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Antibacterial, Antifungal, And Antiviral Activities Of Some Flavonoids.
D. D. Orhan, B. Ozçelik, S. Ozgen, F. Ergun
Published 2010 · Biology, Medicine
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Antibacterial and antifungal activities of six plant-derived flavonoids representing two different structural groups were evaluated against standard strains of Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis and their drug-resistant isolates, as well as fungi (Candida albicans, C. krusei) using the microdilution broth method. Herpes simplex virus Type-1 and Parainfluenza-3 virus were employed for antiviral assessment of the flavonoids using Madin-Darby bovine kidney and Vero cell lines. Ampicillin, gentamycin, ofloxacin, levofloxacin, fluconazole, ketoconazole, acyclovir, and oseltamivir were used as the control agents. All tested compounds (32-128 microg/ml) showed strong antimicrobial and antifungal activities against isolated strains of P. aeruginosa, A. baumanni, S. aureus, and C. krusei. Rutin, 5,7-dimethoxyflavanone-4'-O-beta-D-glucopyranoside and 5,7,3'-trihydroxy-flavanone-4'-O-beta-D-glucopyranoside (0.2-0.05 microg/ml) were active against PI-3, while 5,7-dimethoxyflavanone-4'-O-[2''-O-(5'''-O-trans-cinnamoyl)-beta-D-apiofuranosyl]-beta-D-glucopyranoside (0.16-0.2 microg/ml) inhibited potently HSV-1.
This paper references
The Flavonoids: Advances in Research : Edited by J.B. Harborne and T.J. Mabry Chapman and Hall; London, New York, 1982 744 pages. £ 49.50
D. Pilbeam (1983)
Antiviral activity of flavones and flavans.
Selway Jw (1986)
Plant Flavonoids in Biology and Medicine, Biochemical, Pharmacological and Structure-Activity Relationships : Edited by V. Cody, E. Middleton and J. B. Harborne. Alan R. Liss, New York, 1986. 592 pp + xxi. $76.00.
P. Waterman (1986)
The Flavonoids Advances in Research Since 1986
J. Harborne (1988)
Microbiology of the Circulatory System
J. L. Pelletier (1996)
Nosocomial Candida glabrata Colonization: an Epidemiologic Study
Jose A. Vazquez (1998)
Plant Products as Antimicrobial Agents
M. M. Cowan (1999)
Bioactive Compounds from Natural Sources: Isolation, Characterization and Biological Properties
C. Tringali (2000)
Search for antiviral activity in higher plant extracts
M. Abad (2000)
Antimicrobial and antiviral activities of polyphenolics from Cocos nucifera Linn. (Palmae) husk fiber extract.
D. Esquenazi (2002)
Two New Flavonoid Glycosides from Viscum album ssp. album
D. D. Orhan (2002)
In Vitro Activities of Ravuconazole and Voriconazole Compared with Those of Four Approved Systemic Antifungal Agents against 6,970 Clinical Isolates of Candida spp
M. Pfaller (2002)
An Antiviral Meliacarpin from Leaves of Melia azedarach L.
L. Alché (2003)
Novel Flavanone Glucoside with Free Radical Scavenging Properties from Galium fissurense
D. D. Orhan (2003)
Candida krusei renal cyst infection and measurement of amphotericin B levels in cystic fluid in a patient receiving AmBisome.
M. Hepburn (2003)
Sherris Medical Microbiology
K. Ryan (2003)
2-piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities.
Y. He (2003)
In Vitro Susceptibility of Candida Species Isolated from Cancer Patients to Some Antifungal Agents
Baflak Özçelik (2004)
ANTIMICROBIAL ACTIVITY OF BIOACTIVE COMPONENT FROM FLOWER OF LINUM CAPITATUM KIT UDC 547.972.2: 543
S. Ilić (2004)
Multiresistant acinetobacter in the UK: how big a threat?
J. Coelho (2004)
Antimicrobial activity of antibiotics in combination with natural flavonoids against clinical extended‐spectrum β‐lactamase (ESBL)‐producing Klebsiella pneumoniae
R. Lin (2005)
Extracts and molecules from medicinal plants against herpes simplex viruses.
M. Khan (2005)
Design, synthesis, antibacterial and QSAR studies of benzimidazole and imidazole chloroaryloxyalkyl derivatives.
A. Khalafi-nezhad (2005)
Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2)in vitro
Su-Yun Lyu (2005)
Influenza A virus infection of primary differentiated airway epithelial cell cultures derived from Syrian golden hamsters.
Celeste M Newby (2006)
ANTIOXIDANT ACTIVITY OF TWO FLAVONOL GLYCOSIDES FROM CIRSIUM HYPOLEUCUM DC. THROUGH BIOASSAY- GUIDED FRACTIONATION
D. D. Orhan (2007)
Antimicrobial Activity of Flavonoids against Extended-Spectrum -Lactamase (ESL)-Producing Klebsiella pneumoniae
Berrin Özçelik (2008)
Antiviral and antimicrobial activities of three sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis.
B. Ozçelik (2009)
Emergence of Methicillin-Resistant Staphylococcus aureus with Intermediate Glycopeptide Resistance
M. Rybak (2012)
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