Detection Of Minimal Hepatic Encephalopathy: Normalization And Optimization Of The Psychometric Hepatic Encephalopathy Score. A Neuropsychological And Quantified EEG Study.
Piero Amodio, Francesca Campagna, Stefania Olianas, Pamela Iannizzi, Daniela Mapelli, Marco Penzo, P Angeli, Angelo Gatta
Published 2008 · Medicine
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BACKGROUND/AIMS Psychometric Hepatic Encephalopathy Score (PHES) and EEG are used to detect minimal hepatic encephalopathy (MHE). We aimed at standardizing PHES in Italy and comparing Italian, German and Spanish norms in EEG characterized cirrhotic patients. METHODS PHES was standardized on 228 normal individuals. Repeatability was studied in 128 individuals. One hundred patients with liver cirrhosis underwent EEG and PHES which was computed on the Spanish, German and the Italian norms. RESULTS Age and education levels were predictors of psychometric tests; therefore, adjusted Z scores were calculated. Practice effect (p<0.01) was detected. In the patients, the Italian norms were closer to the Spanish norms (difference -0.14+/-1.32, p=0.29) than to the Germans ones (difference 1.97+/-2.07, p<0.001). The PHES calculated on the Italian norms was correlated with the EEG mean dominant frequency more closely than the ones calculated on the German and Spanish norms (r=0.38, r=0.31, r=0.33, respectively -p<0.01). The detection of MHE on the basis of PHES and EEG showed limited agreement (73%, Cohen's K=0.32). CONCLUSIONS (i) Valid norms for PHES were produced, (ii) clues for the use of common norms in Latin Countries were found, (iii) different findings between PHES and EEG possibly reflect various features of MHE.
This paper references
"What's in a name?" Improving the care of cirrhotics.
Alan H. Lockwood (2000)
Hamster W. Quality of life in cirrhotics with minimal hepatic encephalopathy
H Schomerus (2001)
Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients.
Piero Amodio (2001)
Attention Deficits in Minimal Hepatic Encephalopathy
Karin Weissenborn (2004)
The ten-twenty electrode system of the International Federation. The International Federation of Clinical Neurophysiology.
George H. Klem (1999)
Positron - emission tomographic localization of abnormalities of brain metabolism in patients with minimal hepatic encephalopa
AH Lockwood (1993)
Value of the critical flicker frequency in patients with minimal hepatic encephalopathy.
Manuel Romero-Gómez (2007)
Characteristics of Minimal Hepatic Encephalopathy
Piero Amodio (2004)
Hepatic encephalopathy--definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998.
Peter Ferenci (2002)
Visual attention in cirrhotic patients: a study on covert visual attention orienting.
Piero Amodio (1998)
Amino acid challenge in patients with cirrhosis: a model for the assessment of treatments for hepatic encephalopathy.
Angela Douglass (2001)
Statistical methods for assessing agreement between two methods of clinical measurement
J Martin Bland (1986)
Impairment of Response Inhibition Precedes Motor Alteration in the Early Stage of Liver Cirrhosis: A Behavioral and Electrophysiological Study
Sami Schiff (2005)
Attention Dysfunction in Cirrhotic Patients: An Inquiry on the Role of Executive Control, Attention Orienting and Focusing
Piero Amodio (2005)
MINIMAL HEPATIC ENCEPHALOPATHY IMPAIRS FITNESS TO DRIVE
Paul J. Gaglio (2004)
Subclinical hepatic encephalopathy impairs daily functioning.
Michael Groeneweg (1998)
Non alcoholic cirrhosis associated with neuropsycho- P
RE Tarter (2008)
Attention, Memory, and Cognitive Function in Hepatic Encephalopathy
Karin Weissenborn (2005)
Tablas de normalidad de la población española para los tests psicométricos utilizados en el diagnóstico de la encefalopatía hepática mínima
Manuel Romero Gómez (2006)
Spectral versus visual EEG analysis in mild hepatic encephalopathy
Piero Amodio (1999)
Diagnostic tools for the detection of subclinical hepatic encephalopathy: comparison of standard and computerized psychometric tests with spectral-EEG
Piero Amodio (2005)
Positron-emission tomographic localization of abnormalities of brain metabolism in patients with minimal hepatic encephalopathy.
Alan H. Lockwood (1993)
Neuropsychological Aspects of Portal-Systemic Encephalopathy
Hans Schomerus (1998)
Quality of Life in Cirrhotics with Minimal Hepatic Encephalopathy
Hans Schomerus (2004)
The number connection tests A and B: interindividual variability and use for the assessment of early hepatic encephalopathy.
Karin Weissenborn (1998)
What's in a name?
Robert J. Shprintzen (1990)
Clinical features and survivial of cirrhotic patients with subclinical cognitive alterations detected by the number connection test and computerized psychometric tests.
Piero Amodio (1999)
Electrophysiological and neuropsychological tests for the diagnosis of subclinical hepatic encephalopathy and prediction of overt encephalopathy.
Nandini Saxena (2002)
Variability of Trail Making Test, Symbol Digit Test and Line Trait Test in normal people. A normative study taking into account age-dependent decline and sociobiological variables
Piero Amodio (2002)
The diagnosis of subclinical hepatic encephalopathy in patients with cirrhosis using neuropsychological tests and automated electroencephalogram analysis.
Jose Carlos Salazar Quero (1996)
Neuropsychological characterization of hepatic encephalopathy.
Karin Weissenborn (2001)
This paper is referenced by
Diagnosis of minimal hepatic encephalopathy in a tertiary care center from eastern Romania: validation of the psychometric hepatic encephalopathy score (PHES)
M A Badea (2016)
Branched-chain amino acids for people with hepatic encephalopathy.
Lise Lotte Gluud (2017)
A Model for Predicting Development of Overt Hepatic Encephalopathy in Patients With Cirrhosis.
Oliviero Riggio (2015)
Normalization of the psychometric hepatic encephalopathy score in Polish population. A prospective, quantified electroencephalography study.
Ewa Wunsch (2013)
The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis.
Lisa Zarantonello (2019)
Regression-based normative data and equivalent scores for Trail Making Test (TMT): an updated Italian normative study
Mattia Siciliano (2018)
Endozepine-4 levels are increased in hepatic coma.
Giulia Malaguarnera (2015)
Hepatic Encephalopathy: Pathophysiology and Diagnosis
Dae Hee Choi (2014)
Impulsivity toward food reward is related to BMI: Evidence from intertemporal choice in obese and normal-weight individuals
Sami Schiff (2016)
Chapter 81 – Neuropsychiatric Complications
Elisa Ansoleaga Moreno (2015)
Vigilance and wake EEG architecture in simulated hyperammonaemia: a pilot study on the effects of L-Ornithine-L-Aspartate (LOLA) and caffeine
María Garrido (2016)
Standardization and normative data obtained in the Italian population for a new verbal fluency instrument, the phonemic/semantic alternate fluency test
Alberto Costa (2013)
A pilot evaluation of a computer-based psychometric test battery designed to detect impairment in patients with cirrhosis
Nicola A. Cook (2017)
Diagnosis of minimal hepatic encephalopathy.
Karin Weissenborn (2015)
Cognitive dysfunctions and cerebral microbleeds in adult patients with haemophilia A: a clinical and MRI pilot-study.
Ezio Zanon (2014)
Review article: the modern management of hepatic encephalopathy.
Jasmohan S Bajaj (2010)
The why and wherefore of hepatic encephalopathy vijay
P. S. Grover (2015)
Confounders in the detection of minimal hepatic encephalopathy: a neuropsychological and quantified EEG study.
Francesca Campagna (2015)
PHES: one label, different goods?!
Karin Weissenborn (2008)
Comparison of the most favoured methods for the diagnosis of hepatic encephalopathy in liver transplantation candidates
Annemarie Goldbecker (2013)
Muscle alterations are associated with minimal and overt hepatic encephalopathy in patients with liver cirrhosis.
Silvia Nardelli (2019)
The why and wherefore of hepatic encephalopathy
Vijay Pb Grover (2015)
Hepatic encephalopathy 2018: A clinical practice guideline by the Italian Association for the Study of the Liver (AISF).
Sara Montagnese (2019)
18. Hepatic Encephalopathy
M. Ravi Prakash (2011)
Inhibitory control test for the detection of minimal hepatic encephalopathy in patients with cirrhosis of liver.
Sunil Taneja (2012)
Assentment of the influence of liver cirrhosis and minimal hepatic encephalopathy on quality of life
Diana Santos (2014)
Encefalopatía hepática mínima Artículo de revisión
M. Jover (2016)
Diagnosis of covert hepatic encephalopathy: a multi-center study testing the utility of single versus combined testing
Andrés Duarte-Rojo (2018)
Treatment Options for Covert Hepatic Encephalopathy
Nisheet Waghray (2014)
Advances in the Evaluation and Management of Minimal Hepatic Encephalopathy
Jennifer Y Montgomery (2011)
Toward a portable, self-administered critical flicker frequency test
Ravi Karkar (2016)
[Psychometric hepatic encephalopathy score normalization data for the Portuguese population].
Marta Pinho (2011)See more