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Mesothelioma Continues To Increase Even 40 Years After Exposure - Evidence From Long-term Epidemiological Observation.

B. Świątkowska, N. Szeszenia-Dąbrowska
Published 2017 · Medicine

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BACKGROUND Because asbestos dust is considered one of the most dangerous types of dust for people's health, issues related to the effects of asbestos exposure still remain questions about the role of cessation of exposure. OBJECTIVES The aim of the present study was to determine the importance of temporal patterns, especially the time since the end of exposure in the risk of pleural mesothelioma. METHODS A total of 131 patients with pleural mesothelioma and 655 frequency matched by gender and year of birth controls enrolled in the health surveillance programme for asbestos-related diseases over the years 2000-2014, were included in the analysis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS The results show that the risk of pleural mesothelioma continued to increase even after 40 years since the last exposure. The estimated odds ratio for the subjects who had their last exposure 40 years ago, compared with the odds ratio of those who had their last exposure 5 years ago, was 2.68 (95%CI: 1.16-.621). We also observed that crocidolite exposure was associated with a very high significant mesothelioma risk, 5-fold higher for those working with mixed exposure compared to the subjects who worked only with chrysotile. CONCLUSIONS Dose-response relationships in populations occupationally exposed are critical to the study related to environment asbestos contamination. Our findings confirm the strong evidence that mesothelioma risk increases along with the increasing time since exposure termination.
This paper references
Epidemiology of malignant mesothelioma--an outline.
J. C. Mcdonald (2010)
Ecological association between asbestos-related diseases and historical asbestos consumption: an international analysis
Ro-Ting Lin (2007)
Saskia Bonjour (1824)
Models for mesothelioma incidence following exposure to fibers in terms of timing and duration of exposure and the biopersistence of the fibers.
G. Berry (1999)
Cancer risk after cessation of asbestos exposure: a cohort study of Italian asbestos cement workers
C. Magnani (2007)
B. A. R. Kernfach (1824)
Pleural mesothelioma and lung cancer risks in relation to occupational history and asbestos lung burden
C. Gilham (2015)
Temporal patterns of occupational asbestos exposure and risk of pleural mesothelioma
A. Lacourt (2011)
Asbestos: use, bans and disease burden in Europe
T. Kameda (2014)
Pleural mesothelioma and occupational and non-occupational asbestos exposure: a case-control study with quantitative risk assessment
D. Ferrante (2015)
The asbestos paradox: global gaps in the translational science of disease prevention
O. Ogunseitan (2015)
A review of human carcinogens--Part C: metals, arsenic, dusts, and fibres.
K. Straif (2009)
Comments on the causation of malignant mesothelioma: rebutting the false concept that recent exposures to asbestos do not contribute to causation of mesothelioma
C. Ramazzini (2016)
Chrysotile Biopersistence: The Misuse of Biased Studies
H. Pézerat (2009)
M. Sankar (1824)
The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure.
J. Hodgson (2000)
Comments on the causation of malignant mesothelioma: Rebutting the false concept that recent exposures to asbestos do not contribute to causation of mesothelioma.
B. Terracini (2016)
Malignant mesotheliomas in former miners and millers of crocidolite at Wittenoom (Western Australia) after more than 50 years follow-up
G. Berry (2012)
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (incl Sitas F.) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. A Review of Human Carcinogens
F. Sitas (2011)
Mesothelioma risk after 40 years since first exposure to asbestos: a pooled analysis
A. Reid (2014)
Asbestos in Poland: Occupational health problems
N. Szeszenia-Dąbrowska (2011)
A. Spring (2005)
A Meta-Analysis of Asbestos-Related Cancer Risk That Addresses Fiber Size and Mineral Type
D. Berman (2008)
III Italian Consensus Conference on Malignant Mesothelioma of the Pleura. Epidemiology, Public Health and Occupational Medicine related issues.
C. Magnani (2015)
Long‐term mortality from pleural and peritoneal cancer after exposure to asbestos: Possible role of asbestos clearance
F. Barone-Adesi (2008)

This paper is referenced by
Polymeric films loaded with cisplatin for malignant pleural mesothelioma: a pharmacokinetic study in an ovine model.
L. Ampollini (2018)
Geographic study of mortality due to mesothelioma in Peru and its evolution.
J. S. Torres-Roman (2020)
The influence of selected polymorphisms in matrix metalloproteinases on response to treatment and disease progression in patients with mesothelioma
Danijela Štrbac (2019)
Comment on Małgorzata Krówczyńska and Ewa Wilk. Environmental and Occupational Exposure to Asbestos as a Result of Consumption and Use in Poland. Int. J. Environ. Res. Public Health 2019, 16, 2611
B. Świątkowska (2020)
[The Amiantus Program in Poland - 20 years of implementation].
B. Świątkowska (2020)
Mortality for Mesothelioma and Lung Cancer in a Cohort of Asbestos Cement Workers in BARI (Italy): Time Related Aspects of Exposure
F. Cuccaro (2019)
Risk of mesothelioma after cessation of asbestos exposure: a systematic review and meta-regression
P. Boffetta (2019)
Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy
F. Luberto (2019)
Malignant Mesothelioma: Has Anything Changed?
Roger Y Kim (2019)
Change in prevalence of asbestos-related disease among sheet metal workers 1986 to 2016.
G. West (2019)
Epidemiology of Mesothelioma
D. Mirabelli (2019)
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