Online citations, reference lists, and bibliographies.
Referencing for people who value simplicity, privacy, and speed.
Get Citationsy
← Back to Search

Vitamin D Receptor Polymorphisms And Parkinson’s Disease In A Korean Population: Revisited

S. Kang, Suyeon Park, E. Oh, J. Park, W. Jang
Published 2016 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Recently, the effect of genetic variants in the Vitamin D receptor (VDR) gene on Parkinson's disease (PD) has gained interest. However, the precise relationship between VDR polymorphisms and PD remains unclear. In Korea, one study reported an association between VDR gene polymorphisms and PD. However, this study was conducted with a small sample size, and only the Bsml locus was evaluated. Therefore, further investigations about the relationship between VDR polymorphisms and PD are necessary in a Korean population. A total of 300 subjects were included in this study. One hundred and forty-six PD patients were diagnosed according to the United Kingdom Parkinson's Disease Society Brain Bank (UKPDBB) criteria with abnormal dopamine transporter imaging, and 154 healthy control subjects were also enrolled. We used a TaqMan genotyping assay to identify four SNPs of the VDR gene, including BsmI, FokI, ApaI, and TaqI (rs731236, rs2228570, rs7976091, and rs731236). A significant association was not noted between the risk of PD and genetic polymorphisms in the four loci in a Korean population. However, when the genetic variants of the VDR gene were analyzed after adjusting for the serum 25-OH vitamin D3 level, the TaqI and BsmI minor allele increased the risk of PD. Our data suggest no correlation between PD and the VDR polymorphisms, including BsmI, FokI, ApaI, and TaqI, in a Korean population; however, the results should be interpreted carefully because gene-environment interactions may exist. Further investigations of the VDR and its relationship with PD are required to identify the role of vitamin D in the pathogenesis of PD.
This paper references
Biochemical protective effect of 1,25-dihydroxyvitamin D3 through autophagy induction in the MPTP mouse model of Parkinson’s disease
H. Li (2015)
High prevalence of vitamin D deficiency and reduced bone mass in Parkinson's disease [RETRACTED]
Y. Sato (1997)
Vitamin D deficiency in Parkinson's disease patients with orthostatic hypotension
W. Jang (2015)
Genetic variants in sporadic Parkinson's disease: East vs West.
T. Peeraully (2012)
Vitamin D and Parkinson's disease—A hypothesis
H. Newmark (2007)
Association of vitamin D receptor gene polymorphisms and Parkinson's disease in Hungarians
Rita Török (2013)
Association between vitamin D receptor gene polymorphisms and susceptibility to Parkinson's disease: A meta-analysis
Zi-teng Zhang (2014)
1,25-Dyhydroxyvitamin D₃ attenuates rotenone-induced neurotoxicity in SH-SY5Y cells through induction of autophagy.
W. Jang (2014)
The role of vitamin D levels and vitamin D receptor polymorphism on Parkinson's disease in the Faroe Islands
M. Petersen (2014)
Identification of a genetic variant at 2q12.1 associated with blood pressure in East-Asians by genome-wide scan including gene-environment interactions
Y. K. Kim (2014)
High prevalence of hypovitaminosis D status in patients with early Parkinson disease.
M. Evatt (2011)
Distribution of the Vitamin D receptor and 1α-hydroxylase in human brain
D. Eyles (2005)
1,25-dyhydroxyvitamin D3 Attenuates l-DOPA-Induced Neurotoxicity in Neural Stem Cells
W. Jang (2014)
A clinicopathologic study of 100 cases of Parkinson's disease.
A. Hughes (1993)
PLINK: a tool set for whole-genome association and population-based linkage analyses.
S. Purcell (2007)
Vitamin D receptor genetic variants and Parkinson's disease in a Taiwanese population
Chin-Hsien Lin (2014)
[Scans without Evidence of Dopamine Deficit (SWEDDs)].
Y. Mukai (2016)
Association of Vitamin D Receptor Gene Polymorphism and Parkinson's Disease in Koreans
Joong-Seok Kim (2005)
Why vitamin D in Alzheimer's disease? The hypothesis.
D. Gezen-Ak (2014)
Behavioural characterization of Vitamin D receptor knockout mice
T. H. J. Burne (2005)
Unified Parkinson's disease rating scale characteristics and structure
P. Martínez-Martín (1994)
Randomized, double-blind, placebo-controlled trial of vitamin D supplementation in Parkinson disease.
M. Suzuki (2013)
Vitamin D as an early predictor of multiple sclerosis activity and progression.
A. Ascherio (2014)
Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in de novo Parkinson's Disease
K. Kwon (2016)
Serum vitamin D and the risk of Parkinson disease.
P. Knekt (2010)
25‐hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease
M. Suzuki (2012)
Association of vitamin D receptor gene polymorphisms and vitamin D levels with asthma and atopy in Cypriot adolescents: a case–control study
A. Papadopoulou (2015)
Molecular epidemiology of vitamin D receptor gene variants.
J. Zmuda (2000)
Memory, mood, and vitamin D in persons with Parkinson's disease.
A. Peterson (2013)
Vitamin D and metabolites measurement by tandem mass spectrometry
J. M. V. D. Ouweland (2013)
Cardiac sympathetic denervation in Parkinson’s disease patients with SWEDDs
W. Jang (2012)
Epidemiology of Parkinson's disease
L. M. D. Lau (2006)
Vitamin D receptor polymorphisms and susceptibility to Parkinson’s disease and Alzheimer’s disease: a meta-analysis
Y. Lee (2014)
A Prospective Study of Plasma Vitamin D Metabolites, Vitamin D Receptor Polymorphisms, and Prostate Cancer
H. Li (2007)
Interactions between Serum Vitamin D Levels and Vitamin D Receptor Gene FokI Polymorphisms for Renal Function in Patients with Type 2 Diabetes
K. Yokoyama (2012)

This paper is referenced by
Association between vitamin D receptor polymorphisms and susceptibility to Parkinson's disease: An updated meta-analysis
Jinzhao Gao (2020)
Vitamin D receptor gene polymorphisms and cognitive decline in Parkinson's disease
N. Gatto (2016)
Vitamin D receptor rs2228570 polymorphism and Parkinson’s disease risk in a Chinese population
Weihong Hu (2019)
Impaired vitamin D sensitivity.
L. Máčová (2018)
Vitamin D receptor polymorphisms and the susceptibility of Parkinson’s disease
Xiong Wang (2019)
Vitamin D receptor (VDR) gene polymorphism and vascular dementia due to cerebral small vessel disease in an Asian Indian cohort
M. Supriya (2018)
Serum 25-hydroxyvitamin D3 level may be associated with olfactory dysfunction in de novo Parkinson's disease
J. Kim (2018)
Association of ADH 2 and ALDH 2 genetic polymorphisms with susceptibility to Parkinson ’ s disease in a Chinese population
J. Liu (2016)
Genetic polymorphisms in amyotrophic lateral sclerosis: Evidence for implication in detoxification pathways of environmental toxicants.
E. Dardiotis (2018)
Polymorphisms in Vitamin D Receptor Genes in Association with Childhood Autism Spectrum Disorder
Z. Zhang (2018)
The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease
Lingling Lv (2020)
Semantic Scholar Logo Some data provided by SemanticScholar