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Competing Causes Of Death In The Head And Neck Cancer Population.

Sean T Massa, N. Osazuwa-Peters, K. Christopher, Lauren D. Arnold, M. Schootman, R. Walker, M. Varvares
Published 2017 · Medicine
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PURPOSE/OBJECTIVES The increasing survivorship of head and neck squamous cell carcinoma (HNSCC) comes with a risk of death from other causes, known as competing causes. The demographics of HNSCC are also evolving with increasing incidence of Human Papillomavirus (HPV) associated tumors. This study describes competing causes of death for the HNSCC population compared to the general population and identifies associated risk factors. METHODS Adult patients with first mucosal HNSCC (2004-2011) were identified from the Surveillance, Epidemiology and End Result database. Competing causes of death were compared to reference populations using proportion of deaths and Standardized Mortality Ratios (SMR). A multivariable competing risk survival analysis yielded subdistribution hazard ratios (HR) for competing mortality. RESULTS Of 64,598 HNSCC patients, 24,602 (38.1%) were deceased including 7142 deaths (29.0%) from competing causes. The most common were cardiovascular disease, lung cancer, and other cancers. All relative mortality rates were elevated, especially liver disease (SMR 38.7; 95% CI: 29.4-49.3), suicide (SMR 37.1; 95% CI: 26.1-48.6), and subsequent primary cancers (SMR 7.5; 95% CI: 6.78-8.32). Demographic and tumor factors independently increased risk of competing mortality, including age (HR per 5years 1.24; 95% CI: 1.22-1.25), sex (male HR 1.23; 95% CI: 1.16-1.32), race (Black HR 1.17; 95% CI: 1.09-1.26), insurance (uninsured HR 1.28; 95% CI: 1.09-1.50), and marital status (single HR 1.29; 95% CI: 1.21-1.37). CONCLUSION Nearly one in three HNSCC patients died from competing causes. When developing long term survivorship regimens for HNSCC patients, clinicians should be familiar with this population's specific risks.
This paper references
10.1200/JCO.2011.36.4596
Human papillomavirus and rising oropharyngeal cancer incidence in the United States.
Anil K Chaturvedi (2011)
10.1634/theoncologist.2009-0289
Changes in survival in head and neck cancers in the late 20th and early 21st century: a period analysis.
Dianne Pulte (2010)
10.1200/JCO.2015.61.4115
Survivorship and Quality of Life in Head and Neck Cancer.
Jolie Ringash (2015)
10.1002/hed.21022
National Cancer Database report on cancer of the head and neck: 10-year update.
Jay Scott Cooper (2009)
10.1093/annonc/mds540
Risk factors for non-cancer health events in patients with head and neck squamous cell carcinoma.
C. H. Ryu (2013)
10.2105/AJPH.71.3.242
Accuracy of cancer death certificates and its effect on cancer mortality statistics.
C. Percy (1981)
10.3322/canjclin.54.2.72
Poverty, culture, and social injustice: determinants of cancer disparities.
H. Freeman (2004)
10.1002/hed.24327
Predictors of stage at presentation and outcomes of head and neck cancers in a university hospital setting.
Nosayaba Osazuwa-Peters (2016)
10.1146/annurev.publhealth.18.1.341
Measuring social class in US public health research: concepts, methodologies, and guidelines.
N. Krieger (1997)
10.1002/cncr.28357
Improvement in survival of patients with oral cavity squamous cell carcinoma: An international collaborative study.
M. Amit (2013)
10.1002/cncr.23889
African American and poor patients have a dramatically worse prognosis for head and neck cancer: an examination of 20,915 patients.
M. A. Molina (2008)
10.1097/00005537-200004000-00011
Importance of comorbidity in head and neck cancer.
J. Piccirillo (2000)
10.1002/cncr.28588
Causes of death in long-term survivors of head and neck cancer.
Shrujal S Baxi (2014)
10.1001/archotol.128.10.1172
Development of a new head and neck cancer-specific comorbidity index.
J. Piccirillo (2002)
10.1016/j.canep.2015.04.007
Oral cavity and oropharyngeal cancer incidence trends and disparities in the United States: 2000-2010.
Darien Weatherspoon (2015)
10.1111/j.1749-6632.1990.tb32059.x
Effect of changes in cancer classification and the accuracy of cancer death certificates on trends in cancer mortality.
Constance L. Percy (1990)
10.1002/hed.23869
Improved overall survival and mortality in head and neck cancer with adjuvant concurrent chemoradiotherapy in national databases.
Sonia Lin (2016)
10.1093/jnci/djq366
Improved estimates of cancer-specific survival rates from population-based data.
Nadia Howlader (2010)
10.1200/JCO.2008.16.6546
Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy.
G. Smith (2008)
10.1093/annonc/mdu128
Noncancer health events as a leading cause of competing mortality in advanced head and neck cancer.
Min Su Kwon (2014)
10.1016/j.ijrobp.2011.01.013
Impact of gender, partner status, and race on locoregional failure and overall survival in head and neck cancer patients in three radiation therapy oncology group trials.
Thomas J. Dilling (2011)
10.1016/S1047-2797(00)00205-2
The use of census data for determining race and education as SES indicators: a validation study.
R. Kwok (2001)
10.1158/1078-0432.CCR-06-1210
Cumulative Incidence in Competing Risks Data and Competing Risks Regression Analysis
H. Kim (2007)
10.1016/j.otc.2013.04.008
Survivorship--competing mortalities, morbidities, and second malignancies.
Pablo H Montero-Miranda (2013)
10.1016/j.oraloncology.2004.08.012
Severe comorbidity negatively influences prognosis in patients with oral and oropharyngeal cancer after surgical treatment with microvascular reconstruction.
P. Borggreven (2005)
10.1002/1097-0347(200007)22:4<317::AID-HED1>3.0.CO;2-0
The impact of comorbidity on the survival of patients with squamous cell carcinoma of the head and neck.
S. Hall (2000)
10.1002/1097-0142(19940715)74:2<565::AID-CNCR2820740206>3.0.CO;2-I
Trends and differentials in mortality from cancers of the oral cavity and pharynx in the United States, 1973-1987.
Howard I. Goldberg (1994)
10.1038/bmt.2009.359
Regression modeling of competing risk using R: an in depth guide for clinicians
Luca Scrucca (2010)
10.1002/hed.1079
The significance of comorbidity in advanced laryngeal cancer.
A. Chen (2001)
10.1200/JCO.2015.65.4673
Suicide: A Major Threat to Head and Neck Cancer Survivorship.
Nosayaba Osazuwa-Peters (2016)
10.1016/j.ejso.2016.05.037
The impact of treatment on quality of life of patients with head and neck cancer and its association with prognosis.
José Francisco Carrillo (2016)
10.1097/MLR.0b013e3181d99107
Evaluating Health Outcomes in the Presence of Competing Risks: A Review of Statistical Methods and Clinical Applications
R. Varadhan (2010)
Socioeconomic differences in cancer survival: a review of the evidence.
M. Kogevinas (1997)
10.3322/caac.21343
American Cancer Society Head and Neck Cancer Survivorship Care Guideline.
Ezra E. W. Cohen (2016)
10.2105/AJPH.2005.075408
Monitoring socioeconomic disparities in death: comparing individual-level education and area-based socioeconomic measures.
D. Rehkopf (2006)
10.1097/00005537-199711000-00009
Validation of the Charlson comorbidity index in patients with head and neck cancer: a multi-institutional study.
B. Singh (1997)
10.1002/sim.1135
Competing approaches to analysis of failure times with competing risks.
T. M. M. Farley (2001)
10.1200/JCO.2011.35.7301
Population-based study of competing mortality in head and neck cancer.
Brent S. Rose (2011)
10.1002/cncr.28250
Long-term prognosis and risk factors among patients with HPV-associated oropharyngeal squamous cell carcinoma.
B. Lin (2013)
10.2105/ajph.82.5.703
Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology.
N. Krieger (1992)
10.1007/s11912-006-0047-z
Comorbidity in patients with cancer of the head and neck: Prevalence and impact on treatment and prognosis
J. Piccirillo (2006)
NATIONAL SURVEY ON DRUG USE AND HEALTH A COMPARISON OF VARIANCE ESTIMATION METHODS FOR REGRESSION ANALYSES WITH THE MENTAL HEALTH SURVEILLANCE STUDY CLINICAL SAMPLE
Phillip S. Kott (2017)
10.1177/0194599816633690
Trends in the Incidence of Oropharyngeal Cancers in the United States
Laura M Enomoto (2016)
10.1001/jamaoto.2015.2480
Incidence of Suicide in Patients With Head and Neck Cancer.
David Kam (2015)
10.1056/NEJM198511143132005
The autopsy as a measure of accuracy of the death certificate.
T. Kircher (1985)
10.1001/archotol.130.4.401
Clinical predictors of quality of life in patients with head and neck cancer.
J. Terrell (2004)
10.1093/jnci/88.8.542
Alcoholism: independent predictor of survival in patients with head and neck cancer.
F. Deleyiannis (1996)



This paper is referenced by
10.1001/jamaoncol.2017.4478
Primary Cancer vs Competing Causes of Death in Survivors of Head and Neck Cancer
Matthew C. Simpson (2018)
10.1371/journal.pone.0224665
Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC)
Pei Yuan Fong (2019)
10.1002/pon.4816
Depressive symptoms in relation to overall survival in people with head and neck cancer: A longitudinal cohort study
Femke Jansen (2018)
10.1016/j.oraloncology.2019.104444
Radiation induced hypothyroidism - Why is early intervention necessary?
Kshitij Aggarwal (2019)
10.1002/lary.27289
Demographic predictors of head and neck cancer survival differ in the elderly.
Sean T Massa (2019)
Orofacial cancers: pattern and management in Ibadan, Nigeria
Aralola Adepeju Olusanya (2018)
10.1016/j.oraloncology.2017.09.015
40-year incidence trends for oropharyngeal squamous cell carcinoma in the United States.
Nosayaba Osazuwa-Peters (2017)
10.1016/j.urolonc.2019.04.023
Contemporary analysis of the effect of marital status on survival of prostate cancer patients across all stages: A population-based study.
S. Knipper (2019)
10.1002/cncr.32617
Adverse respiratory outcomes among head and neck cancer survivors in the Utah Cancer Survivors Study.
Daisuke Kawakita (2019)
10.17352/2455-1759.000117
Respiratory system pathologies in patients who underwent total laryngectomy due to larynx cancer
Hakan Çelikhisar (2020)
10.1111/odi.12904
Risk factors for competing non-cancer mortality after definitive treatment for advanced-stage head and neck cancer.
Yong Han Kim (2018)
10.1016/j.jgo.2018.03.016
Managing older patients with head and neck cancer: The non-surgical curative approach.
Muhammad Shahid Iqbal (2018)
10.1371/journal.pone.0223154
Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study
Charbél Talani (2019)
10.1007/s10555-017-9690-0
Alcohol and head and neck cancer
Daisuke Kawakita (2017)
Complications, quality of life and outcome after free flap surgery for cancer of the head and neck
Sanna Lahtinen (2019)
10.17037/PUBS.04649756
Valuing Follow-up Programs In Head and Neck Cancer
M. Meregaglia (2018)
10.1002/ijc.31638
miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression.
Shih-Yuan Peng (2018)
10.1186/s12885-018-4970-9
Long-term mortality among women with epithelial ovarian cancer: a population-based study in British Columbia, Canada
Nimisha Arora (2018)
10.1002/lary.27807
Long-term Survival in Head and Neck Cancer: Impact of Site, Stage, Smoking, and Human Papillomavirus Status.
Eugenie Du (2019)
10.1016/j.ejca.2018.01.082
The use of intensive radiological assessments in routine surveillance after treatment for head and neck cancer: An economic evaluation.
M. Meregaglia (2018)
10.1001/jamaoncol.2017.4596
Restaging Abdominopelvic Computed Tomography Before Surgery After Preoperative Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer
Hyo Jung Park (2018)
10.1111/ecc.13022
What's Love Got to do with it? Marital status and survival of head and neck cancer.
Nosayaba Osazuwa-Peters (2019)
10.1016/j.oraloncology.2017.05.019
Survival after refusal of surgical treatment for locally advanced laryngeal cancer.
Sean T Massa (2017)
10.18632/oncotarget.18021
Single-cell genomic analysis of head and neck squamous cell carcinoma.
Andres Stucky (2017)
10.4103/jofs.jofs_2_19
Candidate Genes for Suicide Risk in Head and Neck Squamous Cell Carcinoma Patients
Anusa Arunachalam Mohandoss (2019)
10.1002/hed.25352
Early (90‐day) mortality after radical radiotherapy for head and neck squamous cell carcinoma: A population‐based analysis
Sarah Nicole Hamilton (2018)
10.3389/fonc.2019.01175
STAT3 Promotes Invasion and Aerobic Glycolysis of Human Oral Squamous Cell Carcinoma via Inhibiting FoxO1
Min Zheng (2019)
10.1016/j.oraloncology.2019.104442
Radiation induced hypothyroidism - Why is early intervention necessary?
Kshitij Aggarwal (2019)
10.25259/jgoh-13-2018
Is suicide a significant contributor to mortality in head and neck cancer - A surveillance, epidemiology, and end results database study
Rooban Thavarajah (2019)
10.1002/cncr.31109
Depressive symptoms predict head and neck cancer survival: Examining plausible behavioral and biological pathways
Lauren A Zimmaro (2018)
10.1002/cncr.32652
Short-term mortality risks among patients with oropharynx cancer by human papillomavirus status.
Zoe H Fullerton (2020)
10.1002/lary.27467
Radiation and Second Primary Thyroid Cancer Following Index Head and Neck Cancer.
Katherine M. Polednik (2019)
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