Online citations, reference lists, and bibliographies.
← Back to Search

Retinal Nerve Fiber Layer Imaging With Spectral-domain Optical Coherence Tomography: Patterns Of Retinal Nerve Fiber Layer Progression.

C. Leung, M. Yu, R. Weinreb, G. Lai, G. Xu, D. Lam
Published 2012 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
OBJECTIVE To examine the use of the retinal nerve fiber layer (RNFL) thickness map generated by a spectral-domain optical coherence tomography (OCT) to detect RNFL progression and identify the pattern of progressive changes of RNFL defects in glaucoma. DESIGN Prospective, longitudinal study. PARTICIPANTS One hundred eighty-six eyes of 103 glaucoma patients. METHODS Patients were followed at 4-month intervals for ≥ 36 months for RNFL imaging and visual field examination. Both eyes were imaged by the Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA) and had visual field testing at the same visits. We defined RNFL progression by Guided Progression Analysis (Carl Zeiss Meditec) of serial RNFL thickness maps. The pattern of RNFL progression was evaluated by comparing the baseline RNFL thickness deviation map and the RNFL thickness change map. Visual field progression was defined by trend analysis of visual field index and event analysis based on the Early Manifest Glaucoma Trial criteria. MAIN OUTCOME MEASURES The presence and the pattern of RNFL progression. RESULTS A total of 2135 OCT images were reviewed. Twenty-eight eyes (15.1%) from 24 patients (23.3%) had RNFL progression detected by RNFL thickness map analysis. Three RNFL progression patterns were observed: (1) widening of RNFL defects (24 eyes, 85.7%), (2) deepening of RNFL defects (2 eyes, 7.1%, both had concomitant widening of RNFL defects), and (3) development of new RNFL defects (5 eyes, 17.9%). The inferotemporal meridian (324°-336°) 2.0 mm away from the optic disc center was the most frequent location where RNFL progression was detected. Thirteen eyes (46.4%) had concomitant visual field progression; 61.5% (n = 8) of these had RNFL progression that preceded or occurred concurrently with visual field progression. Forty-two eyes from 37 patients (22.6%) had visual field progression by trend and/or event analyses without progression in the RNFL thickness map. CONCLUSIONS Analysis of serial RNFL thickness maps generated by the spectral-domain OCT facilitates the detection of RNFL progression in glaucoma.
This paper references
10.1167/IOVS.05-1584
Optic disc and visual field progression in ocular hypertensive subjects: detection rates, specificity, and agreement.
N. Strouthidis (2006)
10.1167/iovs.09-3715
Detection of glaucoma progression with stratus OCT retinal nerve fiber layer, optic nerve head, and macular thickness measurements.
F. Medeiros (2009)
10.1167/iovs.07-1187
Longitudinal variability of optic disc and retinal nerve fiber layer measurements.
C. Leung (2008)
10.1001/ARCHOPHT.1984.01040031430017
Evaluation of nerve fiber layer assessment.
A. Sommer (1984)
10.1167/iovs.10-5975
Trend-based analysis of retinal nerve fiber layer thickness measured by optical coherence tomography in eyes with localized nerve fiber layer defects.
Eun Ji Lee (2011)
10.1034/J.1600-0420.2003.00070.X
Measuring visual field progression in the Early Manifest Glaucoma Trial.
A. Heijl (2003)
10.1016/S0161-6420(02)01248-4
Rate and pattern of visual field decline in primary open-angle glaucoma.
M. L. Pereira (2002)
10.1001/ARCHOPHT.1977.04450120055003
The nerve fiber layer in the diagnosis of glaucoma.
A. Sommer (1977)
10.1016/S0002-9394(14)72385-2
Initial glaucomatous optic disk and retinal nerve fiber layer abnormalities and their progression.
A. Tuulonen (1991)
10.1001/ARCHOPHT.123.4.464
Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma.
G. Wollstein (2005)
10.1016/j.ophtha.2009.04.013
Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study.
C. Leung (2009)
10.1016/S0161-6420(96)30410-7
Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography.
J. Schuman (1996)
10.1167/iovs.10-5222
Reproducibility of peripapillary retinal nerve fiber layer thickness and optic nerve head parameters measured with cirrus HD-OCT in glaucomatous eyes.
Jean-Claude Mwanza (2010)
Clinical Decisions In Glaucoma
E. Hodapp (1993)
10.1016/j.preteyeres.2004.10.002
Longitudinal changes in the visual field and optic disc in glaucoma
P. Artes (2005)
10.1016/j.ophtha.2011.01.026
Evaluation of retinal nerve fiber layer progression in glaucoma: a comparison between spectral-domain and time-domain optical coherence tomography.
C. Leung (2011)
10.1016/j.ophtha.2010.12.035
Evaluation of retinal nerve fiber layer progression in glaucoma a prospective analysis with neuroretinal rim and visual field progression.
C. K. S. Leung (2011)
10.1016/j.ophtha.2010.01.026
Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: analysis of the retinal nerve fiber layer map for glaucoma detection.
C. Leung (2010)
10.1167/iovs.10-6818
β-Zone parapapillary atrophy and the rate of retinal nerve fiber layer thinning in glaucoma.
Eun Ji Lee (2011)
10.1001/ARCHOPHT.1982.01030030811018
Quantitative studies of retinal nerve fiber layer defects.
H. Quigley (1982)
10.1038/eye.2009.209
Patterns of progression of localized retinal nerve fibre layer defect on red-free fundus photographs in normal-tension glaucoma
M. Suh (2010)
10.1016/j.ophtha.2010.08.014
Evaluation of retinal nerve fiber layer progression in glaucoma: a comparison between the fast and the regular retinal nerve fiber layer scans.
C. Leung (2011)
10.1016/j.ophtha.2010.04.002
Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: pattern of RNFL defects in glaucoma.
C. Leung (2010)
10.1136/bjo.2009.157875
Retinal nerve fibre layer thickness measurement reproducibility improved with spectral domain optical coherence tomography
J. S. Kim (2009)
10.1167/iovs.09-3468
Evaluation of retinal nerve fiber layer progression in glaucoma: a study on optical coherence tomography guided progression analysis.
C. Leung (2010)



This paper is referenced by
10.1007/978-3-319-94905-5_12
Optical Coherence Tomography and Progression
Ahmet Akman (2018)
10.1016/j.ajo.2013.04.015
Estimated retinal ganglion cell counts in glaucomatous eyes with localized retinal nerve fiber layer defects.
A. Tatham (2013)
10.1016/j.ophtha.2018.03.052
Patterns of Progressive Ganglion Cell-Inner Plexiform Layer Thinning in Glaucoma Detected by OCT.
J. Shin (2018)
10.2174/1874364101509010078
The Use of Spectral-Domain Optical Coherence Tomography to Detect Glaucoma Progression
Ricardo Y Abe (2015)
10.1167/tvst.7.3.5
Evaluation of a Qualitative Approach for Detecting Glaucomatous Progression Using Wide-Field Optical Coherence Tomography Scans
Zhichao Wu (2018)
10.1097/APO.0000000000000177
Update on the Prevalence, Etiology, Diagnosis, and Monitoring of Normal-Tension Glaucoma
K. Kim (2016)
10.1136/bjophthalmol-2017-310731
5-year disease progression of patients across the glaucoma spectrum assessed by structural and functional tools
N. Seth (2017)
10.1097/ICU.0000000000000024
Diagnosing glaucoma progression with optical coherence tomography.
C. Leung (2014)
10.1371/journal.pone.0165538
The Effect of Optic Disc Center Displacement on Retinal Nerve Fiber Layer Measurement Determined by Spectral Domain Optical Coherence Tomography
J. Shin (2016)
10.1117/1.NPh.7.1.015006
Retinal analysis of a mouse model of Alzheimer’s disease with multicontrast optical coherence tomography
Danielle J. Harper (2020)
10.1007/978-3-319-94905-5_3
Role of Optical Coherence Tomography in Glaucoma
Ahmet Akman (2018)
Title Microcystic inner nuclear layer changes and retinal nerve fiberlayer defects in eyes with glaucoma
Tomoko Hasegawa (2019)
structural and functional tools the glaucoma spectrum assessed by 5-year disease progression of patients across
Natasha Gautam Seth ()
Variability of the risk factors measurements and 5-year risk glaucoma risk estimation.
Thomas C. Lam (2020)
10.1117/1.JBO.17.7.076026
Phase-sensitive optical coherence tomography characterization of pulse-induced trabecular meshwork displacement in ex vivo nonhuman primate eyes.
P. Li (2012)
10.1167/iovs.13-12344
Difference in the properties of retinal nerve fiber layer defect between superior and inferior visual field loss in glaucoma.
Jin A Choi (2013)
10.1038/s41598-017-06580-7
Impact of Natural Blind Spot Location on Perimetry
Mengyu Wang (2017)
Clinical Study Trends in the Retinal Nerve Fiber Layer Thickness Changes with Different Degrees of Visual Field Defects
Wenhui Geng (2020)
10.1016/j.ophtha.2019.12.004
Artificial Intelligence Classification of Central Visual Field Patterns in Glaucoma.
Mengyu Wang (2019)
10.1016/j.ophtha.2012.12.048
Ability of cirrus high-definition spectral-domain optical coherence tomography clock-hour, deviation, and thickness maps in detecting photographic retinal nerve fiber layer abnormalities.
Y. H. Hwang (2013)
10.1007/s00417-013-2527-9
Baseline thickness of macular ganglion cell complex predicts progression of visual field loss
A. Anraku (2013)
10.1371/journal.pone.0185573
Evaluation of retinal nerve fiber layer defect using wide-field en-face swept-source OCT images by applying the inner limiting membrane flattening
N. Miura (2017)
10.1016/j.tjo.2015.04.003
Detecting optic nerve head deformation and retinal nerve fiber layer thinning in glaucoma progression
Christopher K. S. Leung (2015)
10.1097/IJG.0000000000000286
Histologic RNFL Thickness in Glaucomatous Versus Normal Human Eyes
Corinne Maurice (2016)
Changes in RNFL Thickness Using OCT in Primary Open Angle Glaucoma Before and After Trabeculectomy in Sub-Himalayan Region
Dr. Yash Pal Sharma (2020)
10.1016/j.ajo.2015.04.001
Quantitative Trait Locus Analysis of SIX1-SIX6 With Retinal Nerve Fiber Layer Thickness in Individuals of European Descent.
J. Kuo (2015)
10.1167/iovs.61.5.56
Vulnerability Zone of Glaucoma Progression in Combined Wide-field Optical Coherence Tomography Event-based Progression Analysis
W. J. Lee (2020)
Early Detection of Primary Open Angle Glaucoma by Using Optical Coherence Tomography (OCT)
A. Malik (2015)
10.1155/2017/6078365
The Pattern of Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness Changes in Glaucoma
Jin A Choi (2017)
10.1016/j.jcjo.2016.07.021
Retrospective analysis of translaminar, demographic, and physiologic parameters in relation to papilledema severity.
D. Fleischman (2017)
10.1371/journal.pone.0130175
Microcystic Inner Nuclear Layer Changes and Retinal Nerve Fiber Layer Defects in Eyes with Glaucoma
Tomoko Hasegawa (2015)
10.1007/s00347-018-0670-8
Strukturelle Endpunkte für Glaukomstudien
A. Popa-Cherechenau (2018)
See more
Semantic Scholar Logo Some data provided by SemanticScholar