Online citations, reference lists, and bibliographies.
← Back to Search

A Critical Evaluation Of Comparative Regulatory Strategies For Monitoring Pharmaceuticals In Recycled Wastewater.

Olga Miarov, A. Tal, D. Avisar
Published 2019 · Medicine, Business

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Pharmaceuticals are a subset of micropollutants, present in the environment in trace concentrations. Because of their persistent nature, these chemicals are of particular concern. Little is known about how mixtures of pharmaceutical residues, found in WWTP effluents, affect the environment or public health. Yet, numerous studies show negative outcomes for both aquatic and terrestrial organisms, suggesting that they are given both to bioaccumulation and uptake in plants. Israel leads the world in effluent reuse (86%), almost exclusively utilized for purposes of agricultural irrigation. Pharmaceuticals, however, are not included in Israel's water regulatory oversight or management, essentially creating an epidemiological experiment among its citizens and environment. Globally, these compounds also are not commonly subject to monitoring or regulation. This study reviews and analyzes water policies and regulation worldwide that address the presence of pharmaceuticals in water resources, with a particular focus on Australia, Singapore, Switzerland, and the USA. Furthermore, the study investigates the reasons why these chemicals are not yet regulated in Israel. Based on a comprehensive evaluation of the data and analysis of the regulatory rationale in other countries, a list of recommended pharmaceutical standards that should be measured and monitored in Israel's wastewater treatment system is proposed. The suggested prioritization criteria should be at the heart of a new regulatory agenda for controlling pharmaceutical contamination in wastewater.
This paper references
10.1016/0361-3682(78)90008-9
Policy analysis is what information systems are not
A. Wildavsky (1978)
10.1016/S0140-6736(00)02270-4
Presence of therapeutic drugs in the environment
E. Zuccato (2000)
10.1021/ES020158E
Strategic Survey of Therapeutic Drugs in the Rivers Po and Lambro in Northern Italy
D. Calamari (2003)
10.1016/S0045-6535(02)00860-3
Do pharmaceuticals affect freshwater invertebrates? A study with the cnidarian Hydra vulgaris.
D. Pascoe (2003)
10.1016/J.WATRES.2004.03.029
Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant.
M. Carballa (2004)
10.1016/J.WATRES.2003.10.058
Carbamazepine as a possible anthropogenic marker in the aquatic environment: investigations on the behaviour of Carbamazepine in wastewater treatment and during groundwater infiltration.
M. Clara (2004)
10.1038/nature02317
Diclofenac residues as the cause of vulture population decline in Pakistan
J. Oaks (2004)
10.1016/J.TIBTECH.2004.05.003
Hindsight rather than foresight: reality versus the EU draft guideline on pharmaceuticals in the environment.
E. O'brien (2004)
10.1511/2004.45.921
Human Biomonitoring of Environmental Chemicals
K. Sexton (2004)
10.2166/WST.2005.0321
Quantification of sewer exfiltration using the anti-epileptic drug carbamazepine as marker species for wastewater.
R. Fenz (2005)
Mammalian sex hormones in plants.
A. Janeczko (2005)
10.1897/05-495R.1
Neuropharmaceuticals in the environment: mianserin-induced neuroendocrine disruption in zebrafish (Danio rerio) using cDNA microarrays.
K. van der Ven (2006)
10.13140/RG.2.2.21187.91683
Development of an International Priority List of Pharmaceuticals relevant for the Water Cycle
P. Voogt (2007)
10.1080/10807030802235078
Exposure Assessment of Pharmaceuticals and Their Metabolites in the Aquatic Environment: Application to the French Situation and Preliminary Prioritization
J. Besse (2008)
10.1007/s00128-008-9558-7
Norfluoxetine Induces Spawning and Parturition in Estuarine and Freshwater Bivalves
P. P. Fong (2008)
10.1007/S12665-009-0088-3
The processes affecting oxytetracycline contamination of groundwater in a phreatic aquifer underlying industrial fish ponds in Israel
D. Avisar (2009)
10.1016/j.envpol.2008.11.045
Fate of pharmaceuticals and personal care products in wastewater treatment plants--conception of a database and first results.
C. Miège (2009)
10.1080/10934520903263306
Detection of amoxicillin-diketopiperazine-2′, 5′ in wastewater samples
Assaf Lamm (2009)
10.1016/j.scitotenv.2009.03.032
Sulfamethoxazole contamination of a deep phreatic aquifer.
D. Avisar (2009)
10.1016/j.envpol.2008.09.040
Effects of fluoxetine on the reproduction of two prosobranch mollusks: Potamopyrgus antipodarum and Valvata piscinalis.
M. Gust (2009)
Economics of Environment
S. Muthukrishnan (2010)
10.1071/EN10037
Investigation of an amoxicillin oxidative degradation product formed under controlled environmental conditions
I. Gozlan (2010)
10.1021/es100604c
Quantitative evaluation of tracers for quantification of wastewater contamination of potable water sources.
G. Gasser (2010)
10.2166/9781780401447
Treatment of Micropollutants in Water and Wastewater
J. Virkutyte (2010)
10.1007/S11270-009-0212-8
Sorption of Sulfonamides and Tetracyclines to Montmorillonite Clay
D. Avisar (2010)
Further evidence on the high prevalence of male factor infertility diagnosis in Israel.
T. Sella (2011)
10.1586/eem.11.20
Estrogen action and prostate cancer
Jason L Nelles (2011)
10.1007/s11270-011-1049-5
Development Method for Extracting and Analyzing Antibiotic and Hormone Residues from Treated Wastewater Sludge and Composted Biosolids
Michelle Shafrir (2012)
10.1016/j.scitotenv.2012.01.039
Prioritising pharmaceuticals for environmental risk assessment: Towards adequate and feasible first-tier selection.
V. Roos (2012)
10.1289/ehp.1104477
Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions?
A. Boxall (2012)
10.1016/j.chemosphere.2013.01.095
Amoxicillin-degradation products formed under controlled environmental conditions: identification and determination in the aquatic environment.
I. Gozlan (2013)
10.1021/es402065a
The Read-Across Hypothesis and Environmental Risk Assessment of Pharmaceuticals
M. Rand-Weaver (2013)
10.1016/j.watres.2013.04.059
Treating wastewater from a pharmaceutical formulation facility by biological process and ozone.
Y. Lester (2013)
10.1111/eva.12093
The effects of synthetic estrogen exposure on premating and postmating episodes of selection in sex-role-reversed Gulf pipefish
E. Rose (2013)
10.1021/es3030148
Global Synthesis and Critical Evaluation of Pharmaceutical Data Sets Collected from River Systems
S. Hughes (2013)
10.1007/s11356-014-3796-5
POCIS passive samplers as a monitoring tool for pharmaceutical residues and their transformation products in marine environment
M. M. Martínez Bueno (2014)
10.1159/000357444
Long-Term Secular Trends in the Age at Menarche in Israel: A Systematic Literature Review and Pooled Analysis
Shira Flash-Luzzatti (2014)
10.1021/es5008615
Insights into the uptake processes of wastewater-borne pharmaceuticals by vegetables.
Myah Goldstein (2014)
10.1021/es5017894
Irrigation of root vegetables with treated wastewater: evaluating uptake of pharmaceuticals and the associated human health risks.
Tomer Malchi (2014)
10.1016/S1473-3099(14)70780-7
Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data.
T. V. Van Boeckel (2014)
10.1016/j.envpol.2013.10.038
Biodegradability of pharmaceutical compounds in agricultural soils irrigated with treated wastewater.
Amnon Grossberger (2014)
Antimicrobial residues in foods of animal origin in Africa: public health risks.
S. Mensah (2014)
10.1007/s11270-015-2454-y
Naproxen-Enriched Artificial Sediment Induces Oxidative Stress and Genotoxicity in Hyalella azteca
García-Medina Alba Lucero (2015)
10.3934/ENVIRONSCI.2015.3.782
Major national human biomonitoring programs in chemical exposure assessment
Judy Choi (2015)
10.1016/j.watres.2015.07.034
A hybrid process of biofiltration of secondary effluent followed by ozonation and short soil aquifer treatment for water reuse.
I. Zucker (2015)
10.1021/acs.est.5b02222
Transformation Pathways of the Recalcitrant Pharmaceutical Compound Carbamazepine by the White-Rot Fungus Pleurotus ostreatus: Effects of Growth Conditions.
Naama Golan-Rozen (2015)
Fourth Unregulated Contaminant Monitoring Rule
Ow (2015)
10.1016/j.etap.2015.07.009
Effects of the non-steroidal anti-inflammatory drug(NSAID) naproxen on gene expression of antioxidant enzymes in zebrafish (Danio rerio).
V. Stancová (2015)
10.1016/j.envpol.2016.02.027
Environmental exposure to pharmaceuticals: A new technique for trace analysis of carbamazepine and its metabolites in human urine.
G. Fedorova (2016)
10.1016/j.envint.2016.09.014
Diclofenac and its transformation products: Environmental occurrence and toxicity - A review.
Linson Lonappan (2016)
10.1007/s11356-016-7069-3
Fate and effects of the residues of anticancer drugs in the environment
E. Heath (2016)
10.1021/acs.est.6b03233
Fluoxetine Exhibits Pharmacological Effects and Trait-Based Sensitivity in a Marine Worm.
Cameron M. Hird (2016)
10.1016/j.watres.2015.12.016
Rethinking the sustainability of Israel's irrigation practices in the Drylands.
A. Tal (2016)
10.1002/etc.3339
Pharmaceuticals in the environment--Global occurrences and perspectives.
Tim aus der Beek (2016)
10.1016/j.aquatox.2015.09.011
Age matters: Developmental stage of Danio rerio larvae influences photomotor response thresholds to diazinion or diphenhydramine.
L. Kristofco (2016)
10.1002/etc.3240
Effects of trophic exposure to diclofenac and dexamethasone on hematological parameters and immune response in freshwater fish.
J. L. C. Ribas (2016)
10.1007/s11356-016-6679-0
Risk-based prioritization of pharmaceuticals in the natural environment in Iraq
O. Al-Khazrajy (2016)
10.1016/j.scitotenv.2015.12.117
Dynamics of active pharmaceutical ingredients loads in a Swiss university hospital wastewaters and prediction of the related environmental risk for the aquatic ecosystems.
S. Daouk (2016)
10.1093/jnci/djw103
Endogenous Estrogens, Estrogen Metabolites, and Breast Cancer Risk in Postmenopausal Chinese Women.
S. Moore (2016)
10.1007/398_2015_5002
Pharmaceuticals May Disrupt Natural Chemical Information Flows and Species Interactions in Aquatic Systems: Ideas and Perspectives on a Hidden Global Change.
E. van Donk (2016)
10.1021/acs.est.5b06256
Human Exposure to Wastewater-Derived Pharmaceuticals in Fresh Produce: A Randomized Controlled Trial Focusing on Carbamazepine.
O. Paltiel (2016)
10.1186/s13584-016-0108-1
Household medical waste disposal policy in Israel
Zohar Barnett-Itzhaki (2016)
10.1002/etc.3087
The effects of antidepressants appear to be rapid and at environmentally relevant concentrations.
A. Ford (2016)
10.1016/j.chemosphere.2016.06.048
Fate of carbamazepine, its metabolites, and lamotrigine in soils irrigated with reclaimed wastewater: Sorption, leaching and plant uptake.
A. Paz (2016)
10.1002/etc.3319
Toxicological and ecotoxicological risk-based prioritization of pharmaceuticals in the natural environment.
Jiahua Guo (2016)
10.1016/j.aquatox.2017.05.017
Diclofenac affects kidney histology in the three-spined stickleback (Gasterosteus aculeatus) at low μg/L concentrations.
J. Näslund (2017)
10.1016/j.scitotenv.2017.06.076
SSRIs antidepressants in marine mussels from Atlantic coastal areas and human risk assessment.
L. Silva (2017)
10.1016/j.envint.2016.12.010
Environmental impact of estrogens on human, animal and plant life: A critical review.
Muhammad Adeel (2017)
10.1002/ieam.1895
Prioritization of pharmaceuticals based on risks to aquatic environments in Kazakhstan.
B. Aubakirova (2017)
10.1016/j.aquatox.2016.11.007
Effect of antidepressants on circadian rhythms in fish: Insights and implications regarding the design of behavioural toxicity tests.
S. Melvin (2017)
10.1007/s11356-017-9293-x
Occurrence and risk assessment of antidepressants in Huangpu River of Shanghai, China
M. Wu (2017)
10.1016/j.scitotenv.2017.03.120
Global scanning of antihistamines in the environment: Analysis of occurrence and hazards in aquatic systems.
L. Kristofco (2017)
10.1016/j.ijheh.2016.09.008
Human biomonitoring in Israel: Recent results and lessons learned.
T. Berman (2017)
10.1016/j.ecoenv.2017.01.053
Effects of environmentally relevant concentrations of the anti-inflammatory drug diclofenac in freshwater fish Rhamdia quelen.
I. C. Guiloski (2017)
10.1080/01919512.2017.1346465
The Role of Soil Aquifer Treatment (SAT) for Effective Removal of Organic Matter, Trace Organic Compounds and Microorganisms from Secondary Effluents Pre-Treated by Ozone
A. Lakretz (2017)
10.1016/J.EMCON.2017.04.001
Pay special attention to the transformation products of PPCPs in environment
Lina Yin (2017)
10.3390/W10020197
Addressing Desalination’s Carbon Footprint: The Israeli Experience
A. Tal (2018)
10.1002/etc.3948
Acute exposure to an environmentally relevant concentration of diclofenac elicits oxidative stress in the culturally important galaxiid fish Galaxias maculatus.
N. McRae (2018)
Customer Service Advisor
Sophie Hawes (2018)
10.1016/j.envpol.2017.09.029
Composted biosolids and treated wastewater as sources of pharmaceuticals and personal care products for plant uptake: A case study with carbamazepine.
Evyatar Ben Mordechay (2018)



This paper is referenced by
10.1016/J.JWPE.2021.102098
Analysis of WWTPs technologies based on the removal efficiency of Pharmaceutical Activated Compounds for water reuse purposes. A Fuzzy Multi-Criteria Decision Making approach
C. Fernández-López (2021)
10.1016/J.PSEP.2021.04.045
Occurrence and removal of pharmaceuticals in wastewater treatment plants
Omar Fawzi Suleiman Khasawneh (2021)
10.1016/B978-0-12-822956-9.00024-6
Treatment of pharmaceutical and personal care products in wastewater
Purvi Mathur (2021)
10.1016/j.scitotenv.2020.142177
Emerging contaminants in the water bodies of the Middle East and North Africa (MENA): A critical review.
Mariam Ouda (2021)
10.1016/j.jenvman.2020.111131
Application of Pleurotus ostreatus to efficient removal of selected antidepressants and immunosuppressant.
Bartosz Kózka (2020)
10.1007/698_2020_555
Risk Evaluation and Legal Framework of the Nonsteroidal Anti-inflammatory Drugs Around the World
Jesús Daniel Cardoso-Vera (2020)
10.3390/en13143599
Advanced Wastewater Treatment to Eliminate Organic Micropollutants in Wastewater Treatment Plants in Combination with Energy-Efficient Electrolysis at WWTP Mainz
Oliver Gretzschel (2020)
10.1007/698_2020_623
Sources of Pharmaceuticals in Water
R. Parra-Saldívar (2020)
10.5902/2236117062660
Development of poly(vinyl alcohol)-based membranes by the response surface methodology for environmental applications
J. Merck (2020)
10.1016/j.wri.2020.100132
Water efficiency and safe re-use of different grades of water - Topical issues for the pharmaceutical industry
E. Strade (2020)
10.1016/j.envpol.2020.115891
Toxic effects of NSAIDs in non-target species: A review from the perspective of the aquatic environment.
K. Świacka (2020)
10.1007/978-3-030-56294-6
Non-Steroidal Anti-Inflammatory Drugs in Water: Emerging Contaminants and Ecological Impact
A. Kostianoy (2020)
Semantic Scholar Logo Some data provided by SemanticScholar