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Chitosan Capsules With Hydrogel Core For Encapsulation And Controlled-release Of Small Molecule Materials

Song Weizheng, Guangyu Zhao, Z. Hang, He Guang-yao, J. Li, J. Zhang, Y. Chen, Yifeng Wang
Published 2020 · Materials Science

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Abstract Chitosan capsules have an important application value in encapsulation and controlled-release of active substances. However, applications of chitosan capsules have been restricted by the leakage of small molecules (molecular weights below 1000) from the capsules during storage. The purpose of the study is to prepare a novel core–shell chitosan capsule which allows small molecular to be less or not leaked during storage and controlled release in delivery. Here, we prepared chitosan sustained release capsules with chitosan/β-Glycerol phosphate disodium (CS/β-GP) hydrogel as a core and chitosan/ sodium dodecyl sulphate (CS/SDS) as a shell. The structure and morphology of the sustained release chitosan capsules were characterized. The release behaviors of the capsules were investigated against three dyes (molecular weights below 1000). The release results showed that the core–shell capsules exhibited good pH stability and a low release leakage of small molecules. The controlled-release of the core–shell capsules was realized through the stimuli-responsiveness to α-CD.
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