Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Effects Of Repeated Nerve Injuries At Different Time Intervals On Functional Recovery And Nerve Innervation

Mika Karasawa, K. Yokouchi, K. Kawagishi, T. Moriizumi, N. Fukushima
Published 2018 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Effects of repeated nerve injuries on functional recovery and nerve innervation were examined in rodents. Crush injuries of the sciatic nerve were inflicted on adult rats and repeated twice or thrice at different time intervals of 1, 2, 3, and 4 weeks. Motor function was assessed by the static sciatic index at 1, 7, 14, 21, 28, 35, 42, 49, and 56 days after the final crush. The rates of nerve innervation of the tibialis anterior muscle, a main muscle innervated by the common peroneal nerve, were evaluated by the quantification of βIII-tubulin-positive nerve terminals and α-bungarotoxin-positive acetylcholine receptors 21 and 56 days after the final crush of triple nerve injuries at 1-, 2-, 3-, and 4-week intervals. Compared with single nerve crush injury, delayed recovery of motor function was observed in repeated crush injuries. In addition, recoveries in the triple crush groups were slower than those in the double crush groups. The rates of reinnervation were lower in the triple crush groups than in the single crush groups, both at 21 days (single: 59.7%; triple: 54.1%-56.1%) and 56 days (single: 88.8%; triple: 72.5%-83.0%) after the final crush, except in the groups with 1-week (triple: 73.8%) and 2-week (triple: 70.5%) intervals at 21 days after the final crush. We concluded that the recovery of motor function was delayed according to the number of repetitions of crush injuries, and that the rates of nerve innervation were still low in the triple crush groups 8 weeks after the final crush.
This paper references
10.1016/j.mcn.2007.02.020
Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal α5 integrin
N. Gardiner (2007)
10.1002/lary.24216
Embryologic innervation of the rat laryngeal musculature—a model for investigation of recurrent laryngeal nerve reinnervation
Michael J Pitman (2013)
10.1016/j.neuroscience.2013.02.059
Peripheral axon regrowth: New molecular approaches
K. Christie (2013)
10.1179/1743132812Y.0000000089
Effects of repeated crush injuries on motor functional recovery of the sciatic nerve
T. Itsubo (2012)
10.1016/S0165-0270(00)00281-8
Video analysis of standing — an alternative footprint analysis to assess functional loss following injury to the rat sciatic nerve
M. Bervar (2000)
10.1111/ejn.13059
Lack of motor recovery after prolonged denervation of the neuromuscular junction is not due to regenerative failure
Miyuki Sakuma (2016)
10.1016/j.expneurol.2007.09.016
Local stabilization of microtubule assembly improves recovery of facial nerve function after repair
M. Grosheva (2008)
10.1111/j.1460-9568.2005.03877.x
Factors limiting motor recovery after facial nerve transection in the rat: combined structural and functional analyses
O. Guntinas-Lichius (2005)
10.1001/ARCHNEUR.1973.00490250071008
Axon outgrowth enhanced by a previous nerve injury.
I. Mcquarrie (1973)
10.3171/2014.9.JNS141451
Effect of graded nerve pressure injuries on motor function.
Mika Karasawa (2015)
10.1016/0006-8993(77)90193-7
Axonal regeneration in the rat sciatic nerve: Effect of a conditioning lesion and of dbcAMP
I. Mcquarrie (1977)
10.1007/s12565-014-0236-z
Correlation between motor function and axonal morphology in neonatally sciatic nerve-injured rats
Akira Kakegawa (2014)
10.1080/01616412.2016.1275461
Stereological assessment of the total number of hypoglossal neurons after repeated crush injuries to the hypoglossal nerve in adult rats
N. Fukushima (2017)
10.1097/01.WNR.0000230502.47973.FE
Motor neurons essential for normal sciatic function in neonatally nerve-injured rats
Akira Kakegawa (2006)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar