Online citations, reference lists, and bibliographies.

Circulating Thyrotropin Receptor Messenger RNA For Evaluation Of Thyroid Nodules And Surveillance Of Thyroid Cancer In Children.

Jesse Gutnick, Oliver S. Soldes, Manjula Gupta, Mira Milas
Published 2012 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
PURPOSE The aim of this study was to determine the role of thyrotropin receptor messenger RNA as a novel blood test for evaluation of thyroid nodules and cancer in children. METHODS We reviewed thyroid disease management of patients younger than 18 years with thyrotropin receptor messenger RNA measurements identified from a prospective, institutional review board-approved registry during 2008 to 2010. RESULTS Thirty-nine thyrotropin receptor messenger RNA measurements were made in 21 female patients (12-17 years old; median, 16 years). Four patients with fine-needle aspiration only had benign thyroid cytology, and 3 of 4 had undetectable thyrotropin receptor messenger RNA. Seventeen patients underwent 22 thyroid operations. Preoperative thyrotropin receptor messenger RNA was measured in 9 patients: 3 of 4 with thyroid cancer had elevated levels and 3 of 5 with goiters undetectable. Postthyroidectomy surveillance (median, 16 months; range, 6-24) of 11 thyroid cancer patients (8 papillary, 3 follicular) showed that thyrotropin receptor messenger RNA was concordant with thyroglobulin in 14 (73%) of 19 measurements. In 3 (16%) of 19 measurements, thyrotropin receptor messenger RNA was the only blood test useful for disease assessment because of elevated antithyroglobulin antibodies. Overall, to predict thyroid cancer, thyrotropin receptor messenger RNA demonstrated 73% sensitivity, 82% specificity, 62% positive predictive value, 88% negative predictive value, and 79% accuracy. CONCLUSION Thyrotropin receptor messenger RNA provides complementary evaluation to thyroglobulin and fine-needle aspiration for pediatric thyroid nodule management.
This paper references
The utility of peripheral thyrotropin mRNA in the diagnosis of follicular neoplasms and surveillance of thyroid cancers.
M. Milas (2007)
Pediatric thyroid fine-needle aspiration cytology: a meta-analysis.
C. Stevens (2009)
Detection of circulating thyroid cancer cells in patients with thyroid microcarcinomas.
Tomislav Novosel (2009)
Differentiated pediatric thyroid cancer: correlates with adult disease, controversies in treatment.
M. Parisi (2007)
Diagnostic Utility of Fine-Needle Aspiration Cytology in Pediatric Differentiated Thyroid Cancer
Anna E Bargren (2010)
Detection of Circulating Thyroid Cancer Cells by Reverse Transcription-PCR for Thyroid-stimulating Hormone Receptor and Thyroglobulin: The Importance of Primer Selection
M. Gupta (2002)
Population-based outcomes for pediatric thyroid carcinoma.
N. Shapiro (2005)
Thyroid cancer in children.
C. Dinauer (2007)
Thyroid nodules and cancers in children.
J. Josefson (2008)
Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer.
D. Cooper (2009)
Serum thyroglobulin in thyroid carcinoma and other thyroid disorders
F. Pacini (1980)
Long-Term Outcome in 215 Children and Adolescents with Papillary Thyroid Cancer Treated During 1940 Through 2008
I. Hay (2009)
Initial management and follow-up of differentiated thyroid cancer in children.
S. Waguespack (2010)
Circulating Thyrotropin Receptor mRNA as a Novel Marker of Thyroid Cancer: Clinical Applications Learned From 1758 Samples
M. Milas (2010)
Thyroid fine‐needle aspiration biopsy in children and adolescents: Experience with 218 aspirates
M. Amrikachi (2005)
Thyroid-stimulating hormone receptor messenger ribonucleic acid measurement in blood as a marker for circulating thyroid cancer cells and its role in the preoperative diagnosis of thyroid cancer.
Su-Ynn Chia (2007)
Pediatric thyroid carcinoma: incidence and outcomes in 1753 patients.
A. Hogan (2009)
Outcomes of surgically managed pediatric thyroid cancer.
Anna E Bargren (2009)
Peripheral thyrotropin receptor mRNA as a novel marker for differentiated thyroid cancer diagnosis and surveillance
German F. Barbosa (2008)
Cytopathologic analysis of thyroid lesions in the pediatric population
G. Hosler (2006)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar