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Alcohol Drinking Pattern And Risk Of Alcoholic Liver Cirrhosis: A Prospective Cohort Study.
G. Askgaard, M. Grønbæk, M. Kjær, A. Tjønneland, J. Tolstrup
Published 2015 · Medicine
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BACKGROUND & AIMS Alcohol is the main contributing factor of alcoholic cirrhosis, but less is known about the significance of drinking pattern. METHODS We investigated the risk of alcoholic cirrhosis among 55,917 participants (aged 50-64 years) in the Danish Cancer, Diet, and Health study (1993-2011). Baseline information on alcohol intake, drinking pattern, and confounders was obtained from a questionnaire. Follow-up information came from national registers. We calculated hazard ratios (HRs) for alcoholic cirrhosis in relation to drinking frequency, lifetime alcohol amount, and beverage type. RESULTS We observed 257 and 85 incident cases of alcoholic cirrhosis among men and women, respectively, none among lifetime abstainers. In men, HR for alcoholic cirrhosis among daily drinkers was 3.65 (95% CI: 2.39; 5.55) compared to drinking 2-4 days/week. Alcohol amount in recent age periods (40-49 and 50-59 years) was associated with an increased risk, whereas the amount in 20-29 and 30-39 years was not. In men drinking 14-28 drinks/week, HR was 7.47 (95% CI: 1.68; 33.12), 3.12 (95% CI: 1.53; 6.39), and 1.69 (95% CI: 0.79; 3.65) in drinkers of little (<1% of weekly amount), some (1-15%), and mostly wine (50-100%), compared to drinking <14 drinks/week. In general, results were similar for women. CONCLUSIONS In men, daily drinking was associated with an increased risk of alcoholic cirrhosis. Recent alcohol consumption rather than earlier in life was associated with risk of alcoholic cirrhosis. Compared to beer and liquor, wine might be associated with a lower risk of alcoholic cirrhosis.
This paper references
Patterns of alcohol drinking and all-cause mortality: results from a large-scale population-based cohort study in Japan.
T. Marugame (2007)
Drinking patterns, dependency and life-time drinking history in alcohol-related liver disease.
J. Hatton (2009)
EASL clinical practical guidelines: management of alcoholic liver disease.
P. Mathurin (2012)
Features, diagnosis, and treatment of nonalcoholic fatty liver disease.
D. Torres (2012)
A prospective study of risk drinking: at risk for what? Drug Alcohol Depend 2008;95:62–72
D Dawson (2008)
Drinking pattern and mortality in middle-aged men and women.
J. Tolstrup (2004)
Hepatitis C prevalence in Denmark -an estimate based on multiple national registers
P. Christensen (2012)
The Danish National Patient Register
E. Lynge (2011)
Alcoholic cirrhosis in Denmark – population-based incidence, prevalence, and hospitalization rates between 1988 and 2005: A descriptive cohort study
P. Jepsen (2008)
Alcohol and cirrhosis: dose--response or threshold effect?
M. Kamper-Jørgensen (2004)
The changes in the social class distribution of moderate and high alcohol consumption and of alcohol-related disabilities over time in Stockholm County and in Sweden.
A. Romelsjö (1996)
Treatment of nonalcoholic fatty liver disease.
P. Angulo (2002)
Database on Danish population-based registers for public health and welfare research
C. Sortsø (2011)
Prediction of risk of liver disease by alcohol intake, sex, and age: A prospective population study
U. Becker (1996)
Validity of self-reported intakes of wine, beer and spirits in population studies.
M. Grønbaek (1996)
Letter: The double peak in the plasma-drug curve after oral digoxin and lanatoside C.
R. Thomas (1973)
Liver Cirrhosis Mortality in Europe, with Special Attention to Central and Eastern Europe
W. Zatónski (2010)
Body fat distribution and risk factors for fibrosis in patients with alcoholic liver disease.
S. Naveau (2013)
Excess weight risk factor for alcoholic liver disease
S. Naveau (1997)
Different drinking patterns for women and men with alcohol dependence with and without alcoholic cirrhosis.
K. Stokkeland (2008)
Lower risk for alcohol‐induced cirrhosis in wine drinkers
U. Becker (2002)
Alcohol as a risk factor for liver cirrhosis: a systematic review and meta-analysis.
J. Rehm (2010)
PROSPECTIVE EVALUATION OF ALCOHOL ABUSE AND ALCOHOLIC LIVER INJURY IN MEN AS PREDICTORS OF DEVELOPMENT OF CIRRHOSIS
ThorkildI. A. Sørensen (1984)
ALCOHOL AND MORTALITY IN BRITISH MEN: EXPLAINING THE U-SHAPED CURVE
A. Shaper (1988)
CIRRHOSIS IN THE ALCOHOLIC AND ITS RELATION TO THE VOLUME OF ALCOHOL ABUSE
W. K. Lelbach (1975)
Per capita alcohol consumption and liver cirrhosis mortality in 14 European countries.
M. Ramstedt (2001)
Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men
K. Mukamal (2003)
A prospective study of risk drinking: at risk for what?
D. Dawson (2008)
Effect of binge drinking on the liver: an alarming public health issue?
P. Mathurin (2009)
Smoking and risk of liver cirrhosis: a population-based cohort study
M. Dam (2013)
Alcoholic liver disease: pathogenesis and new therapeutic targets.
B. Gao (2011)
Drinking habits as cofactors of risk for alcohol induced liver damage
S. Bellentani (1997)
Wine consumption is not associated with a decreased risk of alcoholic cirrhosis in heavy drinkers.
Stéphanie Pelletier (2002)
Influence of alcohol on the progression of hepatitis C virus infection: a meta-analysis.
S. Hutchinson (2005)
Study design, exposure variables, and socioeconomic determinants of participation in Diet, Cancer and Health: A population-based prospective cohort study of 57,053 men and women in Denmark
A. Tjønneland (2007)
Alcoholic liver injury: influence of gender and hormones.
P. Eagon (2010)
A comparative study of two methods for the measurement of alcohol consumption in the general population.
A. Romelsjö (1995)
This paper is referenced by
Incidence, survival and cause-specific mortality in alcoholic liver disease: a population-based cohort study
Perttu Sahlman (2016)
Patterns of drinking and liver cirrhosis - what do we know and where do we go?
J. Rehm (2015)
Alcoholic Liver Disease in Asia, Europe, and North America.
S. Liangpunsakul (2016)
A metabolomics investigation on experimental interventions of acute alcohol consumption
Cindy Irwin (2018)
Drinking and Obesity: Alcoholic Liver Disease/Nonalcoholic Fatty Liver Disease Interactions.
F. Åberg (2020)
Is teenage heavy drinking more hazardous than we thought?
H. Hagström (2019)
Binge Drinking: Predictors, Patterns, and Consequences
Richard W. Wilsnack (2018)
Intensity of Daily Drinking and Its Relation to Alcohol Use Disorders
Alvaro Vergés (2018)
Alcoholic liver disease and mast cells: What's your gut got to do with it?
Julie Ann Tolefree (2019)
Liver Injury and Endotoxemia in Male and Female Alcohol‐Dependent Individuals Admitted to an Alcohol Treatment Program
I. Kirpich (2017)
Lifestyle of Patients with Alcoholic Liver Disease and Factors Leading to Hospital Readmission: A Prospective Observational Study.
S. Park (2019)
Opportunities to Prevent Alcoholic Liver Cirrhosis in High-Risk Populations: A Systematic Review With Meta-Analysis
G. Askgaard (2019)
Guidelines EASL Clinical Practice Guidelines : Management of alcohol-related liver disease q European Association for the Study of the Liver ⇑
C. Lackner (2018)
Hepatocellular carcinoma and the risk of occupational exposure.
V. Rapisarda (2016)
Hospital admissions and mortality in the 15 years after a first-time hospital contact with an alcohol problem: a prospective cohort study using the entire Danish population.
G. Askgaard (2019)
EASL Clinical Practice Guidelines: Management of alcohol-related liver disease.
M. Thursz (2018)
Contribution of alcohol use disorders on the burden of chronic hepatitis C in France, 2008-2013: A nationwide retrospective cohort study.
M. Schwarzinger (2017)
A narrative review of alcohol consumption as a risk factor for global burden of disease
J. Rehm (2016)
A measure of alcohol consumption in late adolescence associated with liver disease after 39 years of follow-up is insufficient to guide alcohol safe limits.
G. Askgaard (2018)
Diagnosis and Treatment of Alcohol‐Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases
D. Crabb (2019)
Lifetime drinking history in patients with alcoholic liver disease and patients with alcohol use disorder without liver disease
Jon Kristinn Nielsen (2017)
Trends in the management and burden of alcoholic liver disease
P. Mathurin (2015)
Binge drinking as a risk factor for advanced alcoholic liver disease
M. Ventura-Cots (2017)
Gender Differences in Binge Drinking
R. Wilsnack (2018)
Rodent Models of Alcoholic Liver Disease: Role of Binge Ethanol Administration
Shubha Ghosh Dastidar (2018)
Clinical and biochemical profile of patients hospitalized with jaundice: Experience from a teaching hospital in north India
Suneel Chauhan (2019)
Clinical Aspects of Alcoholic Liver Disease
Mads Israelsen (2019)
Moderate Alcohol Intake in Non-Alcoholic Fatty Liver Disease: To Drink or Not to Drink?
M. Petroni (2019)
Protective effect of exogenous melatonin in rats and their offspring on the genotoxic response induced by the chronic consumption of alcohol during pregnancy.
Ilka Dayane Duarte de Sousa Coelho (2018)
Linking Dysregulated AMPK Signaling and ER Stress in Ethanol-Induced Liver Injury in Hepatic Alcohol Dehydrogenase Deficient Deer Mice
M. Srinivasan (2019)
Alcohol Use in Patients with Chronic Liver Disease
D. Fuster (2018)
Treatment of alcohol use disorders in patients with alcoholic liver disease.
G. Addolorato (2016)See more