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Mechanical Evaluation By Patient-specific Finite Element Analyses Demonstrates Therapeutic Effects For Osteoporotic Vertebrae.

Daisuke Tawara, J. Sakamoto, H. Murakami, N. Kawahara, J. Oda, K. Tomita
Published 2010 · Medicine, Materials Science

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Osteoporosis can lead to bone compressive fractures in the lower lumbar vertebrae. In order to assess the recovery of vertebral strength during drug treatment for osteoporosis, it is necessary not only to measure the bone mass but also to perform patient-specific mechanical analyses, since the strength of osteoporotic vertebrae is strongly dependent on patient-specific factors, such as bone shape and bone density distribution in cancellous bone, which are related to stress distribution in the vertebrae. In the present study, patient-specific general (not voxel) finite element analyses of osteoporotic vertebrae during drug treatment were performed over time. We compared changes in bone density and compressive principal strain distribution in a relative manner using models for the first lumbar vertebra based on computer tomography images of four patients at three time points (before therapy, and after 6 and 12 months of therapy). The patient-specific mechanical analyses indicated that increases in bone density and decreases in compressive principal strain were significant in some osteoporotic vertebrae. The data suggested that the vertebrae were strengthened structurally and the drug treatment was effective in preventing compression fractures. The effectiveness of patient-specific mechanical analyses for providing useful and important information for the prognosis of osteoporosis is demonstrated.
This paper references
10.1016/0021-9290(75)90075-5
The elastic and ultimate properties of compact bone tissue.
D. Reilly (1975)
10.1007/BF01623230
The sequelae of vertebral crush fractures in men
A. Scane (2005)
10.1016/8756-3282(96)00028-2
In vivo measurement of human tibial strains during vigorous activity.
D. Burr (1996)
10.1016/S0021-9290(00)00169-X
First cervical vertebra (atlas) fracture mechanism studies using finite element method.
E. Teo (2001)
10.1002/JBMR.5650040103
The direct examination of three-dimensional bone architecture in vitro by computed tomography.
L. Feldkamp (1989)
10.1007/s001980050010
Randomized Trial of the Effects of Risedronate on Vertebral Fractures in Women with Established Postmenopausal Osteoporosis
J. Reginster (2000)
10.1016/S0021-9290(97)00123-1
Prediction of femoral fracture load using automated finite element modeling.
J. Keyak (1997)
10.1007/s001980070122
Prevention of Bone Loss with Risedronate in Glucocorticoid-Treated Rheumatoid Arthritis Patients
R. Eastell (2000)
10.1016/0141-5425(93)90066-8
Validation of an automated method of three-dimensional finite element modelling of bone.
J. Keyak (1993)
10.1016/S0268-0033(01)00110-3
High-resolution MRI and micro-FE for the evaluation of changes in bone mechanical properties during longitudinal clinical trials: application to calcaneal bone in postmenopausal women after one year of idoxifene treatment.
B. van Rietbergen (2002)
10.1016/J.JBIOMECH.2006.08.003
Prediction of strength and strain of the proximal femur by a CT-based finite element method.
M. Bessho (2007)
10.1002/JOR.1100160305
Computed tomography-based finite element analysis predicts failure loads and fracture patterns for vertebral sections.
M. Silva (1998)
10.1007/s001980050218
Vertebral Fractures Predict Subsequent Fractures
L. Melton Iii (1999)
10.1007/BF00171297
Current methods and advances in bone densitometry
G. Guglielmi (1995)
10.1097/01.BRS.0000076914.32408.85
Reconstruction After Total Sacrectomy Using a New Instrumentation Technique: A Biomechanical Comparison
N. Kawahara (2003)
10.1046/J.1532-5415.2001.49041.X
Pain management in older adults: prevention and treatment.
F. M. Gloth (2001)
10.1056/nejm199511303332201
Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group.
U. Liberman (1995)
10.1002/art.1780360603
Quality of life issues in women with vertebral fractures due to osteoporosis.
D. Cook (1993)
10.1016/0021-9290(94)90056-6
Predicting the compressive mechanical behavior of bone.
T. Keller (1994)
10.1016/S8756-3282(03)00210-2
Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography.
R. Crawford (2003)
10.1016/S0021-9290(98)00118-3
Finite element analysis of trabecular bone structure: a comparison of image-based meshing techniques.
D. Ulrich (1998)
10.1016/j.jbiomech.2007.11.018
Compressive properties of trabecular bone in the distal femur.
T. Burgers (2008)
10.1097/00007632-198101000-00020
Disc Pressure Measurements
A. Nachemson (1981)
10.7326/0003-4819-117-1-1
Treatment of postmenopausal osteoporosis with transdermal estrogen.
E. Lufkin (1992)
10.1515/bmte.1998.43.4.82
Noninvasive Assessment of Stiffness and Failure Load of Human Vertebrae from CT-Data. Nichtinvasive Abschätzung von Steifigkeit und Versagenslast von osteoporotischen Wirbelkörpern nach CT-Daten
H. Martin (1998)
10.1016/S1297-319X(01)00297-4
Comparative efficacy and safety study of etidronate and alendronate in postmenopausal osteoporosis. effect of adding hormone replacement therapy.
B. Cortet (2001)
10.1056/NEJM199007123230201
Intermittent cyclical etidronate treatment of postmenopausal osteoporosis
N. Watts (1990)
10.1302/0301-620X.82B4.0820591
In-vivo strain measurements to evaluate the strengthening potential of exercises on the tibial bone.
C. Milgrom (2000)
10.1007/s00223-001-1066-2
Alendronate for the Treatment of Osteoporosis in Men
S. Adami (2001)
10.1016/1350-4533(95)91884-J
Three-dimensional finite element modelling of non-invasively assessed trabecular bone structures.
R. Mueller (1995)
10.1016/S0021-9290(99)00099-8
Femoral strength is better predicted by finite element models than QCT and DXA.
D. Cody (1999)
10.1016/0141-5425(90)90022-F
Automated three-dimensional finite element modelling of bone: a new method.
J. Keyak (1990)
10.1001/JAMA.282.7.637
Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators.
B. Ettinger (1999)
10.1097/00007632-200107150-00010
Osteoporosis Changes the Amount of Vertebral Trabecular Bone at Risk of Fracture but Not the Vertebral Load Distribution
J. Homminga (2001)
10.1111/J.1532-5415.2004.52506.X
Safety and efficacy of risedronate in reducing fracture risk in osteoporotic women aged 80 and older: implications for the use of antiresorptive agents in the old and oldest old.
S. Boonen (2004)
10.1056/NEJM199807303390502
Alendronate for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis
K. Saag (1998)
10.1016/S0021-9290(98)00150-X
Tissue stresses and strain in trabeculae of a canine proximal femur can be quantified from computer reconstructions.
B. van Rietbergen (1999)
10.1359/JBMR.1997.12.10.1721
Prediction of vertebral strength in vitro by spinal bone densitometry and calcaneal ultrasound.
X. Cheng (1997)
10.2106/00004623-197759070-00021
The compressive behavior of bone as a two-phase porous structure.
D. Carter (1977)
10.1016/S0140-6736(02)08761-5
Diagnosis of osteoporosis and assessment of fracture risk
J. Kanis (2002)
10.1115/1.1352734
High-resolution three-dimensional-pQCT images can be an adequate basis for in-vivo μFE analysis of bone
W. Pistoia (2001)
10.7326/0003-4819-123-6-199509150-00001
Treatment of Postmenopausal Osteoporosis with Slow-Release Sodium Fluoride: Final Report of a Randomized Controlled Trial
C. Pak (1995)
10.1097/01.BRS.0000049923.27694.47
Finite Element Modeling of the Human Thoracolumbar Spine
M. Liebschner (2003)
10.1016/S0142-9612(03)00516-7
Individualised, micro CT-based finite element modelling as a tool for biomechanical analysis related to tissue engineering of bone.
S. Jaecques (2004)
10.1016/0268-0033(94)90019-1
In-vitro relationships between vertebral body density, size, and compressive strength the elderly thoracolumbar spine.
S. Edmondston (1994)
10.1093/oxfordjournals.aje.a115204
Epidemiology of vertebral fractures in women.
L. J. Melton (1989)
10.1002/JBMR.5650090514
Improved assessment of lumbar vertebral body strength using supine lateral dual-energy x-ray absorptiometry.
B. Myers (1994)
10.1016/J.CLINBIOMECH.2006.10.005
A method for patient-specific evaluation of vertebral cancellous bone strength: in vitro validation.
I. Diamant (2007)
10.1097/01.brs.0000225993.57349.df
Nonlinear Finite Element Model Predicts Vertebral Bone Strength and Fracture Site
K. Imai (2006)



This paper is referenced by
10.1299/JBSE.5.499
Mechanical Therapeutic Effects in Osteoporotic L1-Vertebrae Evaluated by Nonlinear Patient-specific Finite Element Analysis
Daisuke Tawara (2010)
10.1016/j.jbiomech.2012.08.022
A new approach to determine the accuracy of morphology-elasticity relationships in continuum FE analyses of human proximal femur.
Javad Hazrati Marangalou (2012)
nate, minodronic acid, risedronate, ibandronate suppress the onset of vertebral fractures by 36-62% (13-17), teriparatide suppresses onset of vertebral fracture by 65-80% (18-19) and denosumab suppressed onset of vertebral fracture by 68% (20). Regarding the treatment of osteoporotic vertebral fract
Daisuke Nakashima (2018)
10.1038/bonekey.2013.120
Finite element analysis for prediction of bone strength.
P. Zysset (2013)
10.1109/TBME.2013.2246865
Method to Geometrically Personalize a Detailed Finite-Element Model of the Spine
Nadine Lalonde (2013)
10.1115/1.4004190
A new material mapping procedure for quantitative computed tomography-based, continuum finite element analyses of the vertebra.
G. Unnikrishnan (2011)
Development, validation and clinical evaluation of a subject-specific finite element model of the vertebra with adjacent intervertebral disc to estimate vertebral strength
Chuhee Lee (2014)
10.4236/ojo.2019.911025
Calculation of Intervertebral Disc Pressure in the Thoracic and Lumbar Spine in Elderly Women with Kyphosis Using a Novel Musculoskeletal Model with Isolated Thoracic Vertebrae and Rib Cage
Jumpei Iida (2019)
10.1080/10255842.2013.869320
Comparison between mechanical stress and bone mineral density in the femur after total hip arthroplasty by using subject-specific finite element analyses
H. Ike (2015)
10.1299/JBSE.13-00163
Nonlinear mechanical analysis of posterior spinal instrumentation for osteoporotic vertebra: Effects of mechanical properties of the rod on the failure risks around the screw
Daisuke Tawara (2014)
10.4236/JAMP.2017.54084
Biomechanical Study of Vertebral Compression Fracture Using Finite Element Analysis
Hiromitsu Takano (2017)
10.1080/10255842.2019.1699542
Relating mechanical properties of vertebral trabecular bones to osteoporosis
R Cesar (2019)
10.1177/0954411913508054
Dental application of novel finite element analysis software for three-dimensional finite element modeling of a dentulous mandible from its computed tomography images
Keiko Nakamura (2013)
10.7763/IJAPM.2014.V4.297
Finite Element Analysis of Osteoporotic Vertebrae with First Lumbar (L1) Vertebral Compression Fracture
Muhammad Hazli Mazlan (2014)
10.1016/J.APSUSC.2012.02.060
A comparative biomechanical study of bone ingrowth in two porous hydroxyapatite bioceramics
Li Mei Ren (2012)
10.1299/JBSE.6.248
Patient-Specific Finite Element Analyses Detect Significant Mechanical Therapeutic Effects on Osteoporotic Vertebrae During a Three-Year Treatment
Daisuke Tawara (2011)
10.3951/SOBIM.33.277
Mechanical Finder : イメージベースの骨強度評価ソフトウェア
二郎 坂本 (2009)
10.1186/s12891-019-2719-5
Endplate and intervertebral disc injuries in acute and single level osteoporotic vertebral fractures: is there any association with the process of bone healing?
Tatsuhiko Fujiwara (2019)
CARACTERIZAÇÃO DO COMPORTAMENTO MECÂNICO DE UMA VÉRTEBRA LOMBAR; COM E SEM CIMENTAÇÃO
D. Apresentada (2014)
10.4233/UUID:5648E091-EBB2-4AC9-B2DE-82EC3BD3146E
Subject-specific upper extremity modelling
Bart Bolsterlee (2014)
10.1080/10255842.2012.753067
Transformation methods for estimation of subject-specific scapular muscle attachment sites
Bart Bolsterlee (2014)
10.3892/etm.2018.5848
Finite element analysis of compression fractures at the thoracolumbar junction using models constructed from medical images
D. Nakashima (2018)
Modélisation du corps vertébral en chargement dynamique : Intégration de l'effet de l'âge
Anaïs Garo (2010)
10.1115/1.4040122
Methods for Post Hoc Quantitative Computed Tomography Bone Density Calibration: Phantom-Only and Regression.
Jacob M. Reeves (2018)
Finite Element Analysis of Osteoporotic Vertebrae with First Lumbar ( L 1 ) Vertebral Compression Fracture
M. H. Mazlan ()
10.1186/s40634-016-0072-2
Quantitative Computed Tomography (QCT) derived Bone Mineral Density (BMD) in finite element studies: a review of the literature
N. Knowles (2016)
10.4236/JBISE.2016.910043
Biomechanical Study of the Effects of Balloon Kyphoplasty on the Adjacent Vertebrae
Hiromitsu Takano (2016)
10.5772/65031
Evaluation of Adaptive Bone Remodeling after Total Hip Arthroplasty Using Finite Element Analysis
Y. Inaba (2016)
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