← Back to Search
Stimuli-responsive Chitosan As An Advantageous Platform For Efficient Delivery Of Bioactive Agents.
Parinaz Sabourian, M. Tavakolian, Hossein Yazdani, M. Frounchi, T. V. D. van de Ven, D. Maysinger, A. Kakkar
Published 2019 · Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
Despite a diverse range of active pharmaceutical agents currently at our disposal, high morbidity rate diseases continue to pose a major health crisis globally. One of the important parameters in this regard is the controlled cargo delivery at desired sites. Among a variety of synthetic and natural macromolecular systems, chitosan, an abundant biopolymer, offers a platform for tailored architectures that could have high loading capacity of cargo, target and deliver. Stimuli directed accumulation of vehicles and drug release is an area of direct relevance to biomedical applications. In this review, we highlight essential characteristics of modified chitosan that present themselves for efficient response through an internal (glutathione, reactive oxygen species, pH, temperature, enzymes, and chemical/electrical potential gradient), and external stimuli (ultrasound, light, mechanical stimuli, magnetic and electrical fields). With a brief review of the pertinent properties of chitosan that are relevant to biology, the design and critical evaluation of varied chitosan-based platforms is discussed. Future directions in exploiting important features of chitosan in this area can be derived from the presented comparative evaluation of the current literature in drug delivery.
This paper references
Thermoresponsive drug controlled release from chitosan‐based hydrogel embedded with poly(N‐isopropylacrylamide) nanogels
Bomina Shin (2018)
Enhanced cell affinity of chitosan membranes mediated by superficial cross-linking: a straightforward method attainable by standard laboratory procedures.
Eustolia Rodríguez-Velázquez (2014)
Mechanical stimuli responsive and highly elastic biopolymer/nanoparticle hybrid microcapsules for controlled release.
R. Rajamanickam (2016)
Targeted Delivery of Doxorubicin via CD147-Mediated ROS/pH Dual-Sensitive Nanomicelles for the Efficient Therapy of Hepatocellular Carcinoma
Chenxi Qu (2018)
Stimuli-responsive polymers and their applications
Menglian Wei (2017)
Synthesis and characterization of pH-responsive N-naphthyl-N,O-succinyl chitosan micelles for oral meloxicam delivery.
Thisirak Woraphatphadung (2015)
Targeted Therapeutic Nanoparticles: An Immense Promise to Fight against Cancer
S. Jahan (2017)
pH-sensitive liposomes: possible clinical implications.
M. Yatvin (1980)
Synthesis of cationic chitosan hydrogel with long chain alkyl and its controlled glucose-responsive drug delivery behavior
Xue Zou (2015)
Pharmaceutical applications of chitosan.
Z. Shariatinia (2019)
Spray-dried mucoadhesives for intravesical drug delivery using N-acetylcysteine- and glutathione-glycol chitosan conjugates.
N. Denora (2016)
Effect of pH on chitosan hydrogel polymer network structure.
H. Xu (2017)
A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery.
Sung-Ching Chen (2004)
Chitosan-Based Nanomaterials for Drug Delivery
Jianghua Li (2018)
pH- and voltage-responsive chitosan hydrogel through covalent cross-linking with catechol.
Yongchao Zhang (2012)
Chitosan‐based multifunctional nanomedicines and theranostics for targeted therapy of cancer
M. Fathi (2018)
Anticancer and Anti-Inflammatory Properties of Chitin and Chitosan Oligosaccharides
K. Azuma (2015)
Synthesis and anticervical cancer activity of novel pH responsive micelles for oral curcumin delivery.
Warayuth Sajomsang (2014)
Stimuli-responsive chitosan-based nanocarriers for cancer therapy
M. Fathi (2017)
Using a kinase/phosphatase switch to regulate a supramolecular hydrogel and forming the supramolecular hydrogel in vivo.
Z. Yang (2006)
Three-dimensional microscaffolds exhibiting spatially resolved surface chemistry.
Benjamin Richter (2013)
Future perspectives and recent advances in stimuli-responsive materials
D. Roy (2010)
Zwitterionic chitosan derivatives for pH-sensitive stealth coating.
Peisheng Xu (2010)
Effective deactivation of A549 tumor cells in vitro and in vivo by RGD‐decorated chitosan‐functionalized single‐walled carbon nanotube loading docetaxel
B. Li (2018)
Increased wound pH as an indicator of local wound infection in second degree burns.
Sayaka Ono (2015)
Biological effects of chitosan and its derivatives
Dai-Hung Ngo (2015)
High‐molecular intestinal alkaline phosphatase in chronic liver diseases
K. Ooi (2007)
Water-soluble chitosan derivatives and pH-responsive hydrogels by selective C-6 oxidation mediated by TEMPO-laccase redox system.
Suse Botelho da Silva (2018)
A Boronic Acid Conjugate of Angiogenin that Shows ROS-Responsive Neuroprotective Activity.
Trish T. Hoang (2017)
Enzyme-sensing chitosan hydrogels.
Mir Morteza Sadat Ebrahimi (2014)
Serum levels of bone alkaline phosphatase in breast and prostate cancers with bone metastasis
G. Ramaswamy (2008)
Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery.
M. Chen (2012)
Mucoadhesive chitosan-coated nanostructured lipid carriers for oral delivery of amphotericin B
Janet Sui Ling Tan (2019)
A review of stimuli-responsive nanocarriers for drug and gene delivery.
Srinivas Ganta (2008)
Chitosan from Marine Crustaceans: Production, Characterization and Applications
J. B. Dima (2017)
Chitosan-based formulations for delivery of DNA and siRNA.
S. Mao (2010)
Development of Responsive Chitosan–Genipin Hydrogels for the Treatment of Wounds
Abitha M. Heimbuck (2019)
pH and Glutathione Dual-Responsive Dynamic Cross-Linked Supramolecular Network on Mesoporous Silica Nanoparticles for Controlled Anticancer Drug Release.
Qing-Lan Li (2015)
Design strategies for physical-stimuli-responsive programmable nanotherapeutics.
F. F. Sahle (2018)
In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract
G. Fuhrmann (2011)
Preparation of Reductant-Responsive N-Maleoyl-Functional Chitosan/Poly(vinyl alcohol) Nanofibers for Drug Delivery.
Chih-Kuang Chen (2016)
Redox-responsive polymer-drug conjugates based on doxorubicin and chitosan oligosaccharide-g-stearic acid for cancer therapy.
Yigang Su (2015)
Stimuli-responsive graphene-incorporated multifunctional chitosan for drug delivery applications: a review
Sahar Gooneh-Farahani (2018)
Identification of pancreatic tumors in vivo with ligand-targeted, pH responsive mesoporous silica nanoparticles by multispectral optoacoustic tomography.
M. Gurka (2016)
Conformational flexibility of chitosan: a molecular modeling study.
Søren Skovstrup (2010)
Biodegradable, Hydrogen Peroxide, and Glutathione Dual Responsive Nanoparticles for Potential Programmable Paclitaxel Release.
Daiqin Chen (2018)
Immobilization of Enzymes by Covalent Attachment
S. Novick (2005)
Sulfonated and sulfated chitosan derivatives for biomedical applications: A review.
S. Dimassi (2018)
Simply constructed chitosan nanocarriers with precise spatiotemporal control for efficient intracellular drug delivery.
M. Kong (2017)
The search for the hydrophobic force law.
Malte U. Hammer (2010)
Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles.
M. Curcio (2015)
Stability of Chitosan—A Challenge for Pharmaceutical and Biomedical Applications
E. Szymańska (2015)
Electric field responsive chitosan–poly(N,N-dimethyl acrylamide) semi-IPN gel films and their dielectric, thermal and swelling characterization
S. Sarmad (2013)
Enzyme-responsive polymeric supra-amphiphiles formed by the complexation of chitosan and ATP.
Yuetong Kang (2012)
Elastic-Plastic Transformation of Polyelectrolyte Complex Hydrogels from Chitosan and Sodium Hyaluronate.
R. Shi (2018)
Enzyme-responsive polymer assemblies constructed through covalent synthesis and supramolecular strategy.
Y. Ding (2015)
pH-responsive cancer-targeted selenium nanoparticles: a transformable drug carrier with enhanced theranostic effects.
Bo Yu (2014)
Lysozyme-Responsive Spray-Dried Chitosan Particles for Early Detection of Wound Infection
Claudia Tallian (2019)
Chitosan-based nanocarriers with pH and light dual response for anticancer drug delivery.
L. Meng (2013)
Reversible Programing of Soft Matter with Reconfigurable Mechanical Properties
Huimin He (2017)
Dually responsive injectable hydrogel prepared by in situ cross-linking of glycol chitosan and benzaldehyde-capped PEO-PPO-PEO.
C. Ding (2010)
Stimuli-responsive polymers: Fundamental considerations and applications
Yongfeng Gao (2017)
Redox and pH dual-responsive PEG and chitosan-conjugated hollow mesoporous silica for controlled drug release.
J. Jiao (2016)
Synthesis of photo-responsive chitosan-cinnamate for efficient entrapment of β-galactosidase enzyme
M. Monier (2018)
Channelled scaffolds for engineering myocardium with mechanical stimulation
T. Zhang (2012)
Thermal and osmotic deswelling of poly(NIPAM) microgel particles
B. Saunders (1996)
Drug-Free ROS Sponge Polymeric Microspheres Reduce Tissue Damage from Ischemic and Mechanical Injury.
Kristin P. O'Grady (2018)
Biomarkers for infection: enzymes, microbes, and metabolites
Gregor Tegl (2015)
Chitosan-Based Conventional and Pickering Emulsions with Long-Term Stability.
X. Wang (2016)
Thermo-responsive transfection of DNA complexes with well-defined chitosan terpolymers
Hongqian Bao (2012)
Tough Magnetic Chitosan Hydrogel Nanocomposites for Remotely Stimulated Drug Release.
Y. Wang (2018)
Novel peptidoglycan-based diagnostic devices for detection of wound infection.
A. Hasmann (2011)
Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications
R. Cheung (2015)
Insights on the interactions of chitosan with phospholipid vesicles. Part I: Effect of polymer deprotonation.
Omar Mertins (2013)
pH-sensitive chitosan-derived nanoparticles as doxorubicin carriers for effective anti-tumor activity: preparation and in vitro evaluation.
Yun-Huan Jin (2012)
Convenient preparation of charge-adaptive chitosan nanomedicines for extended blood circulation and accelerated endosomal escape
Y. Zhang (2018)
Supersensitive Oxidation-Responsive Biodegradable PEG Hydrogels for Glucose-Triggered Insulin Delivery.
Mei Zhang (2017)
Bacterial magnetic particles as a novel and efficient gene vaccine delivery system
Y-S Tang (2012)
Design of genipin-crosslinked microgels from concanavalin A and glucosyloxyethyl acrylated chitosan for glucose-responsive insulin delivery.
R. Yin (2014)
Cholinesterase-responsive supramolecular vesicle.
D. Guo (2012)
Light-Triggered Drug Release from 3D-Printed Magnetic Chitosan Microswimmers.
Ugur Bozuyuk (2018)
pH-Responsive polymeric micelles based on amphiphilic chitosan derivatives: Effect of hydrophobic cores on oral meloxicam delivery.
Thisirak Woraphatphadung (2016)
Dual thermo-and pH-sensitive injectable hydrogels of chitosan/(poly(N-isopropylacrylamide-co-itaconic acid)) for doxorubicin delivery in breast cancer.
M. Fathi (2019)
Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal caco-2 cell monolayers.
M. Thanou (2000)
Causes and consequences of tumour acidity and implications for treatment.
M. Stubbs (2000)
A positive feedback strategy for enhanced chemotherapy based on ROS-triggered self-accelerating drug release nanosystem.
Jingjing Hu (2017)
Increased expression of MMP-2 and MMP-9 in esophageal squamous cell carcinoma.
S. Samantaray (2003)
Dual‐Stimuli‐Responsive Gut Microbiota‐Targeting Berberine‐CS/PT‐NPs Improved Metabolic Status in Obese Hamsters
Hui-hui Guo (2019)
In situ diselenide-crosslinked polymeric micelles for ROS-mediated anticancer drug delivery.
V.G. Deepagan (2016)
Stimuli-responsive nanocarriers for drug delivery.
S. Mura (2013)
Stimuli responsive biopolymer (chitosan) based blend hydrogels for wound healing application.
Atta Rasool (2019)
Radical Scavenging Activities of Biomimetic Catechol-Chitosan Films.
C. Cao (2018)
A self-healing and multi-responsive hydrogel based on biodegradable ferrocene-modified chitosan
Ya-Kun Li (2014)
Estrone-modified pH-sensitive glycol chitosan nanoparticles for drug delivery in breast cancer.
H. Yang (2018)
pH-responsive self-healing injectable hydrogel based on N-carboxyethyl chitosan for hepatocellular carcinoma therapy.
J. Qu (2017)
Novel pH responsive supramolecular hydrogels of chitosan hydrochloride and polyoxometalate: In-vitro, in-vivo and preliminary safety evaluation.
Serum lysozyme: a potential marker of monocyte/macrophage activity in rheumatoid arthritis.
I. Torsteinsdóttir (1999)
Intraluminal pH of the human gastrointestinal tract.
J. Fallingborg (1999)
Glucose-responsive microgels integrated with enzyme nanocapsules for closed-loop insulin delivery.
Z. Gu (2013)
Drug release behavior of chitosan-montmorillonite nanocomposite hydrogels following electrostimulation.
Kun-Ho Liu (2008)
Doxorubicin and siRNA Codelivery via Chitosan-Coated pH-Responsive Mixed Micellar Polyplexes for Enhanced Cancer Therapy in Multidrug-Resistant Tumors.
A. M. Butt (2016)
Progress in internal/external stimuli responsive fluorescent carbon nanoparticles for theranostic and sensing applications.
Z. A. I. Mazrad (2018)
Smart human serum albumin-indocyanine green nanoparticles generated by programmed assembly for dual-modal imaging-guided cancer synergistic phototherapy.
Zonghai Sheng (2014)
Antimicrobial properties of chitosan and mode of action: a state of the art review.
M. Kong (2010)
Exploring pH-Responsive, Switchable Crosslinking Mechanisms for Programming Reconfigurable Hydrogels Based on Aminopolysaccharides
Cheng-Chieh Tsai (2018)
In situ quantitative visualization and characterization of chitosan electrodeposition with paired sidewall electrodes
Y. Cheng (2010)
Recent progress in the structural modification of chitosan for applications in diversified biomedical fields
H. Mittal (2018)
Chitosan-based nanoparticles for mucosal delivery of RNAi therapeutics.
A. Martirosyan (2014)
Extracellular pH Changes during Spreading Depression and Cerebral Ischemia: Mechanisms of Brain pH Regulation
W. Mutch (1984)
Natural Salep/PEGylated Chitosan Double Layer toward a More Sustainable pH-Responsive Magnetite Nanocarrier for Targeted Delivery of DOX and Hyperthermia Application
Nasrin Zohreh (2019)
Effective co-delivery of doxorubicin and curcumin using a glycyrrhetinic acid-modified chitosan-cystamine-poly(ε-caprolactone) copolymer micelle for combination cancer chemotherapy.
Tingsheng Yan (2016)
Reduction-responsive disassemblable core-cross-linked micelles based on poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)-lipoic acid conjugates for triggered intracellular anticancer drug release.
R. Wei (2012)
Synthesis of stimuli-responsive chitosan-based hydrogels by Diels-Alder cross-linking `click´ reaction as potential carriers for drug administration.
O. Guaresti (2018)
The relevance of tumour pH to the treatment of malignant disease.
J. Wike-Hooley (1984)
Thermo-responsive hydroxybutyl chitosan hydrogel as artery intervention embolic agent for hemorrhage control.
Guohui Sun (2017)
Nanocontact electrification: patterned surface charges affecting adhesion, transfer, and printing.
Jesse J. Cole (2011)
Stimuli-Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine.
Jiaul Hoque (2019)
Chitosan/Hyaluronic Acid Nanoparticles: Rational Design Revisited for RNA Delivery.
E. Lallana (2017)
pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates.
Arnaud E Felber (2012)
The pH sensitive properties of carboxymethyl chitosan nanoparticles cross-linked with calcium ions.
Simo Kalliola (2017)
Biodegradable and redox-responsive chitosan/poly(l-aspartic acid) submicron capsules for transmucosal delivery of proteins and peptides
C. Zheng (2013)
Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer.
L. Gerweck (1996)
Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils.
Pasquale Sacco (2017)
Reduction-responsive core-crosslinked micelles based on a glycol chitosan–lipoic acid conjugate for triggered release of doxorubicin
Yunfeng Zhou (2016)
The chitosan hydrogels: From structure to function
Jing Fu (2018)
Biomedical applications of chitin and chitosan based nanomaterials—A short review
R. Jayakumar (2010)
Chitosan-Based Polysaccharide-Gated Flexible Indium Tin Oxide Synaptic Transistor with Learning Abilities.
Fei Yu (2018)
Conjugated-polyelectrolyte-based polyprodrug: targeted and image-guided photodynamic and chemotherapy with on-demand drug release upon irradiation with a single light source.
Y. Yuan (2014)
Thermo-sensitive chitosan copolymer-gold hybrid nanoparticles as a nanocarrier for delivery of erlotinib.
M. Fathi (2018)
Characterization of a Thermoresponsive Chitosan Derivative as a Potential Draw Solute for Forward Osmosis.
R. L. G. Lecaros (2016)
The implications of recent advances in carboxymethyl chitosan based targeted drug delivery and tissue engineering applications.
Laxmi Upadhyaya (2014)
Facile Fabrication of Near-Infrared-Responsive and Chitosan-Functionalized Cu2 Se Nanoparticles for Cancer Photothermal Therapy.
Z. Liu (2016)
Multi-polysaccharide based stimuli responsive polymeric network for the in vitro release of 5-fluorouracil and levamisole hydrochloride
T. Anirudhan (2017)
Redox-responsive catiomer based on PEG-ss-chitosan oligosaccharide-ss-polyethylenimine copolymer for effective gene delivery
Lejiao Jia (2013)
Effect of pH-responsive alginate/chitosan multilayers coating on delivery efficiency, cellular uptake and biodistribution of mesoporous silica nanoparticles based nanocarriers.
W. Feng (2014)
UV-crosslinkable and thermo-responsive chitosan hybrid hydrogel for NIR-triggered localized on-demand drug delivery.
L. Wang (2017)
Stimuli-Responsive Polymers in the 21st Century: Elaborated Architecture to Achieve High Sensitivity, Fast Response, and Robust Behavior
H. Kirsebom (2011)
Polymeric micelles for oral drug delivery.
G. Gaucher (2010)
A core/shell stabilized polysaccharide-based nanoparticle with intracellular environment-sensitive drug delivery for breast cancer therapy.
Y. Wu (2018)
Highly Biocompatible Chlorin e6-Loaded Chitosan Nanoparticles for Improved Photodynamic Cancer Therapy.
Yuanfu Ding (2018)
Charge reversible and biodegradable nanocarriers showing dual pH-/reduction-sensitive disintegration for rapid site-specific drug delivery.
Yalei Miao (2018)
Development of Photo-Activated ROS-Responsive Nanoplatform as a Dual-Functional Drug Carrier in Combinational Chemo-Photodynamic Therapy
Y. Chang (2019)
Enzymatic hydrogelation of small molecules.
Zhimou Yang (2008)
Improvement of chitosan solubility and bactericidity by synthesis of N-benzimidazole-O-acetyl-chitosan and its electrodeposition.
N. Rahmouni (2018)
Functionalized-chitosan/quantum dot nano-hybrids for nanomedicine applications: towards biolabeling and biosorbing phosphate metabolites.
H. Mansur (2013)
pH sensitive N-succinyl chitosan grafted polyacrylamide hydrogel for oral insulin delivery.
Piyasi Mukhopadhyay (2014)
Chitosan nanoparticles triggered the induction of ROS-mediated cytoprotective autophagy in cancer cells
H. Wang (2018)
Near-infrared light stimuli-responsive synergistic therapy nanoplatforms based on the coordination of tellurium-containing block polymer and cisplatin for cancer treatment.
F. Li (2017)
Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
M. Lutolf (2005)
Reactive oxygen species: from health to disease.
K. Brieger (2012)
Smart Chitosan-Based Stimuli-Responsive Nanocarriers for the Controlled Delivery of Hydrophobic Pharmaceuticals
Daoben Hua (2011)
pH sensitive chitosan-mesoporous silica nanoparticles for targeted delivery of a ruthenium complex with enhanced anticancer effects.
Gaochao Lv (2016)
Thermo-Magnetoresponsive Dual Function Nanoparticles: An Approach for Magnetic Entrapable-Releasable Chitosan.
Chutamart Pitakchatwong (2017)
Oxidation-responsive polymeric vesicles
A. Napoli (2004)
Redox-responsive nanocarriers for drug and gene co-delivery based on chitosan derivatives modified mesoporous silica nanoparticles.
Jian-tao Lin (2017)
alpha-Lipoic acid as a biological antioxidant.
L. Packer (1995)
Glutathione-dependent micelles based on carboxymethyl chitosan for delivery of doxorubicin
X. Zhang (2016)
pH and Glucose Dual-Responsive Injectable Hydrogels with Insulin and Fibroblasts as Bioactive Dressings for Diabetic Wound Healing.
L. Zhao (2017)
Chitosan hydrogels cross-linked with tris(2-(2-formylphenoxy)ethyl)amine: Swelling and drug delivery.
A. Karimi (2018)
Thermosensitive chitosan/phosphate hydrogel‐composites fortified with Ag versus Ag@Pd for biomedical applications
G. W. Ali (2018)
Nanoparticles with dual responses to oxidative stress and reduced ph for drug release and anti-inflammatory applications.
Hsiao-Lan Pu (2014)
Targeted delivery of insoluble cargo (paclitaxel) by PEGylated chitosan nanoparticles grafted with Arg-Gly-Asp (RGD).
P. Lv (2012)
Mechanically strong dual responsive nanocomposite double network hydrogel for controlled drug release of asprin.
Y. Chen (2018)
Thermoresponsive chitosan-agarose hydrogel for skin regeneration.
S. Miguel (2014)
Reusable Green Aerogels from Cross-Linked Hairy Nanocrystalline Cellulose and Modified Chitosan for Dye Removal.
H. Yang (2016)
Chitosan-based composite hydrogels for biomedical applications
Tepeng Wu (2017)
Chitosan Microgels Embedded with Catalase Nanozyme-Loaded Mesocellular Silica Foam for Glucose-Responsive Drug Delivery.
M. Y. Kim (2017)
Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44
T. Wang (2017)
PEGylated chitosan derivatives: synthesis, characterizations and pharmaceutical applications
L. Casettari (2012)
A polysaccharide-based micelle-hydrogel synergistic therapy system for diabetes and vascular diabetes complications treatment.
N. Wen (2019)
Ionization behavior of chitosan and chitosan-DNA polyplexes indicate that chitosan has a similar capability to induce a proton-sponge effect as PEI.
I. Richard (2013)
Enzyme-responsive release of encapsulated proteins from biodegradable hollow capsules.
Y. Itoh (2006)
pH-responsive chitosan/alginate polyelectrolyte complex membranes reinforced by tripolyphosphate
Magdalena Gierszewska (2018)
Smart Polymers and Their Applications as Biomaterials
M. Aguilar (2007)
Chitin and chitosan in selected biomedical applications
A. Anitha (2014)
An electric field responsive drug delivery system based on chitosan–gold nanocomposites for site specific and controlled delivery of 5-fluorouracil
P. Chandran (2014)
A phenylboronate-functionalized polyion complex micelle for ATP-triggered release of siRNA.
M. Naito (2012)
Thermo-responsive association of chitosan-graft-poly(N-isopropylacrylamide) in aqueous solutions.
Hongqian Bao (2010)
Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
Logan R Boles (2018)
Fundamentals of chitosan for biomedical applications
E. Vunain (2017)
Mechanoactive materials in cardiac science.
J. Ponniah (2016)
This paper is referenced by
Advances in tracking of polysaccharides in vivo: Labeling strategies, potential factors and applications based on pharmacokinetic characteristics.
Ziming Zheng (2020)
Crude Oil/Water Nanoemulsions Stabilized by Biosurfactant: Stability and pH-Switchability
S. Onaizi (2020)
Chemical and physical chitosan hydrogels as prospective carriers for drug delivery: a review.
Bingren Tian (2020)
Multifunctional chitosan-copper-gallic acid based antibacterial nanocomposite wound dressing.
X. Sun (2020)
Chitosan as a machine for biomolecule delivery: A review.
Z. Mohammadi (2021)
Smart stimuli-responsive biopolymeric nanomedicines for targeted therapy of solid tumors.
M. Fathi (2020)
Facile design of autogenous stimuli-responsive chitosan/hyaluronic acid nanoparticles for efficient small molecules to protein delivery.
Parinaz Sabourian (2020)
Absorption, distribution, metabolism, and excretion of nanocarriers in vivo and their influences.
Aoxue Zhang (2020)
Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology
Hossein Yazdani (2020)
From microporous to mesoporous mineral frameworks: An alliance between zeolite and chitosan.
G. Mahmodi (2020)
Potential of lactic acid bacteria derived polysaccharides for the delivery and controlled release of oral probiotics.
N. Liao (2020)
Niosome-based hydrogel as a potential drug delivery system for topical and transdermal applications
Fiammetta Nigro (2020)
Miktoarm Star Polymers with Environment-Selective ROS/GSH Responsive Locations: From Modular Synthesis to Tuned Drug Release through Micellar Partial Corona Shedding and/or Core Disassembly.
V. Lotocki (2021)