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Catechin Adsorption On Magnetic Hydroxyapatite Nanoparticles: A Synergistic Interaction With Calcium Ions
Published 2020 · Chemistry
Abstract Chemotherapeutic drug in the treatment of cancer is the developing strategy that includes the usage of herbal catechin, is being explored to get more insights. On the other hand, the broad dispersal of flavonoid compounds invariably restricts the therapeutic dosage of the drug at the point of delivery. This study is creating an effective transport mechanism for the delivery of catechin, a core-shell magnetite-hydroxyapatite nano agent (Fe3O4/HA) was used. A batch adsorption portrayed by Vibrating Sample Magnetometer, UV–Vis Spectroscopy, Transmission Electron Microscopy, Field-emission Scanning Electron Microscopy, X-ray powder Diffraction and Fourier-transform Infrared Spectroscopy was employed to investigate Fe3O4/HA on catechin adsorption. Accordingly, it was discovered that the herbal catechin functionalised on the Fe3O4/HA (Fe3O4/HA/Cat) exhibited a dimension of 93 nm and 8.81 nm for the magnetic core. In addition, the Fe3O4/HA/Cat at ambient room temperature was found to consist with properties that were superparamagnetic including acquiring a saturation magnetisation of 9.127 emu/g. Employing the Langmuir model, the data pertaining to catechin adsorption showed that the process was positive in acquiring the capacity and mechanism for higher adsorption (110.97 mg/g). Furthermore, the ability of the catechin to kinetically adsorb on the Fe3O4/HA was well evidenced as observed by applying the pseudo-second-order equation. Accordingly, the findings of this research help to show the chemical compounds and their associated interactions. Also, based on the findings of this study, the ability of Fe3O4/HA to transport catechin electrostatically was possibly attributed to the –OH component of the catechol moiety of catechin and Ca2+ on the HA shell.