Online citations, reference lists, and bibliographies.

Pediatric Thyroid Carcinoma: Incidence And Outcomes In 1753 Patients.

Anthony Richard Hogan, Ying Zhuge, Eduardo Perez, Leonidas G. Koniaris, John I Lew, Juan Antonio Estévez Sola
Published 2009 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
OBJECTIVE To examine outcomes and predictors of survival for pediatric patients with thyroid carcinoma. METHODS The Surveillance, Epidemiology, and End Results (SEER) registry from 1973 to 2004 was queried for all patients with thyroid carcinoma less than 20 y of age. RESULTS A total of 1753 patients with malignant thyroid neoplasms were identified with an age-adjusted annual incidence of 0.54 cases per 100,000 persons. There has been a significant increase in the annual incidence by 1.1% per y. Female patients outnumbered males 4 to 1. Tumors were classified as papillary (n=1044, 60%), follicular variant of papillary (n=389, 23%), follicular (n=165, 10%), and medullary (n=87, 5%). The majority of patients presented with localized and regional disease. Overall mean survival time (MST) was 30.5 y. The MST for females was 40 y, whereas males survived an average of 20.4 y (P=0.0001). Patients with medullary cancer had significantly shorter mean survival than those with papillary cancer (P=0.006). Surgical treatment significantly improved outcome. Multivariate analysis demonstrated that male gender, nonpapillary histology, distant disease, and no surgery were all independent prognostic factors of worse outcome. For patients with medullary thyroid carcinoma, radiation therapy was also identified as an independent predictor of lower survival. CONCLUSION The incidence of pediatric thyroid cancer is increasing. Females have a higher incidence than males, but enjoy longer survival. Papillary thyroid cancer has overall excellent survival. Male gender, nonpapillary tumor, distant metastases, and nonsurgical treatment all predict worse outcome.
This paper references
10.1002/(SICI)1097-0142(19971201)80:11<2156::AID-CNCR16>3.0.CO;2-Y
Characteristics of differentiated thyroid carcinoma in children and adolescents with respect to age, gender, and histology.
Jamshid Farahati (1997)
Cancer of the thyroid in children.
Timothy R. Winship (1970)
Malignant pancreatic tumors in children: Incidence and outcomes in 58 patients
EA Perez (2009)
10.1111/j.1365-2265.2008.03229.x
Long-term prognosis of medullary thyroid carcinoma.
Gundula Rendl (2008)
10.14310/horm.2002.1111023
Thyroid cancer in childhood: management strategy, including dosimetry and long-term results.
Markus Luster (2007)
10.1053/j.semnuclmed.2007.05.001
Differentiated pediatric thyroid cancer: correlates with adult disease, controversies in treatment.
Marguerite T. Parisi (2007)
10.1002/hed.20791
Postoperative radiotherapy for advanced medullary thyroid cancer--local disease control in the modern era.
David L. Schwartz (2008)
10.1053/nm.2000.5412
The Chernobyl accident and its consequences: update at the millennium.
Robert Michael Tuttle (2000)
10.1016/j.jpedsurg.2004.06.016
Surgical therapy of the thyroid papillary carcinoma in children: experience with 56 patients < or =16 years old.
Claud Spinelli (2004)
10.1016/S0960-7404(03)00033-1
Management of hereditary thyroid cancer in children.
Michael A Skinner (2003)
10.1016/j.jss.2006.12.200
185: Markedly improving survival of neuroblastoma: A 30-year analysis of 1646 patients
J Claudio Gutierrez (2007)
10.1097/00000658-199804000-00014
Differentiated thyroid cancer: determinants of disease progression in patients <21 years of age at diagnosis: a report from the Surgical Discipline Committee of the Children's Cancer Group.
Kurt D. Newman (1998)
10.1016/j.jpedsurg.2007.12.019
The Canadian Pediatric Thyroid Nodule Study: an evaluation of current management practices.
Chris Stevens (2008)
10.1097/01.mlg.0000154743.71184.09
Population-based outcomes for pediatric thyroid carcinoma.
Nina Lisbeth Shapiro (2005)
10.1002/jso.20690
Current approaches to medullary thyroid carcinoma, sporadic and familial.
Elizabeth A. Fialkowski (2006)
10.1016/j.ecl.2008.02.001
External beam radiation therapy for thyroid cancer.
James Brierley (2008)
10.1016/0002-9343(94)90321-2
Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer.
Ernest L. Mazzaferri (1994)
10.1002/cncr.10725
Childhood and adolescent thyroid carcinoma.
Perry Grigsby (2002)
10.1097/CCO.0b013e3282f30220
Differentiated thyroid cancer in children: diagnosis and management
Catherine A. Dinauer (2008)
10.1016/j.jss.2008.03.026
Malignant breast cancer in children: a review of 75 patients.
Juan C Gutierrez (2008)
10.1016/S0022-3468(03)00563-3
Thyroid carcinoma presenting in childhood or after treatment of childhood malignancies: An institutional experience and review of the literature.
Kenneth William Gow (2003)
10.1007/s00383-007-1933-7
Markedly improving survival of neuroblastoma: a 30-year analysis of 1,646 patients
Juan C. Gutiérrez (2007)
Institute, Surveillance Research Program, Cancer Statistics Branch
SEER National Cance (2008)
10.1245/s10434-008-9812-6
The Basis of Racial Differences in the Incidence of Thyroid Cancer
Luc G. T. Morris (2008)
10.1007/s002590000271
Multivariate analysis of prognostic factors for differentiated thyroid carcinoma in children
Barbara Jarzab (2000)
Endogenous sex hormone and estrogen binding activity in thyroid cancer.
Yu Imai (1989)
10.1016/j.jss.2008.12.003
Primary solid tumors of the colon and rectum in the pediatric patient: a review of 270 cases.
Relin Yang (2010)
10.1016/S0002-9610(05)80539-2
Survival discriminants for differentiated thyroid cancer.
M P Cunningham (1990)
10.1080/00313020220131291
Differentiated thyroid carcinomas with vascular invasion: a comparative study of follicular, Hürthle cell and papillary thyroid carcinoma
K T Mai (2002)
10.1016/s0084-3954(08)70249-5
Primary Thyroid Cancer After a First Tumour in Childhood (the Childhood Cancer Survivor Study): A Nested Case-Control Study
James A. Stockman (2007)
Thyroid nodules and cancers in children.
Isil Halac (2005)
10.1016/j.ijrobp.2008.05.012
Role of external beam radiotherapy in patients with advanced or recurrent nonanaplastic thyroid cancer: Memorial Sloan-kettering Cancer Center experience.
Stephanie A Terezakis (2009)



This paper is referenced by
10.1002/cncy.21400
The role of thyroid fine-needle aspiration cytology in the pediatric population: an institutional experience.
Esther Diana Rossi (2014)
10.1111/jpc.13569
Clinical analysis of the factors that influence disease progression of differentiated thyroid carcinoma in children
Yuan Qu (2017)
10.3919/JJSA.72.2797
A child case of thyroid follicular carcinoma
Asumi Iesato (2011)
10.2147/OTT.S100512
Pediatric papillary thyroid cancer: current management challenges
Frederik Anton Verburg (2017)
10.1016/j.otc.2014.09.005
Pediatric thyroid nodules and malignancy.
Kris R Jatana (2015)
10.1530/EJE-17-0741
Psychosocial development in survivors of childhood differentiated thyroid carcinoma: a cross-sectional study
Marloes Nies (2018)
10.1007/s13193-012-0130-x
Pediatric Thyroid Cancers: An Indian Perspective
Devendra Arvind Chaukar (2012)
10.1089/thy.2011.0005
Clinical and pathologic features of "sporadic" papillary thyroid carcinoma registered in the years 2005 to 2008 in children and adolescents of Belarus.
Mikhail Fridman (2012)
10.1177/2473974X17728257
Does Surgical Volume Influence the Need for Second Surgery? A Pilot Study
Paul D Judge (2017)
10.1177/0194599817715629
McGill Thyroid Nodule Score in Differentiating Benign and Malignant Pediatric Thyroid Nodules: A Pilot Study
Michael W Canfarotta (2017)
10.1016/j.prp.2019.01.031
Expression of HBME-1 and CD56 in follicular variant of papillary carcinoma in children: An immunohistochemical study and their diagnostic utility.
Priya Skaria (2019)
10.1136/jclinpath-2014-202625
Expression of CD133 in differentiated thyroid cancer of young patients
Myriam Decaussin-Petrucci (2015)
10.1007/978-1-4939-1729-7_7
Pediatric Cancer in the Head and Neck
Zhongxin Yu (2015)
10.1016/j.ijporl.2015.06.002
Review of clinical and pathological features of 93 cases of well-differentiated thyroid carcinoma in pediatric age at the Lisbon Centre of the Portuguese Institute of Oncology between 1964 and 2006.
Margarida Silva-Vieira (2015)
10.2995/JACSURG.26.444
A case of pulmonary metastasis from papillary thyroid carcinoma resected 55 years earlier
Takeshi Fukami (2012)
10.4061/2011/845362
Thyroid Carcinoma in Children and Adolescents—Systematic Review of the Literature
Fernanda Vaisman (2011)
10.1002/cam4.698
AGK‐BRAF gene fusion is a recurrent event in sporadic pediatric thyroid carcinoma
Maria Isabel Cunha Vieira Cordioli (2016)
10.1089/THY.2012.0468
Response to sorafenib in a pediatric patient with papillary thyroid carcinoma with diffuse nodular pulmonary disease requiring mechanical ventilation.
IyerPallavi (2014)
10.1017/CBO9781139084239.070
Thyroid colloid cyst
Richard A. Barth (2014)
10.1111/cen.13720
Young age is associated with increased rates of residual and recurrent paediatric differentiated thyroid carcinoma
Sarah Cote Hampson (2018)
10.3329/bjo.v25i1.45198
Papillary thyroid carcinoma with neck metastasis in a 6 year old child: A case report
Ma Matin (2020)
10.5124/JKMA.2018.61.10.607
소아청소년 시기의 갑상선질환
신 영림 (2018)
10.2217/EBO.12.534
Differentiated thyroid cancer in children
Andrew J. Bauer (2013)
10.15591/MTP.2015.016
VAIKŲ SKYDLIAUKĖS VĖŽYS PO PERSIRGTOS ONKOLOGINĖS LIGOS@@@CHILDHOOD THYROID CANCER FOLLOWING TREATMENT FOR PAEDIATRIC MALIGNANCY
Ingrida Albužytė (2015)
10.1007/978-3-030-03777-2_14
Radioisotope Therapies: Iodine-131, I-131-MIBG, and Beyond
Neha Kwatra (2019)
10.1210/jc.2012-1823
Quality of life and anxiety in adolescents with differentiated thyroid cancer.
Asaf Oren (2012)
10.1038/nrendo.2011.139
Management of medullary thyroid carcinoma and MEN2 syndromes in childhood
Steven G. Waguespack (2011)
Papillary Carcinoma Thyroid in a Seven Year Old Child: A Case Report
N Santhoshkumar (2014)
10.1007/s00431-019-03507-4
Adolescents with thyroid nodules: retrospective analysis of factors predicting malignancy
Junghwan Suh (2019)
10.1089/THY.2014.0367
Prevalence of Ectopic Intrathyroidal Thymus in Japan: The Fukushima Health Management Survey
FukushimaToshihiko (2015)
10.1016/j.ijporl.2016.08.005
Pediatric thyroid cancer: An update from the SEER database 2007-2012.
Sarah M Dermody (2016)
10.11374/SHONIJIBI.37.58
内視鏡補助下甲状腺切除術(VANS 法)が行われた小児症例の検討
野村 研一郎 (2016)
See more
Semantic Scholar Logo Some data provided by SemanticScholar