Online citations, reference lists, and bibliographies.

New Optical Imaging Technologies For Bladder Cancer: Considerations And Perspectives.

Jen‐Jane Liu, M. Droller, J. Liao
Published 2012 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
PURPOSE Bladder cancer presents as a spectrum of different diatheses. Accurate assessment for individualized treatment depends on initial diagnostic accuracy. Detection relies on white light cystoscopy accuracy and comprehensiveness. Aside from invasiveness and potential risks, white light cystoscopy shortcomings include difficult flat lesion detection, precise tumor delineation to enable complete resection, inflammation and malignancy differentiation, and grade and stage determination. Each shortcoming depends on surgeon ability and experience with the technology available for visualization and resection. Fluorescence cystoscopy/photodynamic diagnosis, narrow band imaging, confocal laser endomicroscopy and optical coherence tomography address the limitations and have in vivo feasibility. They detect suspicious lesions (photodynamic diagnosis and narrow band imaging) and further characterize lesions (optical coherence tomography and confocal laser endomicroscopy). We analyzed the added value of each technology beyond white light cystoscopy and evaluated their maturity to alter the cancer course. MATERIALS AND METHODS Detailed PubMed® searches were done using the terms "fluorescence cystoscopy," "photodynamic diagnosis," "narrow band imaging," "optical coherence tomography" and "confocal laser endomicroscopy" with "optical imaging," "bladder cancer" and "urothelial carcinoma." Diagnostic accuracy reports and all prospective studies were selected for analysis. We explored technological principles, preclinical and clinical evidence supporting nonmuscle invasive bladder cancer detection and characterization, and whether improved sensitivity vs specificity translates into improved correlation of diagnostic accuracy with recurrence and progression. Emerging preclinical technologies with potential application were reviewed. RESULTS Photodynamic diagnosis and narrow band imaging improve nonmuscle invasive bladder cancer detection, including carcinoma in situ. Photodynamic diagnosis identifies more papillary lesions than white light cystoscopy, enabling more complete resection and fewer residual tumors. Despite improved treatment current data on photodynamic diagnosis do not support improved high risk diathetic detection and characterization or correlation with disease progression. Prospective recurrence data are lacking on narrow band imaging. Confocal laser endomicroscopy and optical coherence tomography potentially grade and stage lesions but data are lacking on diagnostic accuracy. Several emerging preclinical technologies may enhance the diagnostic capability of endoscopic imaging. CONCLUSIONS New optical imaging technologies may improve bladder cancer detection and characterization, and transurethral resection quality. While data on photodynamic diagnosis are strongest, the clinical effectiveness of these technologies is not proven. Prospective studies are needed, particularly of narrow band imaging, confocal laser endomicroscopy and optical coherence tomography. As each technology matures and new ones emerge, cost-effectiveness analysis must be addressed in the context of the various bladder cancer types.
This paper references
10.1111/j.1464-410X.2008.07846.x
A comparison of white‐light cystoscopy and narrow‐band imaging cystoscopy to detect bladder tumour recurrences
H. Herr (2008)
10.3322/caac.20073
Cancer Statistics, 2010
A. Jemal (2010)
10.1097/01.JU.0000100480.70769.0E
Improved detection of urothelial carcinoma in situ with hexaminolevulinate fluorescence cystoscopy.
J. Schmidbauer (2004)
10.1021/ac100448p
In vivo bladder cancer diagnosis by high-volume Raman spectroscopy.
R. Draga (2010)
10.1016/J.UROLOGY.2006.01.026
The diagnosis and staging of bladder cancer: from RBCs to TURs.
A. Carmack (2006)
10.1111/j.1464-410X.2009.08839.x
Hexylaminolaevulinate fluorescence cystoscopy in patients previously treated with intravesical bacille Calmette‐Guérin
E. Ray (2010)
10.3322/caac.20107
Global cancer statistics
A. Jemal (2011)
10.1016/j.juro.2009.06.039
Optical biopsy of human bladder neoplasia with in vivo confocal laser endomicroscopy.
G. Sonn (2009)
10.1016/j.eururo.2009.10.030
Transurethral resection of non-muscle-invasive bladder transitional cell cancers with or without 5-aminolevulinic Acid under visible and fluorescent light: results of a prospective, randomised, multicentre study.
M. Schumacher (2010)
10.1046/j.1464-410x.1999.00917.x
Diagnosis of bladder carcinoma using protoporphyrin IX fluorescence induced by 5‐aminolaevulinic acid
F. Koenig (1999)
10.1590/S1677-55382011000500027
Detection and clinical outcome of urinary bladder cancer with 5-aminolevulinic acid-induced fluorescence cystoscopy: a multicenter randomized, double-blind, placebo-controlled trial
A. Stenzl (2011)
10.1111/j.1365-2036.2009.04207.x
The safety of intravenous fluorescein for confocal laser endomicroscopy in the gastrointestinal tract
M. Wallace (2010)
Chapter 5 A new generation of optical diagnostics for bladder cancer : technology , diagnostic accuracy and future applications
E. Cauberg (2011)
10.1200/JCO.2008.16.5951
Grade and stage at presentation do not predict mortality in patients with bladder cancer who survive their disease.
E. Messing (2009)
Grading and staging of bladder carcinoma in transurethral resection specimens: correlation with 105 matched cystectomy specimens.
M. Droller (2000)
10.1016/j.urolonc.2006.02.012
Surveillance for recurrent bladder cancer using a point-of-care proteomic assay
W. See (2006)
10.1186/2047-783X-15-3-131
Optical coherence tomography for bladder cancer - ready as a surrogate for optical biopsy? - Results of a prospective mono-centre study
A. Karl (2010)
10.1117/1.2978059
High-resolution imaging diagnosis and staging of bladder cancer: comparison between optical coherence tomography and high-frequency ultrasound.
Z. Yuan (2008)
10.1016/j.urology.2009.11.075
Narrow band imaging cystoscopy improves the detection of non-muscle-invasive bladder cancer.
E. Cauberg (2010)
10.1089/END.2005.19.570
Evaluation of superficial bladder transitional-cell carcinoma by optical coherence tomography.
M. Manyak (2005)
10.1089/end.2010.0686
Comparison of 2.6- and 1.4-mm imaging probes for confocal laser endomicroscopy of the urinary tract.
Winifred Adams (2011)
10.1089/END.2006.20.698
Endocytoscopy: novel endoscopic imaging technology for in-situ observation of bladder cancer cells.
T. Ohigashi (2006)
Tarin TV et al: Optical biopsy of human bladder neoplasia with in vivo confocal laser endomicroscopy
Ga Sonn (2009)
10.1007/s00345-009-0387-z
Application of new technology in bladder cancer diagnosis and treatment
A. Goh (2009)
10.1111/j.1464-410X.2010.09547.x
Reduced bladder tumour recurrence rate associated with narrow‐band imaging surveillance cystoscopy
H. Herr (2011)
10.1097/01.JU.0000060782.52358.04
Hexyl aminolevulinate fluorescence cystoscopy: new diagnostic tool for photodiagnosis of superficial bladder cancer--a multicenter study.
P. Jichlinski (2003)
10.1016/j.urology.2009.06.088
Hexaminolevulinate is equal to 5-aminolevulinic acid concerning residual tumor and recurrence rate following photodynamic diagnostic assisted transurethral resection of bladder tumors.
M. Burger (2009)
10.1089/END.1999.13.117
Clinical Results of the Transurethral Resection and Evaluation of Superficial Bladder Carcinomas by Means of Fluorescence Diagnosis after Intravesical Instillation of 5-Aminolevulinic Acid
T. Filbeck (1999)
10.1016/j.urology.2010.02.067
HAL blue-light cystoscopy in high-risk nonmuscle-invasive bladder cancer--re-TURBT recurrence rates in a prospective, randomized study.
B. Geavlete (2010)
10.1016/j.media.2011.02.003
A smart atlas for endomicroscopy using automated video retrieval
Barbara André (2011)
10.1159/000313495
Bronchoscopic Advances: On the Way to the Cells
L. Thiberville (2010)
10.1364/OE.18.003840
Time- and Spectral-resolved two-photon imaging of healthy bladder mucosa and carcinoma in situ.
R. Cicchi (2010)
10.1111/j.1464-410X.2007.07314.x
Does photodynamic transurethral resection of bladder tumour improve the outcome of initial T1 high‐grade bladder cancer? A long‐term follow‐up of a randomized study
S. Denzinger (2008)
10.1016/j.juro.2010.06.148
Hexaminolevulinate guided fluorescence cystoscopy reduces recurrence in patients with nonmuscle invasive bladder cancer.
A. Stenzl (2010)
10.1016/j.urology.2008.02.002
Optical coherence tomography as an adjunct to white light cystoscopy for intravesical real-time imaging and staging of bladder cancer.
A. Goh (2008)
10.1111/j.1464-410X.2011.10090.x
Fluorescence‐guided transurethral resection of bladder tumours reduces bladder tumour recurrence due to less residual tumour tissue in T  a/T1 patients: a randomized two‐centre study
G. Hermann (2011)
10.1111/j.1464-410X.2009.08701.x
Narrow band imaging for detecting residual/recurrent cancerous tissue during second transurethral resection of newly diagnosed non‐muscle‐invasive high‐grade bladder cancer
A. Naselli (2010)
10.1053/j.gastro.2010.06.029
Confocal laser endomicroscopy: technical advances and clinical applications.
H. Neumann (2010)
10.1007/s11255-011-0036-5
Narrow-band imaging flexible cystoscopy in the detection of primary non-muscle invasive bladder cancer: a “second look” matters?
Yi-jun Shen (2011)
10.1038/nm1692
Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy.
P. Hsiung (2008)
10.2165/00019053-200321180-00003
The health economics of bladder cancer: a comprehensive review of the published literature.
M. Botteman (2003)
10.1117/12.878299
Constructing spherical panoramas of a bladder phantom from endoscopic video using bundle adjustment
Timothy D. Soper (2011)
10.1089/end.2011.1548
Dynamic real-time microscopy of the urinary tract using confocal laser endomicroscopy
Katherine Wu (2011)
10.1002/1097-0142(19950901)76:5<833::AID-CNCR2820760518>3.0.CO;2-M
Radical cystectomy for high risk patients with superficial bladder cancer in the era of orthotopic urinary reconstruction
J. A. Freeman (1995)
10.1111/j.1464-410X.2008.07964.x
The past, present and future of cystoscopy: the fusion of cystoscopy and novel imaging technology
Christopher S. D. Lee (2008)
10.1089/end.2010.1510
A multi-center, randomized international study to compare the impact of narrow band imaging versus white light cystoscopy in the recurrence of bladder cancer.
J. de la Rosette (2010)
10.1016/j.eururo.2009.07.042
Fluorescence cystoscopy with high-resolution optical coherence tomography imaging as an adjunct reduces false-positive findings in the diagnosis of urothelial carcinoma of the bladder.
J. Schmidbauer (2009)
10.1089/end.2010.0055
Evaluation of narrow-band imaging as a complementary method for the detection of bladder cancer.
K. Tatsugami (2010)



This paper is referenced by
10.3233/BLC-170111
Proceedings of the 3rd Annual Albert Institute for Bladder Cancer Research Symposium
Thomas Flaig (2017)
Confocal Laser Endomicroscopy Policy
(2014)
10.3233/BLC-170119
Image-Guided Transurethral Resection of Bladder Tumors – Current Practice and Future Outlooks
Timothy Chang (2017)
10.1007/978-3-319-93339-9_7
Optical and Cross-Sectional Imaging Technologies for Bladder Cancer.
Bernhard M. Kiss (2018)
10.1016/j.juro.2013.05.026
Turning on the lights: new technologies in optical diagnostics and therapeutics.
Joseph C Liao (2013)
10.1007/s11934-014-0437-y
Confocal Laser Endomicroscopy of Bladder and Upper Tract Urothelial Carcinoma: A New Era of Optical Diagnosis?
Stephanie P Chen (2014)
10.1016/B978-0-12-809939-1.00010-2
Recent Technological Advances in Cystoscopy for the Detection of Bladder Cancer
Byong Chang Jeong (2018)
10.4143/crt.2014.190
Decision Based on Narrow Band Imaging Cystoscopy without a Referential Normal Standard Rather Increases Unnecessary Biopsy in Detection of Recurrent Bladder Urothelial Carcinoma Early after Intravesical Instillation
Phil Hyun Song (2016)
Molecular markers in development, diagnosis and progression of nonmuscle invasive bladder cancer
Willemien Beukers (2015)
10.1016/j.juro.2013.01.046
How to avoid local side effects of bladder photodynamic therapy: impact of the fluence rate.
Aurélie François (2013)
10.1007/s11934-015-0527-5
Role of Narrow Band Imaging in Management of Urothelial Carcinoma
Emanuela Altobelli (2015)
10.1007/s40291-013-0068-x
Hexaminolevulinate Blue Light Cystoscopy: A Review of Its Use in the Diagnosis of Bladder Cancer
L. Yang (2013)
10.1007/978-1-4939-1881-2_11
Improved Diagnostic Techniques
S. Lerner (2015)
10.1016/j.ajur.2016.05.001
Narrow band imaging for bladder cancer
T. Hsueh (2016)
10.1089/end.2012.0549
Interobserver agreement of confocal laser endomicroscopy for bladder cancer.
Timothy Chang (2013)
10.3791/4409
Probe-based confocal laser endomicroscopy of the urinary tract: the technique.
Timothy Chang (2013)
10.1159/000490875
Identification of Carbonic Anhydrase IX as a Novel Target for Endoscopic Molecular Imaging of Human Bladder Cancer
J. Wang (2018)
10.1186/s12885-019-6366-x
Detection of carcinogen-induced bladder cancer by fluorocoxib A
Jennifer Bourn (2019)
10.1097/CEJ.0000000000000188
Real-time in-vivo microscopic imaging of the cervix using confocal laser endomicroscopy: preliminary observations and feasibility study
M. Degueldre (2016)
10.1016/j.juro.2013.01.100
Detection of bladder urothelial carcinoma using in vivo noncontact, ultraviolet excited autofluorescence measurements converted into simple color coded images: a feasibility study.
Christof Schaefauer (2013)
10.5772/67473
Cross-Polarization OCT for In Vivo Diagnostics and Prediction of Bladder Cancer
Elena Kiseleva (2017)
10.1002/9781118674826.CH5
Transurethral resection of bladder tumors
Jen‐Jane Liu (2015)
10.5858/arpa.2014-0076-OA
Multiphoton microscopy: a potential intraoperative tool for the detection of carcinoma in situ in human bladder.
Manu Jain (2015)
10.14989/ActaUrolJap_64_1_1
[Clinical Benefits of Transurethral Resection Under Narrow Band Imaging for Non-Muscle Invasive Bladder Cancer].
K. Mita (2018)
Risk-based Management of Non-muscle Invasive Bladder Cancer: Experience from Tribhuvan University Teaching Hospital.
B. R. Luitel (2016)
10.1016/j.urology.2013.06.033
Comparison of optics and performance of a distal sensor high definition cystoscope, a distal sensor standard definition cystoscope, and a fiberoptic cystoscope.
A. Lusch (2013)
10.1016/j.ejogrb.2017.07.002
Dynamic real-time in vivo confocal laser endomicroscopy of the fallopian tube during laparoscopy in the prevention of ovarian cancer.
Gautier Chene (2017)
10.18632/oncotarget.13054
Narrow band imaging-assisted transurethral resection reduces the recurrence risk of non-muscle invasive bladder cancer: A systematic review and meta-analysis
Weiting Kang (2017)
10.1016/j.pdpdt.2019.05.036
Methods of bladder cancer diagnostics - the role of autofluorescence and photodynamic diagnosis.
Kamil Bochenek (2019)
10.1070/QE2014V044N12ABEH015380
Monitoring of permeability of different analytes in human normal and cancerous bladder tissues in vitro using optical coherence tomography
Bingsong Lei (2014)
NBI Guided TURBT in NMIBC Management - "The Right Path" to Better Tumor Ablation
Bogdan Geavlete* (2015)
Confocal Laser Endomicroscopy Effective : August 1 , 2017
(2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar