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Genotoxicity Of Disinfection Byproducts And Disinfected Waters: A Review Of Recent Literature.
Constanza Cortés, R. Marcos
Published 2018 · Chemistry, Medicine
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The presence of water disinfection byproducts (DBPs) in tap water, resulting from disinfection processes involving chlorination or chloramination, increases the mutagenicity of the water and may pose adverse health effects. The topic was reviewed by DeMarini and coworkers in 2007. Here, we review research on the genotoxicity of DBPs published since that time. Studies, primarily using the Salmonella mutagenicity assay, have continued to show that chlorination or chloramination of source waters results in finished, tap, or swimming pool/spa water that is more mutagenic than the original source water. The genotoxic potencies of DBPs in both bacterial and mammalian cells generally rank as iodinated > brominated > chlorinated. Several DBPs are genotoxic in vivo in plants as well as in animals such as the worm Caenorhabditis elegans and the zebrafish Danio rerio. Studies primarily using the comet assay in mammalian cells have identified several non-regulated DBPs as genotoxic. However, the comet assay detects DNA damage that is generally repaired by the cells; thus, genotoxicity data more relevant to persistent mutations, such as chromosomal or gene mutations, are needed for these DBPs. Recent molecular epidemiology has indicated that activation of brominated trihalomethanes by the enzyme GSTT1 and the lack of metabolism of haloacetic acids by a variant of enzyme GSTZ1 are likely causative mechanisms for bladder cancer associated with exposure to chlorinated water. Further studies, especially in vivo, are needed to determine the ability of various DBPs, especially unregulated ones, to induce both gene as well as chromosomal mutations. Such investigations, along with additional molecular epidemiology studies, are required for a comprehensive understanding of the genotoxic and carcinogenic risks associated with DBP exposure.
This paper references
In vitro toxicity and genotoxicity assessment of disinfection by‐products, organic N‐chloramines
S. Laingam (2012)
Evaluation of genotoxic effects caused by extracts of chlorinated drinking water using a combination of three different bioassays.
Q. Zeng (2015)
Human cell toxicogenomic analysis of bromoacetic acid: A regulated drinking water disinfection by‐product
Mark G. Muellner (2010)
Modulation of cytochrome P450 and induction of DNA damage in Cyprinus carpio exposed in situ to surface water treated with chlorine or alternative disinfectants in different seasons.
D. Canistro (2012)
Evaluating Evidence for Association of Human Bladder Cancer with Drinking-Water Chlorination Disinfection By-Products
S. Hrudey (2015)
In vitro studies on the tumorigenic potential of the halonitromethanes trichloronitromethane and bromonitromethane.
A. Marsà (2017)
Effect of drinking water disinfection by-products in human peripheral blood lymphocytes and sperm.
Aftab Ali (2014)
Comparative toxicity of chloro- and bromo-nitromethanes in mice based on a metabolomic method.
Jinbao Yin (2017)
What’s in the Pool? A Comprehensive Identification of Disinfection By-products and Assessment of Mutagenicity of Chlorinated and Brominated Swimming Pool Water
S. Richardson (2010)
Toxicity of Wastewater with Elevated Bromide and Iodide after Chlorination, Chloramination, or Ozonation Disinfection.
S. Dong (2017)
Evaluation of wastewater reclamation technologies based on in vitro and in vivo bioassays.
N. Cao (2009)
Genotoxicity testing of three monohaloacetic acids in TK6 cells using the cytokinesis-block micronucleus assay.
D. Liviac (2010)
Reactions of chlorine with inorganic and organic compounds during water treatment-Kinetics and mechanisms: a critical review.
M. Deborde (2008)
Genotoxicity analysis of two hydroxyfuranones, byproducts of water disinfection, in human cells treated in vitro
D. Liviac (2009)
Cytotoxicity and genotoxicity of phenazine in two human cell lines.
C. McGuigan (2014)
Genotoxicity of a Low-Dose Nitrosamine Mixture as Drinking Water Disinfection Byproducts in NIH3T3 Cells
H. Wang (2017)
Environmental risk factors of pregnancy outcomes: a summary of recent meta-analyses of epidemiological studies
M. Nieuwenhuijsen (2013)
Genotoxic and clastogenic effects of monohaloacetic acid drinking water disinfection by-products in primary human lymphocytes.
L. Escobar-Hoyos (2013)
Formation of Haloacetonitriles, Haloacetamides, and Nitrogenous Heterocyclic Byproducts by Chloramination of Phenolic Compounds.
Maolida Nihemaiti (2017)
Assessing the human health impacts of exposure to disinfection by-products--a critical review of concepts and methods.
J. Grellier (2015)
Polymorphisms in GSTT1, GSTZ1, and CYP2E1, Disinfection By-products, and Risk of Bladder Cancer in Spain
K. Cantor (2010)
Comparative genotoxicity of nitrosamine drinking water disinfection byproducts in Salmonella and mammalian cells.
E. Wagner (2012)
Drinking water disinfection byproduct iodoacetic acid induces tumorigenic transformation of NIH3T3 cells.
Xiao Wei (2013)
The Occurrence of Organohalides in Chlorinated Drinking Waters
T. A. Bellar (1974)
Comparison of DNA damage in human-derived hepatoma line (HepG2) exposed to the fifteen drinking water disinfection byproducts using the single cell gel electrophoresis assay.
L. Zhang (2012)
Mutagenic analysis of six disinfection by-products in the Tk gene of mouse lymphoma cells.
D. Liviac (2011)
Removal of the precursors of N-nitrosodiethylamine (NDEA), an emerging disinfection byproduct, in drinking water treatment process and its toxicity to adult zebrafish (Danio rerio).
Jian Zheng (2018)
Occurrence and health risk assessment of halogenated disinfection byproducts in indoor swimming pool water.
C. Hang (2016)
Combined exposure to 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone and microsytin-LR increases genotoxicity in Chinese hamster ovary cells through oxidative stress.
Shu Wang (2013)
Monohalogenated acetamide-induced cellular stress and genotoxicity are related to electrophilic softness and thiol/thiolate reactivity.
Justin A. Pals (2017)
Cell-based genotoxicity testing : genetically modified and genetically engineered bacteria in environmental genotoxicology.
G. Reifferscheid (2010)
Formation of known and unknown disinfection by-products from natural organic matter fractions during chlorination, chloramination, and ozonation.
C. Li (2017)
Identification of disinfection by-products in freshwater and seawater swimming pools and evaluation of genotoxicity.
Tarek Manasfi (2016)
Occurrence, synthesis, and mammalian cell cytotoxicity and genotoxicity of haloacetamides: an emerging class of nitrogenous drinking water disinfection byproducts.
M. Plewa (2008)
Effect of ammonia nitrogen and dissolved organic matter fractions on the genotoxicity of wastewater effluent during chlorine disinfection.
Li-sha Wang (2007)
Occurrence of nitrogenous and carbonaceous disinfection byproducts in drinking water distributed in Shenzhen, China.
H. Huang (2017)
Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research.
S. Richardson (2007)
Determination of halonitromethanes in treated water.
I. Montesinos (2011)
Comparative cytotoxic and genotoxic potential of 13 drinking water disinfection by-products using a microplate-based cytotoxicity assay and a developed SOS/umu assay.
Shao-Hui Zhang (2016)
Detection of genotoxic effects of drinking water disinfection by-products using Vicia faba bioassay
Yu Hu (2016)
Toxic impact of bromide and iodide on drinking water disinfected with chlorine or chloramines.
Y. Yang (2014)
Developmental effects and genotoxicity of 10 water disinfection by-products in zebrafish.
E. Teixidó (2015)
Biological mechanism for the toxicity of haloacetic acid drinking water disinfection byproducts.
Justin A. Pals (2011)
Disparity in disinfection byproducts concentration between hot and cold tap water.
B. Liu (2015)
Concentration, chlorination, and chemical analysis of drinking water for disinfection byproduct mixtures health effects research: U.S. EPA's Four Lab Study.
J. Pressman (2010)
Mammalian cell DNA damage and repair kinetics of monohaloacetic acid drinking water disinfection by-products.
Yukako Komaki (2009)
Transformation of pharmaceuticals during oxidation/disinfection processes in drinking water treatment.
C. Postigo (2014)
Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water.
Clara H. Jeong (2015)
Water Security for Better Lives
Portland Press Ltd (2013)
DNA damage and oxidative stress in human liver cell L‐02 caused by surface water extracts during drinking water treatment in a waterworks in China
S. Xie (2010)
Assessment of the cytotoxicity and genotoxicity of haloacetic acids using microplate-based cytotoxicity test and CHO/HGPRT gene mutation assay.
Shao-Hui Zhang (2010)
Chloramination of wastewater effluent: Toxicity and formation of disinfection byproducts.
Julien Le Roux (2017)
Estimation of chlorination by-products presence in drinking water in epidemiological studies on adverse reproductive outcomes: a review.
C. Legay (2010)
In Vitro Cytotoxicity and Adaptive Stress Responses to Selected Haloacetic Acid and Halobenzoquinone Water Disinfection Byproducts.
Erik Procházka (2015)
Ca Stewart (1991)
Genotoxicity of water concentrates from recreational pools after various disinfection methods.
D. Liviac (2010)
Human Fibroblasts and 900 MHz Radiofrequency Radiation: Evaluation of DNA Damage after Exposure and Co-exposure to 3-Chloro-4-(dichloromethyl)-5-Hydroxy-2(5h)-furanone (MX)
A. Sannino (2009)
Differential toxicity of drinking water disinfected with combinations of ultraviolet radiation and chlorine.
M. Plewa (2012)
Genotoxicity testing: progress and prospects for the next decade
H. Turkez (2017)
Evaluation of drinking water treatment combined filter backwash water recycling technology based on comet and micronucleus assay.
Ting Chen (2016)
Analytical and toxicity characterization of halo-hydroxyl-benzoquinones as stable halobenzoquinone disinfection byproducts in treated water.
Wei Wang (2014)
Formation of toxic iodinated disinfection by-products from compounds used in medical imaging.
Stephen E. Duirk (2011)
Human cell toxicogenomic analysis linking reactive oxygen species to the toxicity of monohaloacetic acid drinking water disinfection byproducts.
Justin A. Pals (2013)
Overview of Disinfection By-products and Associated Health Effects
C. Villanueva (2014)
Occurrence of a new generation of disinfection byproducts.
S. Krasner (2006)
DNA damage induction by two halogenated acetaldehydes, byproducts of water disinfection.
D. Liviac (2010)
Occurrence and mammalian cell toxicity of iodinated disinfection byproducts in drinking water.
S. Richardson (2008)
Genotoxic Effects in Swimmers Exposed to Disinfection By-products in Indoor Swimming Pools
M. Kogevinas (2010)
Haloacetonitriles vs. regulated haloacetic acids: are nitrogen-containing DBPs more toxic?
Mark G. Muellner (2007)
Pyruvate remediation of cell stress and genotoxicity induced by haloacetic acid drinking water disinfection by‐products
A. Dad (2013)
Genotoxicity analysis of two halonitromethanes, a novel group of disinfection by-products (DBPs), in human cells treated in vitro.
D. Liviac (2009)
Formation of N-nitrosodiphenylamine and two new N-containing disinfection byproducts from chloramination of water containing diphenylamine.
W. Zhou (2009)
Progressive Increase in Disinfection Byproducts and Mutagenicity from Source to Tap to Swimming Pool and Spa Water: Impact of Human Inputs.
Eric J. Daiber (2016)
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Raquel S. Chaves (2019)
Review of in-water hull encapsulation and enclosure treatments for eliminating marine biofouling
U. Ammon (2019)
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Effects of ascorbate and carbonate on the conversion and developmental toxicity of halogenated disinfection byproducts during boiling of tap water.
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Recreational Use of Spa Thermal Waters: Criticisms and Perspectives for Innovative Treatments
F. Valeriani (2018)
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A. Chow (2019)
Water disinfection using fixed bed reactors packed with silver nanoparticle immobilized glass capillary tubes.
S. Bharti (2019)
Application of biomarkers in the study of the health effects of disinfection by-products
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Ferrate(VI) pretreatment before disinfection: An effective approach to controlling unsaturated and aromatic halo-disinfection byproducts in chlorinated and chloraminated drinking waters
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The occurrence, characteristics, transformation and control of aromatic disinfection by-products: A review.
X. Liu (2020)
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P. K. Panda (2019)
Toxicity of chlorinated and ozonated wastewater effluents probed by genetically modified bioluminescent bacteria and cyanobacteria Spirulina sp.
M. Bhuvaneshwari (2019)
Genotoxicity of source, treated and distributed water from four drinking water treatment plants supplied by surface water in Sardinia, Italy.
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APPLICATIONS OF NANOTECHNOLOGY IN WATER TREATMENT APLICAÇÕES DA NANOTECNOLOGIA NO TRATAMENTO DE ÁGUA
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Iodinated disinfection byproducts: Formation and concerns
C. Postigo (2019)
Low-concentration of dichloroacetonitrile (DCAN) in drinking water perturbs the health-associated gut microbiome and metabolic profile in rats.
Bin Xue (2020)
Degradation of haloacetic acids with the Fenton-like and analysis by GC-MS: use of bioassays for monitoring of genotoxic, mutagenic and cytotoxic effects
A. Mourao (2019)
Disinfection by-products in Croatian drinking water supplies with special emphasis on the water supply network in the city of Zagreb.
L. Kurajica (2020)
Removal of the precursors of regulated DBPs and TOX from surface waters and wastewater effluents using mixed anion exchange resins.
Amer Kanan (2021)
Investigation of the effective factors on the mutagen X formation in drinking water by response surface methodology.
Mahtab Bagheban (2019)
Disinfection by-products in drinking water: Occurrence, toxicity and abatement.
A. L. Srivastav (2020)
Addition of lemon before boiling chlorinated tap water: A strategy to control halogenated disinfection byproducts.
J. Liu (2020)
A review on the 40th anniversary of the first regulation of drinking water disinfection by‐products
D. DeMarini (2020)
Comparison of UV-induced AOPs (UV/Cl2, UV/NH2Cl, UV/ClO2 and UV/H2O2) in the degradation of iopamidol: Kinetics, energy requirements and DBPs-related toxicity in sequential disinfection processes
Fuxiang Tian (2020)