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Development Of Analytical Methods For Functional Analysis Of Intracellular Protein Using Signal-responsive Silica Or Organic Nanoparticles.
Published 2016 · Chemistry, Medicine
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Because proteins control cellular function, intracellular protein analysis is needed to gain a better understanding of life and disease. However, in situ protein analysis still faces many difficulties because proteins are heterogeneously located within the cell and the types and amount of proteins within the cell are ever changing. Recently, nanotechnology has received increasing attention and multiple protein-containing nanoparticles have been developed. Nanoparticles offer a promising tool for intracellular protein analysis because (1) they can permeate the cellular membrane after modification or changing composition, (2) the stability of various proteins is improved by encapsulation within nanoparticles, and (3) protein release and activity can be controlled. In this review, we discuss the development of analytical methods for intracellular functional protein analysis using signal-responsive silica and organic nanoparticles.
This paper references
Monolithic bioreactor immobilizing trypsin for high-throughput analysis.
Masaru Kato (2005)
Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials.
F. Zhao (2011)
Emerging nanomaterials for targeting subcellular organelles
Jasper Huang (2011)
Protein nanocapsule weaved with enzymatically degradable polymeric network.
Z. Gu (2009)
Ataxia Telangiectasia Mutated (ATM) Signaling Network Is Modulated by a Novel Poly(ADP-ribose)-dependent Pathway in the Early Response to DNA-damaging Agents*
Jean-François Haince (2007)
Challenges Facing Complete Human Proteome Analysis
M. Iwasaki (2014)
Influence of process parameters on the protein stability encapsulated in poly-DL-lactide-poly(ethylene glycol) microspheres.
X. Li (2000)
Development of peptide and protein nanotherapeutics by nanoencapsulation and nanobioconjugation
S. C. Yadav (2011)
Quantitative three-dimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivery system using confocal laser scanning microscopy.
H. Akita (2004)
A novel magnetic crystal-lipid nanostructure for magnetically guided in vivo gene delivery.
Y. Namiki (2009)
Protein nanoparticles for intracellular delivery of therapeutic enzymes.
L. H. Estrada (2014)
Multifunctional NaYF4 : Yb3+,Er3+@Ag core/shell nanocomposites: integration of upconversion imaging and photothermal therapy
B. Dong (2011)
Cationic amphiphilic polysaccharide nanoballs: protein stabilization and intracellular delivery by nano-encapsulation.
H. Takahashi (2013)
Ferritin nanocages to encapsulate and deliver photosensitizers for efficient photodynamic therapy against cancer.
Zipeng Zhen (2013)
Delivery, stabilization, and spatiotemporal activation of cargo molecules in cells with positively charged nanoparticles.
Shuhei Murayama (2012)
Investigation of chromatographic performances and binding characteristics of BSA-encapsulated capillary column prepared by the sol-gel method.
Masaru Kato (2003)
Dynamics of Endocytosis and Exocytosis of Poly(D,L-Lactide-co-Glycolide) Nanoparticles in Vascular Smooth Muscle Cells
J. Panyam (2004)
A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy.
S. Moghimi (2005)
Drug release from electric-field-responsive nanoparticles.
Jun Ge (2012)
Polyethylenimine‐cationized β‐catenin protein transduction activates the Wnt canonical signaling pathway more effectively than cationic lipid‐based transduction
M. Kitazoe (2010)
Delivery of chemically glycosylated cytochrome c immobilized in mesoporous silica nanoparticles induces apoptosis in HeLa cancer cells.
Jessica Méndez (2014)
Efficient Protein Transduction Method Using Cationic Peptides and Lipids
K. Yamaguchi (2011)
Intracellular trafficking of nuclear localization signal conjugated nanoparticles for cancer therapy.
R. Misra (2010)
Near infrared light triggered release of biomacromolecules from hydrogels loaded with upconversion nanoparticles.
B. Yan (2012)
Delivery of proteins to mammalian cells via gold nanoparticle mediated laser transfection.
D. Heinemann (2014)
Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage.
Dominique A. Rothenfluh (2008)
Boron dipyrromethene as a fluorescent caging group for single-photon uncaging with long-wavelength visible light.
Nobuhiro Umeda (2014)
Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination.
E. Kuranaga (2007)
Gold nanocages covered by smart polymers for controlled release with near-infrared light
M. Yavuz (2009)
Photocontrolled nanoparticle delivery systems for biomedical applications.
Akshaya Bansal (2014)
Bioconjugates of smart polymers and proteins: synthesis and applications
A. Hoffman (2004)
Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells.
R. P. Crefcoeur (2013)
An HPLC with evaporative light scattering detection method for the quantification of PEGs and Gantrez in PEGylated nanoparticles.
V. Zabaleta (2007)
Cell-penetrating peptides: achievements and challenges in application for cancer treatment.
M. C. Shin (2014)
Spatiotemporal activation of molecules within cells using silica nanoparticles responsive to blue-green light.
Takaki Amamoto (2015)
Integration of on-line protein digestion, peptide separation, and protein identification using pepsin-coated photopolymerized sol-gel columns and capillary electrophoresis/mass spectrometry.
M. Kato (2004)
Reduction of molecular leaching from a gel matrix for the precisely controlled release of encapsulated molecules by light stimulus.
Takaki Amamoto (2014)
Activation of caspase-dependent apoptosis by intracellular delivery of cytochrome c-based nanoparticles
Moraima Morales-Cruz (2014)
Analytical assessment about the simultaneous quantification of releasable pharmaceutical relevant inorganic nanoparticles in tap water and domestic waste water.
P. Krystek (2015)
Controlled protein delivery from photosensitive nanoparticles.
Zhi-Qiang Jiang (2015)
Mesoporous Silica Spheres as Supports for Enzyme Immobilization and Encapsulation
Yajun Wang (2005)
Cellular trajectories of peptide-modified gold particle complexes: comparison of nuclear localization signals and peptide transduction domains.
A. Tkachenko (2004)
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.
O. Boussif (1995)
Bioengineered Vaults: Self-Assembling Protein Shell–Lipophilic Core Nanoparticles for Drug Delivery
Daniel C. Buehler (2014)
Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility
Q. He (2011)
Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles.
Chunbai He (2010)
Progress in developing cationic vectors for non-viral systemic gene therapy against cancer.
M. Morille (2008)
The promises and pitfalls of RNA-interference-based therapeutics
D. Castanotto (2009)
Near-infrared light-triggered dissociation of block copolymer micelles using upconverting nanoparticles.
B. Yan (2011)
Surfactant-free aqueous preparation from a star polymer of size-controlled nanoparticles with encapsulated functional molecules
Yuka Shibata (2015)
Endoprotease-mediated intracellular protein delivery using nanocapsules.
A. Biswas (2011)
Self-assembly and optically triggered disassembly of hierarchical dendron-virus complexes.
Mauri A. Kostiainen (2010)
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
A. Fire (1998)
Protein nanoparticles as drug carriers in clinical medicine.
M. Hawkins (2008)
Multifunctional hybrid nanogel for integration of optical glucose sensing and self-regulated insulin release at physiological pH.
Weitai Wu (2010)
Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology*
C. Michel (2013)
NanoPARCEL: a method for controlling cellular behavior with external light.
Shuhei Murayama (2012)
Photoresponsive nanogels formed by the self-assembly of spiropyrane-bearing pullulan that act as artificial molecular chaperones.
Tai Hirakura (2004)
Targeted delivery of magnetic aerosol droplets to the lung
P. Dames (2007)
Breaking up the correlation between efficacy and toxicity for nonviral gene delivery
M. Breunig (2007)
Self-assembled pH-sensitive cholesteryl pullulan nanogel as a protein delivery vehicle.
N. Morimoto (2013)
Small mesh size hydrogel for functional photocontrol of encapsulated enzymes and small probe molecules.
Shuhei Murayama (2012)
Stimuli-responsive nanocarriers for drug delivery.
S. Mura (2013)
Understanding enzymatic acceleration at nanoparticle interfaces: Approaches and challenges
Brandy J. Johnson (2014)
Functional nanomaterials for phototherapies of cancer.
Liang Cheng (2014)
Viral nanoparticle-encapsidated enzyme and restructured DNA for cell delivery and gene expression
J. Liu (2014)
Intracellular Delivery of Proteins with a New Lipid-mediated Delivery System*
O. Zelphati (2001)
Designing Caged Compounds for Spatiotemporal Control of Cellular Chemistry
Toshiaki Furuta (2012)
Photocontrol of biological activities of protein by means of a hydrogel.
Shuhei Murayama (2010)
The simple preparation of polyethylene glycol-based soft nanoparticles containing dual imaging probes.
Shuhei Murayama (2013)
Redox-responsive nanocapsules for intracellular protein delivery.
Muxun Zhao (2011)
Flow field-flow fractionation for the analysis of nanoparticles used in drug delivery.
A. Zattoni (2014)
Albumin-bound paclitaxel: a next-generation taxane
W. Gradishar (2006)
Strategies for the intracellular delivery of nanoparticles.
L. Chou (2011)
Improving Drug Potency and Efficacy by Nanocarrier-Mediated Subcellular Targeting
M. Murakami (2011)
Polyethylenimine-based non-viral gene delivery systems.
U. Lungwitz (2005)
Delivery of molecules into cells using carbon nanoparticles activated by femtosecond laser pulses
Prerona Chakravarty (2010)
A computer simulation of the networked structure of a hydrogel prepared from a tetra-armed star pre-polymer.
K. Takagi (2014)
Gene regulation by intracellular delivery and photodegradation of nanoparticles containing small interfering RNA.
Shuhei Murayama (2014)
A Complementary Strategy for Enhancement of Nanoparticle Intracellular Uptake
Yingjia Li (2014)
Targeted delivery of nanoparticles for the treatment of lung diseases.
S. Azarmi (2008)
Development of a spatiotemporal method to control molecular function by using silica-based photodegradable nanoparticles.
Fumi Ishizuka (2014)
Tailoring nanocarriers for intracellular protein delivery.
Z. Gu (2011)
Mass-spectrometry-based draft of the human proteome
M. Wilhelm (2014)
Protein Nanoparticles as Drug Delivery Carriers for Cancer Therapy
Warangkana Lohcharoenkal (2014)
Function Analysis of Intracellular Protein Using Nanoparticles Containing Protein
M. Kato (2015)
This paper is referenced by
Enrichment of liposomal nanomedicines using monolithic solid phase extraction discs following preactivation with bivalent metal ion solutions.
A. Watanabe (2018)
Effect of Nanoparticle Surface on the HPLC Elution Profile of Liposomal Nanoparticles
N. Itoh (2016)
Overview of the state-of-the-art liposomal drug analysis using high-performance liquid chromatography
Masaru Kato (2018)
Simultaneous Analytical and Purification Methods for Nanoparticles and Small Molecules Using a Silica Monolith
Masaru Kato (2016)
Surface modification of silica nanoparticles using 4-aryloxy boron dipyrromethene (BODIPY) enhances skin permeation.
Takaki Amamoto (2016)
Controlled in-cell release of caspase from photodegradable nanoparticles using the PARCEL method
Yuka Shibata (2016)
Trimethylammonium modification of a polymer-coated monolith column for rapid and simultaneous analysis of nanomedicines.
M. Kato (2019)
High performance liquid chromatography analysis of 100-nm liposomal nanoparticles using polymer-coated, silica monolithic columns with aqueous mobile phase.
N. Itoh (2017)