
R. Pérez-Soler (2006)
10.1038/nnano.2009.314
Design considerations for tumour-targeted nanoparticles.
H. Choi (2010)
10.1038/NATREVMATS.2016.14
Analysis of nanoparticle delivery to tumours
Stefan Wilhelm (2016)
Nanotized Curcumin and Miltefosine
B. Tiwari (2017)
10.1016/J.JCONREL.2006.07.012
Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug.
Fariyal Ahmed (2006)
10.3322/canjclin.39.6.399
Cancer statistics
N. Dubrawsky (1989)
10.1128/AAC.01169-16
Nanotized Curcumin and Miltefosine, a Potential Combination for Treatment of Experimental Visceral Leishmaniasis
B. Tiwari (2016)
10.1016/j.addr.2013.12.009
Nanoprecipitation and the "Ouzo effect": Application to drug delivery devices.
E. Lepeltier (2014)
10.1111/j.2042-7158.2012.01523.x
Overcoming sink limitations in dissolution testing: a review of traditional methods and the potential utility of biphasic systems
D. J. Phillips (2012)
10.3390/biology3020345
Advanced Cell Culture Techniques for Cancer Drug Discovery
C. Lovitt (2014)
10.1039/C6CC08146K
Co-delivery of all-trans-retinoic acid enhances the anti-metastasis effect of albumin-bound paclitaxel nanoparticles.
H. Huang (2016)
10.1002/mabi.200900415
In vitro and in vivo evaluation of docetaxel loaded biodegradable polymersomes.
K. K. Upadhyay (2010)
[HDAC inhibitor].
K. Saijo (2015)



This paper is referenced by
Synthesis and self-assembly of polysaccharide-b-elastin-like polypeptide bioconjugates
Ye Xiao (2019)
10.1016/j.jconrel.2020.05.043
Nanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer.
Zi-Xian Liao (2020)
10.1002/anie.202005212
Hyaluronic acid presentation at the surface of self-assembled nanoparticles transforms a hyaluronidase HYAL1 substrate into an efficient and selective inhibitor.
S. Lecommandoux (2020)
10.3390/cancers11111760
Verteporfin-Loaded Lipid Nanoparticles Improve Ovarian Cancer Photodynamic Therapy In Vitro and In Vivo
T. Michy (2019)
10.1039/d0cc00165a
Novel copper-based and pH-sensitive nanomedicine for enhanced chemodynamic therapy.
L. Wang (2020)
10.1016/j.nano.2019.102105
Desirable PEGylation for improving tumor selectivity of hyaluronic acid-based nanoparticles via low hepatic captured, long circulation times and CD44 receptor-mediated tumor targeting.
Chao Teng (2019)
10.1002/ange.202005212
Hyaluronic‐Acid‐Presenting Self‐Assembled Nanoparticles Transform a Hyaluronidase HYAL1 Substrate into an Efficient and Selective Inhibitor
Haohao Duan (2020)
10.1007/s10311-019-00897-7
Nanocarrier-mediated co-delivery systems for lung cancer therapy: recent developments and prospects
M. A. Farooq (2019)
10.29245/2689-999X/2019/2.1148
Pulmonary Nano-Drug Delivery Systems for Lung Cancer: Current Knowledge and Prospects
M. Amararathna (2019)
10.1007/s11051-019-4580-8
Docetaxel-loaded biomimetic nanoparticles for targeted lung cancer therapy in vivo
C. Chi (2019)
10.3389/fphar.2020.01199
Attenuation of Radiation-Induced Lung Injury by Hyaluronic Acid Nanoparticles
Anna Lierová (2020)
10.1021/acs.biomac.9b01058
Design of polysaccharide-b-elastin like polypeptide bioconjugates and their thermoresponsive self-assembly.
Ye Xiao (2019)
10.1016/j.actbio.2018.12.007
Co-delivery of cisplatin and doxorubicin by covalently conjugating with polyamidoamine dendrimer for enhanced synergistic cancer therapy.
X. Guo (2019)
10.1016/j.drudis.2019.09.023
Physicochemical properties affecting the fate of nanoparticles in pulmonary drug delivery.
Qiaoyu Liu (2019)
10.2174/2211738507666190321112237
Co-delivery Nanosystems for cancer treatment: A review.
R. Eftekhari (2019)
10.1016/j.jconrel.2020.01.026
Ligand-installed anti-VEGF genomic nanocarriers for effective gene therapy of primary and metastatic tumors.
Huaping Zhang (2020)
10.1016/j.ejps.2020.105352
Comparative study of intratracheal and oral gefitinib for the treatment of primary lung cancer.
T. Zhang (2020)
10.7150/thno.40971
Stapled peptide targeting the CDK4/Cyclin D interface combined with Abemaciclib inhibits KRAS mutant lung cancer growth
Céline Bouclier (2020)
10.1016/j.ijpharm.2020.119537
Nanoparticles based on natural, engineered or synthetic proteins and polypeptides for drug delivery applications.
Evangelos Georgilis (2020)
10.2147/IJN.S242490
99mTc Radiolabeled HA/TPGS-Based Curcumin-Loaded Nanoparticle for Breast Cancer Synergistic Theranostics: Design, in vitro and in vivo Evaluation
Chong Huang (2020)
10.3390/ijms21103504
Role of the Hyaluronan Receptor, Stabilin-2/HARE, in Health and Disease
E. N. Harris (2020)
10.1038/s41598-018-32994-y
Multivalent and multifunctional polysaccharide-based particles for controlled receptor recognition
Haohao Duan (2018)
10.1016/j.ijbiomac.2019.10.060
Facile preparation of hyaluronic acid-based quercetin nanoformulation for targeted tumor therapy.
Qi Xion (2019)
10.1002/ADFM.201806175
pH and Reactive Oxygen Species-Sequential Responsive Nano-in-Micro Composite For Targeted Therapy of Inflammatory Bowel Disease
Serena Bertoni (2018)
Semantic Scholar Logo Some data provided by SemanticScholar